ES2492538T3 - Derivados aminoamida de seis miembros como inhibidores de la angiogénesis - Google Patents

Derivados aminoamida de seis miembros como inhibidores de la angiogénesis Download PDF

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ES2492538T3
ES2492538T3 ES04754512.4T ES04754512T ES2492538T3 ES 2492538 T3 ES2492538 T3 ES 2492538T3 ES 04754512 T ES04754512 T ES 04754512T ES 2492538 T3 ES2492538 T3 ES 2492538T3
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heterocyclyl
lower alkyl
cycloalkenyl
cycloalkyl
aryl
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Guoqing Paul Chen
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Pyridine Compounds (AREA)
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Abstract

Un derivado aminoamida de seis miembros de fórmula (I) donde X es O o S; Y es N(R4)-; Z1, Z2, Z3 y Z4 son independientemente CR5 o N; A es un enlace directo, B es seleccionado entre un enlace directo, alquilenilo inferior, alquenlenilo inferior, -O-, -N(R4)-, -C(O)N(R4)-, -OC(O)N(R4)-, -N(R4)C(O)-, -N(R4)C(O)-, -N(R4)C(O)N(R4)-, -C(O)-, -S(O)-, -S(O)2-, -S(O)N(R4)-, -S(O)2N(R4)-, -N(R4)S(O)-, N(R4)S(O)2-, -N(R4)S(O)N(R4)- y N(R4)S(O)2N(R4)-; R1 es fenilo; Cy es seleccionado entre cicloalquilo, cicloalquenilo y heterociclilo; R2 es seleccionado entre halógeno-alquilo inferior, alquilo inferior, alquenilo inferior, alquinilo inferior, donde inferior significa que están presentes de 1 a 6 átomos de carbono, C0-C6 ciano, C0-C6 hidroxi, C0-C6 alcoxi, C0-C6 alcoxialcoxilo, C0-C6 amino, C0-C6 alcoxiamino, C0-C6 carboxi, C0-C6 carboxialquilo, C0-C6 carbonilamino, C0-C6 carbonilalquilo, C0-C6 oxicarbonilalquilo, C0-C6 oxicarbonilamino, C0-C6 aminocarbonilalquilo, C0-C6 aminocarboniloxialquilo, C0-C6 aminocarbonilamino, C0-C6 aminosulfonilalquilo, C0-C6 cicloalquilo, C0-C6 cicloalquenilo, C0-C6 arilo, C0-C6 oxiarilo, C0-C6 alcoxiarilo, C0-C6 aminoarilo, C0-C6 aminoalquilarilo, C0-C6 heterociclilo, C0-C6 oxiheterociclilo, C0-C6 alcoxiheterociclilo, C0-C6 aminoheterociclilo y C0-C6 aminoalquilheterociclilo; donde cualquiera de los grupos C1-C6 y grupos amino anteriores puede estar eventualmente sin substituir, monosubstituido o posiblemente disubstituido por alquilo inferior; R1 y R2 se combinan entre sí como un espiroanillo G fusionado que comprende C, N, O o S, donde el anillo G es seleccionado entre cicloalquilo, cicloalquenilo, arilo y heterociclilo, que pueden estar saturados o parcialmente saturados y sin substituir o mono- o polisubstituidos; V W W' es CH2; n es un número entero de 0 a 6; R3 es un heterociclilo o un arilo; R4 es H o un alquilo inferior; R5 es H, halógeno o alquilo inferior; o un N-óxido o un posible tautómero del mismo; o una sal farmacéuticamente aceptable del mismo.

Description

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Claims (1)

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ES04754512.4T 2003-06-16 2004-06-04 Derivados aminoamida de seis miembros como inhibidores de la angiogénesis Expired - Lifetime ES2492538T3 (es)

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US47893703P 2003-06-16 2003-06-16
US478937P 2003-06-16
US10/859,733 US7129252B2 (en) 2003-06-16 2004-06-02 Six membered amino-amide derivatives an angiogenisis inhibitors
US859733 2004-06-02
PCT/US2004/017915 WO2005000232A2 (en) 2003-06-16 2004-06-04 Six membered amino-amide derivatives as angiogenesis inhibitors

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ES2492538T3 true ES2492538T3 (es) 2014-09-09

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US (1) US7129252B2 (es)
EP (1) EP1633712B1 (es)
JP (1) JP5046643B2 (es)
KR (1) KR101159034B1 (es)
CA (1) CA2568608C (es)
DK (1) DK1633712T3 (es)
ES (1) ES2492538T3 (es)
PL (1) PL1633712T3 (es)
PT (1) PT1633712E (es)
SI (1) SI1633712T1 (es)
WO (1) WO2005000232A2 (es)

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CN105622498A (zh) * 2014-10-28 2016-06-01 华东理工常熟研究院有限公司 硫酸阿帕替尼的新晶型
CN105541708A (zh) * 2014-10-28 2016-05-04 华东理工常熟研究院有限公司 硫酸阿帕替尼的新晶型
CN105622499A (zh) * 2014-10-28 2016-06-01 华东理工常熟研究院有限公司 硫酸阿帕替尼的新晶型
TWI771344B (zh) 2016-12-01 2022-07-21 大陸商江蘇恆瑞醫藥股份有限公司 一種ｖｅｇｆｒ抑制劑與ｐａｒｐ抑制劑聯合在製備治療胃癌的藥物中的用途
GB201709456D0 (en) * 2017-06-14 2017-07-26 Ucb Biopharma Sprl Therapeutic agents
USD841829S1 (en) 2017-08-15 2019-02-26 Phoebe Evans Massage device
MX2020005659A (es) 2017-12-06 2020-08-20 Jiangsu Hengrui Medicine Co Uso de un inhibidor de parp en el tratamiento del cancer de ovario o cancer de mama resistente a la quimioterapia.
KR20200105825A (ko) 2017-12-29 2020-09-09 지앙수 헨그루이 메디슨 컴퍼니 리미티드 삼중 음성 유방암의 치료를 위한 ｐｄ－１ 항체 및 아파티닙의 조합 치료의 용도
CN108409647B (zh) * 2018-03-14 2020-03-24 盐城师范学院 一种阿帕替尼的制备方法
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KR101159034B1 (ko) 2012-06-21
US20040259916A1 (en) 2004-12-23
CA2568608C (en) 2012-01-24
SI1633712T1 (sl) 2014-11-28
CA2568608A1 (en) 2005-01-06
EP1633712B1 (en) 2014-06-25
JP2007526879A (ja) 2007-09-20
EP1633712A2 (en) 2006-03-15
PL1633712T3 (pl) 2014-12-31
EP1633712A4 (en) 2009-12-23
WO2005000232A3 (en) 2005-04-28
KR20070025900A (ko) 2007-03-08
US7129252B2 (en) 2006-10-31
JP5046643B2 (ja) 2012-10-10
DK1633712T3 (da) 2014-08-11
PT1633712E (pt) 2014-08-04
WO2005000232A2 (en) 2005-01-06

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