ES2484417T3 - Perfil de expresión génica como marcador de la receptividad endometrial - Google Patents

Perfil de expresión génica como marcador de la receptividad endometrial Download PDF

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Publication number
ES2484417T3
ES2484417T3 ES09800092.0T ES09800092T ES2484417T3 ES 2484417 T3 ES2484417 T3 ES 2484417T3 ES 09800092 T ES09800092 T ES 09800092T ES 2484417 T3 ES2484417 T3 ES 2484417T3
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Prior art keywords
gene expression
expression profile
endometrial receptivity
marker
receptivity
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ES09800092.0T
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English (en)
Inventor
Carlos SIMÓN VALLES
José Antonio HORCAJADAS ALMANSA
Patricia Díaz Gimeno
Antonio PELLICER MARTÍNEZ
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Equipo IVI Investigacion SL
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Equipo IVI Investigacion SL
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La presente invención se refiere a la determinación de la receptividad del endometrio humano a partir de un perfil de expresión génica. Más concretamente, consiste en la elaboración de un microarray de expresión específico de receptividad endometrial (Endometrial Receptivity Array o ERA) que permita evaluar el estado receptivo de un endometrio humano, así como valorar dicho estado con fines diagnósticos y terapéuticos.

Description

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Claims (1)

  1. imagen1
ES09800092.0T 2008-07-22 2009-07-22 Perfil de expresión génica como marcador de la receptividad endometrial Active ES2484417T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
WOPCT/ES2008/000513 2008-07-22
PCT/ES2008/000513 WO2010010201A1 (es) 2008-07-22 2008-07-22 Perfil de expresion genetica como marcador de la receptividad endometrial
PCT/ES2009/000386 WO2010010213A1 (es) 2008-07-22 2009-07-22 Perfil de expresión génica como marcador de la receptividad endometrial

Publications (1)

Publication Number Publication Date
ES2484417T3 true ES2484417T3 (es) 2014-08-11

Family

ID=41570044

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09800092.0T Active ES2484417T3 (es) 2008-07-22 2009-07-22 Perfil de expresión génica como marcador de la receptividad endometrial

Country Status (7)

Country Link
US (1) US10081840B2 (es)
EP (1) EP2333107B1 (es)
CA (1) CA2732849C (es)
DK (1) DK2333107T3 (es)
ES (1) ES2484417T3 (es)
PL (1) PL2333107T3 (es)
WO (2) WO2010010201A1 (es)

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AU2012220540B2 (en) 2011-02-23 2016-11-10 The Board Of Trustees Of The Leland Stanford Junior University Methods of detecting aneuploidy in human embryos
EP2687851A1 (en) 2012-07-20 2014-01-22 Matricelab Innove Method for increasing implantation success in assisted fertilization
CA2900741C (en) 2013-02-01 2022-01-18 Progyny, Inc. Abnormal syngamy phenotypes observed with time lapse imaging for early identification of embryos with lower developmental potential
EP3158057B1 (en) 2014-06-17 2019-04-17 Igenomix S.L. Stem cell therapy in endometrial pathologies
PL3037101T3 (pl) 2014-12-22 2019-06-28 Ferring B.V. Terapia antagonistą receptora oksytocyny w fazie lutealnej w celu implantacji i uzyskania ciąży u kobiet poddawanych technikom wspomaganego rozrodu
US10918327B2 (en) 2017-02-02 2021-02-16 Coopersurgical, Inc. Compositions and methods for determining receptivity of an endometrium for embryonic implantation
EP3569718A1 (en) * 2018-05-16 2019-11-20 Integrated Genetic Lab Services SLU Kit and method for determining the receptivity status of an endometrium
CN110042156B (zh) * 2019-04-22 2021-12-28 苏州亿康医学检验有限公司 一种判断子宫内膜容受性的方法及其应用
US20220196670A1 (en) 2019-05-17 2022-06-23 Tervisetehnoloogiate Arenduskeskus As Endometrial receptivity determination
CN111778326B (zh) * 2020-07-14 2021-10-22 和卓生物科技（上海）有限公司 用于子宫内膜容受性评估的基因标志物组合及其应用
CN114517232A (zh) * 2022-03-15 2022-05-20 苏州亿康医学检验有限公司 无创方式判断子宫内膜容受性的方法、模型和标志物
EP4311862A1 (en) 2022-07-29 2024-01-31 Ivi Rma Global, Sl. Methods for detection of embryo implantation failure of endometrial origen
GB202216420D0 (en) 2022-11-04 2022-12-21 Univ Warwick Biomarkers of pregnancy loss

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US6979533B2 (en) 1992-06-12 2005-12-27 The Trustees Of The University Of Pennsylvania Determination of endometrial receptivity toward embryo implantation
CA2203718A1 (en) 1997-04-25 1998-10-25 University Of British Columbia Cadherin-11 as an indicator of viable pregnancy
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GB0201284D0 (en) 2002-01-21 2002-03-06 Isis Innovation Screening methods for contraceptive and fertility agents
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US20040005612A1 (en) * 2002-05-14 2004-01-08 Giudice Linda C. Endometrial genes in endometrial disorders
EP1525215B1 (de) 2002-08-02 2006-09-06 Schering Aktiengesellschaft Progesteronrezeptormodulatoren mit erhöhter antigonadotroper aktivität für die weibliche fertilitätskontrolle und hormonersatztherapie
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US8673850B2 (en) 2008-05-30 2014-03-18 Institut De Recherches Cliniques De Montreal PCSK9 inhibitors and methods of use thereof
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EP2768976B1 (en) 2011-10-21 2018-01-10 Institut National de la Santé et de la Recherche Médicale (INSERM) Methods for assessing endometrial receptivity of a patient after controlled ovarian hyperstimulation
KR20140106550A (ko) 2011-11-30 2014-09-03 에이전시 포 사이언스, 테크놀로지 앤드 리서치 생물학적 모니터링을 위한 ｇｍ1 갱글리오사이드와 아넥신 ⅴ 마이크로입자 폴리펩타이드 비율
CN104412107B (zh) 2012-06-27 2018-06-08 弗·哈夫曼-拉罗切有限公司 用sFlt-1/PlGF或内皮糖蛋白/PlGF比值来排除先兆子痫在某时期内发病的手段和方法
CA2943284A1 (en) 2014-03-21 2015-11-05 Igenomix S.L. Early detection of preeclampsia
EP3158057B1 (en) 2014-06-17 2019-04-17 Igenomix S.L. Stem cell therapy in endometrial pathologies

Also Published As

Publication number Publication date
EP2333107A4 (en) 2012-03-14
EP2333107B1 (en) 2014-04-23
US20120040849A1 (en) 2012-02-16
CA2732849C (en) 2022-06-21
WO2010010213A1 (es) 2010-01-28
WO2010010201A1 (es) 2010-01-28
DK2333107T3 (da) 2014-07-21
PL2333107T3 (pl) 2014-11-28
EP2333107A1 (en) 2011-06-15
CA2732849A1 (en) 2010-01-28
US10081840B2 (en) 2018-09-25

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