BRPI1008936B8 - método in vitro para detectar pré-disposição para ou diagnóstico e/ou prognóstico de fibrose hepática ou cirrose ocorrendo em um indivíduo humano - Google Patents

método in vitro para detectar pré-disposição para ou diagnóstico e/ou prognóstico de fibrose hepática ou cirrose ocorrendo em um indivíduo humano

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Publication number
BRPI1008936B8
BRPI1008936B8 BRPI1008936A BRPI1008936A BRPI1008936B8 BR PI1008936 B8 BRPI1008936 B8 BR PI1008936B8 BR PI1008936 A BRPI1008936 A BR PI1008936A BR PI1008936 A BRPI1008936 A BR PI1008936A BR PI1008936 B8 BRPI1008936 B8 BR PI1008936B8
Authority
BR
Brazil
Prior art keywords
prognosis
diagnosis
vitro method
fibrosis
predisposition
Prior art date
Application number
BRPI1008936A
Other languages
English (en)
Inventor
Dessein Alain
Chevillard Christophe
Arnaud Violaine
Original Assignee
Inst Nat Sante Rech Med
Univ De La Mediterranee
Univ Aix Marseille
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Nat Sante Rech Med, Univ De La Mediterranee, Univ Aix Marseille filed Critical Inst Nat Sante Rech Med
Publication of BRPI1008936A2 publication Critical patent/BRPI1008936A2/pt
Publication of BRPI1008936B1 publication Critical patent/BRPI1008936B1/pt
Publication of BRPI1008936B8 publication Critical patent/BRPI1008936B8/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

método in vitro para detectar pré-disposição, diagnóstico e / ou prognóstico de fibrose e método de seleção de um composto terapêutico. a presente invenção revela a identificação de um locus do gene de suceptibilidade á fribose, o locus do gene ctgf,que pode ser usado para detectar predisposto a, dignóstico e prognóstico de fibrose, bem como para o rastreamento de medicamentos terapeuticamente ativos. a invenção reside, em uma amostra de indivíduo de presença de uma alteração no locus do gene ctgf, a presença da dita alteração sendo indicativa da presença ou predisposto á fibrose.
BRPI1008936A 2009-02-19 2010-02-18 método in vitro para detectar pré-disposição para ou diagnóstico e/ou prognóstico de fibrose hepática ou cirrose ocorrendo em um indivíduo humano BRPI1008936B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09305159A EP2221387A1 (en) 2009-02-19 2009-02-19 Fibrosis susceptibility gene and uses thereof
EP093051597 2009-02-19
PCT/EP2010/052048 WO2010094740A1 (en) 2009-02-19 2010-02-18 Fibrosis susceptibility gene and uses thereof

Publications (3)

Publication Number Publication Date
BRPI1008936A2 BRPI1008936A2 (pt) 2016-10-11
BRPI1008936B1 BRPI1008936B1 (pt) 2021-04-06
BRPI1008936B8 true BRPI1008936B8 (pt) 2021-07-27

Family

ID=40568438

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1008936A BRPI1008936B8 (pt) 2009-02-19 2010-02-18 método in vitro para detectar pré-disposição para ou diagnóstico e/ou prognóstico de fibrose hepática ou cirrose ocorrendo em um indivíduo humano

Country Status (8)

Country Link
US (2) US9297044B2 (pt)
EP (2) EP2221387A1 (pt)
JP (2) JP5837825B2 (pt)
KR (1) KR101748679B1 (pt)
CN (2) CN102325904B (pt)
BR (1) BRPI1008936B8 (pt)
CA (1) CA2752802C (pt)
WO (1) WO2010094740A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012085217A1 (en) * 2010-12-22 2012-06-28 Universite De La Mediterranee (Aix-Marseille Ii) A diagnostic method for dementias
US10150989B2 (en) 2011-08-05 2018-12-11 Universite D'aix Marseille Fibrosis susceptibility IL22RA2 gene and uses thereof
ES2422874B1 (es) * 2012-03-12 2014-07-15 Universidad Autnoma De Madrid Método in vitro de pronóstico de fibrosis hepática grave
CN110719958B (zh) * 2017-04-06 2023-07-18 康博国际有限公司 构建核酸文库的方法和试剂盒
EP3425056A1 (en) * 2017-07-07 2019-01-09 Genepred Biotechnologies Method for prognosing fibrosis progression
EP3864175A1 (en) 2018-10-11 2021-08-18 Genepred Biotechnologies Method for detecting fibrosis especially keloid
CN111073884A (zh) * 2020-02-14 2020-04-28 昆明理工大学 提高非编码区域距离＜50bp的SNP中具有功能效应的SNP位点检测准确率的方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5770209A (en) * 1991-08-30 1998-06-23 University Of South Florida Acceleration of wound healing using connective tissue growth factor
EP0730663B1 (en) 1993-10-26 2003-09-24 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
US20030092019A1 (en) * 2001-01-09 2003-05-15 Millennium Pharmaceuticals, Inc. Methods and compositions for diagnosing and treating neuropsychiatric disorders such as schizophrenia
JP4226471B2 (ja) * 2001-09-18 2009-02-18 ファイブローゲン、インコーポレーテッド 結合組織増殖因子の分析方法
US7405274B2 (en) * 2003-06-04 2008-07-29 Fibrogen, Inc. Connective tissue growth factor antibodies
GB0326780D0 (en) 2003-11-18 2003-12-24 Imp College Innovations Ltd Biological materials and uses thereof
AU2007328206B2 (en) * 2006-12-04 2013-08-01 Promedior, Inc. Conjoint therapy for treating fibrotic diseases
CA2797782A1 (en) 2010-05-04 2011-11-10 Universite D'aix-Marseille Antiviral treatment susceptibility gene and uses thereof
US10150989B2 (en) 2011-08-05 2018-12-11 Universite D'aix Marseille Fibrosis susceptibility IL22RA2 gene and uses thereof

Also Published As

Publication number Publication date
EP2398911B1 (en) 2017-10-18
CA2752802A1 (en) 2010-08-26
EP2221387A1 (en) 2010-08-25
US20120135403A1 (en) 2012-05-31
JP2016047045A (ja) 2016-04-07
CN105907843A (zh) 2016-08-31
CA2752802C (en) 2018-04-03
CN102325904A (zh) 2012-01-18
JP2012524520A (ja) 2012-10-18
KR20120004971A (ko) 2012-01-13
US9297044B2 (en) 2016-03-29
US20160230232A1 (en) 2016-08-11
EP2398911A1 (en) 2011-12-28
BRPI1008936B1 (pt) 2021-04-06
CN102325904B (zh) 2016-03-30
WO2010094740A1 (en) 2010-08-26
BRPI1008936A2 (pt) 2016-10-11
JP5837825B2 (ja) 2015-12-24
KR101748679B1 (ko) 2017-07-03

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Owner name: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA REC

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B16C Correction of notification of the grant [chapter 16.3 patent gazette]

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