ES2474176T3 - Composiciones y métodos para inhibir la expresión de genes pro-apopt�ticos - Google Patents
Composiciones y métodos para inhibir la expresión de genes pro-apopt�ticos Download PDFInfo
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- ES2474176T3 ES2474176T3 ES08763631.2T ES08763631T ES2474176T3 ES 2474176 T3 ES2474176 T3 ES 2474176T3 ES 08763631 T ES08763631 T ES 08763631T ES 2474176 T3 ES2474176 T3 ES 2474176T3
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2320/00—Applications; Uses
- C12N2320/10—Applications; Uses in screening processes
- C12N2320/11—Applications; Uses in screening processes for the determination of target sites, i.e. of active nucleic acids
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Applications Claiming Priority (5)
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| US96432507P | 2007-08-10 | 2007-08-10 | |
| US964325P | 2007-08-10 | ||
| PCT/IL2008/000874 WO2009001359A2 (en) | 2007-06-27 | 2008-06-26 | Compositions and methods for inhibiting expression of pro-apoptotic genes |
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| ES2474176T3 true ES2474176T3 (es) | 2014-07-08 |
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| ES08763631.2T Active ES2474176T3 (es) | 2007-06-27 | 2008-06-26 | Composiciones y métodos para inhibir la expresión de genes pro-apopt�ticos |
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| HR (1) | HRP20140522T1 (pl) |
| PL (1) | PL2170403T3 (pl) |
| PT (1) | PT2170403E (pl) |
| SI (1) | SI2170403T1 (pl) |
| WO (1) | WO2009001359A2 (pl) |
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| US9719094B2 (en) | 2002-11-14 | 2017-08-01 | Thermo Fisher Scientific Inc. | RNAi targeting SEC61G |
| US9879266B2 (en) | 2002-11-14 | 2018-01-30 | Thermo Fisher Scientific Inc. | Methods and compositions for selecting siRNA of improved functionality |
| US9719092B2 (en) | 2002-11-14 | 2017-08-01 | Thermo Fisher Scientific Inc. | RNAi targeting CNTD2 |
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| RU2584609C2 (ru) | 2004-09-28 | 2016-05-20 | Кварк Фармасьютикалс, Инк. | Олигорибонуклеотиды и способы их применения для лечения острой почечной недостаточности |
| US7825099B2 (en) | 2006-01-20 | 2010-11-02 | Quark Pharmaceuticals, Inc. | Treatment or prevention of oto-pathologies by inhibition of pro-apoptotic genes |
| US8362229B2 (en) | 2006-02-08 | 2013-01-29 | Quark Pharmaceuticals, Inc. | Tandem siRNAS |
| PT2170403E (pt) | 2007-06-27 | 2014-07-17 | Quark Pharmaceuticals Inc | Composições e métodos para inibição da expressão de genes pró-apoptóticos |
| US20110288155A1 (en) | 2008-12-18 | 2011-11-24 | Elena Feinstein | Sirna compounds and methods of use thereof |
| JP2012529430A (ja) | 2009-06-08 | 2012-11-22 | クォーク ファーマシューティカルズ インコーポレーティッド | 慢性腎臓疾患の治療方法 |
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| AU2010324658A1 (en) | 2009-11-26 | 2012-05-03 | Quark Pharmaceuticals, Inc. | siRNA compounds comprising terminal substitutions |
| EP2862929B1 (en) | 2009-12-09 | 2017-09-06 | Quark Pharmaceuticals, Inc. | Compositions and methods for treating diseases, disorders or injury of the CNS |
| AU2011338682B2 (en) | 2010-12-06 | 2017-04-27 | Quark Pharmaceuticals, Inc. | Double stranded oligonucleotide compounds comprising threose modifications |
| US11058708B2 (en) * | 2011-09-19 | 2021-07-13 | Sweyshen Chen | RNA interference of galectin-3 expression and methods of use thereof |
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| EP2170403B1 (en) | 2014-04-16 |
| SI2170403T1 (sl) | 2014-07-31 |
| WO2009001359A3 (en) | 2010-03-04 |
| DK2170403T3 (da) | 2014-06-16 |
| PL2170403T3 (pl) | 2014-09-30 |
| EP2170403A2 (en) | 2010-04-07 |
| WO2009001359A2 (en) | 2008-12-31 |
| HRP20140522T1 (hr) | 2014-08-15 |
| US8785408B2 (en) | 2014-07-22 |
| PT2170403E (pt) | 2014-07-17 |
| EP2170403A4 (en) | 2011-06-15 |
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