ES2465572T3 - Compuestos de 6-aminoisoquinolinas y métodos para preparar los mismos - Google Patents
Compuestos de 6-aminoisoquinolinas y métodos para preparar los mismos Download PDFInfo
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- ES2465572T3 ES2465572T3 ES12007092.5T ES12007092T ES2465572T3 ES 2465572 T3 ES2465572 T3 ES 2465572T3 ES 12007092 T ES12007092 T ES 12007092T ES 2465572 T3 ES2465572 T3 ES 2465572T3
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- isoquinolin
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Classifications
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- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
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| ES12007093.3T Active ES2535716T3 (es) | 2008-01-17 | 2009-01-15 | Compuestos de 6-aminoisoquinolina y métodos para preparar los mismos |
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| ES2580108T3 (es) | 2005-07-11 | 2016-08-19 | Aerie Pharmaceuticals, Inc | Compuestos de isoquinolina |
| EP2068878B1 (en) | 2006-09-20 | 2019-04-10 | Aerie Pharmaceuticals, Inc. | Rho kinase inhibitors |
| US8455513B2 (en) | 2007-01-10 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-aminoisoquinoline compounds |
| US8455514B2 (en) * | 2008-01-17 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-and 7-amino isoquinoline compounds and methods for making and using the same |
| US8450344B2 (en) | 2008-07-25 | 2013-05-28 | Aerie Pharmaceuticals, Inc. | Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds |
| ES2834451T3 (es) * | 2009-05-01 | 2021-06-17 | Aerie Pharmaceuticals Inc | Inhibidores de mecanismo doble para el tratamiento de enfermedades |
| EA022646B1 (ru) * | 2010-12-22 | 2016-02-29 | Д. Вестерн Терапьютикс Инститьют, Инк. | Замещенное производное изохинолина |
| PT3811943T (pt) | 2013-03-15 | 2023-03-15 | Aerie Pharmaceuticals Inc | Composto para uso no tratamento de distúrbios oculares |
| US10465188B2 (en) | 2014-08-22 | 2019-11-05 | Auckland Uniservices Limited | Channel modulators |
| US9643927B1 (en) | 2015-11-17 | 2017-05-09 | Aerie Pharmaceuticals, Inc. | Process for the preparation of kinase inhibitors and intermediates thereof |
| US10550087B2 (en) | 2015-11-17 | 2020-02-04 | Aerie Pharmaceuticals, Inc. | Process for the preparation of kinase inhibitors and intermediates thereof |
| WO2017184343A1 (en) | 2016-04-20 | 2017-10-26 | Hubbell Incorporated | Electrical clamps |
| US11389441B2 (en) | 2016-08-31 | 2022-07-19 | Aerie Pharmaceuticals, Inc. | Ophthalmic compositions |
| JP7108597B2 (ja) | 2017-02-28 | 2022-07-28 | 興和株式会社 | 医薬品 |
| KR20190119055A (ko) | 2017-02-28 | 2019-10-21 | 코와 가부시키가이샤 | 의약 제제 |
| JP7108596B2 (ja) | 2017-02-28 | 2022-07-28 | 興和株式会社 | 医薬 |
| CN110494138B (zh) | 2017-03-27 | 2023-07-11 | 兴和株式会社 | 医药制剂 |
| JP2020515583A (ja) | 2017-03-31 | 2020-05-28 | アエリエ ファーマシューティカルズ インコーポレイテッド | アリールシクロプロピル−アミノ−イソキノリニルアミド化合物 |
| US10696638B2 (en) | 2017-12-26 | 2020-06-30 | Industrial Technology Research Institute | Compounds for inhibiting AGC kinase and pharmaceutical compositions comprising the same |
| AU2019337703B2 (en) | 2018-09-14 | 2023-02-02 | Aerie Pharmaceuticals, Inc. | Aryl cyclopropyl-amino-isoquinolinyl amide compounds |
| US20220119350A1 (en) * | 2019-02-22 | 2022-04-21 | Glaukos Corporation | Compounds for the treatment of ocular disease |
Family Cites Families (92)
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2008
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| US8871757B2 (en) | 2014-10-28 |
| EP2546239A1 (en) | 2013-01-16 |
| JP2011510014A (ja) | 2011-03-31 |
| EP2546238A1 (en) | 2013-01-16 |
| EP2546237A1 (en) | 2013-01-16 |
| WO2009091898A2 (en) | 2009-07-23 |
| WO2009091898A3 (en) | 2009-11-05 |
| US20090186917A1 (en) | 2009-07-23 |
| AU2009206075B2 (en) | 2014-06-12 |
| CA2923336A1 (en) | 2009-07-23 |
| US8455514B2 (en) | 2013-06-04 |
| EP2252589A2 (en) | 2010-11-24 |
| US20100144713A1 (en) | 2010-06-10 |
| AU2009206075A1 (en) | 2009-07-23 |
| ES2397928T3 (es) | 2013-03-12 |
| CA2712443A1 (en) | 2009-07-23 |
| JP5551613B2 (ja) | 2014-07-16 |
| EP2546238B1 (en) | 2014-04-02 |
| EP2546239B1 (en) | 2015-04-08 |
| ES2535716T3 (es) | 2015-05-14 |
| EP2252589B1 (en) | 2012-11-21 |
| CA2712443C (en) | 2016-05-03 |
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