ES2464868T3 - Nuevo producto intermedio quiral, procedimiento para su preparación y su uso en la fabricación de tolterodina, fesoterodina o de su metabolito activo - Google Patents

Nuevo producto intermedio quiral, procedimiento para su preparación y su uso en la fabricación de tolterodina, fesoterodina o de su metabolito activo Download PDF

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Publication number
ES2464868T3
ES2464868T3 ES07725866.3T ES07725866T ES2464868T3 ES 2464868 T3 ES2464868 T3 ES 2464868T3 ES 07725866 T ES07725866 T ES 07725866T ES 2464868 T3 ES2464868 T3 ES 2464868T3
Authority
ES
Spain
Prior art keywords
formula
compound
reducing agent
process according
fesoterodine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES07725866.3T
Other languages
English (en)
Spanish (es)
Inventor
Claus Meese
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCB Pharma GmbH
Original Assignee
UCB Pharma GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UCB Pharma GmbH filed Critical UCB Pharma GmbH
Application granted granted Critical
Publication of ES2464868T3 publication Critical patent/ES2464868T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/20—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 hydrogenated in the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/12—Formation of amino and carboxyl groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
ES07725866.3T 2006-06-12 2007-06-06 Nuevo producto intermedio quiral, procedimiento para su preparación y su uso en la fabricación de tolterodina, fesoterodina o de su metabolito activo Active ES2464868T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06012052 2006-06-12
EP06012052 2006-06-12
PCT/EP2007/005008 WO2007144097A1 (en) 2006-06-12 2007-06-06 New chiral intermediate, process for producing the same and its use in the manufacture of tolterodine, fesoterodine, or the active metabolite thereof

Publications (1)

Publication Number Publication Date
ES2464868T3 true ES2464868T3 (es) 2014-06-04

Family

ID=36764900

Family Applications (1)

Application Number Title Priority Date Filing Date
ES07725866.3T Active ES2464868T3 (es) 2006-06-12 2007-06-06 Nuevo producto intermedio quiral, procedimiento para su preparación y su uso en la fabricación de tolterodina, fesoterodina o de su metabolito activo

Country Status (16)

Country Link
US (3) US7982058B2 (de)
EP (1) EP2027103B1 (de)
JP (1) JP5220737B2 (de)
KR (2) KR20140010198A (de)
CN (1) CN101466695B (de)
AU (1) AU2007260267B2 (de)
BR (1) BRPI0712842A2 (de)
CA (1) CA2647990C (de)
DK (1) DK2027103T3 (de)
EA (1) EA018376B1 (de)
ES (1) ES2464868T3 (de)
MX (1) MX2008015973A (de)
PL (1) PL2027103T3 (de)
PT (1) PT2027103E (de)
SI (1) SI2027103T1 (de)
WO (1) WO2007144097A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2027103T3 (da) * 2006-06-12 2014-04-22 Ucb Pharma Gmbh Nyt chiralt mellemprodukt, fremgangsmåde til fremstilling deraf og dets anvendelse i fremstillingen af tolterodin, fesoterodin, eller den aktive metabolit deraf
EP2364966A1 (de) 2010-03-09 2011-09-14 LEK Pharmaceuticals d.d. Verfahren zur Herstellung von 3-(2-hydroxy-5-substituierten phenyl)-3-phenylpropylaminen, Zwischenprodukte zur Herstellung von Hydroxytolterodin
WO2011158257A1 (en) 2010-06-18 2011-12-22 Panacea Biotec Ltd Preparation process of fesoterodine and intermediates
IT1403094B1 (it) * 2010-12-09 2013-10-04 Dipharma Francis Srl Procedimento per la preparazione di fesoterodina o un suo sale
ITMI20121232A1 (it) 2012-07-16 2014-01-17 Cambrex Profarmaco Milano Srl Procedimento per la preparazione di 2-(3-n,n-diisopropilamino-1-fenilpropil)-4-idrossimetil-fenolo e suoi derivati
CN103193747A (zh) * 2013-04-18 2013-07-10 中国药科大学 一种富马酸弗斯特罗定中间体的制备方法
KR20230042887A (ko) 2021-09-23 2023-03-30 주식회사 두비컴퓨팅 서버 랙

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8800207D0 (sv) 1988-01-22 1988-01-22 Kabivitrum Ab Nya aminer, deras anvendning och framstellning
SE9203318D0 (sv) 1992-11-06 1992-11-06 Kabi Pharmacia Ab Novel 3,3-diphenylpropylamines, their use and preparation
SE9701144D0 (sv) 1997-03-27 1997-03-27 Pharmacia & Upjohn Ab Novel compounds, their use and preparation
EP0957073A1 (de) * 1998-05-12 1999-11-17 Schwarz Pharma Ag 3,3-Diphenylpropylaminderivate
DE19955190A1 (de) * 1999-11-16 2001-06-21 Sanol Arznei Schwarz Gmbh Stabile Salze neuartiger Derivate von 3,3-Diphenylpropylaminen
SE9904850D0 (sv) 1999-12-30 1999-12-30 Pharmacia & Upjohn Ab Novel process and intermediates
DE10028443C1 (de) * 2000-06-14 2002-05-29 Sanol Arznei Schwarz Gmbh Verfahren zur Herstellung von 3,3-Diarylpropylaminen, (R,S)- und (R)-4-Phenyl-2-chromanon-6-carbonsäure sowie (R)-4-Phenyl-2-chromanon-carbonsäure-cinchonidinsalz und deren Verwendung zur Herstellung eines rechtsdrehenden Hydroxybenzylalkohols und von pharmazeutischen Zusammensetzungen
CN101454304B (zh) * 2006-05-24 2012-05-30 辉瑞有限公司 用于制造苯并吡喃-2-醇衍生物的方法
DK2027103T3 (da) * 2006-06-12 2014-04-22 Ucb Pharma Gmbh Nyt chiralt mellemprodukt, fremgangsmåde til fremstilling deraf og dets anvendelse i fremstillingen af tolterodin, fesoterodin, eller den aktive metabolit deraf

Also Published As

Publication number Publication date
AU2007260267B2 (en) 2012-09-06
US20140228434A1 (en) 2014-08-14
BRPI0712842A2 (pt) 2012-07-24
CN101466695A (zh) 2009-06-24
DK2027103T3 (da) 2014-04-22
EP2027103A1 (de) 2009-02-25
KR20090016451A (ko) 2009-02-13
CA2647990A1 (en) 2007-12-21
US20110245338A1 (en) 2011-10-06
US9309215B2 (en) 2016-04-12
CN101466695B (zh) 2012-06-27
EA018376B1 (ru) 2013-07-30
KR101488740B1 (ko) 2015-02-03
JP5220737B2 (ja) 2013-06-26
PT2027103E (pt) 2014-05-02
CA2647990C (en) 2014-02-04
MX2008015973A (es) 2009-01-12
WO2007144097A1 (en) 2007-12-21
US8742140B2 (en) 2014-06-03
KR20140010198A (ko) 2014-01-23
JP2009539901A (ja) 2009-11-19
SI2027103T1 (sl) 2014-07-31
PL2027103T3 (pl) 2014-12-31
AU2007260267A1 (en) 2007-12-21
EA200900008A1 (ru) 2009-06-30
EP2027103B1 (de) 2014-02-26
US20090192224A1 (en) 2009-07-30
US7982058B2 (en) 2011-07-19

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