ES2459318T3 - Antagonistas no esteroideos del receptor mineralocorticoide derivados de la 6H-dibenzo[B,E]oxepina - Google Patents

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Publication number

ES2459318T3

ES2459318T3 ES12185389.9T ES12185389T ES2459318T3 ES 2459318 T3 ES2459318 T3 ES 2459318T3 ES 12185389 T ES12185389 T ES 12185389T ES 2459318 T3 ES2459318 T3 ES 2459318T3

Authority

ES

Spain

Prior art keywords

mol

formula

compound

bromo

oxepin

Prior art date

2007-12-19

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

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• 229940083712 aldosterone antagonist Drugs 0.000 title description 4
• 239000002394 mineralocorticoid antagonist Substances 0.000 title description 3
• FPIWJQQRYHEICX-UHFFFAOYSA-N 6,11-dihydrobenzo[c][1]benzoxepine Chemical compound C1OC2=CC=CC=C2CC2=CC=CC=C12 FPIWJQQRYHEICX-UHFFFAOYSA-N 0.000 title description 2
• 150000001875 compounds Chemical class 0.000 claims abstract description 194
• 150000003839 salts Chemical class 0.000 claims abstract description 37
• 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 22
• 239000001257 hydrogen Substances 0.000 claims abstract description 22
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 15
• 229910052731 fluorine Inorganic materials 0.000 claims abstract description 12
• 239000011737 fluorine Substances 0.000 claims abstract description 12
• PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims abstract description 10
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 7
• 206010007559 Cardiac failure congestive Diseases 0.000 claims description 8
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• 206010019280 Heart failures Diseases 0.000 claims description 8
• 206010020772 Hypertension Diseases 0.000 claims description 8
• 239000004202 carbamide Substances 0.000 claims description 8
• 208000020832 chronic kidney disease Diseases 0.000 claims description 8
• 208000033679 diabetic kidney disease Diseases 0.000 claims description 8
• 201000009395 primary hyperaldosteronism Diseases 0.000 claims description 8
• 206010020571 Hyperaldosteronism Diseases 0.000 claims description 7
• 239000008194 pharmaceutical composition Substances 0.000 claims description 7
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• 206010003119 arrhythmia Diseases 0.000 claims description 5
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• 239000012267 brine Substances 0.000 description 21
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• 238000012360 testing method Methods 0.000 description 21
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• 239000005909 Kieselgur Substances 0.000 description 20
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• 239000000543 intermediate Substances 0.000 description 19
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• 238000009739 binding Methods 0.000 description 17
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• ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 16
• JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 16
• 238000002330 electrospray ionisation mass spectrometry Methods 0.000 description 16
• SCVFZCLFOSHCOH-UHFFFAOYSA-M potassium acetate Chemical compound [K+].CC([O-])=O SCVFZCLFOSHCOH-UHFFFAOYSA-M 0.000 description 16
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• 229910000030 sodium bicarbonate Inorganic materials 0.000 description 16
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