ES2458291T3 - Derivados de amidas aromáticas como inhibidores de la cinasa C-KIT - Google Patents
Derivados de amidas aromáticas como inhibidores de la cinasa C-KIT Download PDFInfo
- Publication number
- ES2458291T3 ES2458291T3 ES11161399.8T ES11161399T ES2458291T3 ES 2458291 T3 ES2458291 T3 ES 2458291T3 ES 11161399 T ES11161399 T ES 11161399T ES 2458291 T3 ES2458291 T3 ES 2458291T3
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- Prior art keywords
- phenyl
- mmol
- cyano
- cyclohex
- amide
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- 150000008430 aromatic amides Chemical class 0.000 title description 2
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 352
- -1 imidazolyl isoxazolyl Chemical group 0.000 claims abstract description 230
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 57
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract description 57
- 150000003839 salts Chemical class 0.000 claims abstract description 44
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 39
- 239000012453 solvate Substances 0.000 claims abstract description 38
- 125000002541 furyl group Chemical group 0.000 claims abstract description 32
- 229910052799 carbon Inorganic materials 0.000 claims abstract description 26
- 125000004076 pyridyl group Chemical group 0.000 claims abstract description 25
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract description 24
- 238000006467 substitution reaction Methods 0.000 claims abstract description 23
- 125000002883 imidazolyl group Chemical group 0.000 claims abstract description 22
- 125000000449 nitro group Chemical class [O-][N+](*)=O 0.000 claims abstract description 22
- 125000005942 tetrahydropyridyl group Chemical group 0.000 claims abstract description 22
- 125000002971 oxazolyl group Chemical group 0.000 claims abstract description 21
- 125000000168 pyrrolyl group Chemical group 0.000 claims abstract description 21
- 125000001376 1,2,4-triazolyl group Chemical group N1N=C(N=C1)* 0.000 claims abstract description 20
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims abstract description 20
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- 238000001819 mass spectrum Methods 0.000 description 93
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Classifications
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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Landscapes
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- Orthopedic Medicine & Surgery (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| US79347106P | 2006-04-20 | 2006-04-20 | |
| US793471P | 2006-04-20 |
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| ES2458291T3 true ES2458291T3 (es) | 2014-04-30 |
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| ES07760927T Active ES2389678T3 (es) | 2006-04-20 | 2007-04-19 | Un inhibidor de la quinasa C-Kit para su uso en el tratamiento de tumores del estroma gastrointestinal o mastocitosis |
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| EP (2) | EP2015748B1 (https=) |
| JP (1) | JP5595727B2 (https=) |
| KR (1) | KR101448052B1 (https=) |
| CN (2) | CN101610768B (https=) |
| AU (1) | AU2007240400B2 (https=) |
| BR (1) | BRPI0710542B8 (https=) |
| CA (1) | CA2649755C (https=) |
| CO (1) | CO6382175A2 (https=) |
| CR (1) | CR10450A (https=) |
| EA (1) | EA016611B1 (https=) |
| EC (1) | ECSP088842A (https=) |
| ES (2) | ES2458291T3 (https=) |
| GT (1) | GT200800225A (https=) |
| IL (1) | IL194846A (https=) |
| MX (1) | MX2008013528A (https=) |
| MY (1) | MY147226A (https=) |
| NO (1) | NO342001B1 (https=) |
| NZ (1) | NZ572200A (https=) |
| SG (1) | SG171592A1 (https=) |
| WO (1) | WO2007124369A2 (https=) |
| ZA (1) | ZA200809874B (https=) |
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| CN103717591B (zh) | 2011-07-27 | 2016-08-24 | Ab科学有限公司 | 作为选择性蛋白激酶(c-kit)抑制剂的噁唑和噻唑衍生物 |
| CN104370880A (zh) * | 2013-01-24 | 2015-02-25 | 韩冰 | 一类蛋白酶抑制剂及其制备方法和用途 |
| JP6330040B2 (ja) | 2013-07-22 | 2018-05-23 | イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ | １−（ピペラジン−１−イル）−２−（［１，２，４］トリアゾール−１−イル）−エタノン誘導体 |
| AR103399A1 (es) | 2015-01-15 | 2017-05-10 | Actelion Pharmaceuticals Ltd | Derivados de (r)-2-metil-piperazina como moduladores del receptor cxcr3 |
| PL3245203T3 (pl) | 2015-01-15 | 2019-05-31 | Idorsia Pharmaceuticals Ltd | Pochodne hydroksyalkilopiperazyny jako modulatory receptora cxcr3 |
| CN105753770A (zh) * | 2015-05-27 | 2016-07-13 | 上海佐林生物医药有限公司 | 蛋白激酶抑制剂制备方法、中间体、制备方法及应用 |
| EA202192575A1 (ru) | 2019-03-21 | 2022-01-14 | Онксео | Соединения dbait в сочетании с ингибиторами киназ для лечения рака |
| CN114761006A (zh) | 2019-11-08 | 2022-07-15 | Inserm(法国国家健康医学研究院) | 对激酶抑制剂产生耐药性的癌症的治疗方法 |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
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| PT627940E (pt) | 1992-03-05 | 2003-07-31 | Univ Texas | Utilizacao de imunoconjugados para o diagnostico e/ou terapia de tumores vascularizados |
| US6342219B1 (en) | 1999-04-28 | 2002-01-29 | Board Of Regents, The University Of Texas System | Antibody compositions for selectively inhibiting VEGF |
| DE19962924A1 (de) | 1999-12-24 | 2001-07-05 | Bayer Ag | Substituierte Oxazolidinone und ihre Verwendung |
| ITMI992711A1 (it) * | 1999-12-27 | 2001-06-27 | Novartis Ag | Composti organici |
| MXPA05001277A (es) * | 2002-08-02 | 2005-10-06 | Ab Science | 2-(3-aminoaril)amino-4-aril-tiazoles y su uso como inhibidores del c-kit. |
| EP1684750B1 (en) * | 2003-10-23 | 2010-04-28 | AB Science | 2-aminoaryloxazole compounds as tyrosine kinase inhibitors |
| GB0326601D0 (en) * | 2003-11-14 | 2003-12-17 | Novartis Ag | Organic compounds |
| CA2554925A1 (en) * | 2004-01-30 | 2005-08-11 | Ab Science | 2-(3-substituted-aryl)amino-4-aryl-thiazoles as tyrosine kinase inhibitors |
| PT1807077T (pt) * | 2004-10-22 | 2017-01-06 | Janssen Pharmaceutica Nv | Inibidores de quinase c-fms |
| US20060281788A1 (en) | 2005-06-10 | 2006-12-14 | Baumann Christian A | Synergistic modulation of flt3 kinase using a flt3 inhibitor and a farnesyl transferase inhibitor |
| AU2006304897B2 (en) * | 2005-10-18 | 2012-07-12 | Janssen Pharmaceutica N.V. | Method of inhibiting FLT3 kinase |
| WO2007124319A1 (en) * | 2006-04-20 | 2007-11-01 | Janssen Pharmaceutica N.V. | Inhibitors of c-fms kinase |
| JP2009534380A (ja) * | 2006-04-20 | 2009-09-24 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ｃ−ｆｍｓキナーゼインヒビター |
| PL2021335T3 (pl) * | 2006-04-20 | 2011-10-31 | Janssen Pharmaceutica Nv | Związki heterocykliczne jako inhibitory kinazy C-FMS |
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- 2007-04-19 EP EP11161399.8A patent/EP2397138B1/en active Active
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