ES2443170T3 - Elemento de abrasión excéntrico para dispositivos de aterectomía rotacionales de alta velocidad - Google Patents
Elemento de abrasión excéntrico para dispositivos de aterectomía rotacionales de alta velocidad Download PDFInfo
- Publication number
- ES2443170T3 ES2443170T3 ES09755607.0T ES09755607T ES2443170T3 ES 2443170 T3 ES2443170 T3 ES 2443170T3 ES 09755607 T ES09755607 T ES 09755607T ES 2443170 T3 ES2443170 T3 ES 2443170T3
- Authority
- ES
- Spain
- Prior art keywords
- rotational
- polishing element
- center
- mass
- drive shaft
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000005299 abrasion Methods 0.000 title description 4
- 238000005498 polishing Methods 0.000 claims abstract description 99
- 210000001367 artery Anatomy 0.000 claims abstract description 23
- 208000031481 Pathologic Constriction Diseases 0.000 claims abstract description 19
- 230000036262 stenosis Effects 0.000 claims abstract description 15
- 208000037804 stenosis Diseases 0.000 claims abstract description 15
- 239000000463 material Substances 0.000 claims description 20
- 238000005520 cutting process Methods 0.000 claims description 8
- 239000011796 hollow space material Substances 0.000 claims description 8
- 210000001519 tissue Anatomy 0.000 description 38
- 238000000034 method Methods 0.000 description 17
- 230000002966 stenotic effect Effects 0.000 description 17
- 239000002245 particle Substances 0.000 description 12
- 239000007787 solid Substances 0.000 description 8
- 238000000605 extraction Methods 0.000 description 7
- 239000003082 abrasive agent Substances 0.000 description 6
- 238000012986 modification Methods 0.000 description 6
- 230000004048 modification Effects 0.000 description 6
- 208000037260 Atherosclerotic Plaque Diseases 0.000 description 5
- 241000220223 Fragaria Species 0.000 description 5
- 235000016623 Fragaria vesca Nutrition 0.000 description 5
- 235000011363 Fragaria x ananassa Nutrition 0.000 description 5
- 238000009826 distribution Methods 0.000 description 5
- 230000003902 lesion Effects 0.000 description 5
- 238000002399 angioplasty Methods 0.000 description 4
- 239000011248 coating agent Substances 0.000 description 4
- 238000000576 coating method Methods 0.000 description 4
- 238000010276 construction Methods 0.000 description 4
- 229910003460 diamond Inorganic materials 0.000 description 4
- 239000010432 diamond Substances 0.000 description 4
- 238000003801 milling Methods 0.000 description 4
- 238000001816 cooling Methods 0.000 description 3
- 238000013461 design Methods 0.000 description 3
- 230000037361 pathway Effects 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 238000002679 ablation Methods 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 229910052796 boron Inorganic materials 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
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- 208000014674 injury Diseases 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000000284 resting effect Effects 0.000 description 2
- 231100000241 scar Toxicity 0.000 description 2
- 230000008733 trauma Effects 0.000 description 2
- 238000004804 winding Methods 0.000 description 2
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 229910052580 B4C Inorganic materials 0.000 description 1
- 101100004286 Caenorhabditis elegans best-5 gene Proteins 0.000 description 1
- 208000005189 Embolism Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 208000012868 Overgrowth Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- NRTOMJZYCJJWKI-UHFFFAOYSA-N Titanium nitride Chemical compound [Ti]#N NRTOMJZYCJJWKI-UHFFFAOYSA-N 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000003190 augmentative effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- INAHAJYZKVIDIZ-UHFFFAOYSA-N boron carbide Chemical compound B12B3B4C32B41 INAHAJYZKVIDIZ-UHFFFAOYSA-N 0.000 description 1
- 229910010293 ceramic material Inorganic materials 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 210000004351 coronary vessel Anatomy 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
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- 230000004927 fusion Effects 0.000 description 1
- 230000001050 lubricating effect Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 208000037803 restenosis Diseases 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
- 239000010937 tungsten Substances 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- UONOETXJSWQNOL-UHFFFAOYSA-N tungsten carbide Chemical compound [W+]#[C-] UONOETXJSWQNOL-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/32—Surgical cutting instruments
- A61B17/3205—Excision instruments
- A61B17/3207—Atherectomy devices working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions
- A61B17/320758—Atherectomy devices working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions with a rotating cutting instrument, e.g. motor driven
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
- A61B2017/22038—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for with a guide wire
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/32—Surgical cutting instruments
- A61B2017/320004—Surgical cutting instruments abrasive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/32—Surgical cutting instruments
- A61B17/3205—Excision instruments
- A61B17/3207—Atherectomy devices working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions
- A61B17/320758—Atherectomy devices working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions with a rotating cutting instrument, e.g. motor driven
- A61B2017/320766—Atherectomy devices working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions with a rotating cutting instrument, e.g. motor driven eccentric
Landscapes
- Health & Medical Sciences (AREA)
- Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medical Informatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Surgical Instruments (AREA)
- Finish Polishing, Edge Sharpening, And Grinding By Specific Grinding Devices (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US130083 | 1980-03-18 | ||
| US12/130,083 US8702735B2 (en) | 2008-05-30 | 2008-05-30 | Eccentric abrading element for high-speed rotational atherectomy devices |
| PCT/US2009/043409 WO2009146245A1 (en) | 2008-05-30 | 2009-05-11 | Eccentric abrading element for high-speed rotational atherectomy devices |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2443170T3 true ES2443170T3 (es) | 2014-02-18 |
Family
ID=41377522
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES09755607.0T Active ES2443170T3 (es) | 2008-05-30 | 2009-05-11 | Elemento de abrasión excéntrico para dispositivos de aterectomía rotacionales de alta velocidad |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8702735B2 (enExample) |
| EP (1) | EP2280656B1 (enExample) |
| JP (1) | JP5337872B2 (enExample) |
| CN (1) | CN102046099B (enExample) |
| AU (1) | AU2009251464B2 (enExample) |
| CA (1) | CA2719053C (enExample) |
| ES (1) | ES2443170T3 (enExample) |
| WO (1) | WO2009146245A1 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9289230B2 (en) | 2012-09-17 | 2016-03-22 | Cardiovascular Systems, Inc. | Rotational atherectomy device with a system of eccentric abrading heads |
| US9750525B2 (en) * | 2013-03-14 | 2017-09-05 | Cardiovascular Systems, Inc. | Devices, systems and methods for an oscillating crown drive for rotational atherectomy |
| US9936970B2 (en) | 2013-03-14 | 2018-04-10 | Cardiovascular Systems, Inc. | Devices, systems and methods for an oscillating crown drive for rotational atherectomy |
| US20150080795A1 (en) | 2013-07-26 | 2015-03-19 | Cardiovascular Systems, Inc. | Devices, systems and methods for performing atherectomy and subsequent balloon angioplasty without exchanging devices |
| USD766433S1 (en) | 2013-11-04 | 2016-09-13 | Cardiovascular Systems, Inc. | Eccentric crown |
| US10271869B2 (en) | 2014-03-01 | 2019-04-30 | Rex Medical, L.P. | Atherectomy device |
| CN106456208B (zh) | 2014-03-12 | 2020-04-03 | 波士顿科学有限公司 | 注入润滑斑块切除导管 |
| US10405878B2 (en) | 2014-07-25 | 2019-09-10 | Boston Scientific Scimed, Inc. | Rotatable medical device |
| WO2016022284A1 (en) * | 2014-08-07 | 2016-02-11 | Cardiovascular Systems, Inc. | Devices, systems and methods for an oscillating crown drive for rotational atherectomy |
| WO2016089847A1 (en) | 2014-12-04 | 2016-06-09 | Boston Scientific Scimed, Inc. | Rotatable medical device |
| US10433868B2 (en) | 2014-12-27 | 2019-10-08 | Rex Medical, L.P. | Artherectomy device |
| US10463389B2 (en) | 2014-12-27 | 2019-11-05 | Rex Medical, L.P. | Atherectomy device |
| JP6781703B2 (ja) * | 2014-12-30 | 2020-11-04 | バード・ペリフェラル・バスキュラー・インコーポレーテッド | 回転式アテローム切除術用システムのための研磨要素 |
| US10299820B2 (en) | 2015-02-20 | 2019-05-28 | Cardiovascular Systems, Inc. | Methods and systems for disrupting calcified walls of biological conduits and calcified lesions therein |
| US11253292B2 (en) | 2015-09-13 | 2022-02-22 | Rex Medical, L.P. | Atherectomy device |
| US10307175B2 (en) | 2016-03-26 | 2019-06-04 | Rex Medical, L.P | Atherectomy device |
| US10980555B2 (en) * | 2016-07-12 | 2021-04-20 | Cardioprolific Inc. | Methods and devices for clots and tissue removal |
| US11051842B2 (en) | 2017-05-03 | 2021-07-06 | Medtronic Vascular, Inc. | Tissue-removing catheter with guidewire isolation liner |
| US11690645B2 (en) | 2017-05-03 | 2023-07-04 | Medtronic Vascular, Inc. | Tissue-removing catheter |
| CN118697424A (zh) | 2018-11-16 | 2024-09-27 | 美敦力瓦斯科尔勒公司 | 组织去除导管 |
| US11819236B2 (en) | 2019-05-17 | 2023-11-21 | Medtronic Vascular, Inc. | Tissue-removing catheter |
| JP7042861B2 (ja) * | 2020-03-23 | 2022-03-28 | バード・ペリフェラル・バスキュラー・インコーポレーテッド | 回転式アテローム切除術用システムのための研磨要素 |
| EP4236837A1 (en) * | 2020-10-30 | 2023-09-06 | Boston Scientific Scimed, Inc. | Atherectomy burrs with blood flow enhancements |
| CN112494111A (zh) * | 2020-12-10 | 2021-03-16 | 蚌埠冠硕医疗科技有限公司 | 用于动脉斑块的介入式旋磨装置 |
| CN114368161B (zh) * | 2021-11-25 | 2024-03-26 | 广州博鑫医疗技术有限公司 | 一种偏心旋磨组件的制造方法及偏心旋磨组件 |
| CN114559080A (zh) * | 2021-12-06 | 2022-05-31 | 周鸿博 | 发动机内部管路柔性清理铣刀工具 |
| CN115778498A (zh) * | 2022-08-05 | 2023-03-14 | 广州博鑫医疗技术有限公司 | 偏心旋磨头及其制造方法、驱动轴及介入式医疗设备 |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4445509A (en) * | 1982-02-04 | 1984-05-01 | Auth David C | Method and apparatus for removal of enclosed abnormal deposits |
| US5443443A (en) | 1984-05-14 | 1995-08-22 | Surgical Systems & Instruments, Inc. | Atherectomy system |
| US5041082A (en) | 1986-06-16 | 1991-08-20 | Samuel Shiber | Mechanical atherectomy system and method |
| US5007896A (en) | 1988-12-19 | 1991-04-16 | Surgical Systems & Instruments, Inc. | Rotary-catheter for atherectomy |
| US4646736A (en) | 1984-09-10 | 1987-03-03 | E. R. Squibb & Sons, Inc. | Transluminal thrombectomy apparatus |
| CA1293663C (en) | 1986-01-06 | 1991-12-31 | David Christopher Auth | Transluminal microdissection device |
| US4728319A (en) | 1986-03-20 | 1988-03-01 | Helmut Masch | Intravascular catheter |
| US5053044A (en) * | 1988-01-11 | 1991-10-01 | Devices For Vascular Intervention, Inc. | Catheter and method for making intravascular incisions |
| US4883460A (en) | 1988-04-25 | 1989-11-28 | Zanetti Paul H | Technique for removing deposits from body vessels |
| US4935025A (en) | 1989-01-30 | 1990-06-19 | Bundy Mark A | Transluminal lysing device |
| US5431673A (en) | 1989-02-17 | 1995-07-11 | American Biomed, Inc. | Distal atherectomy catheter |
| US5078723A (en) | 1989-05-08 | 1992-01-07 | Medtronic, Inc. | Atherectomy device |
| US5226909A (en) | 1989-09-12 | 1993-07-13 | Devices For Vascular Intervention, Inc. | Atherectomy device having helical blade and blade guide |
| US5116352A (en) | 1989-10-06 | 1992-05-26 | Angiomed Ag | Apparatus for removing deposits from vessels |
| US5026384A (en) | 1989-11-07 | 1991-06-25 | Interventional Technologies, Inc. | Atherectomy systems and methods |
| US5030201A (en) | 1989-11-24 | 1991-07-09 | Aubrey Palestrant | Expandable atherectomy catheter device |
| US5158564A (en) | 1990-02-14 | 1992-10-27 | Angiomed Ag | Atherectomy apparatus |
| US5267955A (en) | 1990-05-10 | 1993-12-07 | Lake Region Manufacturing Company, Inc. | Atherectomy device |
| US5395311A (en) | 1990-05-14 | 1995-03-07 | Andrews; Winston A. | Atherectomy catheter |
| US5217474A (en) | 1991-07-15 | 1993-06-08 | Zacca Nadim M | Expandable tip atherectomy method and apparatus |
| FR2685190B1 (fr) | 1991-12-23 | 1998-08-07 | Jean Marie Lefebvre | Dispositif rotatif d'atherectomie ou de thrombectomie a developpement transversal centrifuge. |
| US5224945A (en) | 1992-01-13 | 1993-07-06 | Interventional Technologies, Inc. | Compressible/expandable atherectomy cutter |
| US5192291A (en) | 1992-01-13 | 1993-03-09 | Interventional Technologies, Inc. | Rotationally expandable atherectomy cutter assembly |
| CA2107741C (en) | 1992-10-07 | 2000-06-27 | Peter T. Keith | Ablation devices and methods of use |
| US5643297A (en) | 1992-11-09 | 1997-07-01 | Endovascular Instruments, Inc. | Intra-artery obstruction clearing apparatus and methods |
| US5490859A (en) | 1992-11-13 | 1996-02-13 | Scimed Life Systems, Inc. | Expandable intravascular occlusion material removal devices and methods of use |
| US5501694A (en) | 1992-11-13 | 1996-03-26 | Scimed Life Systems, Inc. | Expandable intravascular occlusion material removal devices and methods of use |
| US5836868A (en) | 1992-11-13 | 1998-11-17 | Scimed Life Systems, Inc. | Expandable intravascular occlusion material removal devices and methods of use |
| US5540707A (en) | 1992-11-13 | 1996-07-30 | Scimed Life Systems, Inc. | Expandable intravascular occlusion material removal devices and methods of use |
| US5372602A (en) | 1992-11-30 | 1994-12-13 | Device For Vascular Intervention, Inc. | Method of removing plaque using catheter cutter with torque control |
| CA2155187A1 (en) * | 1993-02-02 | 1994-08-18 | Leonid Shturman | Abrasive drive shaft device for rotational atherectomy |
| US5584843A (en) | 1994-12-20 | 1996-12-17 | Boston Scientific Corporation | Shaped wire multi-burr rotational ablation device |
| CN2238619Y (zh) * | 1995-03-29 | 1996-10-30 | 崔连群 | 旋切旋磨导管驱动器 |
| US5556408A (en) | 1995-04-27 | 1996-09-17 | Interventional Technologies Inc. | Expandable and compressible atherectomy cutter |
| US5681336A (en) | 1995-09-07 | 1997-10-28 | Boston Scientific Corporation | Therapeutic device for treating vien graft lesions |
| US6183487B1 (en) | 1997-03-06 | 2001-02-06 | Scimed Life Systems, Inc. | Ablation device for reducing damage to vessels and/or in-vivo stents |
| US6015420A (en) | 1997-03-06 | 2000-01-18 | Scimed Life Systems, Inc. | Atherectomy device for reducing damage to vessels and/or in-vivo stents |
| US5843103A (en) | 1997-03-06 | 1998-12-01 | Scimed Life Systems, Inc. | Shaped wire rotational atherectomy device |
| US6132444A (en) * | 1997-08-14 | 2000-10-17 | Shturman Cardiology Systems, Inc. | Eccentric drive shaft for atherectomy device and method for manufacture |
| US6494890B1 (en) | 1997-08-14 | 2002-12-17 | Shturman Cardiology Systems, Inc. | Eccentric rotational atherectomy device |
| GB9717580D0 (en) | 1997-08-19 | 1997-10-22 | Curry Paul | Device for opening blocked tubes |
| US6183432B1 (en) * | 1997-11-13 | 2001-02-06 | Lumend, Inc. | Guidewire and catheter with rotating and reciprocating symmetrical or asymmetrical distal tip |
| US6146395A (en) | 1998-03-05 | 2000-11-14 | Scimed Life Systems, Inc. | Ablation burr |
| US6001112A (en) | 1998-04-10 | 1999-12-14 | Endicor Medical, Inc. | Rotational atherectomy device |
| US6579299B2 (en) | 2000-01-31 | 2003-06-17 | Rex Medical, L.P. | Atherectomy device |
| GB2426456B (en) | 2005-05-26 | 2010-10-27 | Leonid Shturman | Rotational device with eccentric abrasive element and method of use |
| GB0613982D0 (en) | 2006-07-13 | 2006-08-23 | Shturman Leonid | Rotational atherectomy device with fluid inflatable support elements and two torque transmitting coils |
-
2008
- 2008-05-30 US US12/130,083 patent/US8702735B2/en active Active
-
2009
- 2009-05-11 EP EP09755607.0A patent/EP2280656B1/en active Active
- 2009-05-11 CA CA2719053A patent/CA2719053C/en not_active Expired - Fee Related
- 2009-05-11 JP JP2011511689A patent/JP5337872B2/ja not_active Expired - Fee Related
- 2009-05-11 CN CN200980119223.7A patent/CN102046099B/zh active Active
- 2009-05-11 WO PCT/US2009/043409 patent/WO2009146245A1/en not_active Ceased
- 2009-05-11 AU AU2009251464A patent/AU2009251464B2/en not_active Ceased
- 2009-05-11 ES ES09755607.0T patent/ES2443170T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| HK1148656A1 (en) | 2011-09-16 |
| CA2719053C (en) | 2016-07-05 |
| CA2719053A1 (en) | 2009-12-03 |
| JP5337872B2 (ja) | 2013-11-06 |
| US20090299392A1 (en) | 2009-12-03 |
| AU2009251464A1 (en) | 2009-12-03 |
| JP2011521712A (ja) | 2011-07-28 |
| EP2280656B1 (en) | 2013-10-30 |
| EP2280656A4 (en) | 2012-10-31 |
| EP2280656A1 (en) | 2011-02-09 |
| CN102046099A (zh) | 2011-05-04 |
| US8702735B2 (en) | 2014-04-22 |
| WO2009146245A1 (en) | 2009-12-03 |
| CN102046099B (zh) | 2015-05-20 |
| AU2009251464B2 (en) | 2014-08-07 |
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