ES2422301T3 - Transferencia de gen mediada por vector lentiviral y usos de la misma - Google Patents
Transferencia de gen mediada por vector lentiviral y usos de la mismaInfo
- Publication number
- ES2422301T3 ES2422301T3 ES01985065T ES01985065T ES2422301T3 ES 2422301 T3 ES2422301 T3 ES 2422301T3 ES 01985065 T ES01985065 T ES 01985065T ES 01985065 T ES01985065 T ES 01985065T ES 2422301 T3 ES2422301 T3 ES 2422301T3
- Authority
- ES
- Spain
- Prior art keywords
- endostatin
- lentiviral vector
- domain
- interferon
- gene transfer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0075—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/521—Chemokines
- C07K14/522—Alpha-chemokines, e.g. NAP-2, ENA-78, GRO-alpha/MGSA/NAP-3, GRO-beta/MIP-2alpha, GRO-gamma/MIP-2beta, IP-10, GCP-2, MIG, PBSF, PF-4, KC
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
- C12N2740/13041—Use of virus, viral particle or viral elements as a vector
- C12N2740/13043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15041—Use of virus, viral particle or viral elements as a vector
- C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15041—Use of virus, viral particle or viral elements as a vector
- C12N2740/15045—Special targeting system for viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16041—Use of virus, viral particle or viral elements as a vector
- C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16041—Use of virus, viral particle or viral elements as a vector
- C12N2740/16045—Special targeting system for viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/42—Vector systems having a special element relevant for transcription being an intron or intervening sequence for splicing and/or stability of RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
- C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Physics & Mathematics (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Un vector lentiviral recombinante que comprende un primer gen terapéutico que reduce o inhibe la angiogénesisocular para uso en el tratamiento de degeneración macular relacionad con la edad en un individuo, en el que dichoprimer gen terapéutico está seleccionado del grupo que consiste en endostatina, angiostatina, endostatina XVIII,endostatina XV, el dominio de hemopexina de terminal C de la metaloproteinasa-2 matriz, el dominio kringle 5 deplasminógeno humano, la monoquina inducida por interferón-gamma (Mig), la proteína inducible por interferónalfa (IP10), FLT-1 soluble (receptor de tirosina quinasa 1 similar a fms), y el receptor de dominio de inserción dequinasa (KDR).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25670100P | 2000-12-19 | 2000-12-19 | |
PCT/US2001/049241 WO2002049677A1 (en) | 2000-12-19 | 2001-12-18 | Lentiviral vector-mediated gene transfer and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2422301T3 true ES2422301T3 (es) | 2013-09-10 |
Family
ID=22973247
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES01985065T Expired - Lifetime ES2422301T3 (es) | 2000-12-19 | 2001-12-18 | Transferencia de gen mediada por vector lentiviral y usos de la misma |
ES10177185T Expired - Lifetime ES2393717T3 (es) | 2000-12-19 | 2001-12-18 | Transferencia de gen mediada por vector lentiviral y usos de la misma |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES10177185T Expired - Lifetime ES2393717T3 (es) | 2000-12-19 | 2001-12-18 | Transferencia de gen mediada por vector lentiviral y usos de la misma |
Country Status (15)
Country | Link |
---|---|
US (1) | US20020114783A1 (es) |
EP (2) | EP2301583B1 (es) |
JP (2) | JP4280496B2 (es) |
KR (3) | KR20080080684A (es) |
CN (2) | CN100591359C (es) |
AU (2) | AU2002234053B2 (es) |
CA (1) | CA2432301C (es) |
DK (2) | DK1343532T3 (es) |
ES (2) | ES2422301T3 (es) |
IL (2) | IL156427A0 (es) |
NZ (1) | NZ526558A (es) |
PT (2) | PT1343532E (es) |
RU (1) | RU2288742C2 (es) |
WO (1) | WO2002049677A1 (es) |
ZA (1) | ZA200304664B (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100591359C (zh) * | 2000-12-19 | 2010-02-24 | 研究发展基金会 | 慢病毒载体介导的基因转移及其用途 |
US7122181B2 (en) * | 2000-12-19 | 2006-10-17 | Research Development Foundation | Lentiviral vector-mediated gene transfer and uses thereof |
EP1401480B1 (en) | 2001-02-22 | 2012-11-28 | Novartis AG | Viral vectors encoding endostatin in the treatment of ocular neovascularization |
US20060251621A1 (en) * | 2002-09-27 | 2006-11-09 | Campochiaro Peter A | Ocular gene therapy |
US7601341B2 (en) * | 2003-06-05 | 2009-10-13 | Research Development Foundation | Vascular endothelial growth factor fusion constructs used to inhibit osteoclastogenesis |
AU2004269233A1 (en) * | 2003-08-29 | 2005-03-10 | Kaneka Corporation | Method of constructing transgenic bird using lentivirus vector and transgenic bird obtained thereby |
EP1881849A2 (en) * | 2005-04-29 | 2008-01-30 | Research Development Foundation | Vascular targeting of ocular neovascularization |
WO2008044339A1 (fr) * | 2006-10-13 | 2008-04-17 | Aqumen Biopharmaceuticals K.K. | Agent thérapeutique/de prévention contenant un composé de statine, utilisé pour une maladie intraoculaire |
CN101870734B (zh) * | 2010-05-25 | 2012-06-20 | 北京大学 | 一种抑制新生血管生成的融合多肽及其编码基因与应用 |
RU2444734C1 (ru) * | 2010-11-03 | 2012-03-10 | ФГУ Ростовский НИИ акушерства и педиатрии Министерства по здравоохранению и социальному развитию РФ | Способ прогнозирования невынашивания беременности ранних сроков инфекционного генеза |
WO2015130783A1 (en) | 2014-02-25 | 2015-09-03 | Research Development Foundation | Sty peptides for inhibition of angiogenesis |
US11206977B2 (en) | 2014-11-09 | 2021-12-28 | The Trustees Of The University Of Pennyslvania | Vision test for determining retinal disease progression |
GB2547179A (en) * | 2015-10-26 | 2017-08-16 | Quethera Ltd | Genetic construct |
CN111398595A (zh) * | 2020-02-17 | 2020-07-10 | 天津医科大学眼科医院 | 一种血浆小细胞外囊泡中的蛋白质tnfaip8的应用和检测方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5969120A (en) * | 1993-09-03 | 1999-10-19 | Research Development Foundation | Mutants of the RB and P53 genes |
US5871723A (en) * | 1995-06-06 | 1999-02-16 | The Regent Of The University Of Michigan | CXC chemokines as regulators of angiogenesis |
US5686414A (en) * | 1995-11-14 | 1997-11-11 | Xoma Corporation | Methods of treating conditions associated with corneal transplantation |
IL126626A0 (en) * | 1996-05-03 | 1999-08-17 | Abbott Lab | Novel antiangiogenic peptides polynucleotides encoding same and methods for inhibiting angiogenesis |
US6004798A (en) * | 1997-05-14 | 1999-12-21 | University Of Southern California | Retroviral envelopes having modified hypervariable polyproline regions |
JPH1180024A (ja) * | 1997-09-12 | 1999-03-23 | Toagosei Co Ltd | 角膜血管新生阻害剤 |
CA2367375A1 (en) * | 1999-03-15 | 2000-09-21 | Chiron Corporation | Use of recombinant gene delivery vectors for treating or preventing diseases of the eye |
CN100591359C (zh) * | 2000-12-19 | 2010-02-24 | 研究发展基金会 | 慢病毒载体介导的基因转移及其用途 |
-
2001
- 2001-12-18 CN CN01822491A patent/CN100591359C/zh not_active Expired - Fee Related
- 2001-12-18 WO PCT/US2001/049241 patent/WO2002049677A1/en active IP Right Grant
- 2001-12-18 EP EP10177185A patent/EP2301583B1/en not_active Expired - Lifetime
- 2001-12-18 CA CA2432301A patent/CA2432301C/en not_active Expired - Lifetime
- 2001-12-18 IL IL15642701A patent/IL156427A0/xx unknown
- 2001-12-18 PT PT1985065T patent/PT1343532E/pt unknown
- 2001-12-18 AU AU2002234053A patent/AU2002234053B2/en not_active Ceased
- 2001-12-18 AU AU3405302A patent/AU3405302A/xx active Pending
- 2001-12-18 NZ NZ526558A patent/NZ526558A/en not_active IP Right Cessation
- 2001-12-18 DK DK01985065.0T patent/DK1343532T3/da active
- 2001-12-18 RU RU2003122214/14A patent/RU2288742C2/ru not_active IP Right Cessation
- 2001-12-18 KR KR1020087020793A patent/KR20080080684A/ko not_active Application Discontinuation
- 2001-12-18 CN CN200910266851XA patent/CN101732731B/zh not_active Expired - Fee Related
- 2001-12-18 KR KR1020097027248A patent/KR101026078B1/ko active IP Right Grant
- 2001-12-18 EP EP01985065.0A patent/EP1343532B1/en not_active Expired - Lifetime
- 2001-12-18 ES ES01985065T patent/ES2422301T3/es not_active Expired - Lifetime
- 2001-12-18 ES ES10177185T patent/ES2393717T3/es not_active Expired - Lifetime
- 2001-12-18 DK DK10177185.5T patent/DK2301583T3/da active
- 2001-12-18 PT PT101771855T patent/PT2301583E/pt unknown
- 2001-12-18 JP JP2002551014A patent/JP4280496B2/ja not_active Expired - Fee Related
- 2001-12-18 KR KR10-2003-7008168A patent/KR20030075152A/ko not_active Application Discontinuation
- 2001-12-19 US US10/025,264 patent/US20020114783A1/en not_active Abandoned
-
2003
- 2003-06-12 IL IL156427A patent/IL156427A/en active IP Right Grant
- 2003-06-17 ZA ZA200304664A patent/ZA200304664B/en unknown
-
2009
- 2009-01-28 JP JP2009016488A patent/JP2009137998A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
ES2393717T3 (es) | 2012-12-27 |
EP1343532A1 (en) | 2003-09-17 |
CN1487841A (zh) | 2004-04-07 |
DK1343532T3 (da) | 2013-07-29 |
US20020114783A1 (en) | 2002-08-22 |
KR20080080684A (ko) | 2008-09-04 |
EP2301583A1 (en) | 2011-03-30 |
EP1343532A4 (en) | 2006-03-15 |
AU3405302A (en) | 2002-07-01 |
AU2002234053B2 (en) | 2004-07-15 |
ZA200304664B (en) | 2007-02-28 |
RU2288742C2 (ru) | 2006-12-10 |
KR101026078B1 (ko) | 2011-03-31 |
JP4280496B2 (ja) | 2009-06-17 |
CA2432301C (en) | 2013-06-04 |
CA2432301A1 (en) | 2002-06-27 |
CN100591359C (zh) | 2010-02-24 |
KR20030075152A (ko) | 2003-09-22 |
DK2301583T3 (da) | 2012-12-10 |
CN101732731B (zh) | 2013-04-10 |
JP2009137998A (ja) | 2009-06-25 |
EP1343532B1 (en) | 2013-04-24 |
IL156427A0 (en) | 2004-01-04 |
WO2002049677A1 (en) | 2002-06-27 |
KR20100011994A (ko) | 2010-02-03 |
PT2301583E (pt) | 2012-12-06 |
JP2004520307A (ja) | 2004-07-08 |
NZ526558A (en) | 2004-06-25 |
CN101732731A (zh) | 2010-06-16 |
IL156427A (en) | 2011-06-30 |
EP2301583B1 (en) | 2012-08-22 |
PT1343532E (pt) | 2013-07-29 |
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