ATE330019T1 - Vektor zur gewebespezifischen replikation und expression - Google Patents
Vektor zur gewebespezifischen replikation und expressionInfo
- Publication number
- ATE330019T1 ATE330019T1 AT98962352T AT98962352T ATE330019T1 AT E330019 T1 ATE330019 T1 AT E330019T1 AT 98962352 T AT98962352 T AT 98962352T AT 98962352 T AT98962352 T AT 98962352T AT E330019 T1 ATE330019 T1 AT E330019T1
- Authority
- AT
- Austria
- Prior art keywords
- tissue
- vectors
- replication
- vector
- expression vectors
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/15—Vector systems having a special element relevant for transcription chimeric enhancer/promoter combination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/30—Vector systems having a special element relevant for transcription being an enhancer not forming part of the promoter region
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/32—Vector systems having a special element relevant for transcription being an silencer not forming part of the promoter region
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
- C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/974,391 US6638762B1 (en) | 1994-11-28 | 1997-11-19 | Tissue-vectors specific replication and gene expression |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE330019T1 true ATE330019T1 (de) | 2006-07-15 |
Family
ID=25521982
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT98962352T ATE330019T1 (de) | 1997-11-19 | 1998-11-17 | Vektor zur gewebespezifischen replikation und expression |
Country Status (10)
Country | Link |
---|---|
US (2) | US6638762B1 (de) |
EP (1) | EP1032696B1 (de) |
JP (1) | JP2002507382A (de) |
AT (1) | ATE330019T1 (de) |
AU (1) | AU1755299A (de) |
CA (1) | CA2310563A1 (de) |
DE (1) | DE69834936T2 (de) |
IL (1) | IL136104A0 (de) |
NZ (1) | NZ504367A (de) |
WO (1) | WO1999025860A1 (de) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6638762B1 (en) * | 1994-11-28 | 2003-10-28 | Genetic Therapy, Inc. | Tissue-vectors specific replication and gene expression |
US5998205A (en) * | 1994-11-28 | 1999-12-07 | Genetic Therapy, Inc. | Vectors for tissue-specific replication |
US20020068049A1 (en) * | 1998-09-10 | 2002-06-06 | Henderson Daniel R. | Tissue specific adenoviral vectors |
US6610839B1 (en) | 1997-08-14 | 2003-08-26 | Geron Corporation | Promoter for telomerase reverse transcriptase |
US7378244B2 (en) * | 1997-10-01 | 2008-05-27 | Geron Corporation | Telomerase promoters sequences for screening telomerase modulators |
US7780962B2 (en) * | 1997-10-09 | 2010-08-24 | Wellstat Biologics Corporation | Treatment of neoplasms with RNA viruses |
US20030044384A1 (en) * | 1997-10-09 | 2003-03-06 | Pro-Virus, Inc. | Treatment of neoplasms with viruses |
US6900049B2 (en) * | 1998-09-10 | 2005-05-31 | Cell Genesys, Inc. | Adenovirus vectors containing cell status-specific response elements and methods of use thereof |
US6495130B1 (en) | 1998-12-30 | 2002-12-17 | Calydon, Inc. | Target cell-specific adenoviral vectors containing E3 and methods of use thereof |
GB9906815D0 (en) | 1999-03-24 | 1999-05-19 | Isrec | Anti-neoplastic viral agents |
EP1390046A4 (de) * | 1999-04-15 | 2005-04-20 | Wellstat Biologics Corp | Behandlung von neoplasmen mit viren |
US20020115202A1 (en) * | 1999-08-13 | 2002-08-22 | Paul Hallenbeck | Adenoviral vectors including dna sequences encoding angiogenic inhibitors |
GB9924981D0 (en) * | 1999-10-21 | 1999-12-22 | Univ Manchester | Gene therapy |
US6692736B2 (en) | 2000-03-24 | 2004-02-17 | Cell Genesys, Inc. | Cell-specific adenovirus vectors comprising an internal ribosome entry site |
US6852528B2 (en) | 2000-03-24 | 2005-02-08 | Cell Genesys, Inc. | Human and mouse uroplakin II gene transcriptional regulatory elements |
US6911200B2 (en) * | 2000-03-24 | 2005-06-28 | Cell Genesys, Inc. | Methods of treating neoplasia with combination of target-cell specific adenovirus, chemotherapy and radiation |
US7048920B2 (en) | 2000-03-24 | 2006-05-23 | Cell Genesys, Inc. | Recombinant oncolytic adenovirus for human melanoma |
DE60136268D1 (de) * | 2000-03-24 | 2008-12-04 | Cell Genesys Inc | Interne ribosomenzugangsstelle-enthaltende zell-spezifische adenovirale vektoren |
AU4370401A (en) * | 2000-03-24 | 2001-10-08 | Cell Genesys Inc | Methods of treating neoplasia with combinations of target cell-specific adenovirus, chemotherapy and radiation |
US8071740B2 (en) * | 2000-11-17 | 2011-12-06 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis |
EP1327688A1 (de) * | 2002-01-14 | 2003-07-16 | Vereniging Voor Christelijk Wetenschappelijk Onderwijs | Adenoviren mit erhöhter Lysisfähigkeit |
US7364727B2 (en) * | 2002-07-22 | 2008-04-29 | Cell Genesys, Inc. | Metastatic colon cancer specific promoter and uses thereof |
WO2004042025A2 (en) | 2002-11-01 | 2004-05-21 | Cell Genesys, Inc. | Cell-specific adenovirus vector comprising ebv-specific promoter |
JP2007524380A (ja) * | 2003-04-02 | 2007-08-30 | ボード オブ リージェンツ ザ ユニバーティー オブ テキサス システム | 抗腫瘍効果をもつBik変異型 |
WO2004092396A2 (en) * | 2003-04-15 | 2004-10-28 | Novartis Ag | Flap endonuclease 1 (fen1) regulatory sequences and uses thereof |
US20070275915A1 (en) * | 2003-04-15 | 2007-11-29 | Cell Genesys, Inc. | Tmprss2 Regulatory Sequences and Uses Thereof |
US20050136035A1 (en) * | 2003-06-03 | 2005-06-23 | Derek Ko | Cell specific replication-competent viral vectors comprising a self processing peptide cleavage site |
WO2005017149A1 (en) * | 2003-06-03 | 2005-02-24 | Cell Genesys, Inc. | Compositions and methods for enhanced expression of recombinant polypeptides from a single vector using a peptide cleavage site |
ES2359473T3 (es) | 2003-07-21 | 2011-05-23 | Transgene S.A. | Citoquinas multifuncionales. |
US20050186178A1 (en) * | 2003-08-28 | 2005-08-25 | Ennist David L. | Oncolytic adenoviral vectors encoding GM-CSF |
US7482156B2 (en) * | 2003-10-15 | 2009-01-27 | Cell Genesys, Inc. | Hepatocellular carcinoma specific promoter and uses thereof |
US20050097066A1 (en) * | 2003-10-31 | 2005-05-05 | Pitney Bowes Incorporated | Method and system for a mailing machine to verify the integrity of printed postage |
US7473418B2 (en) | 2004-03-25 | 2009-01-06 | Cell Genesys, Inc. | Pan cancer oncolytic vectors and methods of use thereof |
JP2007535315A (ja) * | 2004-04-02 | 2007-12-06 | ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム | 癌特異的プロモーター |
NZ550430A (en) | 2004-04-27 | 2009-06-26 | Wellstat Biologics Corp | Cancer treatment using viruses and camptothecins |
WO2006020949A2 (en) * | 2004-08-12 | 2006-02-23 | Cedars-Sinai Medical Center | Combined gene therapy for the treatment of macroscopic gliomas |
US7935788B2 (en) * | 2004-10-04 | 2011-05-03 | National Research Council Of Canada | Reverse cumate repressor mutant |
WO2006037215A1 (en) * | 2004-10-04 | 2006-04-13 | National Research Council Of Canada | Expression system, components thereof and methods of use |
JPWO2006043354A1 (ja) * | 2004-10-20 | 2008-05-22 | 独立行政法人放射線医学総合研究所 | 組込型の低線量放射線誘導性ベクター |
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EP1910550A4 (de) | 2005-07-21 | 2009-11-04 | Abbott Lab | Expression mehrerer gene unter einschluss von sorf-konstrukten und verfahren mit polyproteinen, proproteinen und proteolyse |
US20090192101A1 (en) * | 2006-11-22 | 2009-07-30 | Mien-Chie Hung | Cancer-specific promoters |
EP2390340A3 (de) | 2007-01-30 | 2012-02-22 | Transgene SA | Papillomavirus E1 und E2-Polypeptiden mit reduziertem Identitätsanteil kodierender Vektor |
US8883493B2 (en) * | 2007-01-30 | 2014-11-11 | Cedars-Sinai Medical Center | Adenoviral vector comprising herpes simplex virus type 1 thymidine kinase and a transgene for increasing the expression of the transgene |
PL2382474T3 (pl) | 2009-01-20 | 2015-08-31 | Transgene Sa | Rozpuszczalny ICAM-1 jako biomarker do prognozowania odpowiedzi terapeutycznej |
KR20110138354A (ko) | 2009-03-24 | 2011-12-27 | 트랜스진 에스.에이. | 환자를 모니터링하기 위한 바이오마커 |
SG175060A1 (en) | 2009-04-17 | 2011-11-28 | Transgene Sa | Biomarker for monitoring patients |
HUE028240T2 (en) | 2009-07-10 | 2016-12-28 | Transgene Sa | Biomarker Patient Selection and Related Procedures |
CN102812040A (zh) * | 2009-10-30 | 2012-12-05 | 雅培制药有限公司 | Sorf构建体和多基因表达 |
WO2011074564A1 (ja) * | 2009-12-15 | 2011-06-23 | タカラバイオ株式会社 | アデノウイルスベクターの製造方法 |
ES2728248T3 (es) * | 2012-01-24 | 2019-10-23 | Univ Georgia | Vacunas basadas en el virus paragripal 5 |
BR112014019431A8 (pt) | 2012-02-07 | 2017-07-11 | Global Bio Therapeutics Usa Inc | Método compartimentalizado de distribuição de ácido nucleico e composições e usos desses |
EP2912069B1 (de) | 2012-10-23 | 2019-07-31 | Emory University | Gm-csf- und il-4-konjugate, zusammensetzungen und zugehörige verfahren |
DK3030163T3 (da) | 2013-08-08 | 2019-07-01 | Global Bio Therapeutics Inc | Klemmeindretning til minimalt invasive procedurer |
WO2021214279A1 (en) * | 2020-04-24 | 2021-10-28 | Hsf Pharmaceuticals | Replication-competent controlled herpesviruses expressing a sars cov-2 antigen |
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US6432700B1 (en) | 1997-03-03 | 2002-08-13 | Cell Genesys, Inc. | Adenovirus vectors containing heterologous transcription regulatory elements and methods of using same |
WO1998039467A2 (en) | 1997-03-03 | 1998-09-11 | Calydon, Inc. | Adenovirus vectors specific for cells expressing carcinoembryonic antigen and methods of use thereof |
CN1281512A (zh) | 1997-12-12 | 2001-01-24 | 昂尼克斯药物公司 | p53+肿瘤细胞的选择性杀伤和诊断 |
WO2000020296A1 (en) * | 1998-10-06 | 2000-04-13 | Kao Corporation | Wrapping films |
-
1997
- 1997-11-19 US US08/974,391 patent/US6638762B1/en not_active Expired - Fee Related
-
1998
- 1998-11-17 JP JP2000521223A patent/JP2002507382A/ja active Pending
- 1998-11-17 DE DE69834936T patent/DE69834936T2/de not_active Expired - Fee Related
- 1998-11-17 NZ NZ504367A patent/NZ504367A/xx unknown
- 1998-11-17 WO PCT/EP1998/007380 patent/WO1999025860A1/en active IP Right Grant
- 1998-11-17 EP EP98962352A patent/EP1032696B1/de not_active Expired - Lifetime
- 1998-11-17 CA CA002310563A patent/CA2310563A1/en not_active Abandoned
- 1998-11-17 IL IL13610498A patent/IL136104A0/xx unknown
- 1998-11-17 AT AT98962352T patent/ATE330019T1/de not_active IP Right Cessation
- 1998-11-17 AU AU17552/99A patent/AU1755299A/en not_active Abandoned
-
2003
- 2003-06-24 US US10/602,853 patent/US20040009588A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US6638762B1 (en) | 2003-10-28 |
JP2002507382A (ja) | 2002-03-12 |
NZ504367A (en) | 2002-10-25 |
IL136104A0 (en) | 2001-05-20 |
EP1032696A1 (de) | 2000-09-06 |
US20040009588A1 (en) | 2004-01-15 |
EP1032696B1 (de) | 2006-06-14 |
CA2310563A1 (en) | 1999-05-27 |
DE69834936D1 (de) | 2006-07-27 |
AU1755299A (en) | 1999-06-07 |
DE69834936T2 (de) | 2007-01-25 |
WO1999025860A1 (en) | 1999-05-27 |
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