ES2404061T3 - 2-Metileno-19-nor-(20S-24S)-1-alfa,25-dihidroxivitamina-D2 - Google Patents
2-Metileno-19-nor-(20S-24S)-1-alfa,25-dihidroxivitamina-D2 Download PDFInfo
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- ES2404061T3 ES2404061T3 ES06720601T ES06720601T ES2404061T3 ES 2404061 T3 ES2404061 T3 ES 2404061T3 ES 06720601 T ES06720601 T ES 06720601T ES 06720601 T ES06720601 T ES 06720601T ES 2404061 T3 ES2404061 T3 ES 2404061T3
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- dihydroxyvitamin
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- C—CHEMISTRY; METALLURGY
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- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
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Landscapes
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- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Toxicology (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65247305P | 2005-02-11 | 2005-02-11 | |
| US652473P | 2005-02-11 | ||
| PCT/US2006/004699 WO2006086613A2 (en) | 2005-02-11 | 2006-02-10 | 2-METHYLENE-19-NOR- (20S-24S) - 1α, 25-D IHYDROXYVITAMIN-D2 |
Publications (1)
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|---|---|
| ES2404061T3 true ES2404061T3 (es) | 2013-05-23 |
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| Application Number | Title | Priority Date | Filing Date |
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|---|---|
| US (1) | US7563783B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1853274B1 (cg-RX-API-DMAC7.html) |
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| MX (1) | MX2007009726A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2006086613A2 (cg-RX-API-DMAC7.html) |
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| US20060079490A1 (en) * | 2001-01-25 | 2006-04-13 | Deluca Hector F | Method of treatment of type I diabetes |
| EP1656157B1 (en) * | 2003-08-20 | 2011-12-21 | Wisconsin Alumni Research Foundation | 2-methylene-19-nor-vitamin d2 compounds |
| CA2662992A1 (en) * | 2006-09-28 | 2008-04-03 | Wisconsin Alumni Research Foundation | 2-methylene-(20r,25s)-19,27-dinor-(22e)-vitamin d analogs |
| WO2011017165A1 (en) * | 2009-08-03 | 2011-02-10 | Wisconsin Alumni Research Foundation | Method of preventing renal disease and treating symptoms thereof |
| MX2012003883A (es) * | 2009-10-02 | 2012-06-27 | Wisconsin Alumni Res Found | Analogos de (20s,22e)-2-metileno-19-nor-22-ene-1a,25-dihidroxovita mina d3. |
| US8664206B2 (en) | 2010-03-23 | 2014-03-04 | Wisconsin Alumni Research Foundation | Diastereomers of 2-methylene-19-nor-22-methyl-1α,25-dihydroxyvitamin D3 |
| WO2011119622A1 (en) * | 2010-03-23 | 2011-09-29 | Wisconsin Alumni Research Foundation | DIASTEREOMERS OF 2-METHYLENE-19-NOR-22-METHYL-1α,25- DIHYDROXYVITAMIN D3 |
| ES2545403T3 (es) * | 2010-03-23 | 2015-09-10 | Wisconsin Alumni Research Foundation | (20S)-2-metilen-19-nor-22-dimetil-1alfa,25-dihidroxivitamina D3 y (20R)-2-metilen-19-nor-22-dimetil-1alfa,25-hidroxivitamina D3 |
| CA2824870C (en) * | 2011-06-14 | 2018-08-14 | Wisconsin Alumni Research Foundation | 3-desoxy-2-methylene-19-nor-vitamin d analogs and their uses |
| RU2666995C2 (ru) | 2012-06-29 | 2018-09-13 | Висконсин Алюмни Рисерч Фаундейшн | ПРИМЕНЕНИЕ 2-МЕТИЛЕН-19-НОР-(20S)-1α,25-ДИГИДРОКСИВИТАМИНА D3 ДЛЯ ЛЕЧЕНИЯ ВТОРИЧНОГО ГИПЕРПАРАТИРЕОЗА |
| US10369161B2 (en) | 2014-12-30 | 2019-08-06 | Wisconsin Alumni Research Foundation | Use of 2-methylene-19-NOR-(20S)-1-alpha,25-dihydroxyvitamin D3 to treat primary hyperparathyroidism |
| US9539264B2 (en) | 2014-12-30 | 2017-01-10 | Wisconsin Alumni Research Foundation | Use of 2-methylene-19-nor-(20S)-1-alpha,25-dihydroxyvitamin D3 to treat secondary hyperparathyroidism in patients previously treated with calcimimetics |
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| US4588716A (en) * | 1984-05-04 | 1986-05-13 | Wisconsin Alumni Research Foundation | Method for treating metabolic bone disease in mammals |
| US4666634A (en) * | 1984-12-05 | 1987-05-19 | Chugai Seiyaku Kabushiki Kaisha | vitamin D3 derivatives having a substituent at 2-position |
| US5086191A (en) * | 1991-05-28 | 1992-02-04 | Wisconsin Alumni Research Foundation | Intermediates for the synthesis of 19-nor vitamin D compounds |
| DE69400495T2 (de) * | 1993-04-05 | 1997-04-30 | Wisconsin Alumni Res Found | 19-Nor-vitamin-D3-Verbindung mit einem Substituent an die 2. Stelle |
| US5552392A (en) * | 1993-11-03 | 1996-09-03 | Wisconsin Alumni Research Foundation | Method of treating hypoparathyroidism with (20S) vitamin D compounds |
| US5843928A (en) * | 1997-03-17 | 1998-12-01 | Wisconsin Alumni Research Foundation | 2-alkylidene-19-nor-vitamin D compounds |
| US6392071B1 (en) * | 1997-03-17 | 2002-05-21 | Wisconsin Alumni: Research Foundation | 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds |
| US5945410A (en) * | 1997-03-17 | 1999-08-31 | Wisconsin Alumni Research Foundation | 2-alkyl-19-nor-vitamin D compounds |
| US6673782B2 (en) * | 1999-04-29 | 2004-01-06 | Wisconsin Alumni Research Foundation | Treatment of systemic lupus erythematosis |
| US6479474B2 (en) * | 1999-07-08 | 2002-11-12 | Wisconsin Alumni Research Foundation | Dietary calcium as a supplement to vitamin D compound treatment of multiple sclerosis |
| US7704979B2 (en) * | 2000-09-01 | 2010-04-27 | The University Of Tennessee Research Foundation | Materials and methods for the treatment or prevention of obesity |
| US6384087B1 (en) * | 2000-09-01 | 2002-05-07 | University Of Tennesseee Research Corporation, Inc. | Materials and methods for the treatment or prevention of obesity |
| BR0113703A (pt) * | 2000-09-08 | 2003-07-22 | Wisconsin Alumni Researcg Foun | Compostos e métodos de tratamento de psorìase, leucemia, câncer do cólon, do seio ou da próstata, osteodistrofia renal, de doenças auto-imune, inflamatória e de condição de pele |
| US6627622B2 (en) * | 2002-02-18 | 2003-09-30 | Wisconsin Alumni Research Foundation | (20S)-1α-hydroxy-2-methylene-19-nor-bishomopregnacalciferol and its uses |
| US6566352B1 (en) * | 2002-02-18 | 2003-05-20 | Wisconsin Alumni Research Foudation | 1 α-hydroxy-2-methylene-19-nor-pregnacalciferol and its uses |
| DE60310050T2 (de) * | 2002-03-29 | 2007-07-05 | Wisconsin Alumni Research Foundation, Madison | Ein verfahren zur herstellung von 1-alpha-hydroxy-2-methylen-19-nor-homopregnacalciferol |
| US7259143B2 (en) * | 2002-09-05 | 2007-08-21 | Wisconsin Alumni Research Foundation | Method of extending the dose range of vitamin D compounds |
| US7241747B2 (en) * | 2003-04-10 | 2007-07-10 | Wisconsin Alumni Research Foundation | 2-propylidene-19-nor-vitamin D compounds |
| EP1656157B1 (en) * | 2003-08-20 | 2011-12-21 | Wisconsin Alumni Research Foundation | 2-methylene-19-nor-vitamin d2 compounds |
| CA2539357A1 (en) * | 2003-09-19 | 2005-03-31 | Pfizer Products Inc. | Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and parathyroid hormone |
| WO2005027931A1 (en) * | 2003-09-19 | 2005-03-31 | Pfizer Products Inc. | Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and an ep2 or ep4 selective agonist |
| WO2005027913A1 (en) * | 2003-09-19 | 2005-03-31 | Pfizer Products Inc. | Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and a growth hormone secretagogue |
| CA2539361A1 (en) * | 2003-09-19 | 2005-03-31 | Pfizer Products Inc. | Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and an estrogen agonist/antagonist |
| US7053075B2 (en) * | 2003-11-25 | 2006-05-30 | Deluca Hector F | Methods for reducing body fat using vitamin D compounds |
-
2006
- 2006-02-10 WO PCT/US2006/004699 patent/WO2006086613A2/en not_active Ceased
- 2006-02-10 ES ES06720601T patent/ES2404061T3/es active Active
- 2006-02-10 US US11/352,454 patent/US7563783B2/en not_active Expired - Fee Related
- 2006-02-10 MX MX2007009726A patent/MX2007009726A/es active IP Right Grant
- 2006-02-10 CA CA2597624A patent/CA2597624C/en not_active Expired - Fee Related
- 2006-02-10 AU AU2006213727A patent/AU2006213727B2/en not_active Ceased
- 2006-02-10 JP JP2007555236A patent/JP5036566B2/ja not_active Expired - Fee Related
- 2006-02-10 EP EP06720601A patent/EP1853274B1/en not_active Not-in-force
Also Published As
| Publication number | Publication date |
|---|---|
| CA2597624C (en) | 2012-08-14 |
| JP2008530110A (ja) | 2008-08-07 |
| AU2006213727B2 (en) | 2011-08-18 |
| MX2007009726A (es) | 2007-09-26 |
| EP1853274B1 (en) | 2013-01-23 |
| EP1853274A2 (en) | 2007-11-14 |
| US7563783B2 (en) | 2009-07-21 |
| WO2006086613A2 (en) | 2006-08-17 |
| AU2006213727A1 (en) | 2006-08-17 |
| JP5036566B2 (ja) | 2012-09-26 |
| CA2597624A1 (en) | 2006-08-17 |
| US20060183716A1 (en) | 2006-08-17 |
| WO2006086613A3 (en) | 2006-11-09 |
| EP1853274A4 (en) | 2010-12-15 |
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