ES2402746T3 - Compuestos de (fenil)(imidazolil)metilheteroarilo - Google Patents

Compuestos de (fenil)(imidazolil)metilheteroarilo Download PDF

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Publication number
ES2402746T3
ES2402746T3 ES08769462T ES08769462T ES2402746T3 ES 2402746 T3 ES2402746 T3 ES 2402746T3 ES 08769462 T ES08769462 T ES 08769462T ES 08769462 T ES08769462 T ES 08769462T ES 2402746 T3 ES2402746 T3 ES 2402746T3
Authority
ES
Spain
Prior art keywords
imidazol
compound
pain
nmr
mhz
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES08769462T
Other languages
English (en)
Spanish (es)
Inventor
Santosh C. Sinha
Todd M. Heidelbaugh
Ken Chow
Smita S. Bhat
Phong X. Nguyen
Michael E. Garst
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allergan Inc
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Application granted granted Critical
Publication of ES2402746T3 publication Critical patent/ES2402746T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ES08769462T 2007-05-14 2008-05-13 Compuestos de (fenil)(imidazolil)metilheteroarilo Active ES2402746T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91783307P 2007-05-14 2007-05-14
US917833P 2007-05-14
PCT/US2008/063489 WO2008141312A1 (en) 2007-05-14 2008-05-13 ((phenyl)imidazolyl)methylheteroaryl compounds

Publications (1)

Publication Number Publication Date
ES2402746T3 true ES2402746T3 (es) 2013-05-08

Family

ID=39683865

Family Applications (1)

Application Number Title Priority Date Filing Date
ES08769462T Active ES2402746T3 (es) 2007-05-14 2008-05-13 Compuestos de (fenil)(imidazolil)metilheteroarilo

Country Status (16)

Country Link
US (1) US20100273814A1 (enExample)
EP (1) EP2155715B1 (enExample)
JP (1) JP5323059B2 (enExample)
KR (1) KR20100031502A (enExample)
CN (1) CN101743240B (enExample)
AU (1) AU2008251324B2 (enExample)
BR (1) BRPI0811860A2 (enExample)
CA (1) CA2687303C (enExample)
DK (1) DK2155715T3 (enExample)
ES (1) ES2402746T3 (enExample)
IL (1) IL202137A0 (enExample)
MX (1) MX2009012349A (enExample)
NZ (1) NZ599554A (enExample)
RU (1) RU2478631C2 (enExample)
WO (1) WO2008141312A1 (enExample)
ZA (1) ZA200908088B (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009091735A1 (en) * 2008-01-18 2009-07-23 Allergan.Inc Substitued-aryl-(imidazole)-methyl)-phenyl compounds as subtype selective modulators of alpha 2b and/or alpha 2c adrenergic receptors
JP2019517524A (ja) * 2016-06-02 2019-06-24 パーデュー ファーマ エルピー 疼痛治療のための微量アミン関連受容体１アゴニスト及び部分アゴニスト
WO2024220941A1 (en) * 2023-04-21 2024-10-24 Alceptor Therapeutics, Inc. Triaryl agonists of alpha-2 adrenergic receptors
WO2024226608A2 (en) * 2023-04-25 2024-10-31 Aglaeapharma Inc. Imidazole containing compounds, derivatives therefore, and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5098811A (en) * 1988-09-22 1992-03-24 Minolta Camera Kabushiki Kaisha Ioner for developing electrostatic latent image comprising specified imidazoles
US5750720A (en) * 1996-03-28 1998-05-12 Ortho Pharmaceutical Corporation 4- (thien-3-yl)methyl!-imidazole analgesics
US6841684B2 (en) * 1997-12-04 2005-01-11 Allergan, Inc. Imidiazoles having reduced side effects
TWI283669B (en) * 1999-06-10 2007-07-11 Allergan Inc Compounds and method of treatment having agonist-like activity selective at alpha 2B or 2B/2C adrenergic receptors
BRPI0516025A (pt) * 2004-09-24 2008-08-19 Allergan Sales Inc 4-(heteroaril-metil e heteroaril-metil substituìda)-imidazol-2-tionas que atuam como agonistas alfa2 adrenérgicos

Also Published As

Publication number Publication date
JP2010527369A (ja) 2010-08-12
CN101743240B (zh) 2013-07-17
JP5323059B2 (ja) 2013-10-23
AU2008251324B2 (en) 2014-05-01
RU2009145817A (ru) 2011-06-20
WO2008141312A1 (en) 2008-11-20
AU2008251324A1 (en) 2008-11-20
CN101743240A (zh) 2010-06-16
EP2155715A1 (en) 2010-02-24
DK2155715T3 (da) 2013-05-13
IL202137A0 (en) 2010-06-16
BRPI0811860A2 (pt) 2014-11-18
US20100273814A1 (en) 2010-10-28
MX2009012349A (es) 2009-12-01
NZ599554A (en) 2013-12-20
EP2155715B1 (en) 2013-03-13
CA2687303A1 (en) 2008-11-20
KR20100031502A (ko) 2010-03-22
RU2478631C2 (ru) 2013-04-10
CA2687303C (en) 2015-05-05
ZA200908088B (en) 2010-12-29

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