RU2478631C2 - Соединения ((фенил)имидазолил)метилгетероарила, их применение, фармацевтическая композиция, содержащая указанные соединения, и набор, включающий такую композицию - Google Patents
Соединения ((фенил)имидазолил)метилгетероарила, их применение, фармацевтическая композиция, содержащая указанные соединения, и набор, включающий такую композицию Download PDFInfo
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- RU2478631C2 RU2478631C2 RU2009145817/04A RU2009145817A RU2478631C2 RU 2478631 C2 RU2478631 C2 RU 2478631C2 RU 2009145817/04 A RU2009145817/04 A RU 2009145817/04A RU 2009145817 A RU2009145817 A RU 2009145817A RU 2478631 C2 RU2478631 C2 RU 2478631C2
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- Prior art keywords
- compounds
- methyl
- imidazol
- phenyl
- nmr
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Anesthesiology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91783307P | 2007-05-14 | 2007-05-14 | |
| US60/917,833 | 2007-05-14 | ||
| PCT/US2008/063489 WO2008141312A1 (en) | 2007-05-14 | 2008-05-13 | ((phenyl)imidazolyl)methylheteroaryl compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2009145817A RU2009145817A (ru) | 2011-06-20 |
| RU2478631C2 true RU2478631C2 (ru) | 2013-04-10 |
Family
ID=39683865
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2009145817/04A RU2478631C2 (ru) | 2007-05-14 | 2008-05-13 | Соединения ((фенил)имидазолил)метилгетероарила, их применение, фармацевтическая композиция, содержащая указанные соединения, и набор, включающий такую композицию |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20100273814A1 (enExample) |
| EP (1) | EP2155715B1 (enExample) |
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| WO2009091735A1 (en) * | 2008-01-18 | 2009-07-23 | Allergan.Inc | Substitued-aryl-(imidazole)-methyl)-phenyl compounds as subtype selective modulators of alpha 2b and/or alpha 2c adrenergic receptors |
| JP2019517524A (ja) * | 2016-06-02 | 2019-06-24 | パーデュー ファーマ エルピー | 疼痛治療のための微量アミン関連受容体１アゴニスト及び部分アゴニスト |
| WO2024220941A1 (en) * | 2023-04-21 | 2024-10-24 | Alceptor Therapeutics, Inc. | Triaryl agonists of alpha-2 adrenergic receptors |
| WO2024226608A2 (en) * | 2023-04-25 | 2024-10-31 | Aglaeapharma Inc. | Imidazole containing compounds, derivatives therefore, and uses thereof |
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| RU2232154C2 (ru) * | 1999-06-10 | 2004-07-10 | Оллерган Инк. | Замещенные производные имидазола, способ введения фармацевтической композиции и способ лечения на основе этих соединений |
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| US5098811A (en) * | 1988-09-22 | 1992-03-24 | Minolta Camera Kabushiki Kaisha | Ioner for developing electrostatic latent image comprising specified imidazoles |
| US5750720A (en) * | 1996-03-28 | 1998-05-12 | Ortho Pharmaceutical Corporation | 4- (thien-3-yl)methyl!-imidazole analgesics |
| US6841684B2 (en) * | 1997-12-04 | 2005-01-11 | Allergan, Inc. | Imidiazoles having reduced side effects |
| BRPI0516025A (pt) * | 2004-09-24 | 2008-08-19 | Allergan Sales Inc | 4-(heteroaril-metil e heteroaril-metil substituìda)-imidazol-2-tionas que atuam como agonistas alfa2 adrenérgicos |
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- 2008-05-13 EP EP08769462A patent/EP2155715B1/en not_active Not-in-force
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2232154C2 (ru) * | 1999-06-10 | 2004-07-10 | Оллерган Инк. | Замещенные производные имидазола, способ введения фармацевтической композиции и способ лечения на основе этих соединений |
Non-Patent Citations (2)
| Title |
|---|
| Boyd R.E. et al: "α 2 -Adrenoceptor agonists as potential analgesic agents. 1. (Imidazolylmethel)oxazoles and -thiazoles", Journal of Medicinal Chemistry, vol.42, 1999, pp.5064-5071. * |
| ZHANG X. et al: "Medetomidine analogs as alpha 2-adrenergic ligands. 2. Design, synthesis and biological naphthalene derivatives of medetomidine", JOURNAL OF MEDICINAL CHEMISTRY, vol.39, 1996, pp.3001-3013. * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2010527369A (ja) | 2010-08-12 |
| CN101743240B (zh) | 2013-07-17 |
| JP5323059B2 (ja) | 2013-10-23 |
| AU2008251324B2 (en) | 2014-05-01 |
| RU2009145817A (ru) | 2011-06-20 |
| WO2008141312A1 (en) | 2008-11-20 |
| AU2008251324A1 (en) | 2008-11-20 |
| CN101743240A (zh) | 2010-06-16 |
| EP2155715A1 (en) | 2010-02-24 |
| DK2155715T3 (da) | 2013-05-13 |
| IL202137A0 (en) | 2010-06-16 |
| BRPI0811860A2 (pt) | 2014-11-18 |
| US20100273814A1 (en) | 2010-10-28 |
| MX2009012349A (es) | 2009-12-01 |
| NZ599554A (en) | 2013-12-20 |
| EP2155715B1 (en) | 2013-03-13 |
| CA2687303A1 (en) | 2008-11-20 |
| KR20100031502A (ko) | 2010-03-22 |
| CA2687303C (en) | 2015-05-05 |
| ES2402746T3 (es) | 2013-05-08 |
| ZA200908088B (en) | 2010-12-29 |
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