ES2400091T3 - Dispositivo de suministro de fármacos intravesical y método - Google Patents
Dispositivo de suministro de fármacos intravesical y método Download PDFInfo
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- ES2400091T3 ES2400091T3 ES06801285T ES06801285T ES2400091T3 ES 2400091 T3 ES2400091 T3 ES 2400091T3 ES 06801285 T ES06801285 T ES 06801285T ES 06801285 T ES06801285 T ES 06801285T ES 2400091 T3 ES2400091 T3 ES 2400091T3
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/63—Crystals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/02—General characteristics of the apparatus characterised by a particular materials
- A61M2205/0216—Materials providing elastic properties, e.g. for facilitating deformation and avoid breaking
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/10—Trunk
- A61M2210/1078—Urinary tract
- A61M2210/1085—Bladder
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Heart & Thoracic Surgery (AREA)
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- Reproductive Health (AREA)
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- Gynecology & Obstetrics (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medicinal Preparation (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
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| US72649005P | 2005-10-12 | 2005-10-12 | |
| US726490P | 2005-10-12 | ||
| PCT/US2006/031428 WO2007021964A2 (en) | 2005-08-11 | 2006-08-11 | Intravesical drug delivery device and method |
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Families Citing this family (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10327880B2 (en) | 2000-04-14 | 2019-06-25 | Attenuex Technologies, Inc. | Attenuation device for use in an anatomical structure |
| US8574146B2 (en) | 2000-04-14 | 2013-11-05 | Attenuex Technologies, Inc. | Implant with high vapor pressure medium |
| US6682473B1 (en) | 2000-04-14 | 2004-01-27 | Solace Therapeutics, Inc. | Devices and methods for attenuation of pressure waves in the body |
| US8257963B2 (en) * | 2007-06-01 | 2012-09-04 | Depuy Mitek, Inc. | Chondrocyte container and method of use |
| US7927599B2 (en) | 2003-09-08 | 2011-04-19 | Ethicon, Inc. | Chondrocyte therapeutic delivery system |
| US20100003297A1 (en) | 2005-08-11 | 2010-01-07 | Massachusetts Institute Of Technology | Implantable Drug Delivery Device and Methods of Treating Male Genitourinary and Surrounding Tissues |
| DK1933810T3 (da) | 2005-08-11 | 2013-01-28 | Childrens Medical Center | Intravesikal lægemiddelafgivelsesindretning og fremgangsmåde |
| EP1940316B1 (en) | 2005-09-26 | 2015-10-21 | AttenueX Technologies, Inc. | Pressure attenuation device |
| US20080085294A1 (en) * | 2006-10-04 | 2008-04-10 | Toby Freyman | Apparatuses and methods to treat atherosclerotic plaques |
| DK2231254T3 (da) * | 2007-12-11 | 2014-07-21 | Massachusetts Inst Technology | Implanterbar lægemiddelafgivelsesindretning |
| CN102387833B (zh) * | 2009-03-20 | 2016-01-13 | 因卡伯实验室有限责任公司 | 固体药物给药设备 |
| US8343516B2 (en) * | 2009-06-26 | 2013-01-01 | Taris Biomedical, Inc. | Solid drug tablets for implantable drug delivery devices |
| GB0914287D0 (en) | 2009-08-14 | 2009-09-30 | Pci Biotech As | Compositions |
| GB0914286D0 (en) | 2009-08-14 | 2009-09-30 | Pci Biotech As | Method |
| US20110052497A1 (en) * | 2009-08-27 | 2011-03-03 | Taris Biomedical, Inc. | Minimally Invasive Systems and Methods for In Vivo Testing of Materials |
| US8721621B2 (en) | 2009-09-10 | 2014-05-13 | Taris Biomedical, Inc. | Systems and methods for deploying devices to genitourinary sites |
| US9017312B2 (en) * | 2009-09-10 | 2015-04-28 | Taris Biomedical Llc | Implantable device for controlled drug delivery |
| US8167836B2 (en) * | 2009-12-08 | 2012-05-01 | Taris Biomedical, Inc. | Tissue expander configured for drug delivery |
| US8679094B2 (en) * | 2009-12-17 | 2014-03-25 | Taris Biomedical, Inc. | Implantable device with intravesical tolerability and methods of treatment |
| AU2015201123B2 (en) * | 2009-12-17 | 2016-04-21 | Taris Biomedical Llc | Implantable device with intravesical tolerability and methods of treatment |
| JP2013535992A (ja) * | 2010-06-22 | 2013-09-19 | テバ ウィメンズ ヘルス インコーポレイテッド | 抗コリン作動剤を含む膣内用デバイスおよびそれを作る方法 |
| PT2600800T (pt) | 2010-08-05 | 2020-11-05 | Taris Biomedical Llc | Dispositivo de administração de drogas por stent ureteral, kit e método |
| PL3517101T3 (pl) | 2010-08-05 | 2021-02-22 | Taris Biomedical Llc | Wszczepiane urządzenia do podawania leków w miejscach moczowo-płciowych |
| US9566420B2 (en) * | 2010-08-25 | 2017-02-14 | Ocure Ltd. | Medical instruments of treating and/or diagnosing of anorectal disorders, and devices and methods for insertion of such |
| US9457176B2 (en) | 2010-10-06 | 2016-10-04 | Taris Biomedical Llc | Implantable drug delivery device with bladder retention feature |
| US8690840B2 (en) | 2010-10-06 | 2014-04-08 | Taris Biomedical, Inc. | Time-selective bioresorbable or collapsible drug delivery systems and methods |
| US8679093B2 (en) | 2010-11-23 | 2014-03-25 | Microchips, Inc. | Multi-dose drug delivery device and method |
| US9114111B2 (en) | 2011-01-10 | 2015-08-25 | Allergan, Inc. | Methods for sustained treatment of bladder pain and irritative voiding |
| WO2012106714A1 (en) * | 2011-02-04 | 2012-08-09 | Taris Biomedical, Inc. | Implantable device for controlled release of low solubility drug |
| US10058688B2 (en) * | 2012-05-09 | 2018-08-28 | Massachusetts Institute Of Technology | Medicament, method, and drug delivery device for treatment of ovarian cancer |
| RU2651128C2 (ru) | 2012-05-19 | 2018-04-18 | ТАРИС Биомедикал ЛЛК | Имплантируемое урологическое устройство с улучшенной характеристикой извлечения |
| US8894563B2 (en) | 2012-08-10 | 2014-11-25 | Attenuex Technologies, Inc. | Methods and systems for performing a medical procedure |
| RU2657591C2 (ru) | 2012-08-31 | 2018-06-14 | ТАРИС Биомедикал ЛЛК | Способ лечения рака мочевого пузыря оксалиплатином, соответствующее устройство его доставки, способ и устройство его введения |
| KR102383496B1 (ko) | 2012-08-31 | 2022-04-08 | 타리스 바이오메디컬 엘엘씨 | 젬시타빈을 포함하는 전립선 질환의 치료를 위한 약물 전달 시스템과 방법 |
| MX379066B (es) | 2012-09-18 | 2025-03-04 | Taris Biomedical Llc | Sistemas de administracion de farmaco y metodos para el tratamiento de la disfuncion miccional de la vejiga y otros trastornos del tracto urinario inferior. |
| JP2016508842A (ja) | 2013-03-05 | 2016-03-24 | タリス バイオメディカル エルエルシー | 装置の開口部を通じて制御された薬物放出のための薬物送達装置及び方法 |
| ES2660572T3 (es) * | 2013-03-14 | 2018-03-23 | C. R. Bard, Inc. | Sistema de inserción y fijación de semillas de braquiterapia |
| EP2968120A1 (en) | 2013-03-15 | 2016-01-20 | TARIS Biomedical LLC | Drug delivery devices and methods for drug delivery |
| US9370645B2 (en) * | 2013-03-15 | 2016-06-21 | Boston Scientific Scimed, Inc. | Delivery devices and related methods of use |
| SG11201507294WA (en) | 2013-03-15 | 2015-10-29 | Taris Biomedical Llc | Drug delivery devices with drug-permeable component and methods |
| US10080676B2 (en) | 2013-03-15 | 2018-09-25 | Boston Scientific Scimed, Inc. | Delivery devices and related methods of use |
| US9555218B2 (en) * | 2013-03-15 | 2017-01-31 | Boston Scientific Scimed, Inc. | Methods and systems for treatment of a bladder |
| WO2015026813A1 (en) | 2013-08-19 | 2015-02-26 | Taris Biomedical Llc | Multi-unit drug delivery devices and methods |
| JP6154718B2 (ja) * | 2013-10-03 | 2017-06-28 | 株式会社N.M.A | 下部尿路疾患治療剤 |
| KR20160083061A (ko) | 2013-11-05 | 2016-07-11 | 타리스 바이오메디컬 엘엘씨 | 삼투 약물 전달 디바이스들, 키트, 및 방법들 |
| HRP20251264T1 (hr) | 2014-03-06 | 2025-12-05 | Taris Biomedical Llc | Sustavi za primjenu lijeka i metode za liječenje karcinoma mokraćnog mjehura gemcitabinom |
| WO2015175538A1 (en) * | 2014-05-12 | 2015-11-19 | Taris Biomedical Llc | Drug delivery devices and methods |
| KR102391761B1 (ko) | 2014-06-26 | 2022-04-27 | 타리스 바이오메디컬 엘엘씨 | 탄성 폴리머-약물 매트릭스 시스템을 포함하는 방광내 약물 전달 장치 및 방법 |
| CN106573133B (zh) | 2014-08-19 | 2020-03-03 | 加利福尼亚大学董事会 | 用于局部药物递送的植入物及其使用方法 |
| US20160256611A1 (en) * | 2015-03-04 | 2016-09-08 | Microvention, Inc. | Drug Delivery Device |
| JP6743041B2 (ja) | 2015-03-30 | 2020-08-19 | タリス バイオメディカル エルエルシー | 上部尿路への薬剤の局所的な送達装置及び方法 |
| WO2016172704A1 (en) | 2015-04-23 | 2016-10-27 | Taris Biomedical Llc | Drug delivery devices with drug-permeable component and methods |
| US10179190B2 (en) | 2015-05-29 | 2019-01-15 | Boston Scientific Scimed, Inc. | Compositions and methods for treatment of tissue |
| JP6785301B2 (ja) | 2015-11-04 | 2020-11-18 | ボストン サイエンティフィック サイムド,インコーポレイテッドBoston Scientific Scimed,Inc. | 医療デバイス及びそれと関連する方法 |
| WO2017132372A1 (en) | 2016-01-26 | 2017-08-03 | Taris Biomedical Llc | Multi-lumen drug delivery devices |
| WO2017155866A1 (en) * | 2016-03-07 | 2017-09-14 | SinuSys Corporation | Osmotic therapeutic agent delivery device |
| GB2555373A (en) * | 2016-08-23 | 2018-05-02 | Reproductive Medicine And Gynaecology Associates Ltd | Implant |
| US11707611B2 (en) * | 2016-11-08 | 2023-07-25 | W. L. Gore & Associates, Inc. | Implantable apparatus for retention of biological moieties |
| LT3432970T (lt) | 2017-02-01 | 2021-05-10 | Taris Biomedical Llc | In vivo vaistų vartojimo įtaisai |
| WO2019023388A1 (en) | 2017-07-25 | 2019-01-31 | Taris Biomedical Llc | METHODS OF TREATING TUMOR METASTASIS |
| PE20210041A1 (es) | 2017-11-08 | 2021-01-08 | Taris Biomedical Llc | Metodos de tratamiento y terapia de mantenimiento para el cancer de vejiga con gemcitabina |
| US12376835B2 (en) | 2018-02-22 | 2025-08-05 | The Regents Of The University Of Michigan | Liquid activated devices and systems |
| EP3801462A4 (en) | 2018-05-24 | 2022-03-16 | Celanese EVA Performance Polymers LLC | Implantable device for sustained release of a macromolecular drug compound |
| WO2019226519A1 (en) | 2018-05-24 | 2019-11-28 | Celanese EVA Performance Polymers Corporation | Implantable device for sustained release of a macromolecular drug compound |
| WO2019222856A1 (en) | 2018-05-24 | 2019-11-28 | Nureva Inc. | Method, apparatus and computer-readable media to manage semi-constant (persistent) sound sources in microphone pickup/focus zones |
| US20190365645A1 (en) | 2018-05-31 | 2019-12-05 | Massachusetts Institute Of Technology | Drug delivery articles for gram-level dosing |
| CA3107461A1 (en) | 2018-08-01 | 2020-02-06 | Taris Biomedical Llc | Methods of treating overactive bladder using trospium |
| US20200254226A1 (en) | 2019-02-07 | 2020-08-13 | Solace Therapeutics, Inc. | Pressure attenuation device |
| CN113395988B (zh) | 2019-02-08 | 2023-03-31 | 科洛普拉斯特公司 | 导尿管 |
| US11679243B2 (en) * | 2019-05-08 | 2023-06-20 | David R. Elmaleh | Non-digestible, controlled release system for soluble drug delivery |
| US11173291B2 (en) | 2020-03-20 | 2021-11-16 | The Regents Of The University Of California | Implantable drug delivery devices for localized drug delivery |
| US11338119B2 (en) | 2020-03-20 | 2022-05-24 | The Regents Of The University Of California | Implantable drug delivery devices for localized drug delivery |
| US11344526B2 (en) | 2020-03-20 | 2022-05-31 | The Regents Of The University Of California | Implantable drug delivery devices for localized drug delivery |
| JP2024515220A (ja) | 2021-04-26 | 2024-04-05 | セラニーズ・イーブイエイ・パフォーマンス・ポリマーズ・エルエルシー | 高分子薬剤化合物の持続放出用の埋め込み型デバイス |
| WO2025012892A1 (en) * | 2023-07-11 | 2025-01-16 | Utt Urine Topical Treatment Ltd | Medical systems for treating conditions and diseases of the patient's body cavities |
Family Cites Families (100)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3854480A (en) | 1969-04-01 | 1974-12-17 | Alza Corp | Drug-delivery system |
| US4016251A (en) * | 1972-08-17 | 1977-04-05 | Alza Corporation | Vaginal drug dispensing device |
| US3888975A (en) * | 1972-12-27 | 1975-06-10 | Alza Corp | Erodible intrauterine device |
| US3901232A (en) | 1973-10-26 | 1975-08-26 | Alza Corp | Integrated device for administering beneficial drug at programmed rate |
| US3935860A (en) * | 1974-08-21 | 1976-02-03 | Alza Corporation | Intrauterine device with restrictor for maintaining device in uterine cavity |
| US4235236A (en) | 1979-02-12 | 1980-11-25 | Alza Corporation | Device for dispensing drug by combined diffusional and osmotic operations |
| US4392848A (en) * | 1979-06-25 | 1983-07-12 | The Procter & Gamble Company | Catheterization |
| GB2079158B (en) | 1980-06-09 | 1985-01-09 | Ahi Operations Ltd | Intra-vaginal devices |
| US4475916A (en) | 1982-03-18 | 1984-10-09 | Merck & Co., Inc. | Osmotic drug delivery system |
| US4629449A (en) | 1982-07-29 | 1986-12-16 | Alza Corporation | Vaginal dispenser for dispensing beneficial hormone |
| US5366738A (en) * | 1982-07-29 | 1994-11-22 | Merck & Co., Inc. | Controlled release drug dispersion delivery device |
| US4655219A (en) | 1983-07-22 | 1987-04-07 | American Hospital Supply Corporation | Multicomponent flexible grasping device |
| DE3332156A1 (de) | 1983-09-06 | 1985-03-21 | Peter 6000 Frankfurt Prezelj | Nasenspange |
| NZ207341A (en) | 1984-03-01 | 1988-02-29 | Harvey Alex Ind Ltd | Device containing chemical impregnants for insertion into a body cavity of an animal |
| US4968507A (en) | 1984-06-20 | 1990-11-06 | Merck & Co., Inc. | Controlled porosity osmotic pump |
| US4871542A (en) | 1987-04-30 | 1989-10-03 | Ferring Service Center, N.V. | Method and apparatus useful for delivering medicinal compositions into the bladder and urinary tract |
| US5545208A (en) | 1990-02-28 | 1996-08-13 | Medtronic, Inc. | Intralumenal drug eluting prosthesis |
| WO1993006792A1 (en) | 1991-10-04 | 1993-04-15 | Scimed Life Systems, Inc. | Biodegradable drug delivery vascular stent |
| EP0607321A1 (en) * | 1991-10-10 | 1994-07-27 | Alza Corporation | Osmotic drug delivery devices with hydrophobic wall materials |
| US5441550A (en) | 1992-03-26 | 1995-08-15 | The University Of Tennessee Research Corporation | Post-treatment of laminated nonwoven cellulosic fiber webs |
| US5499997A (en) | 1992-04-10 | 1996-03-19 | Sharpe Endosurgical Corporation | Endoscopic tenaculum surgical instrument |
| ES2150427T3 (es) * | 1992-06-02 | 2000-12-01 | Bard Inc C R | Procedimiento y dispositivo de implante para el suministro de farmacos a largo plazo. |
| US5523092A (en) | 1993-04-14 | 1996-06-04 | Emory University | Device for local drug delivery and methods for using the same |
| US5516522A (en) * | 1994-03-14 | 1996-05-14 | Board Of Supervisors Of Louisiana State University | Biodegradable porous device for long-term drug delivery with constant rate release and method of making the same |
| IL116433A (en) | 1994-12-19 | 2002-02-10 | Galen Chemicals Ltd | INTRAVAGINAL DRUG DELIVERY DEVICES FOR THE ADMINISTRATION OF 17β-OESTRADIOL PRECURSORS |
| GB9522403D0 (en) | 1995-11-01 | 1996-01-03 | Hoechst Roussel Ltd | Intravaginal drug delivery device |
| US6171298B1 (en) * | 1996-05-03 | 2001-01-09 | Situs Corporation | Intravesical infuser |
| US5869081A (en) | 1996-06-28 | 1999-02-09 | The Population Council | Progesterone vaginal ring for treatment of infertility |
| US5797898A (en) | 1996-07-02 | 1998-08-25 | Massachusetts Institute Of Technology | Microchip drug delivery devices |
| US5972372A (en) | 1996-07-31 | 1999-10-26 | The Population Council, Inc. | Intravaginal rings with insertable drug-containing core |
| US5830230A (en) | 1997-03-07 | 1998-11-03 | Micro Therapeutics, Inc. | Method of intracranial vascular embolotherapy using self anchoring coils |
| WO1998043555A1 (en) | 1997-04-03 | 1998-10-08 | Point Biomedical Corporation | Intravesical drug delivery system |
| IL123813A0 (en) | 1997-04-11 | 1998-10-30 | Akzo Nobel Nv | Drug delivery system for two or more active substances |
| NZ501236A (en) | 1997-05-07 | 2002-02-01 | Galen Chemicals Ltd | Intravaginal drug delivery devices for the administration of testosterone and testosterone precursors in a polymer matrix and surrounded by a sheath |
| AU723217B2 (en) | 1997-05-28 | 2000-08-24 | Interag | Intra-vaginal device for pigs |
| US6197327B1 (en) | 1997-06-11 | 2001-03-06 | Umd, Inc. | Device and method for treatment of dysmenorrhea |
| US6039968A (en) | 1997-06-24 | 2000-03-21 | Hoechst Marion Roussel | Intravaginal drug delivery device |
| US6267761B1 (en) | 1997-09-09 | 2001-07-31 | Sherwood Services Ag | Apparatus and method for sealing and cutting tissue |
| WO1999018884A1 (en) | 1997-10-10 | 1999-04-22 | Duirs Nz Limited | Drug delivery system |
| US20020164374A1 (en) | 1997-10-29 | 2002-11-07 | John Jackson | Polymeric systems for drug delivery and uses thereof |
| US6749617B1 (en) | 1997-11-04 | 2004-06-15 | Scimed Life Systems, Inc. | Catheter and implants for the delivery of therapeutic agents to tissues |
| US6183461B1 (en) * | 1998-03-11 | 2001-02-06 | Situs Corporation | Method for delivering a medication |
| US6482837B1 (en) | 1998-04-24 | 2002-11-19 | University Of Rochester | Antimuscarinic compounds and methods for treatment of bladder diseases |
| US6464999B1 (en) | 1998-06-17 | 2002-10-15 | Galt Incorporated | Bioadhesive medical devices |
| WO2000040234A1 (en) | 1999-01-06 | 2000-07-13 | Richard Henry | Topical anesthesia of the urinary bladder |
| US6293923B1 (en) | 1999-03-15 | 2001-09-25 | Innoventions, Inc. | Intravesicular balloon |
| US6083933A (en) | 1999-04-19 | 2000-07-04 | Stellar International Inc. | Treatment of cystitis-like symptoms with chondroitin sulfate following administration of a challenge solution |
| US6139535A (en) | 1999-05-27 | 2000-10-31 | Situs Corporation | Method and apparatus for placement and activation of a medical device within a body cavity |
| EP1690527B1 (en) | 1999-11-17 | 2015-01-07 | Boston Scientific Limited | Microfabricated devices for the delivery of molecules into a carrier fluid |
| CA2393603C (en) | 1999-12-10 | 2010-09-21 | Massachusetts Institute Of Technology | Microchip devices for delivery of molecules and methods of fabrication thereof |
| US20050238733A1 (en) | 2000-01-05 | 2005-10-27 | Richard Henry | Topical anesthesia of the urinary bladder |
| US6753011B2 (en) | 2000-01-14 | 2004-06-22 | Osmotica Corp | Combined diffusion/osmotic pumping drug delivery system |
| US7470228B2 (en) | 2000-04-14 | 2008-12-30 | Attenuex Technologies, Inc. | Method of treating benign hypertrophy of the prostate |
| US6682473B1 (en) | 2000-04-14 | 2004-01-27 | Solace Therapeutics, Inc. | Devices and methods for attenuation of pressure waves in the body |
| US6730072B2 (en) | 2000-05-30 | 2004-05-04 | Massachusetts Institute Of Technology | Methods and devices for sealing microchip reservoir devices |
| US6398718B1 (en) | 2000-06-15 | 2002-06-04 | Innoventions, Inc. | Intravesicular device |
| US7521064B2 (en) | 2000-08-24 | 2009-04-21 | Saxena Brij B | Non-hormonal vaginal contraceptive |
| NZ528377A (en) | 2001-03-27 | 2005-05-27 | Galen Chemicals Ltd | Intravaginal drug delivery devices for the administration of an antimicrobial agent |
| US6632217B2 (en) | 2001-04-19 | 2003-10-14 | Microsolutions, Inc. | Implantable osmotic pump |
| WO2002096389A1 (en) | 2001-05-30 | 2002-12-05 | Microchips, Inc. | Conformal coated microchip reservoir devices |
| WO2002099457A1 (en) | 2001-05-31 | 2002-12-12 | Massachusetts Inst Technology | Microchip devices with improved reservoir opening |
| US7438701B2 (en) * | 2001-07-26 | 2008-10-21 | Durect Corporation | Local concentration management system |
| US20030118649A1 (en) * | 2001-10-04 | 2003-06-26 | Jinming Gao | Drug delivery devices and methods |
| US7722894B2 (en) | 2001-10-22 | 2010-05-25 | Massachusetts Institute Of Technology | Biodegradable polymer |
| US7005138B2 (en) | 2001-12-21 | 2006-02-28 | Duramed Pharmaceuticals, Inc. | Method of systematically delivering SSRIs |
| US7473273B2 (en) | 2002-01-22 | 2009-01-06 | Medtronic Vascular, Inc. | Stent assembly with therapeutic agent exterior banding |
| US20030147936A1 (en) | 2002-02-07 | 2003-08-07 | Velayudhan Sahadevan | Prostatic hormonal implants treatment of prostate cancer |
| US8685427B2 (en) | 2002-07-31 | 2014-04-01 | Boston Scientific Scimed, Inc. | Controlled drug delivery |
| GB2385273B (en) * | 2002-02-13 | 2004-05-26 | Deborah Huang | Drug delivery device |
| US6899890B2 (en) | 2002-03-20 | 2005-05-31 | Kv Pharmaceutical Company | Bioadhesive drug delivery system |
| US6949125B2 (en) | 2002-04-16 | 2005-09-27 | Boston Scientific Scimed, Inc. | Ureteral stent with end-effector and related methods |
| WO2004003718A1 (ja) * | 2002-07-01 | 2004-01-08 | Hitachi, Ltd. | 方向性結合器を用いたデータ転送方式 |
| US20040013702A1 (en) | 2002-07-16 | 2004-01-22 | Glover Eugene G. | Implantable devices for the controlled release of cytotoxic agents |
| DE10247689A1 (de) | 2002-10-12 | 2004-04-22 | Martin Rahe | Implantat in der Harnblase |
| US7504387B2 (en) | 2002-10-16 | 2009-03-17 | Arthrodynamic Technologies, Animal Health Division, Inc. | Glycosaminoglycan composition and method for treatment and prevention of interstitial cystitis |
| AU2003301669B2 (en) | 2002-10-22 | 2009-04-30 | Biomerix Corporation | Method and system for intravesicular delivery of the therapeutic agents |
| EP1581285B1 (en) * | 2002-12-23 | 2009-02-25 | Medtronic, Inc. | Drug solution density adjustment systems and methods |
| US20050234431A1 (en) | 2004-02-10 | 2005-10-20 | Williams Michael S | Intravascular delivery system for therapeutic agents |
| US20050228482A1 (en) * | 2003-09-26 | 2005-10-13 | William Herzog | Stent covered by a layer having a layer opening |
| BRPI0414941A (pt) | 2003-09-30 | 2006-11-07 | Alza Corp | dispositivo de distribuição de agente ativo acionado osmoticamente proporcionando um perfil de liberação ascendente |
| EP2813231A1 (en) | 2004-01-28 | 2014-12-17 | The Regents of The University of California | Novel interstitial therapy for immediate symptom relief and chronic therapy in interstitial cystitis |
| US7647112B2 (en) | 2004-02-11 | 2010-01-12 | Ethicon, Inc. | System and method for selectively stimulating different body parts |
| WO2005115245A1 (en) | 2004-05-28 | 2005-12-08 | Dynaventions Inc. | Intravesicular device |
| EP1861161A4 (en) | 2005-01-24 | 2012-05-16 | Neurosystec Corp | APPARATUS AND METHOD FOR DISPENSING THERAPEUTIC AND / OR OTHER AGENTS IN THE INTERNAL EAR AND OTHER FABRICS |
| WO2006113913A2 (en) | 2005-04-20 | 2006-10-26 | Cook Incorporated | Joint for medical device delivery system |
| US7862552B2 (en) * | 2005-05-09 | 2011-01-04 | Boston Scientific Scimed, Inc. | Medical devices for treating urological and uterine conditions |
| US20100003297A1 (en) | 2005-08-11 | 2010-01-07 | Massachusetts Institute Of Technology | Implantable Drug Delivery Device and Methods of Treating Male Genitourinary and Surrounding Tissues |
| DK1933810T3 (da) | 2005-08-11 | 2013-01-28 | Childrens Medical Center | Intravesikal lægemiddelafgivelsesindretning og fremgangsmåde |
| US20070196423A1 (en) | 2005-11-21 | 2007-08-23 | Med Institute, Inc. | Implantable medical device coatings with biodegradable elastomer and releasable therapeutic agent |
| US20070172508A1 (en) | 2006-01-26 | 2007-07-26 | Paul Zupkas | Transluminal drug delivery methods and devices |
| US20070172507A1 (en) | 2006-01-26 | 2007-07-26 | Paul Zupkas | Transluminal drug delivery methods and devices |
| BRPI0709344A2 (pt) | 2006-03-20 | 2011-07-12 | Duramed Pharmaceuticals Inc | anel intravaginal comprimido flexìvel, seu uso e processo de preparação, método de fornecer um agente ativo, kit terapêutico e produto |
| ES2640458T3 (es) | 2006-03-31 | 2017-11-03 | Mati Therapeutics Inc. | Implantes del sistema de drenaje nasolagrimal para terapia medicamentosa |
| US7824383B2 (en) | 2006-06-16 | 2010-11-02 | Family Health International | Vaginal drug delivery system and method |
| WO2008023374A2 (en) | 2006-08-23 | 2008-02-28 | Svip 2 Llc | Devices and methods for altering eating behavior |
| EP2096983A2 (en) | 2006-09-28 | 2009-09-09 | Medvision Inc. | Examination device |
| JP2010522023A (ja) | 2007-03-20 | 2010-07-01 | ボストン サイエンティフィック サイムド,インコーポレイテッド | 前立腺に対して有益な治療薬を放出するための泌尿器科学的医療機器 |
| SG195525A1 (en) | 2007-06-26 | 2013-12-30 | Warner Chilcott Co Llc | Intravaginal drug delivery devices for the delivery of macromolecules and water-soluble drugs |
| US8303536B2 (en) | 2007-08-30 | 2012-11-06 | Sunstorm Research Corp. | Implantable delivery device |
| DK2231254T3 (da) | 2007-12-11 | 2014-07-21 | Massachusetts Inst Technology | Implanterbar lægemiddelafgivelsesindretning |
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2006
- 2006-08-11 DK DK06801285.5T patent/DK1933810T3/da active
- 2006-08-11 CA CA2618349A patent/CA2618349C/en active Active
- 2006-08-11 JP JP2008526239A patent/JP5265359B2/ja active Active
- 2006-08-11 EP EP06801285A patent/EP1933810B1/en active Active
- 2006-08-11 ES ES06801285T patent/ES2400091T3/es active Active
- 2006-08-11 WO PCT/US2006/031428 patent/WO2007021964A2/en not_active Ceased
- 2006-08-11 US US11/463,956 patent/US8801694B2/en active Active
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2010
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2014
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Also Published As
| Publication number | Publication date |
|---|---|
| WO2007021964A3 (en) | 2007-05-18 |
| WO2007021964A2 (en) | 2007-02-22 |
| US9561353B2 (en) | 2017-02-07 |
| US8182464B2 (en) | 2012-05-22 |
| US8801694B2 (en) | 2014-08-12 |
| JP5265359B2 (ja) | 2013-08-14 |
| US20100152704A1 (en) | 2010-06-17 |
| US20140350473A1 (en) | 2014-11-27 |
| DK1933810T3 (da) | 2013-01-28 |
| EP1933810A2 (en) | 2008-06-25 |
| CA2618349C (en) | 2016-05-31 |
| US20070202151A1 (en) | 2007-08-30 |
| CA2618349A1 (en) | 2007-02-22 |
| JP2009504271A (ja) | 2009-02-05 |
| EP1933810B1 (en) | 2012-10-10 |
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