ES2399328T3 - Uso de 2-metilen-19-nor-20(S)-1a,25-dihidroxivitamina D3 para la profilaxis de enfermedades óseas - Google Patents

Uso de 2-metilen-19-nor-20(S)-1a,25-dihidroxivitamina D3 para la profilaxis de enfermedades óseas Download PDF

Info

Publication number
ES2399328T3
ES2399328T3 ES04814798T ES04814798T ES2399328T3 ES 2399328 T3 ES2399328 T3 ES 2399328T3 ES 04814798 T ES04814798 T ES 04814798T ES 04814798 T ES04814798 T ES 04814798T ES 2399328 T3 ES2399328 T3 ES 2399328T3
Authority
ES
Spain
Prior art keywords
bone
dihydroxyvitamin
methylene
compound
osteoporosis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES04814798T
Other languages
English (en)
Spanish (es)
Inventor
Hector F. Deluca
Lori A. Plum
Margaret Clagette-Dame
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Application granted granted Critical
Publication of ES2399328T3 publication Critical patent/ES2399328T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ES04814798T 2004-02-19 2004-12-17 Uso de 2-metilen-19-nor-20(S)-1a,25-dihidroxivitamina D3 para la profilaxis de enfermedades óseas Expired - Lifetime ES2399328T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US782337 1985-10-01
US10/782,337 US7214671B2 (en) 2004-02-19 2004-02-19 Use of 2-methylene-19-nor-20(S)-1α,25-dihydroxyvitamin D3 for the prophylaxis of bone diseases
PCT/US2004/042657 WO2005082456A1 (en) 2004-02-19 2004-12-17 USE OF 2-METHYLENE-19-NOR-20(S)-1α,25-DIHYDROXYVITAMIN D3 FOR THE PROPHYLAXIS OF BONE DISEASES

Publications (1)

Publication Number Publication Date
ES2399328T3 true ES2399328T3 (es) 2013-03-27

Family

ID=34861010

Family Applications (1)

Application Number Title Priority Date Filing Date
ES04814798T Expired - Lifetime ES2399328T3 (es) 2004-02-19 2004-12-17 Uso de 2-metilen-19-nor-20(S)-1a,25-dihidroxivitamina D3 para la profilaxis de enfermedades óseas

Country Status (8)

Country Link
US (1) US7214671B2 (enExample)
EP (1) EP1722856B1 (enExample)
JP (1) JP2007523162A (enExample)
AU (1) AU2004316404B2 (enExample)
CA (1) CA2556931C (enExample)
ES (1) ES2399328T3 (enExample)
NZ (1) NZ549318A (enExample)
WO (1) WO2005082456A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006061683A1 (en) * 2004-12-09 2006-06-15 Pfizer Products Inc. 2-alkylidene-19-nor-vitamin d derivatives for the treatment of osteogenesis imperfecta
MX2008012913A (es) 2006-04-06 2009-03-06 Wisconsin Alumni Res Found 2-metilen-1a,25-dihidroxi-18,19,21-trinorvitamina d3 y sus usos.
AU2007234717B2 (en) * 2006-04-06 2012-04-19 Wisconsin Alumni Research Foundation 2-methylene-1alpha,25-dihydroxy-19,21-dinorvitamin D3 analogs and uses thereof
JP5908402B2 (ja) * 2009-08-03 2016-04-26 ウィスコンシン・アルムニ・リサーチ・ファウンデーションＷｉｓｃｏｎｓｉｎ Ａｌｕｍｎｉ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ 腎疾患の予防方法およびその症状を処置する方法
WO2011119610A2 (en) * 2010-03-23 2011-09-29 Wisconsin Alumni Research Foundation (20S)-2-METHYLENE-19-NOR-22-DIMETHYL-1α,25- DIHYDROXYVITAMIN D3 AND (20R)-2-METHYLENE-19-NOR-22- DIMETHYL-1α,25-HYDROXYVITAMIN D3
US8664206B2 (en) 2010-03-23 2014-03-04 Wisconsin Alumni Research Foundation Diastereomers of 2-methylene-19-nor-22-methyl-1α,25-dihydroxyvitamin D3
JP5931845B2 (ja) * 2010-03-23 2016-06-08 ウイスコンシン アラムニ リサーチ ファンデーション ２−メチレン−１９−ノル−２２−メチル−１α，２５−ジヒドロキシビタミンＤ３のジアステレオマー
MY172886A (en) * 2012-06-29 2019-12-13 Wisconsin Alumni Res Found Use of 2-methylene-19-nor-(20s)-1?25-dihydroxyvitamin d3 to treat secondary hyperparathyroidism
US9539264B2 (en) 2014-12-30 2017-01-10 Wisconsin Alumni Research Foundation Use of 2-methylene-19-nor-(20S)-1-alpha,25-dihydroxyvitamin D3 to treat secondary hyperparathyroidism in patients previously treated with calcimimetics
US10369161B2 (en) 2014-12-30 2019-08-06 Wisconsin Alumni Research Foundation Use of 2-methylene-19-NOR-(20S)-1-alpha,25-dihydroxyvitamin D3 to treat primary hyperparathyroidism
CN119632967B (zh) * 2024-11-14 2025-10-21 广州健尔圣医药科技有限公司 二硫代氨基甲酸类化合物在制备预防和/或治疗骨质疏松药物中的应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3626058A1 (de) * 1986-08-01 1988-02-11 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
CA1333616C (en) * 1989-03-09 1994-12-20 Hector F. Deluca 19-nor-vitamin d compounds
US6392071B1 (en) * 1997-03-17 2002-05-21 Wisconsin Alumni: Research Foundation 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds
US6306844B1 (en) * 1997-03-17 2001-10-23 Wisconsin Alumni Research Foundation Use of 2α-methyl-19-nor-20(S)-1α, 25-dihydroxyvitamin D3 to increase bone strength
US5843928A (en) * 1997-03-17 1998-12-01 Wisconsin Alumni Research Foundation 2-alkylidene-19-nor-vitamin D compounds
US6316642B1 (en) * 1997-03-17 2001-11-13 Wisconsin Alumni Research Foundation 26,27-Homologated-20-EPI-2alkyl-19-nor-vitamin D compounds
US5945410A (en) * 1997-03-17 1999-08-31 Wisconsin Alumni Research Foundation 2-alkyl-19-nor-vitamin D compounds
GB9709082D0 (en) * 1997-05-06 1997-06-25 Ciba Geigy Ag Organic compositions
US6313119B1 (en) * 1998-01-23 2001-11-06 Adventis Pharma Deutschland Gmbh Sulfonamide derivatives as inhibitors of bone resorption and as inhibitors of cell adhesion
US6114317A (en) * 1998-05-21 2000-09-05 Wisconsin Alumni Research Foundation Method of locking 1α-OH of vitamin D compounds in axial orientation
US5972917A (en) * 1998-05-29 1999-10-26 Bone Care Int Inc 1 α-hydroxy-25-ene-vitamin D, analogs and uses thereof
BR0112454A (pt) * 2000-07-14 2003-07-29 Wisconsin Alumni Res Found Métodos de tratamento de doença metabólica do osso, psorìase, leucemia, câncer do cólon, do seio ou da próstata e de aumento da força de um osso e uso de composto
BR0113703A (pt) * 2000-09-08 2003-07-22 Wisconsin Alumni Researcg Foun Compostos e métodos de tratamento de psorìase, leucemia, câncer do cólon, do seio ou da próstata, osteodistrofia renal, de doenças auto-imune, inflamatória e de condição de pele
US6566352B1 (en) * 2002-02-18 2003-05-20 Wisconsin Alumni Research Foudation 1 α-hydroxy-2-methylene-19-nor-pregnacalciferol and its uses
US20030195175A1 (en) * 2002-03-25 2003-10-16 Deluca Hector F. Use of carbon-2-modified-vitamin D analogs to induce the formation of new bone

Also Published As

Publication number Publication date
JP2007523162A (ja) 2007-08-16
NZ549318A (en) 2011-01-28
CA2556931A1 (en) 2005-09-09
AU2004316404B2 (en) 2011-02-10
WO2005082456A1 (en) 2005-09-09
EP1722856A1 (en) 2006-11-22
US7214671B2 (en) 2007-05-08
AU2004316404A1 (en) 2005-09-09
EP1722856B1 (en) 2012-11-28
US20050187201A1 (en) 2005-08-25
CA2556931C (en) 2013-02-05

Similar Documents

Publication Publication Date Title
ES2286129T3 (es) Uso de 2-alfa-metil-19-nor-20(s)-1-alfa,25-dihidroxivitamina d3 en sustitucion osea.
ES2274116T3 (es) 1-alfa-hidroxi-2-metilenj-19-nor-pregnacalciferol y sus usos.
ES2227215T3 (es) 1 alfa-hidroxi.2.metilen-19-nor-homopregnacalciferol y sus aplicaciones terapeuticas.
AU2001278888B2 (en) Use of 2-methylene-19-nor-20(s)-1alpha,25-dihydroxyvitamin D3 to increase bone strength
KR20050057180A (ko) 비타민 ｄ 화합물의 투여량 범위를 확장시키는 방법
AU2001278888A1 (en) Use of 2-methylene-19-nor-20(s)-1alpha,25-dihydroxyvitamin D3 to increase bone strength
EP1722856B1 (en) Use of 2-methylene-19-nor-20(s)-1alpha,25-dihydroxyvitamin d3 for the prophylaxis of bone diseases
ES2312764T3 (es) Uso de analogos de vitamina d modificados en el carbono 2 para inducir la formacion de hueso nuevo.
ES2338428T3 (es) Tratamiento de la enfermedad inflamatoria del intestino con compuestos de 2-metilen-19-nor-vitamina d.
ES2249013T3 (es) Compuestos de 19-nor-vitamina d3 con actividad calcemica.
US5696103A (en) Method for treating osteoporosis
WO1997016193A1 (en) Pharmaceutical composition for treating osteoporosis
MXPA06009640A (en) USE OF 2-METHYLENE-19-NOR-20(S)-1alpha,25-DIHYDROXYVITAMIN D3