JP2007523162A - ２‐メチレン‐１９‐ノル‐２０（Ｓ）‐１α，２５‐ジヒドロキシビタミンＤ３の骨疾患の予防のための使用 - Google Patents

２‐メチレン‐１９‐ノル‐２０（Ｓ）‐１α，２５‐ジヒドロキシビタミンＤ３の骨疾患の予防のための使用 Download PDF

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JP2007523162A
JP2007523162A JP2006554085A JP2006554085A JP2007523162A JP 2007523162 A JP2007523162 A JP 2007523162A JP 2006554085 A JP2006554085 A JP 2006554085A JP 2006554085 A JP2006554085 A JP 2006554085A JP 2007523162 A JP2007523162 A JP 2007523162A
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Prior art keywords
dihydroxyvitamin
methylene
per day
osteoporosis
effective amount
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JP2006554085A
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Japanese (ja)
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JP2007523162A5 (enExample
Inventor
デルーカ，ヘクター・エフ
プラム，ロリ・エイ
クラジェット−ダーム，マーガレット
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Wisconsin Alumni Research Foundation
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Wisconsin Alumni Research Foundation
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2006554085A 2004-02-19 2004-12-17 ２‐メチレン‐１９‐ノル‐２０（Ｓ）‐１α，２５‐ジヒドロキシビタミンＤ３の骨疾患の予防のための使用 Pending JP2007523162A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/782,337 US7214671B2 (en) 2004-02-19 2004-02-19 Use of 2-methylene-19-nor-20(S)-1α,25-dihydroxyvitamin D3 for the prophylaxis of bone diseases
PCT/US2004/042657 WO2005082456A1 (en) 2004-02-19 2004-12-17 USE OF 2-METHYLENE-19-NOR-20(S)-1α,25-DIHYDROXYVITAMIN D3 FOR THE PROPHYLAXIS OF BONE DISEASES

Publications (2)

Publication Number Publication Date
JP2007523162A true JP2007523162A (ja) 2007-08-16
JP2007523162A5 JP2007523162A5 (enExample) 2008-02-07

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ID=34861010

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JP2006554085A Pending JP2007523162A (ja) 2004-02-19 2004-12-17 ２‐メチレン‐１９‐ノル‐２０（Ｓ）‐１α，２５‐ジヒドロキシビタミンＤ３の骨疾患の予防のための使用

Country Status (8)

Country Link
US (1) US7214671B2 (enExample)
EP (1) EP1722856B1 (enExample)
JP (1) JP2007523162A (enExample)
AU (1) AU2004316404B2 (enExample)
CA (1) CA2556931C (enExample)
ES (1) ES2399328T3 (enExample)
NZ (1) NZ549318A (enExample)
WO (1) WO2005082456A1 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013501049A (ja) * 2009-08-03 2013-01-10 ウィスコンシン・アルムニ・リサーチ・ファウンデーション 腎疾患の予防方法およびその症状を処置する方法
US9205096B2 (en) 2012-06-29 2015-12-08 Wisconsin Alumni Research Foundation Use of 2-methylene-19-nor-(20S)-1α,25-dihydroxyvitamin D3 to treat secondary hyperparathyroidism
US9814736B2 (en) 2014-12-30 2017-11-14 Wisconsin Alumni Research Foundation Use of 2-methylene-19-nor-(20S)-1α,25-dihydroxyvitamin D3 and calcimimetics to treat secondary hyperparathyroidism
US10369161B2 (en) 2014-12-30 2019-08-06 Wisconsin Alumni Research Foundation Use of 2-methylene-19-NOR-(20S)-1-alpha,25-dihydroxyvitamin D3 to treat primary hyperparathyroidism

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006061683A1 (en) * 2004-12-09 2006-06-15 Pfizer Products Inc. 2-alkylidene-19-nor-vitamin d derivatives for the treatment of osteogenesis imperfecta
EP2021321B1 (en) 2006-04-06 2012-06-20 Wisconsin Alumni Research Foundation 2-methylene-1alpha,25-dihydroxy-18,19,21-trinorvitamin d3 and uses thereof
ATE523487T1 (de) * 2006-04-06 2011-09-15 Wisconsin Alumni Res Found 2-methylen-1-alpha-dihydroxy-19,21-dinor-vitami - d3-analoga und ihre anwendung
US20110237557A1 (en) * 2010-03-23 2011-09-29 Deluca Hector F Diastereomers of 2-methylene-19-nor-22-methyl-1alpha,25-dihydroxyvitamin d3
US8664206B2 (en) 2010-03-23 2014-03-04 Wisconsin Alumni Research Foundation Diastereomers of 2-methylene-19-nor-22-methyl-1α,25-dihydroxyvitamin D3
US8604009B2 (en) * 2010-03-23 2013-12-10 Wisconsin Alumni Research Foundation (20S)-2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D3 and (20R)-2-methylene-19-nor-22-dimethyl-1α,25-hydroxyvitamin D3
CN119632967B (zh) * 2024-11-14 2025-10-21 广州健尔圣医药科技有限公司 二硫代氨基甲酸类化合物在制备预防和/或治疗骨质疏松药物中的应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001504135A (ja) * 1997-03-17 2001-03-27 ウイスコンシン・アルムニ・リサーチ・ファウンデーション ２−アルキリデン−１９−ノル−ビタミンｄ化合物
WO2002005823A2 (en) * 2000-07-14 2002-01-24 Wisconsin Alumni Research Foundation USE OF 2-METHYLENE-19-NOR-20(S)-1α,25-DIHYDROXYVITAMIN D3 TO INCREASE BONE STRENGTH
WO2003082300A1 (en) * 2002-03-25 2003-10-09 Wisconsin Alumni Research Foundation Use of carbon-2-modified-vitamin d analogs to induce the formation of new bone

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3626058A1 (de) * 1986-08-01 1988-02-11 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
CA1333616C (en) * 1989-03-09 1994-12-20 Hector F. Deluca 19-nor-vitamin d compounds
US5945410A (en) * 1997-03-17 1999-08-31 Wisconsin Alumni Research Foundation 2-alkyl-19-nor-vitamin D compounds
US6392071B1 (en) * 1997-03-17 2002-05-21 Wisconsin Alumni: Research Foundation 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds
US6316642B1 (en) * 1997-03-17 2001-11-13 Wisconsin Alumni Research Foundation 26,27-Homologated-20-EPI-2alkyl-19-nor-vitamin D compounds
US6306844B1 (en) * 1997-03-17 2001-10-23 Wisconsin Alumni Research Foundation Use of 2α-methyl-19-nor-20(S)-1α, 25-dihydroxyvitamin D3 to increase bone strength
GB9709082D0 (en) * 1997-05-06 1997-06-25 Ciba Geigy Ag Organic compositions
US6313119B1 (en) * 1998-01-23 2001-11-06 Adventis Pharma Deutschland Gmbh Sulfonamide derivatives as inhibitors of bone resorption and as inhibitors of cell adhesion
US6114317A (en) * 1998-05-21 2000-09-05 Wisconsin Alumni Research Foundation Method of locking 1α-OH of vitamin D compounds in axial orientation
US5972917A (en) * 1998-05-29 1999-10-26 Bone Care Int Inc 1 α-hydroxy-25-ene-vitamin D, analogs and uses thereof
AU7544501A (en) * 2000-09-08 2002-03-22 Wisconsin Alumni Res Found 1alpha-hydroxy-2-methylene-19-nor-homopregnacalciferol and its therapeutic applications
US6566352B1 (en) * 2002-02-18 2003-05-20 Wisconsin Alumni Research Foudation 1 α-hydroxy-2-methylene-19-nor-pregnacalciferol and its uses

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001504135A (ja) * 1997-03-17 2001-03-27 ウイスコンシン・アルムニ・リサーチ・ファウンデーション ２−アルキリデン−１９−ノル−ビタミンｄ化合物
WO2002005823A2 (en) * 2000-07-14 2002-01-24 Wisconsin Alumni Research Foundation USE OF 2-METHYLENE-19-NOR-20(S)-1α,25-DIHYDROXYVITAMIN D3 TO INCREASE BONE STRENGTH
WO2003082300A1 (en) * 2002-03-25 2003-10-09 Wisconsin Alumni Research Foundation Use of carbon-2-modified-vitamin d analogs to induce the formation of new bone

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013501049A (ja) * 2009-08-03 2013-01-10 ウィスコンシン・アルムニ・リサーチ・ファウンデーション 腎疾患の予防方法およびその症状を処置する方法
US9205096B2 (en) 2012-06-29 2015-12-08 Wisconsin Alumni Research Foundation Use of 2-methylene-19-nor-(20S)-1α,25-dihydroxyvitamin D3 to treat secondary hyperparathyroidism
US9717744B2 (en) 2012-06-29 2017-08-01 Wisconsin Alumni Research Foundation Use of 2-methylene-19-nor-(20S)-1α,25-dihydroxyvitamin D3 to prevent secondary hyperparathyroidism or the symptoms thereof
US10046000B2 (en) 2012-06-29 2018-08-14 Wisconsin Alumni Research Foundation Use of 2-methylene-19-nor-(20S)-1α,25-Dihydroxyvitamin D3 to treat and prevent secondary hyperparathyroidism in a subject having renal failure
US9814736B2 (en) 2014-12-30 2017-11-14 Wisconsin Alumni Research Foundation Use of 2-methylene-19-nor-(20S)-1α,25-dihydroxyvitamin D3 and calcimimetics to treat secondary hyperparathyroidism
US10369161B2 (en) 2014-12-30 2019-08-06 Wisconsin Alumni Research Foundation Use of 2-methylene-19-NOR-(20S)-1-alpha,25-dihydroxyvitamin D3 to treat primary hyperparathyroidism

Also Published As

Publication number Publication date
US20050187201A1 (en) 2005-08-25
CA2556931A1 (en) 2005-09-09
NZ549318A (en) 2011-01-28
AU2004316404A1 (en) 2005-09-09
CA2556931C (en) 2013-02-05
AU2004316404B2 (en) 2011-02-10
US7214671B2 (en) 2007-05-08
WO2005082456A1 (en) 2005-09-09
ES2399328T3 (es) 2013-03-27
EP1722856A1 (en) 2006-11-22
EP1722856B1 (en) 2012-11-28

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