ES2390360T3 - Moléculas de unión para el factor VIII humano y proteínas similares al factor VIII humano - Google Patents
Moléculas de unión para el factor VIII humano y proteínas similares al factor VIII humano Download PDFInfo
- Publication number
- ES2390360T3 ES2390360T3 ES09155033T ES09155033T ES2390360T3 ES 2390360 T3 ES2390360 T3 ES 2390360T3 ES 09155033 T ES09155033 T ES 09155033T ES 09155033 T ES09155033 T ES 09155033T ES 2390360 T3 ES2390360 T3 ES 2390360T3
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- Prior art keywords
- phe
- cys
- factor viii
- polypeptide
- val
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- Expired - Lifetime
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- 230000000740 bleeding effect Effects 0.000 description 1
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- 125000004218 chloromethyl group Chemical group [H]C([H])(Cl)* 0.000 description 1
- 239000012501 chromatography medium Substances 0.000 description 1
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- 229940105778 coagulation factor viii Drugs 0.000 description 1
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- 239000012228 culture supernatant Substances 0.000 description 1
- 150000004294 cyclic thioethers Chemical class 0.000 description 1
- GCFAUZGWPDYAJN-UHFFFAOYSA-N cyclohexyl 3-phenylprop-2-enoate Chemical compound C=1C=CC=CC=1C=CC(=O)OC1CCCCC1 GCFAUZGWPDYAJN-UHFFFAOYSA-N 0.000 description 1
- 150000001945 cysteines Chemical class 0.000 description 1
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- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 description 1
- MGHPNCMVUAKAIE-UHFFFAOYSA-N diphenylmethanamine Chemical compound C=1C=CC=CC=1C(N)C1=CC=CC=C1 MGHPNCMVUAKAIE-UHFFFAOYSA-N 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 239000000147 enterotoxin Substances 0.000 description 1
- 231100000655 enterotoxin Toxicity 0.000 description 1
- 238000007824 enzymatic assay Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
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- 108010025306 histidylleucine Proteins 0.000 description 1
- 108010092114 histidylphenylalanine Proteins 0.000 description 1
- 108010085325 histidylproline Proteins 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 description 1
- 150000002463 imidates Chemical class 0.000 description 1
- 238000001597 immobilized metal affinity chromatography Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- PGLTVOMIXTUURA-UHFFFAOYSA-N iodoacetamide Chemical compound NC(=O)CI PGLTVOMIXTUURA-UHFFFAOYSA-N 0.000 description 1
- JDNTWHVOXJZDSN-UHFFFAOYSA-N iodoacetic acid Chemical compound OC(=O)CI JDNTWHVOXJZDSN-UHFFFAOYSA-N 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
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- 210000004962 mammalian cell Anatomy 0.000 description 1
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- 230000009871 nonspecific binding Effects 0.000 description 1
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- 150000002894 organic compounds Chemical class 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- XYFCBTPGUUZFHI-UHFFFAOYSA-O phosphonium Chemical compound [PH4+] XYFCBTPGUUZFHI-UHFFFAOYSA-O 0.000 description 1
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- 239000004033 plastic Substances 0.000 description 1
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- 238000006268 reductive amination reaction Methods 0.000 description 1
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- 108010038196 saccharide-binding proteins Proteins 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000003118 sandwich ELISA Methods 0.000 description 1
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- 238000004062 sedimentation Methods 0.000 description 1
- 238000010532 solid phase synthesis reaction Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000012089 stop solution Substances 0.000 description 1
- 125000002653 sulfanylmethyl group Chemical group [H]SC([H])([H])[*] 0.000 description 1
- 238000004114 suspension culture Methods 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- 238000011191 terminal modification Methods 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
- WROMPOXWARCANT-UHFFFAOYSA-N tfa trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.OC(=O)C(F)(F)F WROMPOXWARCANT-UHFFFAOYSA-N 0.000 description 1
- 150000003568 thioethers Chemical class 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 230000009261 transgenic effect Effects 0.000 description 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Reciprocating Pumps (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/224,785 US6197526B1 (en) | 1999-01-04 | 1999-01-04 | Polypeptides for binding human factor VIII and fragments of human factor VIII |
| US224785 | 1999-01-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2390360T3 true ES2390360T3 (es) | 2012-11-12 |
Family
ID=22842198
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES09155033T Expired - Lifetime ES2390360T3 (es) | 1999-01-04 | 2000-01-03 | Moléculas de unión para el factor VIII humano y proteínas similares al factor VIII humano |
| ES10182747.5T Expired - Lifetime ES2499040T3 (es) | 1999-01-04 | 2000-01-03 | Moléculas de unión para las proteínas similares al factor VIII y factor VIII humano |
| ES10182741.8T Expired - Lifetime ES2524965T3 (es) | 1999-01-04 | 2000-01-03 | Moléculas de unión para las proteínas similares al factor VIII y factor VIII humano |
| ES06009040T Expired - Lifetime ES2328722T3 (es) | 1999-01-04 | 2000-01-03 | Moleculas de union para proteinas de factor humano viii y de tipo factor viii. |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES10182747.5T Expired - Lifetime ES2499040T3 (es) | 1999-01-04 | 2000-01-03 | Moléculas de unión para las proteínas similares al factor VIII y factor VIII humano |
| ES10182741.8T Expired - Lifetime ES2524965T3 (es) | 1999-01-04 | 2000-01-03 | Moléculas de unión para las proteínas similares al factor VIII y factor VIII humano |
| ES06009040T Expired - Lifetime ES2328722T3 (es) | 1999-01-04 | 2000-01-03 | Moleculas de union para proteinas de factor humano viii y de tipo factor viii. |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US6197526B1 (cg-RX-API-DMAC7.html) |
| EP (5) | EP2298791B8 (cg-RX-API-DMAC7.html) |
| JP (3) | JP4733272B2 (cg-RX-API-DMAC7.html) |
| AT (1) | ATE433992T1 (cg-RX-API-DMAC7.html) |
| AU (3) | AU769745B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2354599C (cg-RX-API-DMAC7.html) |
| DE (1) | DE60042430D1 (cg-RX-API-DMAC7.html) |
| DK (4) | DK2090582T3 (cg-RX-API-DMAC7.html) |
| ES (4) | ES2390360T3 (cg-RX-API-DMAC7.html) |
| HK (1) | HK1038756A1 (cg-RX-API-DMAC7.html) |
| PT (3) | PT2298791E (cg-RX-API-DMAC7.html) |
| WO (1) | WO2000040602A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7820796B2 (en) * | 1998-03-12 | 2010-10-26 | Genetics Institute, Llc. | Methods for producing Factor VIII proteins |
| US6197526B1 (en) * | 1999-01-04 | 2001-03-06 | Dyax Corp. | Polypeptides for binding human factor VIII and fragments of human factor VIII |
| US7112438B2 (en) * | 1999-01-04 | 2006-09-26 | Dyax Corp. | Binding molecules for human factor VIII and factor VIII-like proteins |
| FR2830865B1 (fr) * | 2001-10-17 | 2004-10-22 | Centre Nat Rech Scient | Leurres peptidiques pour la preparation de medicaments destines a la prevention ou au traitement des pathologies auto-immunes, ou des troubles lies a l'apparition d'anticorps diriges contre des proteines exogenes |
| US20030149246A1 (en) * | 2002-02-01 | 2003-08-07 | Russell John C. | Macromolecular conjugates and processes for preparing the same |
| AU2003230509B2 (en) * | 2002-04-29 | 2009-03-12 | Affibody Ab | Sandwich assay and kit |
| WO2007065691A2 (en) * | 2005-12-07 | 2007-06-14 | Technische Universität München | Small peptidic and peptido-mimetic affinity ligands for factor viii and factor viii-like proteins |
| TW200745163A (en) * | 2006-02-17 | 2007-12-16 | Syntonix Pharmaceuticals Inc | Peptides that block the binding of IgG to FcRn |
| EP2156179B1 (en) | 2007-04-04 | 2021-08-18 | The Regents of The University of California | Methods for using a nanopore |
| EA201070231A1 (ru) | 2007-08-09 | 2010-10-29 | Синтоникс Фармасьютикалз, Инк. | Иммуномодулирующие пептиды |
| AR071478A1 (es) | 2008-04-17 | 2010-06-23 | Baxter Healthcare Sa | Peptidos de bajo peso molecular con actividad procoagulante para el tratamiento de pacientes con deficiencia de factor v (fv), fvii, fviii, fx y/o fxi |
| US20100048488A1 (en) * | 2008-08-01 | 2010-02-25 | Syntonix Pharmaceuticals, Inc. | Immunomodulatory peptides |
| US8324914B2 (en) | 2010-02-08 | 2012-12-04 | Genia Technologies, Inc. | Systems and methods for characterizing a molecule |
| SG191186A1 (en) | 2010-12-15 | 2013-07-31 | Baxter Int | Eluate collection using conductivity gradient |
| EP3527218A1 (en) * | 2011-06-10 | 2019-08-21 | Bioverativ Therapeutics Inc. | Pro-coagulant compounds and methods of use thereof |
| JP6702866B2 (ja) | 2013-11-18 | 2020-06-03 | ルビウス セラピューティクス， インコーポレイテッド | 合成膜−レシーバー複合体 |
| CN116731197A (zh) * | 2016-09-19 | 2023-09-12 | 豪夫迈·罗氏有限公司 | 基于补体因子的亲和层析 |
| SG11202000979SA (en) | 2017-08-04 | 2020-02-27 | Shire Human Genetic Therapies | Antibody-resin coupling apparatus and methods |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4757006A (en) | 1983-10-28 | 1988-07-12 | Genetics Institute, Inc. | Human factor VIII:C gene and recombinant methods for production |
| SE8501050D0 (sv) | 1985-03-05 | 1985-03-05 | Kabivitrum Ab | Biologically active fragments of human antihemophilic factor and method for preparation thereof |
| EP0218712B1 (en) | 1985-04-12 | 1992-02-26 | Genetics Institute, Inc. | Novel procoagulant proteins |
| DE68927933T2 (de) * | 1988-09-02 | 1997-08-14 | Dyax Corp | Herstellung und auswahl von rekombinantproteinen mit verschiedenen bindestellen |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5661008A (en) | 1991-03-15 | 1997-08-26 | Kabi Pharmacia Ab | Recombinant human factor VIII derivatives |
| SE468050C (sv) * | 1991-03-15 | 1998-04-27 | Pharmacia & Upjohn Ab | Rekombinant derivat av human faktor VIII |
| AU1757592A (en) * | 1991-03-27 | 1992-11-02 | Scripps Research Institute, The | Therapeutic fragments of von willebrand factor |
| AU713744B2 (en) * | 1996-03-20 | 1999-12-09 | Dyax Corp. | Engineering affinity ligands for macromolecules |
| US5817752A (en) | 1996-06-06 | 1998-10-06 | La Jolla Pharmaceutical Company | Cyclic polypeptides comprising a thioether linkage and methods for their preparation |
| KR20000016414A (ko) | 1996-06-06 | 2000-03-25 | 와이즈먼 앤드루 | Apl 면역반응성 펩티드, 그것의 콘주게이트 및 apl항체-매개병변의 치료방법 |
| EP1095143B1 (en) * | 1998-05-08 | 2008-08-20 | Stichting Sanquin Bloedvoorziening | Inhibitor for diagnosis and treatment of haemophilia a patients |
| US5994310A (en) | 1998-09-03 | 1999-11-30 | Bayer Corporation | Peptide ligands for affinity purification of human Factor VIII |
| US6197526B1 (en) * | 1999-01-04 | 2001-03-06 | Dyax Corp. | Polypeptides for binding human factor VIII and fragments of human factor VIII |
-
1999
- 1999-01-04 US US09/224,785 patent/US6197526B1/en not_active Expired - Lifetime
-
2000
- 2000-01-03 ES ES09155033T patent/ES2390360T3/es not_active Expired - Lifetime
- 2000-01-03 ES ES10182747.5T patent/ES2499040T3/es not_active Expired - Lifetime
- 2000-01-03 PT PT101827418T patent/PT2298791E/pt unknown
- 2000-01-03 EP EP10182741.8A patent/EP2298791B8/en not_active Expired - Lifetime
- 2000-01-03 HK HK02100182.6A patent/HK1038756A1/zh unknown
- 2000-01-03 ES ES10182741.8T patent/ES2524965T3/es not_active Expired - Lifetime
- 2000-01-03 AT AT06009040T patent/ATE433992T1/de active
- 2000-01-03 CA CA2354599A patent/CA2354599C/en not_active Expired - Lifetime
- 2000-01-03 WO PCT/US2000/000043 patent/WO2000040602A1/en not_active Ceased
- 2000-01-03 AU AU25982/00A patent/AU769745B2/en not_active Expired
- 2000-01-03 DK DK09155033.5T patent/DK2090582T3/da active
- 2000-01-03 DK DK06009040T patent/DK1705183T3/da active
- 2000-01-03 DE DE60042430T patent/DE60042430D1/de not_active Expired - Lifetime
- 2000-01-03 JP JP2000592310A patent/JP4733272B2/ja not_active Expired - Lifetime
- 2000-01-03 PT PT06009040T patent/PT1705183E/pt unknown
- 2000-01-03 DK DK10182747.5T patent/DK2301953T3/da active
- 2000-01-03 PT PT101827475T patent/PT2301953E/pt unknown
- 2000-01-03 EP EP10182747.5A patent/EP2301953B1/en not_active Expired - Lifetime
- 2000-01-03 EP EP00904186A patent/EP1147128A4/en not_active Withdrawn
- 2000-01-03 DK DK10182741.8T patent/DK2298791T3/en active
- 2000-01-03 EP EP06009040A patent/EP1705183B1/en not_active Expired - Lifetime
- 2000-01-03 EP EP09155033A patent/EP2090582B1/en not_active Expired - Lifetime
- 2000-01-03 ES ES06009040T patent/ES2328722T3/es not_active Expired - Lifetime
-
2001
- 2001-01-08 US US09/756,594 patent/US6492105B2/en not_active Expired - Lifetime
-
2004
- 2004-04-30 AU AU2004201830A patent/AU2004201830B2/en not_active Expired
- 2004-04-30 AU AU2004201810A patent/AU2004201810A1/en not_active Abandoned
-
2010
- 2010-05-10 JP JP2010108017A patent/JP5368371B2/ja not_active Expired - Lifetime
-
2012
- 2012-12-27 JP JP2012284538A patent/JP5572207B2/ja not_active Expired - Lifetime
Also Published As
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