ES2384911T3 - Inhibidores del virus de la hepatitis C - Google Patents

Inhibidores del virus de la hepatitis C Download PDF

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Publication number
ES2384911T3
ES2384911T3 ES09709849T ES09709849T ES2384911T3 ES 2384911 T3 ES2384911 T3 ES 2384911T3 ES 09709849 T ES09709849 T ES 09709849T ES 09709849 T ES09709849 T ES 09709849T ES 2384911 T3 ES2384911 T3 ES 2384911T3
Authority
ES
Spain
Prior art keywords
alkyl
independently selected
cap
heterocyclylcarbonyl
mmol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES09709849T
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English (en)
Spanish (es)
Inventor
Carol; BELEMA Makonen BACHAND
Daniel H.; GOOD Andrew C. DEON
Jason; JAMES Clint A. GOODRICH
Rico; LOPEZ Omar D. LAVOIE
Alain; MEANWELL Nicholas A. MARTEL
Van N.; ROMINE Jeffrey Lee NGUYEN
Edward H.; SNYDER Lawrence B. RUEDIGER
Denis R.; YANG Fukang ST. LAURENT
David R.; WANG Gan LANGLEY
Lawrence G. Hamann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of ES2384911T3 publication Critical patent/ES2384911T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
ES09709849T 2008-02-13 2009-02-06 Inhibidores del virus de la hepatitis C Active ES2384911T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28277 1987-03-20
US2827708P 2008-02-13 2008-02-13
PCT/US2009/033380 WO2009102633A1 (en) 2008-02-13 2009-02-06 Hepatitis c virus inhibitors

Publications (1)

Publication Number Publication Date
ES2384911T3 true ES2384911T3 (es) 2012-07-13

Family

ID=40581591

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09709849T Active ES2384911T3 (es) 2008-02-13 2009-02-06 Inhibidores del virus de la hepatitis C

Country Status (28)

Country Link
US (1) US8147818B2 (US07794700-20100914-C00152.png)
EP (1) EP2245027B1 (US07794700-20100914-C00152.png)
JP (1) JP5455933B2 (US07794700-20100914-C00152.png)
KR (1) KR101624365B1 (US07794700-20100914-C00152.png)
CN (1) CN102143959B (US07794700-20100914-C00152.png)
AR (1) AR070366A1 (US07794700-20100914-C00152.png)
AT (1) ATE555109T1 (US07794700-20100914-C00152.png)
AU (1) AU2009214997B2 (US07794700-20100914-C00152.png)
BR (1) BRPI0908240A2 (US07794700-20100914-C00152.png)
CA (1) CA2715559A1 (US07794700-20100914-C00152.png)
CL (1) CL2009000324A1 (US07794700-20100914-C00152.png)
CO (1) CO6290682A2 (US07794700-20100914-C00152.png)
CY (1) CY1112999T1 (US07794700-20100914-C00152.png)
DK (1) DK2245027T3 (US07794700-20100914-C00152.png)
EA (1) EA018313B1 (US07794700-20100914-C00152.png)
ES (1) ES2384911T3 (US07794700-20100914-C00152.png)
HK (1) HK1143812A1 (US07794700-20100914-C00152.png)
HR (1) HRP20120523T1 (US07794700-20100914-C00152.png)
IL (1) IL207459A (US07794700-20100914-C00152.png)
MX (1) MX2010008749A (US07794700-20100914-C00152.png)
NZ (1) NZ587322A (US07794700-20100914-C00152.png)
PE (1) PE20091381A1 (US07794700-20100914-C00152.png)
PL (1) PL2245027T3 (US07794700-20100914-C00152.png)
PT (1) PT2245027E (US07794700-20100914-C00152.png)
SI (1) SI2245027T1 (US07794700-20100914-C00152.png)
TW (1) TWI458482B (US07794700-20100914-C00152.png)
WO (1) WO2009102633A1 (US07794700-20100914-C00152.png)
ZA (1) ZA201005484B (US07794700-20100914-C00152.png)

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