CL2009000324A1 - Compuestos derivados de heterociclos no condensados sustituidos, inhibidores de la funcion de la proteina ns5a; composicion farmaceutica que los comprende; y su uso para tratar la infeccion del virus de la hepatitis c. - Google Patents

Compuestos derivados de heterociclos no condensados sustituidos, inhibidores de la funcion de la proteina ns5a; composicion farmaceutica que los comprende; y su uso para tratar la infeccion del virus de la hepatitis c.

Info

Publication number
CL2009000324A1
CL2009000324A1 CL2009000324A CL2009000324A CL2009000324A1 CL 2009000324 A1 CL2009000324 A1 CL 2009000324A1 CL 2009000324 A CL2009000324 A CL 2009000324A CL 2009000324 A CL2009000324 A CL 2009000324A CL 2009000324 A1 CL2009000324 A1 CL 2009000324A1
Authority
CL
Chile
Prior art keywords
pharmaceutical composition
inhibitors
virus infection
protein function
compounds derived
Prior art date
Application number
CL2009000324A
Other languages
English (en)
Inventor
Bachand Carol
Belema Makonen
C Good Andrew
Goodrich Jason
Lavoie Rico
h deon Daniel
a james Clint
d lopez Omar
Martel Alain
A Meanwell Nicholas
N Nguyen Van
Lee Romine Jeffrey
H Ruediger Edward
b snyder Lawrence
R St Laurent Denis
Yang Fukang
R Langley David
Wang Gan
G Hamann Lawrence
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of CL2009000324A1 publication Critical patent/CL2009000324A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered

Abstract

COMPUESTO DE FÓRMULA DONDE, R1 , R2, R3, R4, R1' , R2' ,R3 ', R4', SON COMO SE DEFINEN EN LA MEMORIA DESCRIPTIVA Y PLIEGO DE REIVINDICACIONES, COMPOSICIÓN FARMACÉUTICA QUE LOS COMPRENDE; Y SU USO PARA TRATAR LA INFECCIÓN DEL VIRUS DE LA HEPATITIS C.<br />  
CL2009000324A 2008-02-13 2009-02-12 Compuestos derivados de heterociclos no condensados sustituidos, inhibidores de la funcion de la proteina ns5a; composicion farmaceutica que los comprende; y su uso para tratar la infeccion del virus de la hepatitis c. CL2009000324A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2827708P 2008-02-13 2008-02-13

Publications (1)

Publication Number Publication Date
CL2009000324A1 true CL2009000324A1 (es) 2010-09-21

Family

ID=40581591

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2009000324A CL2009000324A1 (es) 2008-02-13 2009-02-12 Compuestos derivados de heterociclos no condensados sustituidos, inhibidores de la funcion de la proteina ns5a; composicion farmaceutica que los comprende; y su uso para tratar la infeccion del virus de la hepatitis c.

Country Status (28)

Country Link
US (1) US8147818B2 (es)
EP (1) EP2245027B1 (es)
JP (1) JP5455933B2 (es)
KR (1) KR101624365B1 (es)
CN (1) CN102143959B (es)
AR (1) AR070366A1 (es)
AT (1) ATE555109T1 (es)
AU (1) AU2009214997B2 (es)
BR (1) BRPI0908240A2 (es)
CA (1) CA2715559A1 (es)
CL (1) CL2009000324A1 (es)
CO (1) CO6290682A2 (es)
CY (1) CY1112999T1 (es)
DK (1) DK2245027T3 (es)
EA (1) EA018313B1 (es)
ES (1) ES2384911T3 (es)
HK (1) HK1143812A1 (es)
HR (1) HRP20120523T1 (es)
IL (1) IL207459A (es)
MX (1) MX2010008749A (es)
NZ (1) NZ587322A (es)
PE (1) PE20091381A1 (es)
PL (1) PL2245027T3 (es)
PT (1) PT2245027E (es)
SI (1) SI2245027T1 (es)
TW (1) TWI458482B (es)
WO (1) WO2009102633A1 (es)
ZA (1) ZA201005484B (es)

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BRPI0908240A2 (pt) 2017-10-10
HK1143812A1 (en) 2011-01-14
JP5455933B2 (ja) 2014-03-26
MX2010008749A (es) 2010-08-31
TWI458482B (zh) 2014-11-01
ES2384911T3 (es) 2012-07-13
CN102143959B (zh) 2014-10-22
EP2245027B1 (en) 2012-04-25
AR070366A1 (es) 2010-03-31
CO6290682A2 (es) 2011-06-20
CN102143959A (zh) 2011-08-03
NZ587322A (en) 2012-04-27
TW200938192A (en) 2009-09-16
US20090202478A1 (en) 2009-08-13
JP2011511840A (ja) 2011-04-14
SI2245027T1 (sl) 2012-08-31
PL2245027T3 (pl) 2012-09-28
KR20100124290A (ko) 2010-11-26
AU2009214997B2 (en) 2013-09-26
KR101624365B1 (ko) 2016-05-25
WO2009102633A1 (en) 2009-08-20
IL207459A (en) 2015-06-30
DK2245027T3 (da) 2012-08-06
AU2009214997A1 (en) 2009-08-20
EP2245027A1 (en) 2010-11-03
EA201001273A1 (ru) 2011-08-30
PE20091381A1 (es) 2009-09-18
ATE555109T1 (de) 2012-05-15
HRP20120523T1 (hr) 2012-07-31
CA2715559A1 (en) 2009-08-20
IL207459A0 (en) 2010-12-30
CY1112999T1 (el) 2016-04-13
ZA201005484B (en) 2012-01-25
EA018313B1 (ru) 2013-07-30
US8147818B2 (en) 2012-04-03

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