ES2384100T3 - Método para producir anticuerpos híbridos - Google Patents

Método para producir anticuerpos híbridos Download PDF

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Publication number
ES2384100T3
ES2384100T3 ES02794114T ES02794114T ES2384100T3 ES 2384100 T3 ES2384100 T3 ES 2384100T3 ES 02794114 T ES02794114 T ES 02794114T ES 02794114 T ES02794114 T ES 02794114T ES 2384100 T3 ES2384100 T3 ES 2384100T3
Authority
ES
Spain
Prior art keywords
antibody
sequences
sequence
hybrid antibody
hybrid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES02794114T
Other languages
English (en)
Spanish (es)
Inventor
Russell Rother
Dayang Wu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alexion Pharmaceuticals Inc
Original Assignee
Alexion Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alexion Pharmaceuticals Inc filed Critical Alexion Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2384100T3 publication Critical patent/ES2384100T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ES02794114T 2001-12-03 2002-12-03 Método para producir anticuerpos híbridos Expired - Lifetime ES2384100T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33659101P 2001-12-03 2001-12-03
US336591P 2001-12-03
PCT/US2002/038450 WO2003048321A2 (en) 2001-12-03 2002-12-03 Hybrid antibodies

Publications (1)

Publication Number Publication Date
ES2384100T3 true ES2384100T3 (es) 2012-06-29

Family

ID=23316785

Family Applications (1)

Application Number Title Priority Date Filing Date
ES02794114T Expired - Lifetime ES2384100T3 (es) 2001-12-03 2002-12-03 Método para producir anticuerpos híbridos

Country Status (12)

Country Link
US (1) US7399594B2 (https=)
EP (2) EP2298817A1 (https=)
JP (3) JP4723810B2 (https=)
AT (1) ATE550352T1 (https=)
AU (1) AU2002359568B2 (https=)
CA (1) CA2468744C (https=)
CY (1) CY1112843T1 (https=)
DK (1) DK1461428T3 (https=)
ES (1) ES2384100T3 (https=)
PT (1) PT1461428E (https=)
SI (1) SI1461428T1 (https=)
WO (1) WO2003048321A2 (https=)

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US20060263787A1 (en) * 2004-05-10 2006-11-23 Evans Glen A Immunoglobulin-like variable chain binding polypeptides and methods of use
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WO2009131605A2 (en) * 2008-01-28 2009-10-29 Thomas Jefferson University Fusion partner cell line for preparation of hybrid cells expressing human antibodies
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US20110313134A1 (en) * 2008-11-06 2011-12-22 Alexion Pharmaceuticals, Inc. Engineered antibodies with reduced immunogenicity and methods of making
WO2010110838A2 (en) * 2009-03-25 2010-09-30 Vet Therapeutics Inc. Antibody constant domain regions and uses thereof
BR112012022342A2 (pt) * 2010-03-04 2017-02-14 Vet Therapeutics Inc anticorpos monoclonais dirigidos a cd52
US9616120B2 (en) * 2010-03-04 2017-04-11 Vet Therapeutics, Inc. Monoclonal antibodies directed to CD20
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CN102251013A (zh) * 2011-02-22 2011-11-23 北京市肿瘤防治研究所 一个识别肿瘤起始细胞的抗体和抗原及其应用
CN104837502B (zh) 2012-10-12 2018-08-10 麦迪穆有限责任公司 吡咯并苯并二氮杂卓及其结合物
AU2013328625B2 (en) 2012-10-12 2016-12-15 Adc Therapeutics Sa Pyrrolobenzodiazepine-antibody conjugates
DK2906298T3 (en) 2012-10-12 2018-12-17 Adc Therapeutics Sa Pyrrolobenzodiazepine-antibody conjugates
CN105705165B (zh) 2013-03-15 2020-04-24 纪念斯隆-凯特琳癌症中心 高亲和力抗gd2抗体
EP3054985B1 (en) 2013-10-11 2018-12-26 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
GB201416112D0 (en) 2014-09-12 2014-10-29 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
GB201506402D0 (en) 2015-04-15 2015-05-27 Berkel Patricius H C Van And Howard Philip W Site-specific antibody-drug conjugates
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GB201601431D0 (en) 2016-01-26 2016-03-09 Medimmune Ltd Pyrrolobenzodiazepines
GB201602356D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201602359D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201607478D0 (en) 2016-04-29 2016-06-15 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201617466D0 (en) 2016-10-14 2016-11-30 Medimmune Ltd Pyrrolobenzodiazepine conjugates
GB201702031D0 (en) 2017-02-08 2017-03-22 Medlmmune Ltd Pyrrolobenzodiazepine-antibody conjugates
MX375569B (es) 2017-02-08 2025-03-04 Adc Therapeutics Sa Conjugados de pirrolobenzodiazepinas y anticuerpos
PT3612537T (pt) 2017-04-18 2022-08-29 Medimmune Ltd Conjugados de pirrolobenzodiazepina
ES2977788T3 (es) 2017-04-20 2024-08-30 Adc Therapeutics Sa Terapia combinada con un conjugado de anticuerpo anti-AXL y fármaco
MX2019015042A (es) 2017-06-14 2020-08-06 Adc Therapeutics Sa Regimen de dosificacion.
DK3668874T3 (da) 2017-08-18 2022-02-14 Medimmune Ltd Pyrrolobenzodiazepin-konjugater
GB201803342D0 (en) 2018-03-01 2018-04-18 Medimmune Ltd Methods
GB201806022D0 (en) 2018-04-12 2018-05-30 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
KR102890251B1 (ko) 2019-03-15 2025-11-25 메드임뮨 리미티드 암의 치료에 사용하기 위한 아제티도벤조디아제핀 이량체 및 이를 포함하는 컨쥬게이트

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Also Published As

Publication number Publication date
AU2002359568A1 (en) 2003-06-17
EP2298817A1 (en) 2011-03-23
JP5054058B2 (ja) 2012-10-24
JP2009153527A (ja) 2009-07-16
DK1461428T3 (da) 2012-06-04
CA2468744C (en) 2013-05-14
JP4723810B2 (ja) 2011-07-13
CY1112843T1 (el) 2016-02-10
ATE550352T1 (de) 2012-04-15
US20030219861A1 (en) 2003-11-27
JP2012144551A (ja) 2012-08-02
US7399594B2 (en) 2008-07-15
PT1461428E (pt) 2012-05-29
WO2003048321A3 (en) 2003-10-16
CA2468744A1 (en) 2003-06-12
EP1461428A4 (en) 2005-05-25
JP2005511706A (ja) 2005-04-28
WO2003048321A2 (en) 2003-06-12
EP1461428A2 (en) 2004-09-29
EP1461428B1 (en) 2012-03-21
AU2002359568B2 (en) 2008-02-21
SI1461428T1 (sl) 2012-07-31

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