ES2378011T3 - N-fenil-bipirrolidin ureas sustituidas y uso terapéutico de las mismas - Google Patents
N-fenil-bipirrolidin ureas sustituidas y uso terapéutico de las mismas Download PDFInfo
- Publication number
- ES2378011T3 ES2378011T3 ES08838702T ES08838702T ES2378011T3 ES 2378011 T3 ES2378011 T3 ES 2378011T3 ES 08838702 T ES08838702 T ES 08838702T ES 08838702 T ES08838702 T ES 08838702T ES 2378011 T3 ES2378011 T3 ES 2378011T3
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- Prior art keywords
- methyl
- phenyl
- bipyrrolidinyl
- amide
- urea
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- 230000001225 therapeutic effect Effects 0.000 title description 3
- 150000003672 ureas Chemical class 0.000 title description 2
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- RWRDLPDLKQPQOW-UHFFFAOYSA-N tetrahydropyrrole Natural products C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims description 21
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- 229910052757 nitrogen Inorganic materials 0.000 claims description 17
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- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Anesthesiology (AREA)
- Toxicology (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98060607P | 2007-10-17 | 2007-10-17 | |
| US980606P | 2007-10-17 | ||
| PCT/US2008/079763 WO2009052068A1 (en) | 2007-10-17 | 2008-10-14 | Substituted n-phenyl-bipyrrolidine ureas and therapeutic use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2378011T3 true ES2378011T3 (es) | 2012-04-04 |
Family
ID=40248052
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES08838702T Active ES2378011T3 (es) | 2007-10-17 | 2008-10-14 | N-fenil-bipirrolidin ureas sustituidas y uso terapéutico de las mismas |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US8222290B2 (OSRAM) |
| EP (1) | EP2215058B1 (OSRAM) |
| JP (1) | JP5380455B2 (OSRAM) |
| KR (1) | KR20100082349A (OSRAM) |
| CN (1) | CN101903341B (OSRAM) |
| AT (1) | ATE534625T1 (OSRAM) |
| AU (1) | AU2008312641A1 (OSRAM) |
| CA (1) | CA2702933C (OSRAM) |
| CY (1) | CY1112391T1 (OSRAM) |
| DK (1) | DK2215058T3 (OSRAM) |
| ES (1) | ES2378011T3 (OSRAM) |
| HR (1) | HRP20120166T1 (OSRAM) |
| IL (1) | IL205002A0 (OSRAM) |
| MA (1) | MA31889B1 (OSRAM) |
| MX (1) | MX2010003948A (OSRAM) |
| MY (1) | MY148807A (OSRAM) |
| NZ (1) | NZ584692A (OSRAM) |
| PL (1) | PL2215058T3 (OSRAM) |
| PT (1) | PT2215058E (OSRAM) |
| RS (1) | RS52221B (OSRAM) |
| RU (1) | RU2478094C2 (OSRAM) |
| SI (1) | SI2215058T1 (OSRAM) |
| WO (1) | WO2009052068A1 (OSRAM) |
| ZA (1) | ZA201002114B (OSRAM) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5377504B2 (ja) | 2007-10-17 | 2013-12-25 | サノフイ | 置換されたｎ−フェニル−ピロリジニルメチルピロリジンアミドおよびその治療的用途 |
| RU2477720C2 (ru) * | 2007-10-17 | 2013-03-20 | Санофи-Авентис | Замещенные n-фенилбипирролидинкарбоксамиды и их применение в лечебных целях |
| HRP20110953T1 (hr) | 2007-10-17 | 2012-01-31 | Sanofi | Supstituirani n-fenilbipirolidinkarboksamidi i njihova upotreba u terapiji |
| KR20090129927A (ko) | 2008-06-13 | 2009-12-17 | 주식회사 엘지화학 | 발열체 및 이의 제조방법 |
| US10412788B2 (en) | 2008-06-13 | 2019-09-10 | Lg Chem, Ltd. | Heating element and manufacturing method thereof |
| WO2009151203A1 (ko) * | 2008-06-13 | 2009-12-17 | 주식회사 엘지화학 | 발열체 및 이의 제조방법 |
| WO2011143148A1 (en) | 2010-05-11 | 2011-11-17 | Sanofi | Substituted n-heteroaryl spirolactam bipyrrolidines, preparation and therapeutic use thereof |
| TW201206910A (en) | 2010-05-11 | 2012-02-16 | Sanofi Aventis | Substituted N-heterocycloalkyl bipyrrolidinylphenyl amide derivatives, preparation and therapeutic use thereof |
| JP5784110B2 (ja) | 2010-05-11 | 2015-09-24 | サノフイ | 置換されたｎ−ヘテロアリールテトラヒドロ−イソキノリン誘導体、その製造及び治療上の使用 |
| JP5766278B2 (ja) | 2010-05-11 | 2015-08-19 | サノフイ | 置換されたｎ−アルキルおよびｎ−アシルテトラヒドロ−イソキノリン誘導体、それらの製造および治療上の使用 |
| WO2011143163A1 (en) * | 2010-05-11 | 2011-11-17 | Sanofi | Substituted n-phenyl spirolactam bipyrrolidines, preparation and therapeutic use thereof |
| TW201206901A (en) * | 2010-05-11 | 2012-02-16 | Sanofi Aventis | Substituted N-heteroaryl bipyrrolidine carboxamides, preparation and therapeutic use thereof |
| TW201206939A (en) | 2010-05-11 | 2012-02-16 | Sanofi Aventis | Substituted phenyl cycloalkyl pyrrolidine (piperidine) spirolactams and amides, preparation and therapeutic use thereof |
| AR083855A1 (es) * | 2010-11-15 | 2013-03-27 | Abbott Lab | Inhibidores de nampt y rock |
| BR112013021496B1 (pt) * | 2011-02-23 | 2021-10-13 | Suven Life Sciences Limited | Composto, composição farmacêutica, uso da composição farmacêutica, processo para a preparação de um composto e uso do composto |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20020507A1 (es) * | 2000-10-17 | 2002-06-25 | Schering Corp | Compuestos no-imidazoles como antagonistas del receptor histamina h3 |
| JP2006505590A (ja) * | 2002-10-23 | 2006-02-16 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ヒスタミンｈ３受容体調節物質としてのフェニルピペリジンおよびフェニルピロリジン |
| DE10306250A1 (de) * | 2003-02-14 | 2004-09-09 | Aventis Pharma Deutschland Gmbh | Substituierte N-Arylheterozyklen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| US7223788B2 (en) * | 2003-02-14 | 2007-05-29 | Sanofi-Aventis Deutschland Gmbh | Substituted N-aryl heterocycles, process for their preparation and their use as medicaments |
| CA2600757C (en) | 2005-03-17 | 2014-02-18 | Eli Lilly And Company | Pyrrolidine derivatives as histamine h3 receptor antagonists |
| EP1868991B1 (en) * | 2005-04-01 | 2014-07-30 | Eli Lilly And Company | Histamine h3 receptor agents, preparation and therapeutic uses |
| CA2613192C (en) * | 2005-07-01 | 2013-12-31 | Eli Lilly And Company | Histamine h3 receptor agents, preparation and therapeutic uses |
| TW200804274A (en) * | 2005-10-27 | 2008-01-16 | Ucb Sa | Compounds comprising a lactam or a lactam derivative moiety, processes for making them, and their uses |
| JP5377504B2 (ja) | 2007-10-17 | 2013-12-25 | サノフイ | 置換されたｎ−フェニル−ピロリジニルメチルピロリジンアミドおよびその治療的用途 |
| RU2477720C2 (ru) | 2007-10-17 | 2013-03-20 | Санофи-Авентис | Замещенные n-фенилбипирролидинкарбоксамиды и их применение в лечебных целях |
| HRP20110953T1 (hr) | 2007-10-17 | 2012-01-31 | Sanofi | Supstituirani n-fenilbipirolidinkarboksamidi i njihova upotreba u terapiji |
-
2008
- 2008-10-14 PL PL08838702T patent/PL2215058T3/pl unknown
- 2008-10-14 CA CA2702933A patent/CA2702933C/en not_active Expired - Fee Related
- 2008-10-14 NZ NZ584692A patent/NZ584692A/en not_active IP Right Cessation
- 2008-10-14 KR KR1020107010481A patent/KR20100082349A/ko not_active Ceased
- 2008-10-14 PT PT08838702T patent/PT2215058E/pt unknown
- 2008-10-14 DK DK08838702.2T patent/DK2215058T3/da active
- 2008-10-14 MY MYPI2010001300A patent/MY148807A/en unknown
- 2008-10-14 CN CN2008801212096A patent/CN101903341B/zh not_active Expired - Fee Related
- 2008-10-14 MX MX2010003948A patent/MX2010003948A/es active IP Right Grant
- 2008-10-14 SI SI200830552T patent/SI2215058T1/sl unknown
- 2008-10-14 AT AT08838702T patent/ATE534625T1/de active
- 2008-10-14 EP EP08838702A patent/EP2215058B1/en active Active
- 2008-10-14 WO PCT/US2008/079763 patent/WO2009052068A1/en not_active Ceased
- 2008-10-14 JP JP2010530054A patent/JP5380455B2/ja not_active Expired - Fee Related
- 2008-10-14 HR HR20120166T patent/HRP20120166T1/hr unknown
- 2008-10-14 ES ES08838702T patent/ES2378011T3/es active Active
- 2008-10-14 AU AU2008312641A patent/AU2008312641A1/en not_active Abandoned
- 2008-10-14 RS RS20120067A patent/RS52221B/sr unknown
- 2008-10-14 RU RU2010119554/04A patent/RU2478094C2/ru not_active IP Right Cessation
-
2010
- 2010-03-15 US US12/724,045 patent/US8222290B2/en not_active Expired - Fee Related
- 2010-03-25 ZA ZA2010/02114A patent/ZA201002114B/en unknown
- 2010-04-11 IL IL205002A patent/IL205002A0/en unknown
- 2010-05-17 MA MA32842A patent/MA31889B1/fr unknown
-
2012
- 2012-02-23 CY CY20121100185T patent/CY1112391T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2702933C (en) | 2012-12-18 |
| MX2010003948A (es) | 2010-04-30 |
| KR20100082349A (ko) | 2010-07-16 |
| CN101903341B (zh) | 2012-10-03 |
| RU2010119554A (ru) | 2011-11-27 |
| US20100173908A1 (en) | 2010-07-08 |
| HRP20120166T1 (hr) | 2012-03-31 |
| US8222290B2 (en) | 2012-07-17 |
| ATE534625T1 (de) | 2011-12-15 |
| CY1112391T1 (el) | 2015-12-09 |
| PT2215058E (pt) | 2012-03-06 |
| ZA201002114B (en) | 2010-12-29 |
| NZ584692A (en) | 2011-12-22 |
| EP2215058B1 (en) | 2011-11-23 |
| JP2011500697A (ja) | 2011-01-06 |
| MY148807A (en) | 2013-05-31 |
| AU2008312641A1 (en) | 2009-04-23 |
| PL2215058T3 (pl) | 2012-04-30 |
| EP2215058A1 (en) | 2010-08-11 |
| MA31889B1 (fr) | 2010-12-01 |
| HK1146056A1 (en) | 2011-05-13 |
| DK2215058T3 (da) | 2012-03-12 |
| WO2009052068A1 (en) | 2009-04-23 |
| RS52221B (sr) | 2012-10-31 |
| CA2702933A1 (en) | 2009-04-23 |
| CN101903341A (zh) | 2010-12-01 |
| SI2215058T1 (sl) | 2012-03-30 |
| IL205002A0 (en) | 2010-11-30 |
| RU2478094C2 (ru) | 2013-03-27 |
| JP5380455B2 (ja) | 2014-01-08 |
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