ES2365732T3 - Método de diagnóstico del cáncer de mama. - Google Patents

Info

Publication number

ES2365732T3

ES2365732T3 ES04773526T ES04773526T ES2365732T3 ES 2365732 T3 ES2365732 T3 ES 2365732T3 ES 04773526 T ES04773526 T ES 04773526T ES 04773526 T ES04773526 T ES 04773526T ES 2365732 T3 ES2365732 T3 ES 2365732T3

Authority

ES

Spain

Prior art keywords

brc

expression

genes

cells

gene

Prior art date

2003-09-24

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired - Lifetime

Links

• Espacenet
• Global Dossier
• Discuss

• 238000000034 method Methods 0.000 title claims abstract description 116
• 206010028980 Neoplasm Diseases 0.000 title description 167
• 201000011510 cancer Diseases 0.000 title description 99
• 238000003745 diagnosis Methods 0.000 title description 11
• 108090000623 proteins and genes Proteins 0.000 claims abstract description 599
• 206010006187 Breast cancer Diseases 0.000 claims abstract description 447
• 208000026310 Breast neoplasm Diseases 0.000 claims abstract description 446
• 230000014509 gene expression Effects 0.000 claims abstract description 336
• 238000011282 treatment Methods 0.000 claims abstract description 76
• 238000002405 diagnostic procedure Methods 0.000 claims abstract 3
• 210000004027 cell Anatomy 0.000 claims description 287
• 102000004169 proteins and genes Human genes 0.000 claims description 105
• 238000012360 testing method Methods 0.000 claims description 98
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 91
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 82
• 206010073095 invasive ductal breast carcinoma Diseases 0.000 claims description 76
• 229920001184 polypeptide Polymers 0.000 claims description 75
• 201000010985 invasive ductal carcinoma Diseases 0.000 claims description 73
• 230000000694 effects Effects 0.000 claims description 64
• 150000001875 compounds Chemical class 0.000 claims description 52
• 239000000523 sample Substances 0.000 claims description 50
• 108020004999 messenger RNA Proteins 0.000 claims description 48
• 239000000203 mixture Substances 0.000 claims description 38
• 230000000692 anti-sense effect Effects 0.000 claims description 36
• 239000002773 nucleotide Substances 0.000 claims description 30
• 125000003729 nucleotide group Chemical group 0.000 claims description 30
• 210000002919 epithelial cell Anatomy 0.000 claims description 28
• 230000002265 prevention Effects 0.000 claims description 23
• 108020004414 DNA Proteins 0.000 claims description 19
• 230000027455 binding Effects 0.000 claims description 18
• 239000011159 matrix material Substances 0.000 claims description 16
• 238000001514 detection method Methods 0.000 claims description 15
• 108020004459 Small interfering RNA Proteins 0.000 claims description 14
• 239000008194 pharmaceutical composition Substances 0.000 claims description 13
• 108091028043 Nucleic acid sequence Proteins 0.000 claims description 10
• 239000012472 biological sample Substances 0.000 claims description 10
• 230000000295 complement effect Effects 0.000 claims description 10
• 108091028664 Ribonucleotide Proteins 0.000 claims description 9
• 238000002360 preparation method Methods 0.000 claims description 9
• 239000002336 ribonucleotide Substances 0.000 claims description 9
• 125000002652 ribonucleotide group Chemical group 0.000 claims description 9
• 102000001253 Protein Kinase Human genes 0.000 claims description 7
• 238000001727 in vivo Methods 0.000 claims description 7
• 108060006633 protein kinase Proteins 0.000 claims description 7
• 108091000080 Phosphotransferase Proteins 0.000 claims description 6
• 102000020233 phosphotransferase Human genes 0.000 claims description 6
• 108091026890 Coding region Proteins 0.000 claims description 3
• 208000037396 Intraductal Noninfiltrating Carcinoma Diseases 0.000 abstract description 34
• 208000028715 ductal breast carcinoma in situ Diseases 0.000 abstract description 33
• 239000003814 drug Substances 0.000 abstract description 29
• 206010027476 Metastases Diseases 0.000 abstract description 25
• 208000007433 Lymphatic Metastasis Diseases 0.000 abstract description 18
• 230000009401 metastasis Effects 0.000 abstract description 18
• 229940124597 therapeutic agent Drugs 0.000 abstract description 15
• 238000012216 screening Methods 0.000 abstract description 3
• 241000282414 Homo sapiens Species 0.000 description 115
• 235000018102 proteins Nutrition 0.000 description 97
• 230000001105 regulatory effect Effects 0.000 description 90
• 150000007523 nucleic acids Chemical class 0.000 description 70
• 210000001519 tissue Anatomy 0.000 description 69
• 102000039446 nucleic acids Human genes 0.000 description 64
• 108020004707 nucleic acids Proteins 0.000 description 64
• 239000003795 chemical substances by application Substances 0.000 description 51
• 108010038795 estrogen receptors Proteins 0.000 description 44
• 102100038595 Estrogen receptor Human genes 0.000 description 43
• 239000003550 marker Substances 0.000 description 41
• 210000000481 breast Anatomy 0.000 description 38
• 238000002493 microarray Methods 0.000 description 37
• 108091032973 (ribonucleotides)n+m Proteins 0.000 description 36
• 206010073094 Intraductal proliferative breast lesion Diseases 0.000 description 31
• 201000007273 ductal carcinoma in situ Diseases 0.000 description 31
• 238000004458 analytical method Methods 0.000 description 29
• 102100026008 Breakpoint cluster region protein Human genes 0.000 description 23
• 108091060211 Expressed sequence tag Proteins 0.000 description 23
• 238000013035 low temperature curing Methods 0.000 description 22
• 210000001165 lymph node Anatomy 0.000 description 21
• 238000011161 development Methods 0.000 description 20
• 230000018109 developmental process Effects 0.000 description 20
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 20
• 239000012634 fragment Substances 0.000 description 19
• 239000012071 phase Substances 0.000 description 17
• 238000003757 reverse transcription PCR Methods 0.000 description 17
• 239000013598 vector Substances 0.000 description 17
• 230000005809 anti-tumor immunity Effects 0.000 description 16
• 239000000427 antigen Substances 0.000 description 16
• 108091007433 antigens Proteins 0.000 description 16
• 102000036639 antigens Human genes 0.000 description 16
• 210000000349 chromosome Anatomy 0.000 description 16
• 230000007423 decrease Effects 0.000 description 16
• 201000010099 disease Diseases 0.000 description 16
• 230000006870 function Effects 0.000 description 16
• 239000003112 inhibitor Substances 0.000 description 16
• 102000005962 receptors Human genes 0.000 description 16
• 108020003175 receptors Proteins 0.000 description 16
• 229960005486 vaccine Drugs 0.000 description 16
• 239000002246 antineoplastic agent Substances 0.000 description 15
• 230000004071 biological effect Effects 0.000 description 15
• 241000255581 Drosophila <fruit fly, genus> Species 0.000 description 14
• 102100026753 Lymphokine-activated killer T-cell-originated protein kinase Human genes 0.000 description 14
• 210000001744 T-lymphocyte Anatomy 0.000 description 14
• 230000003247 decreasing effect Effects 0.000 description 14
• 229940079593 drug Drugs 0.000 description 14
• 238000009472 formulation Methods 0.000 description 14
• 239000003826 tablet Substances 0.000 description 14
• 230000014616 translation Effects 0.000 description 14
• 208000005623 Carcinogenesis Diseases 0.000 description 13
• 101000762967 Homo sapiens Lymphokine-activated killer T-cell-originated protein kinase Proteins 0.000 description 13
• 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 description 13
• 230000036952 cancer formation Effects 0.000 description 13
• 231100000504 carcinogenesis Toxicity 0.000 description 13
• 230000001965 increasing effect Effects 0.000 description 13
• 230000006698 induction Effects 0.000 description 13
• 238000004393 prognosis Methods 0.000 description 13
• 208000024891 symptom Diseases 0.000 description 13
• 108091034117 Oligonucleotide Proteins 0.000 description 12
• 102220497176 Small vasohibin-binding protein_T47D_mutation Human genes 0.000 description 12
• 239000007924 injection Substances 0.000 description 12
• 238000002347 injection Methods 0.000 description 12
• 238000013519 translation Methods 0.000 description 12
• 210000004881 tumor cell Anatomy 0.000 description 12
• 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 description 11
• 238000009396 hybridization Methods 0.000 description 11
• 230000001939 inductive effect Effects 0.000 description 11
• 102100030613 Carboxypeptidase A1 Human genes 0.000 description 10
• 201000009030 Carcinoma Diseases 0.000 description 10
• 108010078791 Carrier Proteins Proteins 0.000 description 10
• 241000699666 Mus <mouse, genus> Species 0.000 description 10
• 108700020796 Oncogene Proteins 0.000 description 10
• 210000004369 blood Anatomy 0.000 description 10
• 239000008280 blood Substances 0.000 description 10
• 238000001342 constant potential amperometry Methods 0.000 description 10
• 230000003902 lesion Effects 0.000 description 10
• 239000000843 powder Substances 0.000 description 10
• 238000002560 therapeutic procedure Methods 0.000 description 10
• 238000013518 transcription Methods 0.000 description 10
• 230000035897 transcription Effects 0.000 description 10
• 102000040650 (ribonucleotides)n+m Human genes 0.000 description 9
• 102000014914 Carrier Proteins Human genes 0.000 description 9
• 239000004480 active ingredient Substances 0.000 description 9
• 238000003556 assay Methods 0.000 description 9
• 108091008324 binding proteins Proteins 0.000 description 9
• 238000002474 experimental method Methods 0.000 description 9
• 239000007788 liquid Substances 0.000 description 9
• 239000000463 material Substances 0.000 description 9
• 238000001531 micro-dissection Methods 0.000 description 9
• 102000040430 polynucleotide Human genes 0.000 description 9
• 108091033319 polynucleotide Proteins 0.000 description 9
• 230000004083 survival effect Effects 0.000 description 9
• 230000001225 therapeutic effect Effects 0.000 description 9
• 230000002103 transcriptional effect Effects 0.000 description 9
• 230000007704 transition Effects 0.000 description 9
• -1 LOC154467 Proteins 0.000 description 8
• 210000001789 adipocyte Anatomy 0.000 description 8
• 229940041181 antineoplastic drug Drugs 0.000 description 8
• 239000002775 capsule Substances 0.000 description 8
• 230000010261 cell growth Effects 0.000 description 8
• 239000003153 chemical reaction reagent Substances 0.000 description 8
• 210000005075 mammary gland Anatomy 0.000 description 8
• 239000002157 polynucleotide Substances 0.000 description 8
• 239000000243 solution Substances 0.000 description 8
• 241001465754 Metazoa Species 0.000 description 7
• 238000000636 Northern blotting Methods 0.000 description 7
• 102000001406 Perilipin Human genes 0.000 description 7
• 108060006002 Perilipin Proteins 0.000 description 7
• 240000004808 Saccharomyces cerevisiae Species 0.000 description 7
• 101100221606 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) COS7 gene Proteins 0.000 description 7
• 230000003321 amplification Effects 0.000 description 7
• 239000013604 expression vector Substances 0.000 description 7
• 230000002068 genetic effect Effects 0.000 description 7
• 230000012010 growth Effects 0.000 description 7
• 230000002401 inhibitory effect Effects 0.000 description 7
• 239000002609 medium Substances 0.000 description 7
• 238000010208 microarray analysis Methods 0.000 description 7
• 238000003199 nucleic acid amplification method Methods 0.000 description 7
• 230000002018 overexpression Effects 0.000 description 7
• 230000001575 pathological effect Effects 0.000 description 7
• WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 6
• CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 6
• 108020004635 Complementary DNA Proteins 0.000 description 6
• 102100032340 G2/mitotic-specific cyclin-B1 Human genes 0.000 description 6
• 102100024568 Tumor necrosis factor ligand superfamily member 11 Human genes 0.000 description 6
• 239000002671 adjuvant Substances 0.000 description 6
• 230000022131 cell cycle Effects 0.000 description 6
• 230000001413 cellular effect Effects 0.000 description 6
• 230000004069 differentiation Effects 0.000 description 6
• 238000011156 evaluation Methods 0.000 description 6
• 230000002349 favourable effect Effects 0.000 description 6
• 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 description 6
• 238000007417 hierarchical cluster analysis Methods 0.000 description 6
• 230000009545 invasion Effects 0.000 description 6
• 238000012423 maintenance Methods 0.000 description 6
• 230000007246 mechanism Effects 0.000 description 6
• 230000004048 modification Effects 0.000 description 6
• 238000012986 modification Methods 0.000 description 6
• 238000011275 oncology therapy Methods 0.000 description 6
• 210000000056 organ Anatomy 0.000 description 6
• 230000002829 reductive effect Effects 0.000 description 6
• 239000007787 solid Substances 0.000 description 6
• 239000000725 suspension Substances 0.000 description 6
• 239000003981 vehicle Substances 0.000 description 6
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
• 102100022749 Aminopeptidase N Human genes 0.000 description 5
• 102100031611 Collagen alpha-1(III) chain Human genes 0.000 description 5
• 102100023600 Fibroblast growth factor receptor 2 Human genes 0.000 description 5
• 102100024165 G1/S-specific cyclin-D1 Human genes 0.000 description 5
• 101000993285 Homo sapiens Collagen alpha-1(III) chain Proteins 0.000 description 5
• 101000819111 Homo sapiens Trans-acting T-cell-specific transcription factor GATA-3 Proteins 0.000 description 5
• 206010027459 Metastases to lymph nodes Diseases 0.000 description 5
• MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 5
• 102100021386 Trans-acting T-cell-specific transcription factor GATA-3 Human genes 0.000 description 5
• 102000040945 Transcription factor Human genes 0.000 description 5
• 108091023040 Transcription factor Proteins 0.000 description 5
• 238000002668 animal-assisted therapy Methods 0.000 description 5
• 230000008901 benefit Effects 0.000 description 5
• 230000015572 biosynthetic process Effects 0.000 description 5
• 208000014581 breast ductal adenocarcinoma Diseases 0.000 description 5
• 238000010367 cloning Methods 0.000 description 5
• 238000010276 construction Methods 0.000 description 5
• 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 5
• 230000001419 dependent effect Effects 0.000 description 5
• 238000010790 dilution Methods 0.000 description 5
• 239000012895 dilution Substances 0.000 description 5
• 239000002552 dosage form Substances 0.000 description 5
• 239000000262 estrogen Substances 0.000 description 5
• KTUFNOKKBVMGRW-UHFFFAOYSA-N imatinib Chemical compound C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 KTUFNOKKBVMGRW-UHFFFAOYSA-N 0.000 description 5
• 230000028993 immune response Effects 0.000 description 5
• 238000009169 immunotherapy Methods 0.000 description 5
• 230000005764 inhibitory process Effects 0.000 description 5
• 230000003993 interaction Effects 0.000 description 5
• 239000003755 preservative agent Substances 0.000 description 5
• 230000004044 response Effects 0.000 description 5
• 239000000758 substrate Substances 0.000 description 5
• 102100035682 Axin-1 Human genes 0.000 description 4
• 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 description 4
• 102100025064 Cellular tumor antigen p53 Human genes 0.000 description 4
• 108010058546 Cyclin D1 Proteins 0.000 description 4
• 102100031127 Cysteine/serine-rich nuclear protein 1 Human genes 0.000 description 4
• 102000004190 Enzymes Human genes 0.000 description 4
• 108090000790 Enzymes Proteins 0.000 description 4
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
• 102100031758 Extracellular matrix protein 1 Human genes 0.000 description 4
• 101710127949 Extracellular matrix protein 1 Proteins 0.000 description 4
• 102100036089 Fascin Human genes 0.000 description 4
• 108050003772 Fatty acid-binding protein 4 Proteins 0.000 description 4
• 102000013948 Fatty acid-binding protein 4 Human genes 0.000 description 4
• 102100031181 Glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 description 4
• WZUVPPKBWHMQCE-UHFFFAOYSA-N Haematoxylin Chemical compound C12=CC(O)=C(O)C=C2CC2(O)C1C1=CC=C(O)C(O)=C1OC2 WZUVPPKBWHMQCE-UHFFFAOYSA-N 0.000 description 4
• 241000282412 Homo Species 0.000 description 4
• 101000721661 Homo sapiens Cellular tumor antigen p53 Proteins 0.000 description 4
• 101000922196 Homo sapiens Cysteine/serine-rich nuclear protein 1 Proteins 0.000 description 4
• 101001090172 Homo sapiens Kinectin Proteins 0.000 description 4
• 101000814373 Homo sapiens Protein wntless homolog Proteins 0.000 description 4
• 102100034751 Kinectin Human genes 0.000 description 4
• 108010018650 MEF2 Transcription Factors Proteins 0.000 description 4
• 231100000002 MTT assay Toxicity 0.000 description 4
• 238000000134 MTT assay Methods 0.000 description 4
• 108090000744 Mitogen-Activated Protein Kinase Kinases Proteins 0.000 description 4
• 102000004232 Mitogen-Activated Protein Kinase Kinases Human genes 0.000 description 4
• 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 description 4
• 102100039229 Myocyte-specific enhancer factor 2C Human genes 0.000 description 4
• 229930193140 Neomycin Natural products 0.000 description 4
• 206010035226 Plasma cell myeloma Diseases 0.000 description 4
• 239000002202 Polyethylene glycol Substances 0.000 description 4
• 102100039471 Protein wntless homolog Human genes 0.000 description 4
• 108010025832 RANK Ligand Proteins 0.000 description 4
• 102000003890 RNA-binding protein FUS Human genes 0.000 description 4
• 108090000292 RNA-binding protein FUS Proteins 0.000 description 4
• 102000002278 Ribosomal Proteins Human genes 0.000 description 4
• 108010000605 Ribosomal Proteins Proteins 0.000 description 4
• NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 description 4
• 102100029529 Thrombospondin-2 Human genes 0.000 description 4
• 206010054094 Tumour necrosis Diseases 0.000 description 4
• JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Chemical class Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 4
• 230000004913 activation Effects 0.000 description 4
• 210000000577 adipose tissue Anatomy 0.000 description 4
• 150000001413 amino acids Chemical group 0.000 description 4
• 239000000074 antisense oligonucleotide Substances 0.000 description 4
• 238000012230 antisense oligonucleotides Methods 0.000 description 4
• 210000003719 b-lymphocyte Anatomy 0.000 description 4
• 239000011230 binding agent Substances 0.000 description 4
• 238000012258 culturing Methods 0.000 description 4
• 208000035475 disorder Diseases 0.000 description 4
• 230000009977 dual effect Effects 0.000 description 4
• 239000003623 enhancer Substances 0.000 description 4
• 230000002708 enhancing effect Effects 0.000 description 4
• 229940088598 enzyme Drugs 0.000 description 4
• 229940011871 estrogen Drugs 0.000 description 4
• 239000008187 granular material Substances 0.000 description 4
• 230000003054 hormonal effect Effects 0.000 description 4
• 229960002411 imatinib Drugs 0.000 description 4
• 238000000338 in vitro Methods 0.000 description 4
• 208000030776 invasive breast carcinoma Diseases 0.000 description 4
• 239000000314 lubricant Substances 0.000 description 4
• 210000004072 lung Anatomy 0.000 description 4
• 210000002540 macrophage Anatomy 0.000 description 4
• 238000004519 manufacturing process Methods 0.000 description 4
• 239000012528 membrane Substances 0.000 description 4
• 239000013642 negative control Substances 0.000 description 4
• 229960004927 neomycin Drugs 0.000 description 4
• 208000002154 non-small cell lung carcinoma Diseases 0.000 description 4
• 238000001558 permutation test Methods 0.000 description 4
• 239000000546 pharmaceutical excipient Substances 0.000 description 4
• 229920001223 polyethylene glycol Polymers 0.000 description 4
• 230000008569 process Effects 0.000 description 4
• 230000035755 proliferation Effects 0.000 description 4
• LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 description 4
• 230000002441 reversible effect Effects 0.000 description 4
• 230000019491 signal transduction Effects 0.000 description 4
• 239000002904 solvent Substances 0.000 description 4
• 239000003381 stabilizer Substances 0.000 description 4
• 230000004960 subcellular localization Effects 0.000 description 4
• 239000000126 substance Substances 0.000 description 4
• 238000001356 surgical procedure Methods 0.000 description 4
• 239000000375 suspending agent Substances 0.000 description 4
• 238000003786 synthesis reaction Methods 0.000 description 4
• 230000008685 targeting Effects 0.000 description 4
• 230000009466 transformation Effects 0.000 description 4
• 230000004614 tumor growth Effects 0.000 description 4
• 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 4
• 108700026220 vif Genes Proteins 0.000 description 4
• 238000005406 washing Methods 0.000 description 4
• 244000215068 Acacia senegal Species 0.000 description 3
• 108010085238 Actins Proteins 0.000 description 3
• 102000007469 Actins Human genes 0.000 description 3
• 102100021569 Apoptosis regulator Bcl-2 Human genes 0.000 description 3
• 239000004475 Arginine Substances 0.000 description 3
• 206010006256 Breast hyperplasia Diseases 0.000 description 3
• 208000010833 Chronic myeloid leukaemia Diseases 0.000 description 3
• 102100036213 Collagen alpha-2(I) chain Human genes 0.000 description 3
• 108010060385 Cyclin B1 Proteins 0.000 description 3
• 101710088194 Dehydrogenase Proteins 0.000 description 3
• 108010008532 Deoxyribonuclease I Proteins 0.000 description 3
• 102100030012 Deoxyribonuclease-1 Human genes 0.000 description 3
• 208000006402 Ductal Carcinoma Diseases 0.000 description 3
• 102000001301 EGF receptor Human genes 0.000 description 3
• 108060006698 EGF receptor Proteins 0.000 description 3
• 102100033238 Elongation factor Tu, mitochondrial Human genes 0.000 description 3
• 102100031780 Endonuclease Human genes 0.000 description 3
• 241000206602 Eukaryota Species 0.000 description 3
• 102100037362 Fibronectin Human genes 0.000 description 3
• 102000013446 GTP Phosphohydrolases Human genes 0.000 description 3
• 108091006109 GTPases Proteins 0.000 description 3
• 108010010803 Gelatin Proteins 0.000 description 3
• 229920000084 Gum arabic Polymers 0.000 description 3
• 108010013476 HLA-A24 Antigen Proteins 0.000 description 3
• 101000874566 Homo sapiens Axin-1 Proteins 0.000 description 3
• 101000875067 Homo sapiens Collagen alpha-2(I) chain Proteins 0.000 description 3
• 101000868643 Homo sapiens G2/mitotic-specific cyclin-B1 Proteins 0.000 description 3
• 101001112162 Homo sapiens Kinetochore protein NDC80 homolog Proteins 0.000 description 3
• 101000794228 Homo sapiens Mitotic checkpoint serine/threonine-protein kinase BUB1 beta Proteins 0.000 description 3
• 101000825726 Homo sapiens Structural maintenance of chromosomes protein 4 Proteins 0.000 description 3
• 101000633605 Homo sapiens Thrombospondin-2 Proteins 0.000 description 3
• 101000666295 Homo sapiens X-box-binding protein 1 Proteins 0.000 description 3
• 108010021625 Immunoglobulin Fragments Proteins 0.000 description 3
• 102000008394 Immunoglobulin Fragments Human genes 0.000 description 3
• 206010061218 Inflammation Diseases 0.000 description 3
• ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 3
• GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 3
• ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 3
• 108700018351 Major Histocompatibility Complex Proteins 0.000 description 3
• 102000018697 Membrane Proteins Human genes 0.000 description 3
• 108010052285 Membrane Proteins Proteins 0.000 description 3
• 102100030144 Mitotic checkpoint serine/threonine-protein kinase BUB1 beta Human genes 0.000 description 3
• 101100498160 Mus musculus Dach1 gene Proteins 0.000 description 3
• 241000699670 Mus sp. Species 0.000 description 3
• 206010061309 Neoplasm progression Diseases 0.000 description 3
• 229930040373 Paraformaldehyde Natural products 0.000 description 3
• 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 description 3
• 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 description 3
• 102100030264 Pleckstrin Human genes 0.000 description 3
• DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
• 108010029485 Protein Isoforms Proteins 0.000 description 3
• 102000001708 Protein Isoforms Human genes 0.000 description 3
• 102000004022 Protein-Tyrosine Kinases Human genes 0.000 description 3
• 108090000412 Protein-Tyrosine Kinases Proteins 0.000 description 3
• RADKZDMFGJYCBB-UHFFFAOYSA-N Pyridoxal Chemical compound CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 description 3
• 241000700159 Rattus Species 0.000 description 3
• 108091078243 Rho family Proteins 0.000 description 3
• 102000042463 Rho family Human genes 0.000 description 3
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
• DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 3
• 102100022842 Structural maintenance of chromosomes protein 4 Human genes 0.000 description 3
• 229930006000 Sucrose Natural products 0.000 description 3
• CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
• 108010082684 Transforming Growth Factor-beta Type II Receptor Proteins 0.000 description 3
• 102000004060 Transforming Growth Factor-beta Type II Receptor Human genes 0.000 description 3
• 241000219793 Trifolium Species 0.000 description 3
• 102100038151 X-box-binding protein 1 Human genes 0.000 description 3
• 230000002159 abnormal effect Effects 0.000 description 3
• 230000005856 abnormality Effects 0.000 description 3
• 235000010489 acacia gum Nutrition 0.000 description 3
• 239000000205 acacia gum Substances 0.000 description 3
• 230000003213 activating effect Effects 0.000 description 3
• 239000012190 activator Substances 0.000 description 3
• 238000009098 adjuvant therapy Methods 0.000 description 3
• 239000000556 agonist Substances 0.000 description 3
• 235000001014 amino acid Nutrition 0.000 description 3
• 229940024606 amino acid Drugs 0.000 description 3
• 230000033115 angiogenesis Effects 0.000 description 3
• 210000000612 antigen-presenting cell Anatomy 0.000 description 3
• 230000006907 apoptotic process Effects 0.000 description 3
• ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 3
• 230000033228 biological regulation Effects 0.000 description 3
• 238000001574 biopsy Methods 0.000 description 3
• 230000037396 body weight Effects 0.000 description 3
• 201000010983 breast ductal carcinoma Diseases 0.000 description 3
• 238000010804 cDNA synthesis Methods 0.000 description 3
• 238000004422 calculation algorithm Methods 0.000 description 3
• 229910002092 carbon dioxide Inorganic materials 0.000 description 3
• 230000015556 catabolic process Effects 0.000 description 3
• 230000012292 cell migration Effects 0.000 description 3
• 230000004663 cell proliferation Effects 0.000 description 3
• 230000008859 change Effects 0.000 description 3
• 238000012512 characterization method Methods 0.000 description 3
• 239000011651 chromium Substances 0.000 description 3
• 238000010224 classification analysis Methods 0.000 description 3
• 210000001072 colon Anatomy 0.000 description 3
• 230000005757 colony formation Effects 0.000 description 3
• 239000002299 complementary DNA Substances 0.000 description 3
• XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 3
• 235000018417 cysteine Nutrition 0.000 description 3
• 229940127089 cytotoxic agent Drugs 0.000 description 3
• 230000002950 deficient Effects 0.000 description 3
• 238000006731 degradation reaction Methods 0.000 description 3
• 238000005516 engineering process Methods 0.000 description 3
• 230000007717 exclusion Effects 0.000 description 3
• 239000008273 gelatin Substances 0.000 description 3
• 229920000159 gelatin Polymers 0.000 description 3
• 235000019322 gelatine Nutrition 0.000 description 3
• 235000011852 gelatine desserts Nutrition 0.000 description 3
• 230000009368 gene silencing by RNA Effects 0.000 description 3
• 230000000762 glandular Effects 0.000 description 3
• 239000003102 growth factor Substances 0.000 description 3
• 230000036541 health Effects 0.000 description 3
• 230000001900 immune effect Effects 0.000 description 3
• 238000003018 immunoassay Methods 0.000 description 3
• 238000012760 immunocytochemical staining Methods 0.000 description 3
• 230000004054 inflammatory process Effects 0.000 description 3
• 108010044426 integrins Proteins 0.000 description 3
• 102000006495 integrins Human genes 0.000 description 3
• 230000002452 interceptive effect Effects 0.000 description 3
• 238000001990 intravenous administration Methods 0.000 description 3
• 238000002955 isolation Methods 0.000 description 3
• 239000008101 lactose Substances 0.000 description 3
• 210000004185 liver Anatomy 0.000 description 3
• 210000004698 lymphocyte Anatomy 0.000 description 3
• 230000036210 malignancy Effects 0.000 description 3
• 206010061289 metastatic neoplasm Diseases 0.000 description 3
• 230000002438 mitochondrial effect Effects 0.000 description 3
• 210000004940 nucleus Anatomy 0.000 description 3
• 239000003921 oil Substances 0.000 description 3
• 235000019198 oils Nutrition 0.000 description 3
• 229920002866 paraformaldehyde Polymers 0.000 description 3
• 239000002504 physiological saline solution Substances 0.000 description 3
• 108010026735 platelet protein P47 Proteins 0.000 description 3
• 230000003389 potentiating effect Effects 0.000 description 3
• 230000001737 promoting effect Effects 0.000 description 3
• 230000000069 prophylactic effect Effects 0.000 description 3
• 238000011160 research Methods 0.000 description 3
• 230000035945 sensitivity Effects 0.000 description 3
• 238000000926 separation method Methods 0.000 description 3
• 230000000638 stimulation Effects 0.000 description 3
• 239000005720 sucrose Substances 0.000 description 3
• 230000001629 suppression Effects 0.000 description 3
• 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 description 3
• 239000004094 surface-active agent Substances 0.000 description 3
• 238000001890 transfection Methods 0.000 description 3
• 238000012546 transfer Methods 0.000 description 3
• 229960000575 trastuzumab Drugs 0.000 description 3
• 230000005751 tumor progression Effects 0.000 description 3
• 238000002255 vaccination Methods 0.000 description 3
• 108010005465 AC133 Antigen Proteins 0.000 description 2
• 102000005908 AC133 Antigen Human genes 0.000 description 2
• 230000005730 ADP ribosylation Effects 0.000 description 2
• 102100028357 ADP-ribosylation factor-like protein 8B Human genes 0.000 description 2
• 102100028780 AP-1 complex subunit sigma-2 Human genes 0.000 description 2
• 108091006112 ATPases Proteins 0.000 description 2
• 201000010028 Acrocephalosyndactylia Diseases 0.000 description 2
• 102000057290 Adenosine Triphosphatases Human genes 0.000 description 2
• 108091093088 Amplicon Proteins 0.000 description 2
• 102100038108 Arylamine N-acetyltransferase 1 Human genes 0.000 description 2
• 241000416162 Astragalus gummifer Species 0.000 description 2
• 102100039341 Atrial natriuretic peptide receptor 2 Human genes 0.000 description 2
• 108091012583 BCL2 Proteins 0.000 description 2
• 102100032423 Bcl-2-associated transcription factor 1 Human genes 0.000 description 2
• 102000004506 Blood Proteins Human genes 0.000 description 2
• 108010017384 Blood Proteins Proteins 0.000 description 2
• 208000020084 Bone disease Diseases 0.000 description 2
• 241000283690 Bos taurus Species 0.000 description 2
• 206010055113 Breast cancer metastatic Diseases 0.000 description 2
• 102100031102 C-C motif chemokine 4 Human genes 0.000 description 2
• 108010049990 CD13 Antigens Proteins 0.000 description 2
• 102100027674 CTD small phosphatase-like protein Human genes 0.000 description 2
• 102100026860 CYFIP-related Rac1 interactor A Human genes 0.000 description 2
• OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
• 102000005701 Calcium-Binding Proteins Human genes 0.000 description 2
• 108010045403 Calcium-Binding Proteins Proteins 0.000 description 2
• 241000282472 Canis lupus familiaris Species 0.000 description 2
• 102100032407 Carboxypeptidase D Human genes 0.000 description 2
• 102100035904 Caspase-1 Human genes 0.000 description 2
• 108090000994 Catalytic RNA Proteins 0.000 description 2
• 102000053642 Catalytic RNA Human genes 0.000 description 2
• 102100021391 Cationic amino acid transporter 3 Human genes 0.000 description 2
• 102100032860 Cell division cycle 5-like protein Human genes 0.000 description 2
• VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 2
• 102100032902 Chromobox protein homolog 3 Human genes 0.000 description 2
• 208000037051 Chromosomal Instability Diseases 0.000 description 2
• 102000004360 Cofilin 1 Human genes 0.000 description 2
• 108090000996 Cofilin 1 Proteins 0.000 description 2
• 102100033601 Collagen alpha-1(I) chain Human genes 0.000 description 2
• 206010009944 Colon cancer Diseases 0.000 description 2
• 208000001333 Colorectal Neoplasms Diseases 0.000 description 2
• 108090000056 Complement factor B Proteins 0.000 description 2
• 102000003712 Complement factor B Human genes 0.000 description 2
• 108010047041 Complementarity Determining Regions Proteins 0.000 description 2
• 108010079362 Core Binding Factor Alpha 3 Subunit Proteins 0.000 description 2
• 229920002261 Corn starch Polymers 0.000 description 2
• 206010066946 Craniofacial dysostosis Diseases 0.000 description 2
• 201000006526 Crouzon syndrome Diseases 0.000 description 2
• 102100026398 Cyclic AMP-responsive element-binding protein 3 Human genes 0.000 description 2
• 102000005927 Cysteine Proteases Human genes 0.000 description 2
• 108010005843 Cysteine Proteases Proteins 0.000 description 2
• 102100027417 Cytochrome P450 1B1 Human genes 0.000 description 2
• FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
• 102100033587 DNA topoisomerase 2-alpha Human genes 0.000 description 2
• 102100036238 Dihydropyrimidinase Human genes 0.000 description 2
• 102100024108 Dystrophin Human genes 0.000 description 2
• 102100026245 E3 ubiquitin-protein ligase RNF43 Human genes 0.000 description 2
• 102100030808 Elongation factor 1-delta Human genes 0.000 description 2
• 108010042407 Endonucleases Proteins 0.000 description 2
• 102100021616 Ephrin type-A receptor 4 Human genes 0.000 description 2
• 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 2
• 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 2
• 102100040129 FH1/FH2 domain-containing protein 3 Human genes 0.000 description 2
• 241000282326 Felis catus Species 0.000 description 2
• 102000018233 Fibroblast Growth Factor Human genes 0.000 description 2
• 108050007372 Fibroblast Growth Factor Proteins 0.000 description 2
• 101710182389 Fibroblast growth factor receptor 2 Proteins 0.000 description 2
• 108010067306 Fibronectins Proteins 0.000 description 2
• 102100026559 Filamin-B Human genes 0.000 description 2
• 102100024515 GDP-L-fucose synthase Human genes 0.000 description 2
• 102100036838 GRAM domain-containing protein 2B Human genes 0.000 description 2
• 102100039554 Galectin-8 Human genes 0.000 description 2
• 102100021337 Gap junction alpha-1 protein Human genes 0.000 description 2
• 102100037388 Gasdermin-D Human genes 0.000 description 2
• 102100033299 Glia-derived nexin Human genes 0.000 description 2
• BPDVTFBJZNBHEU-HGNGGELXSA-N Glu-Ala-His Chemical compound OC(=O)CC[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@H](C(O)=O)CC1=CN=CN1 BPDVTFBJZNBHEU-HGNGGELXSA-N 0.000 description 2
• 102100036534 Glutathione S-transferase Mu 1 Human genes 0.000 description 2
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
• 102100028784 HIV Tat-specific factor 1 Human genes 0.000 description 2
• 102100028976 HLA class I histocompatibility antigen, B alpha chain Human genes 0.000 description 2
• 102100030595 HLA class II histocompatibility antigen gamma chain Human genes 0.000 description 2
• 102100031547 HLA class II histocompatibility antigen, DO alpha chain Human genes 0.000 description 2
• 102100022901 Histone acetyltransferase KAT2A Human genes 0.000 description 2
• 208000017604 Hodgkin disease Diseases 0.000 description 2
• 208000021519 Hodgkin lymphoma Diseases 0.000 description 2
• 208000010747 Hodgkins lymphoma Diseases 0.000 description 2
• 101000769042 Homo sapiens ADP-ribosylation factor-like protein 8B Proteins 0.000 description 2
• 101000768016 Homo sapiens AP-1 complex subunit sigma-2 Proteins 0.000 description 2
• 101000884385 Homo sapiens Arylamine N-acetyltransferase 1 Proteins 0.000 description 2
• 101000725950 Homo sapiens CTD small phosphatase-like protein Proteins 0.000 description 2
• 101000912003 Homo sapiens CYFIP-related Rac1 interactor A Proteins 0.000 description 2
• 101000868318 Homo sapiens Cell division cycle 5-like protein Proteins 0.000 description 2
• 101000725164 Homo sapiens Cytochrome P450 1B1 Proteins 0.000 description 2
• 101000669171 Homo sapiens DNA-directed RNA polymerases I and III subunit RPAC2 Proteins 0.000 description 2
• 101000872044 Homo sapiens Dermokine Proteins 0.000 description 2
• 101001053946 Homo sapiens Dystrophin Proteins 0.000 description 2
• 101000692702 Homo sapiens E3 ubiquitin-protein ligase RNF43 Proteins 0.000 description 2
• 101000920062 Homo sapiens Elongation factor 1-delta Proteins 0.000 description 2
• 101000890757 Homo sapiens FH1/FH2 domain-containing protein 3 Proteins 0.000 description 2
• 101001021925 Homo sapiens Fascin Proteins 0.000 description 2
• 101000913551 Homo sapiens Filamin-B Proteins 0.000 description 2
• 101001052793 Homo sapiens GDP-L-fucose synthase Proteins 0.000 description 2
• 101001071433 Homo sapiens GRAM domain-containing protein 2B Proteins 0.000 description 2
• 101000608769 Homo sapiens Galectin-8 Proteins 0.000 description 2
• 101001026262 Homo sapiens Gasdermin-D Proteins 0.000 description 2
• 101000997803 Homo sapiens Glia-derived nexin Proteins 0.000 description 2
• 101001078805 Homo sapiens HIV Tat-specific factor 1 Proteins 0.000 description 2
• 101001082627 Homo sapiens HLA class II histocompatibility antigen gamma chain Proteins 0.000 description 2
• 101000866278 Homo sapiens HLA class II histocompatibility antigen, DO alpha chain Proteins 0.000 description 2
• 101001046967 Homo sapiens Histone acetyltransferase KAT2A Proteins 0.000 description 2
• 101001047912 Homo sapiens Hydroxymethylglutaryl-CoA lyase, mitochondrial Proteins 0.000 description 2
• 101001044432 Homo sapiens Intraflagellar transport protein 46 homolog Proteins 0.000 description 2
• 101001026582 Homo sapiens KAT8 regulatory NSL complex subunit 3 Proteins 0.000 description 2
• 101000868279 Homo sapiens Leukocyte surface antigen CD47 Proteins 0.000 description 2
• 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 description 2
• 101001043352 Homo sapiens Lysyl oxidase homolog 2 Proteins 0.000 description 2
• 101000995932 Homo sapiens Nucleolar protein 58 Proteins 0.000 description 2
• 101000585555 Homo sapiens PCNA-associated factor Proteins 0.000 description 2
• 101001120056 Homo sapiens Phosphatidylinositol 3-kinase regulatory subunit alpha Proteins 0.000 description 2
• 101000935642 Homo sapiens Phosphoinositide 3-kinase adapter protein 1 Proteins 0.000 description 2
• 101000595426 Homo sapiens Polyprenol reductase Proteins 0.000 description 2
• 101000914035 Homo sapiens Pre-mRNA-splicing regulator WTAP Proteins 0.000 description 2
• 101000614347 Homo sapiens Prolyl 4-hydroxylase subunit alpha-2 Proteins 0.000 description 2
• 101000677836 Homo sapiens Protein ABHD13 Proteins 0.000 description 2
• 101000911541 Homo sapiens Protein FAM214A Proteins 0.000 description 2
• 101000848498 Homo sapiens Protein POLR1D, isoform 2 Proteins 0.000 description 2
• 101000574322 Homo sapiens Protein phosphatase 1M Proteins 0.000 description 2
• 101001099586 Homo sapiens Pyridoxal kinase Proteins 0.000 description 2
• 101000825954 Homo sapiens R-spondin-1 Proteins 0.000 description 2
• 101000687459 Homo sapiens REST corepressor 3 Proteins 0.000 description 2
• 101001048702 Homo sapiens RNA polymerase II elongation factor ELL2 Proteins 0.000 description 2
• 101000884234 Homo sapiens Renal cancer differentiation gene 1 protein Proteins 0.000 description 2
• 101001100101 Homo sapiens Retinoic acid-induced protein 3 Proteins 0.000 description 2
• 101000756373 Homo sapiens Retinol-binding protein 1 Proteins 0.000 description 2
• 101000709055 Homo sapiens SLAIN motif-containing protein 1 Proteins 0.000 description 2
• 101000588007 Homo sapiens SPARC-like protein 1 Proteins 0.000 description 2
• 101000654418 Homo sapiens Schwannomin-interacting protein 1 Proteins 0.000 description 2
• 101000587430 Homo sapiens Serine/arginine-rich splicing factor 2 Proteins 0.000 description 2
• 101000984753 Homo sapiens Serine/threonine-protein kinase B-raf Proteins 0.000 description 2
• 101000637835 Homo sapiens Serum amyloid A-4 protein Proteins 0.000 description 2
• 101000632626 Homo sapiens Shieldin complex subunit 2 Proteins 0.000 description 2
• 101000577877 Homo sapiens Stromelysin-3 Proteins 0.000 description 2
• 101000713879 Homo sapiens T-complex protein 1 subunit eta Proteins 0.000 description 2
• 101000846996 Homo sapiens Tetratricopeptide repeat protein 19, mitochondrial Proteins 0.000 description 2
• 101000652726 Homo sapiens Transgelin-2 Proteins 0.000 description 2
• 101000801038 Homo sapiens Translation machinery-associated protein 7 Proteins 0.000 description 2
• 101000787862 Homo sapiens Transmembrane protein 255A Proteins 0.000 description 2
• 101000851431 Homo sapiens Transmembrane protein 70, mitochondrial Proteins 0.000 description 2
• 101000830603 Homo sapiens Tumor necrosis factor ligand superfamily member 11 Proteins 0.000 description 2
• 101000836174 Homo sapiens Tumor protein p53-inducible nuclear protein 1 Proteins 0.000 description 2
• 101000659324 Homo sapiens Twinfilin-1 Proteins 0.000 description 2
• 101000805786 Homo sapiens Vacuolar protein sorting-associated protein 37B Proteins 0.000 description 2
• 101000953818 Homo sapiens Vesicular, overexpressed in cancer, prosurvival protein 1 Proteins 0.000 description 2
• 101000744915 Homo sapiens Zinc finger protein 502 Proteins 0.000 description 2
• 101000857276 Homo sapiens Zinc finger protein GLIS3 Proteins 0.000 description 2
• 101000685848 Homo sapiens Zinc transporter ZIP6 Proteins 0.000 description 2
• 101000848450 Homo sapiens tRNA (guanine(26)-N(2))-dimethyltransferase Proteins 0.000 description 2
• 241000713772 Human immunodeficiency virus 1 Species 0.000 description 2
• 102100024004 Hydroxymethylglutaryl-CoA lyase, mitochondrial Human genes 0.000 description 2
• GRSZFWQUAKGDAV-KQYNXXCUSA-N IMP Chemical compound O[C@@H]1[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]1N1C(NC=NC2=O)=C2N=C1 GRSZFWQUAKGDAV-KQYNXXCUSA-N 0.000 description 2
• 108060003951 Immunoglobulin Proteins 0.000 description 2
• 102000018071 Immunoglobulin Fc Fragments Human genes 0.000 description 2
• 108010091135 Immunoglobulin Fc Fragments Proteins 0.000 description 2
• 102100032817 Integrin alpha-5 Human genes 0.000 description 2
• 102000014150 Interferons Human genes 0.000 description 2
• 108010050904 Interferons Proteins 0.000 description 2
• 102100037795 Interleukin-6 receptor subunit beta Human genes 0.000 description 2
• 102100022489 Intraflagellar transport protein 46 homolog Human genes 0.000 description 2
• 102000004195 Isomerases Human genes 0.000 description 2
• 108090000769 Isomerases Proteins 0.000 description 2
• 208000009289 Jackson-Weiss syndrome Diseases 0.000 description 2
• 102100037489 KAT8 regulatory NSL complex subunit 3 Human genes 0.000 description 2
• OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 2
• 239000005517 L01XE01 - Imatinib Substances 0.000 description 2
• 108090001090 Lectins Proteins 0.000 description 2
• 102000004856 Lectins Human genes 0.000 description 2
• 102100030817 Liver carboxylesterase 1 Human genes 0.000 description 2
• 206010025323 Lymphomas Diseases 0.000 description 2
• 102100021948 Lysyl oxidase homolog 2 Human genes 0.000 description 2
• 241000124008 Mammalia Species 0.000 description 2
• 102000000440 Melanoma-associated antigen Human genes 0.000 description 2
• 108050008953 Melanoma-associated antigen Proteins 0.000 description 2
• 108060004795 Methyltransferase Proteins 0.000 description 2
• 208000034578 Multiple myelomas Diseases 0.000 description 2
• 101100160997 Mus musculus Rchy1 gene Proteins 0.000 description 2
• 108050002826 Neuropeptide Y Receptor Proteins 0.000 description 2
• 102000012301 Neuropeptide Y receptor Human genes 0.000 description 2
• 102100038878 Neuropeptide Y receptor type 1 Human genes 0.000 description 2
• 102100021133 Nuclear protein 1 Human genes 0.000 description 2
• 101710170054 Nuclear protein 1 Proteins 0.000 description 2
• 101710163270 Nuclease Proteins 0.000 description 2
• 102100034532 Nucleolar protein 58 Human genes 0.000 description 2
• 241000283973 Oryctolagus cuniculus Species 0.000 description 2
• 108010014971 PDZ-binding kinase Proteins 0.000 description 2
• 108010077524 Peptide Elongation Factor 1 Proteins 0.000 description 2
• 108010068204 Peptide Elongation Factors Proteins 0.000 description 2
• 102000002508 Peptide Elongation Factors Human genes 0.000 description 2
• 201000004014 Pfeiffer syndrome Diseases 0.000 description 2
• ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
• 102100028238 Phosphoinositide 3-kinase adapter protein 1 Human genes 0.000 description 2
• 102100036020 Polyprenol reductase Human genes 0.000 description 2
• 102100026431 Pre-mRNA-splicing regulator WTAP Human genes 0.000 description 2
• 206010036790 Productive cough Diseases 0.000 description 2
• 102100025803 Progesterone receptor Human genes 0.000 description 2
• 102100040478 Prolyl 4-hydroxylase subunit alpha-2 Human genes 0.000 description 2
• 102100021500 Protein ABHD13 Human genes 0.000 description 2
• 102100026957 Protein FAM214A Human genes 0.000 description 2
• 102100034616 Protein POLR1D, isoform 2 Human genes 0.000 description 2
• 102100025776 Protein phosphatase 1M Human genes 0.000 description 2
• 102100038517 Pyridoxal kinase Human genes 0.000 description 2
• 102100022762 R-spondin-1 Human genes 0.000 description 2
• 102100024871 REST corepressor 3 Human genes 0.000 description 2
• 108091034057 RNA (poly(A)) Proteins 0.000 description 2
• 102000009572 RNA Polymerase II Human genes 0.000 description 2
• 108010009460 RNA Polymerase II Proteins 0.000 description 2
• 102000015097 RNA Splicing Factors Human genes 0.000 description 2
• 108010039259 RNA Splicing Factors Proteins 0.000 description 2
• 102100023750 RNA polymerase II elongation factor ELL2 Human genes 0.000 description 2
• 101710100968 Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 description 2
• 102100038066 Renal cancer differentiation gene 1 protein Human genes 0.000 description 2
• 108700008625 Reporter Genes Proteins 0.000 description 2
• 102100038453 Retinoic acid-induced protein 3 Human genes 0.000 description 2
• 102100022941 Retinol-binding protein 1 Human genes 0.000 description 2
• 102100025369 Runt-related transcription factor 3 Human genes 0.000 description 2
• 102000000395 SH3 domains Human genes 0.000 description 2
• 108050008861 SH3 domains Proteins 0.000 description 2
• 102100032667 SLAIN motif-containing protein 1 Human genes 0.000 description 2
• 108091006629 SLC13A2 Proteins 0.000 description 2
• 108091006230 SLC7A3 Proteins 0.000 description 2
• 102100037599 SPARC Human genes 0.000 description 2
• 102100031581 SPARC-like protein 1 Human genes 0.000 description 2
• 101100501116 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) TUF1 gene Proteins 0.000 description 2
• 102100031396 Schwannomin-interacting protein 1 Human genes 0.000 description 2
• 102100029666 Serine/arginine-rich splicing factor 2 Human genes 0.000 description 2
• 102100027103 Serine/threonine-protein kinase B-raf Human genes 0.000 description 2
• 102100032016 Serum amyloid A-4 protein Human genes 0.000 description 2
• 102100028378 Shieldin complex subunit 2 Human genes 0.000 description 2
• 108091081024 Start codon Proteins 0.000 description 2
• 208000005718 Stomach Neoplasms Diseases 0.000 description 2
• 102100028847 Stromelysin-3 Human genes 0.000 description 2
• 101150026786 TUFM gene Proteins 0.000 description 2
• 102100031473 Tetratricopeptide repeat protein 19, mitochondrial Human genes 0.000 description 2
• 229920001615 Tragacanth Polymers 0.000 description 2
• 108010048999 Transcription Factor 3 Proteins 0.000 description 2
• 102100038313 Transcription factor E2-alpha Human genes 0.000 description 2
• 102100031016 Transgelin-2 Human genes 0.000 description 2
• 102100033696 Translation machinery-associated protein 7 Human genes 0.000 description 2
• 102100025928 Transmembrane protein 255A Human genes 0.000 description 2
• 102100036921 Transmembrane protein 70, mitochondrial Human genes 0.000 description 2
• 108010078184 Trefoil Factor-3 Proteins 0.000 description 2
• 102100039145 Trefoil factor 3 Human genes 0.000 description 2
• 102100027224 Tumor protein p53-inducible nuclear protein 1 Human genes 0.000 description 2
• 102100036223 Twinfilin-1 Human genes 0.000 description 2
• 108010046308 Type II DNA Topoisomerases Proteins 0.000 description 2
• 102000044159 Ubiquitin Human genes 0.000 description 2
• 108090000848 Ubiquitin Proteins 0.000 description 2
• 108091023045 Untranslated Region Proteins 0.000 description 2
• 102100037940 Vacuolar protein sorting-associated protein 37B Human genes 0.000 description 2
• 102100036505 Vesicle-associated membrane protein 8 Human genes 0.000 description 2
• 102100037582 Vesicular, overexpressed in cancer, prosurvival protein 1 Human genes 0.000 description 2
• 102100039965 Zinc finger protein 502 Human genes 0.000 description 2
• 102100025879 Zinc finger protein GLIS3 Human genes 0.000 description 2
• 102100023144 Zinc transporter ZIP6 Human genes 0.000 description 2
• 238000002835 absorbance Methods 0.000 description 2
• 230000009471 action Effects 0.000 description 2
• 239000000654 additive Substances 0.000 description 2
• 239000000443 aerosol Substances 0.000 description 2
• SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 description 2
• 230000004075 alteration Effects 0.000 description 2
• 230000002491 angiogenic effect Effects 0.000 description 2
• 239000003963 antioxidant agent Substances 0.000 description 2
• 235000006708 antioxidants Nutrition 0.000 description 2
• 239000007864 aqueous solution Substances 0.000 description 2
• 239000003886 aromatase inhibitor Substances 0.000 description 2
• 229940046844 aromatase inhibitors Drugs 0.000 description 2
• 239000012298 atmosphere Substances 0.000 description 2
• 108010056708 bcr-abl Fusion Proteins Proteins 0.000 description 2
• 102000004441 bcr-abl Fusion Proteins Human genes 0.000 description 2
• 235000019445 benzyl alcohol Nutrition 0.000 description 2
• SESFRYSPDFLNCH-UHFFFAOYSA-N benzyl benzoate Chemical compound C=1C=CC=CC=1C(=O)OCC1=CC=CC=C1 SESFRYSPDFLNCH-UHFFFAOYSA-N 0.000 description 2
• 210000001124 body fluid Anatomy 0.000 description 2
• 239000010839 body fluid Substances 0.000 description 2
• 201000008275 breast carcinoma Diseases 0.000 description 2
• 210000000069 breast epithelial cell Anatomy 0.000 description 2
• 239000000872 buffer Substances 0.000 description 2
• 239000011575 calcium Substances 0.000 description 2
• 229910052791 calcium Inorganic materials 0.000 description 2
• 238000004364 calculation method Methods 0.000 description 2
• 230000000711 cancerogenic effect Effects 0.000 description 2
• 230000021164 cell adhesion Effects 0.000 description 2
• 238000006243 chemical reaction Methods 0.000 description 2
• HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
• 230000002759 chromosomal effect Effects 0.000 description 2
• 208000029742 colonic neoplasm Diseases 0.000 description 2
• 238000010293 colony formation assay Methods 0.000 description 2
• 238000004590 computer program Methods 0.000 description 2
• 238000011254 conventional chemotherapy Methods 0.000 description 2
• 239000008120 corn starch Substances 0.000 description 2
• 238000005520 cutting process Methods 0.000 description 2
• 230000016396 cytokine production Effects 0.000 description 2
• 230000009089 cytolysis Effects 0.000 description 2
• 230000001461 cytolytic effect Effects 0.000 description 2
• 210000000805 cytoplasm Anatomy 0.000 description 2
• 231100000433 cytotoxic Toxicity 0.000 description 2
• 230000001472 cytotoxic effect Effects 0.000 description 2
• 231100000135 cytotoxicity Toxicity 0.000 description 2
• 230000003013 cytotoxicity Effects 0.000 description 2
• 230000001934 delay Effects 0.000 description 2
• 210000004443 dendritic cell Anatomy 0.000 description 2
• 208000037765 diseases and disorders Diseases 0.000 description 2
• 239000002270 dispersing agent Substances 0.000 description 2
• 238000002224 dissection Methods 0.000 description 2
• 239000006196 drop Substances 0.000 description 2
• 239000003937 drug carrier Substances 0.000 description 2
• 239000000975 dye Substances 0.000 description 2
• 239000003995 emulsifying agent Substances 0.000 description 2
• 239000000839 emulsion Substances 0.000 description 2
• YQGOJNYOYNNSMM-UHFFFAOYSA-N eosin Chemical compound [Na+].OC(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C(O)=C(Br)C=C21 YQGOJNYOYNNSMM-UHFFFAOYSA-N 0.000 description 2
• 210000000981 epithelium Anatomy 0.000 description 2
• 102000015694 estrogen receptors Human genes 0.000 description 2
• 210000002950 fibroblast Anatomy 0.000 description 2
• 229940126864 fibroblast growth factor Drugs 0.000 description 2
• 239000012530 fluid Substances 0.000 description 2
• 238000011223 gene expression profiling Methods 0.000 description 2
• 230000030279 gene silencing Effects 0.000 description 2
• BRZYSWJRSDMWLG-CAXSIQPQSA-N geneticin Chemical compound O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](C(C)O)O2)N)[C@@H](N)C[C@H]1N BRZYSWJRSDMWLG-CAXSIQPQSA-N 0.000 description 2
• 102000006602 glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 description 2
• 208000006359 hepatoblastoma Diseases 0.000 description 2
• 206010073071 hepatocellular carcinoma Diseases 0.000 description 2
• 231100000844 hepatocellular carcinoma Toxicity 0.000 description 2
• 229940022353 herceptin Drugs 0.000 description 2
• IGMNYECMUMZDDF-UHFFFAOYSA-N homogentisic acid Chemical compound OC(=O)CC1=CC(O)=CC=C1O IGMNYECMUMZDDF-UHFFFAOYSA-N 0.000 description 2
• 229940088597 hormone Drugs 0.000 description 2
• 239000005556 hormone Substances 0.000 description 2
• 210000005260 human cell Anatomy 0.000 description 2
• 210000002865 immune cell Anatomy 0.000 description 2
• 102000018358 immunoglobulin Human genes 0.000 description 2
• 238000003364 immunohistochemistry Methods 0.000 description 2
• 238000007901 in situ hybridization Methods 0.000 description 2
• 238000011065 in-situ storage Methods 0.000 description 2
• 230000002779 inactivation Effects 0.000 description 2
• 238000011081 inoculation Methods 0.000 description 2
• 235000013902 inosinic acid Nutrition 0.000 description 2
• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
• 229940079322 interferon Drugs 0.000 description 2
• 230000000968 intestinal effect Effects 0.000 description 2
• 238000007918 intramuscular administration Methods 0.000 description 2
• 108010028930 invariant chain Proteins 0.000 description 2
• 108010029560 keratinocyte growth factor receptor Proteins 0.000 description 2
• 210000003734 kidney Anatomy 0.000 description 2
• 238000000370 laser capture micro-dissection Methods 0.000 description 2
• 238000001001 laser micro-dissection Methods 0.000 description 2
• 239000002523 lectin Substances 0.000 description 2
• 210000004901 leucine-rich repeat Anatomy 0.000 description 2
• 239000003446 ligand Substances 0.000 description 2
• 239000002502 liposome Substances 0.000 description 2
• 208000020816 lung neoplasm Diseases 0.000 description 2
• 230000002132 lysosomal effect Effects 0.000 description 2
• HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
• 230000003211 malignant effect Effects 0.000 description 2
• 238000005259 measurement Methods 0.000 description 2
• 201000001441 melanoma Diseases 0.000 description 2
• 210000004379 membrane Anatomy 0.000 description 2
• 230000011278 mitosis Effects 0.000 description 2
• 239000003068 molecular probe Substances 0.000 description 2
• 238000012544 monitoring process Methods 0.000 description 2
• 238000000465 moulding Methods 0.000 description 2
• 201000000050 myeloid neoplasm Diseases 0.000 description 2
• 230000009826 neoplastic cell growth Effects 0.000 description 2
• 230000001537 neural effect Effects 0.000 description 2
• 108010043412 neuropeptide Y-Y1 receptor Proteins 0.000 description 2
• 230000036961 partial effect Effects 0.000 description 2
• 230000037361 pathway Effects 0.000 description 2
• 239000000137 peptide hydrolase inhibitor Substances 0.000 description 2
• 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 2
• 230000000144 pharmacologic effect Effects 0.000 description 2
• 239000008363 phosphate buffer Substances 0.000 description 2
• 239000013612 plasmid Substances 0.000 description 2
• 238000003752 polymerase chain reaction Methods 0.000 description 2
• 108010005636 polypeptide C Proteins 0.000 description 2
• 238000010837 poor prognosis Methods 0.000 description 2
• 239000013641 positive control Substances 0.000 description 2
• 239000002243 precursor Substances 0.000 description 2
• 230000003449 preventive effect Effects 0.000 description 2
• 108090000468 progesterone receptors Proteins 0.000 description 2
• 230000002062 proliferating effect Effects 0.000 description 2
• 230000002035 prolonged effect Effects 0.000 description 2
• 230000004952 protein activity Effects 0.000 description 2
• 108020003519 protein disulfide isomerase Proteins 0.000 description 2
• 108700042226 ras Genes Proteins 0.000 description 2
• 102000016914 ras Proteins Human genes 0.000 description 2
• 108010014186 ras Proteins Proteins 0.000 description 2
• 230000009467 reduction Effects 0.000 description 2
• 230000022983 regulation of cell cycle Effects 0.000 description 2
• 230000008439 repair process Effects 0.000 description 2
• 230000010076 replication Effects 0.000 description 2
• 229930002330 retinoic acid Natural products 0.000 description 2
• 238000010839 reverse transcription Methods 0.000 description 2
• 238000012552 review Methods 0.000 description 2
• 108091092562 ribozyme Proteins 0.000 description 2
• 229960004641 rituximab Drugs 0.000 description 2
• 210000005005 sentinel lymph node Anatomy 0.000 description 2
• DAEPDZWVDSPTHF-UHFFFAOYSA-M sodium pyruvate Chemical compound [Na+].CC(=O)C([O-])=O DAEPDZWVDSPTHF-UHFFFAOYSA-M 0.000 description 2
• 238000001228 spectrum Methods 0.000 description 2
• 239000007921 spray Substances 0.000 description 2
• 210000003802 sputum Anatomy 0.000 description 2
• 208000024794 sputum Diseases 0.000 description 2
• 238000007619 statistical method Methods 0.000 description 2
• 238000006467 substitution reaction Methods 0.000 description 2
• 102100034541 tRNA (guanine(26)-N(2))-dimethyltransferase Human genes 0.000 description 2
• 229960001603 tamoxifen Drugs 0.000 description 2
• 210000001550 testis Anatomy 0.000 description 2
• 210000001541 thymus gland Anatomy 0.000 description 2
• 229960001727 tretinoin Drugs 0.000 description 2
• 230000004565 tumor cell growth Effects 0.000 description 2
• OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 2
• 238000012795 verification Methods 0.000 description 2
• 230000003612 virological effect Effects 0.000 description 2
• 229940011671 vitamin b6 Drugs 0.000 description 2
• JBFQOLHAGBKPTP-NZATWWQASA-N (2s)-2-[[(2s)-4-carboxy-2-[[3-carboxy-2-[[(2s)-2,6-diaminohexanoyl]amino]propanoyl]amino]butanoyl]amino]-4-methylpentanoic acid Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)C(CC(O)=O)NC(=O)[C@@H](N)CCCCN JBFQOLHAGBKPTP-NZATWWQASA-N 0.000 description 1
• DDMOUSALMHHKOS-UHFFFAOYSA-N 1,2-dichloro-1,1,2,2-tetrafluoroethane Chemical compound FC(F)(Cl)C(F)(F)Cl DDMOUSALMHHKOS-UHFFFAOYSA-N 0.000 description 1
• KKVYYGGCHJGEFJ-UHFFFAOYSA-N 1-n-(4-chlorophenyl)-6-methyl-5-n-[3-(7h-purin-6-yl)pyridin-2-yl]isoquinoline-1,5-diamine Chemical compound N=1C=CC2=C(NC=3C(=CC=CN=3)C=3C=4N=CNC=4N=CN=3)C(C)=CC=C2C=1NC1=CC=C(Cl)C=C1 KKVYYGGCHJGEFJ-UHFFFAOYSA-N 0.000 description 1
• 102100038363 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 Human genes 0.000 description 1
• 102100022586 17-beta-hydroxysteroid dehydrogenase type 2 Human genes 0.000 description 1
• QZDDFQLIQRYMBV-UHFFFAOYSA-N 2-[3-nitro-2-(2-nitrophenyl)-4-oxochromen-8-yl]acetic acid Chemical compound OC(=O)CC1=CC=CC(C(C=2[N+]([O-])=O)=O)=C1OC=2C1=CC=CC=C1[N+]([O-])=O QZDDFQLIQRYMBV-UHFFFAOYSA-N 0.000 description 1
• 102100023287 2-acylglycerol O-acyltransferase 3 Human genes 0.000 description 1
• 102100035352 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial Human genes 0.000 description 1
• 102100040961 26S proteasome non-ATPase regulatory subunit 12 Human genes 0.000 description 1
• 102100040962 26S proteasome non-ATPase regulatory subunit 13 Human genes 0.000 description 1
• AZKSAVLVSZKNRD-UHFFFAOYSA-M 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide Chemical compound [Br-].S1C(C)=C(C)N=C1[N+]1=NC(C=2C=CC=CC=2)=NN1C1=CC=CC=C1 AZKSAVLVSZKNRD-UHFFFAOYSA-M 0.000 description 1
• 208000024801 3-hydroxy-3-methylglutaric aciduria Diseases 0.000 description 1
• 102100040298 39S ribosomal protein L40, mitochondrial Human genes 0.000 description 1
• FWBHETKCLVMNFS-UHFFFAOYSA-N 4',6-Diamino-2-phenylindol Chemical compound C1=CC(C(=N)N)=CC=C1C1=CC2=CC=C(C(N)=N)C=C2N1 FWBHETKCLVMNFS-UHFFFAOYSA-N 0.000 description 1
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
• 102100026744 40S ribosomal protein S10 Human genes 0.000 description 1
• 102100023415 40S ribosomal protein S20 Human genes 0.000 description 1
• 102100022681 40S ribosomal protein S27 Human genes 0.000 description 1
• 102100031928 40S ribosomal protein S29 Human genes 0.000 description 1
• 102100028550 40S ribosomal protein S4, Y isoform 1 Human genes 0.000 description 1
• 108020003589 5' Untranslated Regions Proteins 0.000 description 1
• 102100038074 5'-AMP-activated protein kinase subunit beta-1 Human genes 0.000 description 1
• 102100026112 60S acidic ribosomal protein P2 Human genes 0.000 description 1
• 102100024442 60S ribosomal protein L13 Human genes 0.000 description 1
• 102100023990 60S ribosomal protein L17 Human genes 0.000 description 1
• 102100021690 60S ribosomal protein L18a Human genes 0.000 description 1
• 102100040540 60S ribosomal protein L3 Human genes 0.000 description 1
• 102100026750 60S ribosomal protein L5 Human genes 0.000 description 1
• 102000019050 90-kDa Ribosomal Protein S6 Kinases Human genes 0.000 description 1
• 108010012196 90-kDa Ribosomal Protein S6 Kinases Proteins 0.000 description 1
• 101150007969 ADORA1 gene Proteins 0.000 description 1
• 102100030674 ADP-ribosylation factor-like protein 6-interacting protein 1 Human genes 0.000 description 1
• 102100032897 AMP deaminase 2 Human genes 0.000 description 1
• 102100037651 AP-2 complex subunit sigma Human genes 0.000 description 1
• 102100040008 AP-3 complex subunit mu-2 Human genes 0.000 description 1
• 102100040058 AP-4 complex subunit sigma-1 Human genes 0.000 description 1
• 102100023619 ATP synthase F(0) complex subunit B1, mitochondrial Human genes 0.000 description 1
• 102100021405 ATP-dependent RNA helicase DDX1 Human genes 0.000 description 1
• 102100023388 ATP-dependent RNA helicase DHX15 Human genes 0.000 description 1
• 102100022936 ATPase inhibitor, mitochondrial Human genes 0.000 description 1
• 108010015661 ATPase inhibitory protein Proteins 0.000 description 1
• 101150030271 AXIN1 gene Proteins 0.000 description 1
• 208000004998 Abdominal Pain Diseases 0.000 description 1
• 102100022142 Achaete-scute homolog 1 Human genes 0.000 description 1
• 102100027863 Acidic fibroblast growth factor intracellular-binding protein Human genes 0.000 description 1
• 102100036732 Actin, aortic smooth muscle Human genes 0.000 description 1
• 101710192004 Actin, aortic smooth muscle Proteins 0.000 description 1
• 102100022454 Actin, gamma-enteric smooth muscle Human genes 0.000 description 1
• 208000031261 Acute myeloid leukaemia Diseases 0.000 description 1
• 102100025848 Acyl-coenzyme A thioesterase 8 Human genes 0.000 description 1
• 208000003200 Adenoma Diseases 0.000 description 1
• 102100033346 Adenosine receptor A1 Human genes 0.000 description 1
• 102100032605 Adhesion G protein-coupled receptor B1 Human genes 0.000 description 1
• 101710096306 Adhesion G protein-coupled receptor B1 Proteins 0.000 description 1
• 229920000936 Agarose Polymers 0.000 description 1
• 102100037399 Alanine-tRNA ligase, cytoplasmic Human genes 0.000 description 1
• 108700028369 Alleles Proteins 0.000 description 1
• 102100040344 Allograft inflammatory factor 1-like Human genes 0.000 description 1
• 102100022524 Alpha-1-antichymotrypsin Human genes 0.000 description 1
• GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
• 102100040743 Alpha-crystallin B chain Human genes 0.000 description 1
• 208000026833 Alzheimer disease 4 Diseases 0.000 description 1
• 108010058065 Aminomethyltransferase Proteins 0.000 description 1
• 102100039338 Aminomethyltransferase, mitochondrial Human genes 0.000 description 1
• 101710099461 Aminopeptidase N Proteins 0.000 description 1
• 102100033830 Amphiphysin Human genes 0.000 description 1
• 102100036439 Amyloid beta precursor protein binding family B member 1 Human genes 0.000 description 1
• 102100040016 Amyloid-beta A4 precursor protein-binding family B member 3 Human genes 0.000 description 1
• 102000004881 Angiotensinogen Human genes 0.000 description 1
• 108090001067 Angiotensinogen Proteins 0.000 description 1
• 102100033393 Anillin Human genes 0.000 description 1
• 101710199744 Anionic trypsin-2 Proteins 0.000 description 1
• 102100033900 Ankyrin repeat and SOCS box protein 13 Human genes 0.000 description 1
• 102100040006 Annexin A1 Human genes 0.000 description 1
• 102100031936 Anterior gradient protein 2 homolog Human genes 0.000 description 1
• 102100031930 Anterior gradient protein 3 Human genes 0.000 description 1
• 101710145634 Antigen 1 Proteins 0.000 description 1
• 101710109637 Antigen 43 Proteins 0.000 description 1
• 102100024454 Apoptosis regulatory protein Siva Human genes 0.000 description 1
• 101710088538 Apoptosis regulatory protein Siva Proteins 0.000 description 1
• 101000693933 Arabidopsis thaliana Fructose-bisphosphate aldolase 8, cytosolic Proteins 0.000 description 1
• 235000017060 Arachis glabrata Nutrition 0.000 description 1
• 244000105624 Arachis hypogaea Species 0.000 description 1
• 235000010777 Arachis hypogaea Nutrition 0.000 description 1
• 235000018262 Arachis monticola Nutrition 0.000 description 1
• 102100030287 Arfaptin-1 Human genes 0.000 description 1
• 102100029361 Aromatase Human genes 0.000 description 1
• 108010078554 Aromatase Proteins 0.000 description 1
• 102000006809 Arylamine N-Acetyltransferase Human genes 0.000 description 1
• 108020005224 Arylamine N-acetyltransferase Proteins 0.000 description 1
• 102100023927 Asparagine synthetase [glutamine-hydrolyzing] Human genes 0.000 description 1
• 102100027765 Atlastin-2 Human genes 0.000 description 1
• 206010003694 Atrophy Diseases 0.000 description 1
• 241000271566 Aves Species 0.000 description 1
• 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 description 1
• 102100035080 BDNF/NT-3 growth factors receptor Human genes 0.000 description 1
• 101150050047 BHLHE40 gene Proteins 0.000 description 1
• 101000959414 Bacillus thermoamyloliquefaciens Alpha-glucosidase 2 Proteins 0.000 description 1
• 208000008035 Back Pain Diseases 0.000 description 1
• 102100023045 Band 4.1-like protein 2 Human genes 0.000 description 1
• 102100021971 Bcl-2-interacting killer Human genes 0.000 description 1
• 101150017888 Bcl2 gene Proteins 0.000 description 1
• 102000015735 Beta-catenin Human genes 0.000 description 1
• 108060000903 Beta-catenin Proteins 0.000 description 1
• 102100029963 Beta-galactoside alpha-2,6-sialyltransferase 2 Human genes 0.000 description 1
• 101710136188 Beta-galactoside alpha-2,6-sialyltransferase 2 Proteins 0.000 description 1
• 239000004604 Blowing Agent Substances 0.000 description 1
• 208000010392 Bone Fractures Diseases 0.000 description 1
• 241000167854 Bourreria succulenta Species 0.000 description 1
• 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
• 210000003771 C cell Anatomy 0.000 description 1
• 102100031174 C-C chemokine receptor type 10 Human genes 0.000 description 1
• 102100028667 C-type lectin domain family 4 member A Human genes 0.000 description 1
• 102100037084 C4b-binding protein alpha chain Human genes 0.000 description 1
• 102100024220 CD180 antigen Human genes 0.000 description 1
• 102100031198 CGG triplet repeat-binding protein 1 Human genes 0.000 description 1
• 101150037241 CTNNB1 gene Proteins 0.000 description 1
• 102100030230 CUB and zona pellucida-like domain-containing protein 1 Human genes 0.000 description 1
• 102100025659 Cadherin EGF LAG seven-pass G-type receptor 1 Human genes 0.000 description 1
• 101100000858 Caenorhabditis elegans act-3 gene Proteins 0.000 description 1
• 101100065885 Caenorhabditis elegans sec-15 gene Proteins 0.000 description 1
• 102100027557 Calcipressin-1 Human genes 0.000 description 1
• 102100023074 Calcium-activated potassium channel subunit beta-1 Human genes 0.000 description 1
• 102100036362 Calcium-binding and coiled-coil domain-containing protein 1 Human genes 0.000 description 1
• 102100032583 Calcium-dependent secretion activator 2 Human genes 0.000 description 1
• 102100024436 Caldesmon Human genes 0.000 description 1
• 102100026092 Calmegin Human genes 0.000 description 1
• 102100033620 Calponin-1 Human genes 0.000 description 1
• 102100021848 Calumenin Human genes 0.000 description 1
• 101710191075 Calumenin Proteins 0.000 description 1
• 102100025570 Cancer/testis antigen 1 Human genes 0.000 description 1
• 101800001318 Capsid protein VP4 Proteins 0.000 description 1
• 102100033040 Carbonic anhydrase 12 Human genes 0.000 description 1
• 102100025466 Carcinoembryonic antigen-related cell adhesion molecule 3 Human genes 0.000 description 1
• 102100025475 Carcinoembryonic antigen-related cell adhesion molecule 5 Human genes 0.000 description 1
• 108090000426 Caspase-1 Proteins 0.000 description 1
• 102100025597 Caspase-4 Human genes 0.000 description 1
• 102100035888 Caveolin-1 Human genes 0.000 description 1
• 102100038909 Caveolin-2 Human genes 0.000 description 1
• 241000700198 Cavia Species 0.000 description 1
• 102100027199 Cell death-inducing p53-target protein 1 Human genes 0.000 description 1
• 102100025051 Cell division control protein 42 homolog Human genes 0.000 description 1
• 102100034744 Cell division cycle 7-related protein kinase Human genes 0.000 description 1
• 102100031219 Centrosomal protein of 55 kDa Human genes 0.000 description 1
• 102100035401 Ceramide synthase 2 Human genes 0.000 description 1
• 241000282693 Cercopithecidae Species 0.000 description 1
• 108091006146 Channels Proteins 0.000 description 1
• 108050001186 Chaperonin Cpn60 Proteins 0.000 description 1
• 102000052603 Chaperonins Human genes 0.000 description 1
• 108010078239 Chemokine CX3CL1 Proteins 0.000 description 1
• 102000014464 Chemokine CX3CL1 Human genes 0.000 description 1
• 101710151400 Chitinase 3 Proteins 0.000 description 1
• 102100038731 Chitinase-3-like protein 2 Human genes 0.000 description 1
• 102100030099 Chloride anion exchanger Human genes 0.000 description 1
• 102000009016 Cholera Toxin Human genes 0.000 description 1
• 108010049048 Cholera Toxin Proteins 0.000 description 1
• 102100023460 Choline O-acetyltransferase Human genes 0.000 description 1
• 108010077544 Chromatin Proteins 0.000 description 1
• 101710173111 Chromobox protein homolog 3 Proteins 0.000 description 1
• 102100031266 Chromodomain-helicase-DNA-binding protein 3 Human genes 0.000 description 1
• 102100034624 Cilia- and flagella-associated protein 97 Human genes 0.000 description 1
• 241000238586 Cirripedia Species 0.000 description 1
• 102100026191 Class E basic helix-loop-helix protein 40 Human genes 0.000 description 1
• 108010019804 Class Ia Phosphatidylinositol 3-Kinase Proteins 0.000 description 1
• 102100031047 Coiled-coil domain-containing protein 3 Human genes 0.000 description 1
• 102100031519 Collagen alpha-1(VI) chain Human genes 0.000 description 1
• 102100031544 Collagen alpha-1(XXVII) chain Human genes 0.000 description 1
• 108060005980 Collagenase Proteins 0.000 description 1
• 102000029816 Collagenase Human genes 0.000 description 1
• 102000016917 Complement C1 Human genes 0.000 description 1
• 108010028774 Complement C1 Proteins 0.000 description 1
• 108010028780 Complement C3 Proteins 0.000 description 1
• 102000016918 Complement C3 Human genes 0.000 description 1
• 102100021645 Complex I assembly factor ACAD9, mitochondrial Human genes 0.000 description 1
• 108010069241 Connexin 43 Proteins 0.000 description 1
• 241000699802 Cricetulus griseus Species 0.000 description 1
• 101710128029 Cyclic AMP-responsive element-binding protein 3 Proteins 0.000 description 1
• 102000016736 Cyclin Human genes 0.000 description 1
• 108050006400 Cyclin Proteins 0.000 description 1
• 102100031237 Cystatin-A Human genes 0.000 description 1
• 102100031051 Cysteine and glycine-rich protein 1 Human genes 0.000 description 1
• 102400000011 Cytochrome b-c1 complex subunit 9 Human genes 0.000 description 1
• 101800000778 Cytochrome b-c1 complex subunit 9 Proteins 0.000 description 1
• 102100030497 Cytochrome c Human genes 0.000 description 1
• 102100030449 Cytochrome c oxidase subunit 7A-related protein, mitochondrial Human genes 0.000 description 1
• 102100021999 Cytosolic Fe-S cluster assembly factor NUBP2 Human genes 0.000 description 1
• FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
• FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
• WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 1
• 102000053602 DNA Human genes 0.000 description 1
• 102100024810 DNA (cytosine-5)-methyltransferase 3B Human genes 0.000 description 1
• 230000004544 DNA amplification Effects 0.000 description 1
• 238000001712 DNA sequencing Methods 0.000 description 1
• 102000052510 DNA-Binding Proteins Human genes 0.000 description 1
• 230000004568 DNA-binding Effects 0.000 description 1
• 101710096438 DNA-binding protein Proteins 0.000 description 1
• 108010014303 DNA-directed DNA polymerase Proteins 0.000 description 1
• 102000016928 DNA-directed DNA polymerase Human genes 0.000 description 1
• 108090000626 DNA-directed RNA polymerases Proteins 0.000 description 1
• 102000004163 DNA-directed RNA polymerases Human genes 0.000 description 1
• 102100023348 DNA-directed RNA polymerases I, II, and III subunit RPABC2 Human genes 0.000 description 1
• 102100036727 Deformed epidermal autoregulatory factor 1 homolog Human genes 0.000 description 1
• 102100031242 Deoxyhypusine synthase Human genes 0.000 description 1
• 206010012335 Dependence Diseases 0.000 description 1
• 102100040577 Dermatan-sulfate epimerase-like protein Human genes 0.000 description 1
• 102100033582 Dermokine Human genes 0.000 description 1
• 239000004338 Dichlorodifluoromethane Substances 0.000 description 1
• BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 description 1
• 102100024426 Dihydropyrimidinase-related protein 2 Human genes 0.000 description 1
• 102100020751 Dipeptidyl peptidase 2 Human genes 0.000 description 1
• 102100028572 Disabled homolog 2 Human genes 0.000 description 1
• 206010061818 Disease progression Diseases 0.000 description 1
• 102100022258 Disks large homolog 5 Human genes 0.000 description 1
• 102100031695 DnaJ homolog subfamily C member 2 Human genes 0.000 description 1
• 201000010374 Down Syndrome Diseases 0.000 description 1
• 206010059866 Drug resistance Diseases 0.000 description 1
• 102100023274 Dual specificity mitogen-activated protein kinase kinase 4 Human genes 0.000 description 1
• 102100037569 Dual specificity protein phosphatase 10 Human genes 0.000 description 1
• 102100027088 Dual specificity protein phosphatase 5 Human genes 0.000 description 1
• 102100027274 Dual specificity protein phosphatase 6 Human genes 0.000 description 1
• 206010013801 Duchenne Muscular Dystrophy Diseases 0.000 description 1
• 208000037162 Ductal Breast Carcinoma Diseases 0.000 description 1
• 102100021242 Dymeclin Human genes 0.000 description 1
• 108010044191 Dynamin II Proteins 0.000 description 1
• 102100021238 Dynamin-2 Human genes 0.000 description 1
• 102100033209 Dysbindin domain-containing protein 2 Human genes 0.000 description 1
• 102100032249 Dystonin Human genes 0.000 description 1
• 102100023227 E3 SUMO-protein ligase EGR2 Human genes 0.000 description 1
• 102100032710 E3 ubiquitin-protein ligase Jade-2 Human genes 0.000 description 1
• 102100039627 E3 ubiquitin-protein ligase RNF167 Human genes 0.000 description 1
• 102100031748 E3 ubiquitin-protein ligase SIAH2 Human genes 0.000 description 1
• 102100037175 E3 ubiquitin-protein ligase UBR1 Human genes 0.000 description 1
• 102100031414 EF-hand domain-containing protein D1 Human genes 0.000 description 1
• 101150059401 EGR2 gene Proteins 0.000 description 1
• 102100021558 ER lumen protein-retaining receptor 3 Human genes 0.000 description 1
• 102100030816 ESF1 homolog Human genes 0.000 description 1
• 102100039578 ETS translocation variant 4 Human genes 0.000 description 1
• 239000006145 Eagle's minimal essential medium Substances 0.000 description 1
• 102100021717 Early growth response protein 3 Human genes 0.000 description 1
• 101150039033 Eci2 gene Proteins 0.000 description 1
• 108010089760 Electron Transport Complex I Proteins 0.000 description 1
• 102000008013 Electron Transport Complex I Human genes 0.000 description 1
• 102100027262 Electron transfer flavoprotein subunit beta Human genes 0.000 description 1
• 102100029108 Elongation factor 1-alpha 2 Human genes 0.000 description 1
• 102100023362 Elongation factor 1-gamma Human genes 0.000 description 1
• 101710120274 Elongation factor Tu, mitochondrial Proteins 0.000 description 1
• 102100032052 Elongation of very long chain fatty acids protein 5 Human genes 0.000 description 1
• 101710107426 Endochitinase 3 Proteins 0.000 description 1
• 206010014733 Endometrial cancer Diseases 0.000 description 1
• 206010014759 Endometrial neoplasm Diseases 0.000 description 1
• 102100021957 Endonuclease domain-containing 1 protein Human genes 0.000 description 1
• 102100029109 Endothelin-3 Human genes 0.000 description 1
• 102100021823 Enoyl-CoA delta isomerase 2 Human genes 0.000 description 1
• 108010043945 Ephrin-A1 Proteins 0.000 description 1
• 102000020086 Ephrin-A1 Human genes 0.000 description 1
• 102100023733 Ephrin-B3 Human genes 0.000 description 1
• 108010044085 Ephrin-B3 Proteins 0.000 description 1
• 102100031940 Epithelial cell adhesion molecule Human genes 0.000 description 1
• 102100036725 Epithelial discoidin domain-containing receptor 1 Human genes 0.000 description 1
• 101710131668 Epithelial discoidin domain-containing receptor 1 Proteins 0.000 description 1
• 102100033176 Epithelial membrane protein 2 Human genes 0.000 description 1
• 241000283073 Equus caballus Species 0.000 description 1
• 241000588724 Escherichia coli Species 0.000 description 1
• 102100023400 Estradiol 17-beta-dehydrogenase 11 Human genes 0.000 description 1
• 102100036816 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A Human genes 0.000 description 1
• 102100021699 Eukaryotic translation initiation factor 3 subunit B Human genes 0.000 description 1
• 102100038085 Eukaryotic translation initiation factor 3 subunit L Human genes 0.000 description 1
• 102100026979 Exocyst complex component 4 Human genes 0.000 description 1
• 102100026976 Exocyst complex component 6 Human genes 0.000 description 1
• 108700024394 Exon Proteins 0.000 description 1
• 102100021655 Extracellular sulfatase Sulf-1 Human genes 0.000 description 1
• 102100030862 Eyes absent homolog 2 Human genes 0.000 description 1
• 101710105178 F-box/WD repeat-containing protein 7 Proteins 0.000 description 1
• 102100028138 F-box/WD repeat-containing protein 7 Human genes 0.000 description 1
• 102100040936 FXYD domain-containing ion transport regulator 6 Human genes 0.000 description 1
• 102000007317 Farnesyltranstransferase Human genes 0.000 description 1
• 108010007508 Farnesyltranstransferase Proteins 0.000 description 1
• 102100031509 Fibrillin-1 Human genes 0.000 description 1
• 108010008599 Forkhead Box Protein M1 Proteins 0.000 description 1
• 108090000852 Forkhead Transcription Factors Proteins 0.000 description 1
• 102000004315 Forkhead Transcription Factors Human genes 0.000 description 1
• 102100023374 Forkhead box protein M1 Human genes 0.000 description 1
• 102100028122 Forkhead box protein P1 Human genes 0.000 description 1
• 102100020828 Four-jointed box protein 1 Human genes 0.000 description 1
• 102100027269 Fructose-bisphosphate aldolase C Human genes 0.000 description 1
• 108091006027 G proteins Proteins 0.000 description 1
• 102100024185 G1/S-specific cyclin-D2 Human genes 0.000 description 1
• 102100033423 GDNF family receptor alpha-1 Human genes 0.000 description 1
• 102000030782 GTP binding Human genes 0.000 description 1
• 108091000058 GTP-Binding Proteins 0.000 description 1
• 102100024421 GTPase IMAP family member 6 Human genes 0.000 description 1
• 244000059224 Gaultheria adenothrix Species 0.000 description 1
• 235000001721 Gaultheria adenothrix Nutrition 0.000 description 1
• 108010026132 Gelatinases Proteins 0.000 description 1
• 102000013382 Gelatinases Human genes 0.000 description 1
• 208000031448 Genomic Instability Diseases 0.000 description 1
• 102000034615 Glial cell line-derived neurotrophic factor Human genes 0.000 description 1
• 108091010837 Glial cell line-derived neurotrophic factor Proteins 0.000 description 1
• 102100028689 Glucocorticoid-induced transcript 1 protein Human genes 0.000 description 1
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
• 102100035172 Glucose-6-phosphate 1-dehydrogenase Human genes 0.000 description 1
• 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 description 1
• 102000034575 Glutamate transporters Human genes 0.000 description 1
• 108091006151 Glutamate transporters Proteins 0.000 description 1
• WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
• 102100033429 Glutamine-fructose-6-phosphate aminotransferase [isomerizing] 1 Human genes 0.000 description 1
• 239000004471 Glycine Substances 0.000 description 1
• 102000001539 Glycine cleavage system T proteins Human genes 0.000 description 1
• 102100040094 Glycogen phosphorylase, brain form Human genes 0.000 description 1
• 102000003886 Glycoproteins Human genes 0.000 description 1
• 108090000288 Glycoproteins Proteins 0.000 description 1
• 102100037825 Glycosaminoglycan xylosylkinase Human genes 0.000 description 1
• 102000010956 Glypican Human genes 0.000 description 1
• 108050001154 Glypican Proteins 0.000 description 1
• 108050007237 Glypican-3 Proteins 0.000 description 1
• 102100031488 Golgi-associated plant pathogenesis-related protein 1 Human genes 0.000 description 1
• 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 description 1
• 102100039619 Granulocyte colony-stimulating factor Human genes 0.000 description 1
• 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 description 1
• 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 description 1
• 102000009465 Growth Factor Receptors Human genes 0.000 description 1
• 108010009202 Growth Factor Receptors Proteins 0.000 description 1
• 102100020948 Growth hormone receptor Human genes 0.000 description 1
• 102100040896 Growth/differentiation factor 15 Human genes 0.000 description 1
• 102100033322 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 Human genes 0.000 description 1
• 102100035354 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Human genes 0.000 description 1
• 102100040754 Guanylate cyclase soluble subunit alpha-1 Human genes 0.000 description 1
• 102100028972 HLA class I histocompatibility antigen, A alpha chain Human genes 0.000 description 1
• 102100028966 HLA class I histocompatibility antigen, alpha chain F Human genes 0.000 description 1
• 102100029966 HLA class II histocompatibility antigen, DP alpha 1 chain Human genes 0.000 description 1
• 102100036241 HLA class II histocompatibility antigen, DQ beta 1 chain Human genes 0.000 description 1
• 108010075704 HLA-A Antigens Proteins 0.000 description 1
• 108010088729 HLA-A*02:01 antigen Proteins 0.000 description 1
• 108010058607 HLA-B Antigens Proteins 0.000 description 1
• 108010065026 HLA-DQB1 antigen Proteins 0.000 description 1
• 102100022969 HMG box transcription factor BBX Human genes 0.000 description 1
• 101150096895 HSPB1 gene Proteins 0.000 description 1
• 101710178376 Heat shock 70 kDa protein Proteins 0.000 description 1
• 102100039165 Heat shock protein beta-1 Human genes 0.000 description 1
• 102100028515 Heat shock-related 70 kDa protein 2 Human genes 0.000 description 1
• 108010004889 Heat-Shock Proteins Proteins 0.000 description 1
• 102000002812 Heat-Shock Proteins Human genes 0.000 description 1
• 102100027618 Heme transporter HRG1 Human genes 0.000 description 1
• 229920002971 Heparan sulfate Polymers 0.000 description 1
• 108010014594 Heterogeneous Nuclear Ribonucleoprotein A1 Proteins 0.000 description 1
• 102100035621 Heterogeneous nuclear ribonucleoprotein A1 Human genes 0.000 description 1
• 102100028818 Heterogeneous nuclear ribonucleoprotein L Human genes 0.000 description 1
• 102100031004 Histidine-tRNA ligase, cytoplasmic Human genes 0.000 description 1
• 108010088652 Histocompatibility Antigens Class I Proteins 0.000 description 1
• 108010027412 Histocompatibility Antigens Class II Proteins 0.000 description 1
• 102000018713 Histocompatibility Antigens Class II Human genes 0.000 description 1
• 102100039855 Histone H1.2 Human genes 0.000 description 1
• 102100033069 Histone acetyltransferase KAT8 Human genes 0.000 description 1
• 102100038970 Histone-lysine N-methyltransferase EZH2 Human genes 0.000 description 1
• 102100029234 Histone-lysine N-methyltransferase NSD2 Human genes 0.000 description 1
• 102100039544 Homeobox protein Hox-D10 Human genes 0.000 description 1
• 102100034826 Homeobox protein Meis2 Human genes 0.000 description 1
• 101000605587 Homo sapiens 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 Proteins 0.000 description 1
• 101000691616 Homo sapiens 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 Proteins 0.000 description 1
• 101001045223 Homo sapiens 17-beta-hydroxysteroid dehydrogenase type 2 Proteins 0.000 description 1
• 101001008907 Homo sapiens 2'-5'-oligoadenylate synthase 1 Proteins 0.000 description 1
• 101001115709 Homo sapiens 2-acylglycerol O-acyltransferase 3 Proteins 0.000 description 1
• 101000597665 Homo sapiens 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial Proteins 0.000 description 1
• 101000612528 Homo sapiens 26S proteasome non-ATPase regulatory subunit 12 Proteins 0.000 description 1
• 101000612536 Homo sapiens 26S proteasome non-ATPase regulatory subunit 13 Proteins 0.000 description 1
• 101000691550 Homo sapiens 39S ribosomal protein L13, mitochondrial Proteins 0.000 description 1
• 101001104236 Homo sapiens 39S ribosomal protein L40, mitochondrial Proteins 0.000 description 1
• 101001119189 Homo sapiens 40S ribosomal protein S10 Proteins 0.000 description 1
• 101001114932 Homo sapiens 40S ribosomal protein S20 Proteins 0.000 description 1
• 101000678466 Homo sapiens 40S ribosomal protein S27 Proteins 0.000 description 1
• 101000696103 Homo sapiens 40S ribosomal protein S4, Y isoform 1 Proteins 0.000 description 1
• 101000742701 Homo sapiens 5'-AMP-activated protein kinase subunit beta-1 Proteins 0.000 description 1
• 101000691878 Homo sapiens 60S acidic ribosomal protein P2 Proteins 0.000 description 1
• 101001118201 Homo sapiens 60S ribosomal protein L13 Proteins 0.000 description 1
• 101000681240 Homo sapiens 60S ribosomal protein L13a Proteins 0.000 description 1
• 101000682512 Homo sapiens 60S ribosomal protein L17 Proteins 0.000 description 1
• 101000752293 Homo sapiens 60S ribosomal protein L18a Proteins 0.000 description 1
• 101000673985 Homo sapiens 60S ribosomal protein L3 Proteins 0.000 description 1
• 101000691083 Homo sapiens 60S ribosomal protein L5 Proteins 0.000 description 1
• 101000627872 Homo sapiens 72 kDa type IV collagenase Proteins 0.000 description 1
• 101000974390 Homo sapiens ADP-ribosylation factor-like protein 4C Proteins 0.000 description 1
• 101000793552 Homo sapiens ADP-ribosylation factor-like protein 6-interacting protein 1 Proteins 0.000 description 1
• 101000797458 Homo sapiens AMP deaminase 2 Proteins 0.000 description 1
• 101000806914 Homo sapiens AP-2 complex subunit sigma Proteins 0.000 description 1
• 101000959718 Homo sapiens AP-3 complex subunit mu-2 Proteins 0.000 description 1
• 101000890244 Homo sapiens AP-4 complex subunit sigma-1 Proteins 0.000 description 1
• 101000905623 Homo sapiens ATP synthase F(0) complex subunit B1, mitochondrial Proteins 0.000 description 1
• 101001041697 Homo sapiens ATP-dependent RNA helicase DDX1 Proteins 0.000 description 1
• 101000907886 Homo sapiens ATP-dependent RNA helicase DHX15 Proteins 0.000 description 1
• 101000902767 Homo sapiens ATPase inhibitor, mitochondrial Proteins 0.000 description 1
• 101000901099 Homo sapiens Achaete-scute homolog 1 Proteins 0.000 description 1
• 101001060527 Homo sapiens Acidic fibroblast growth factor intracellular-binding protein Proteins 0.000 description 1
• 101000678433 Homo sapiens Actin, gamma-enteric smooth muscle Proteins 0.000 description 1
• 101000720381 Homo sapiens Acyl-coenzyme A thioesterase 8 Proteins 0.000 description 1
• 101000799712 Homo sapiens Adenosine receptor A1 Proteins 0.000 description 1
• 101000890921 Homo sapiens Allograft inflammatory factor 1-like Proteins 0.000 description 1
• 101000678026 Homo sapiens Alpha-1-antichymotrypsin Proteins 0.000 description 1
• 101000891982 Homo sapiens Alpha-crystallin B chain Proteins 0.000 description 1
• 101000694718 Homo sapiens Amine oxidase [flavin-containing] A Proteins 0.000 description 1
• 101000779845 Homo sapiens Amphiphysin Proteins 0.000 description 1
• 101000732617 Homo sapiens Angiotensinogen Proteins 0.000 description 1
• 101000732632 Homo sapiens Anillin Proteins 0.000 description 1
• 101000925512 Homo sapiens Ankyrin repeat and SOCS box protein 13 Proteins 0.000 description 1
• 101000959738 Homo sapiens Annexin A1 Proteins 0.000 description 1
• 101000775021 Homo sapiens Anterior gradient protein 2 homolog Proteins 0.000 description 1
• 101000775037 Homo sapiens Anterior gradient protein 3 Proteins 0.000 description 1
• 101000792706 Homo sapiens Arfaptin-1 Proteins 0.000 description 1
• 101000936988 Homo sapiens Atlastin-2 Proteins 0.000 description 1
• 101000961040 Homo sapiens Atrial natriuretic peptide receptor 2 Proteins 0.000 description 1
• 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 description 1
• 101100325841 Homo sapiens BCLAF1 gene Proteins 0.000 description 1
• 101000596896 Homo sapiens BDNF/NT-3 growth factors receptor Proteins 0.000 description 1
• 101001049977 Homo sapiens Band 4.1-like protein 2 Proteins 0.000 description 1
• 101000970576 Homo sapiens Bcl-2-interacting killer Proteins 0.000 description 1
• 101001052060 Homo sapiens Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase Proteins 0.000 description 1
• 101000777558 Homo sapiens C-C chemokine receptor type 10 Proteins 0.000 description 1
• 101000777471 Homo sapiens C-C motif chemokine 4 Proteins 0.000 description 1
• 101000766908 Homo sapiens C-type lectin domain family 4 member A Proteins 0.000 description 1
• 101000740685 Homo sapiens C4b-binding protein alpha chain Proteins 0.000 description 1
• 101000980829 Homo sapiens CD180 antigen Proteins 0.000 description 1
• 101000776617 Homo sapiens CGG triplet repeat-binding protein 1 Proteins 0.000 description 1
• 101000914155 Homo sapiens Cadherin EGF LAG seven-pass G-type receptor 1 Proteins 0.000 description 1
• 101000580357 Homo sapiens Calcipressin-1 Proteins 0.000 description 1
• 101001049849 Homo sapiens Calcium-activated potassium channel subunit beta-1 Proteins 0.000 description 1
• 101000714589 Homo sapiens Calcium-binding and coiled-coil domain-containing protein 1 Proteins 0.000 description 1
• 101000867778 Homo sapiens Calcium-dependent secretion activator 2 Proteins 0.000 description 1
• 101000947048 Homo sapiens Calcyphosin-2 Proteins 0.000 description 1
• 101000910297 Homo sapiens Caldesmon Proteins 0.000 description 1
• 101000912631 Homo sapiens Calmegin Proteins 0.000 description 1
• 101000945318 Homo sapiens Calponin-1 Proteins 0.000 description 1
• 101000856237 Homo sapiens Cancer/testis antigen 1 Proteins 0.000 description 1
• 101000914337 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 3 Proteins 0.000 description 1
• 101000715398 Homo sapiens Caspase-1 Proteins 0.000 description 1
• 101000933112 Homo sapiens Caspase-4 Proteins 0.000 description 1
• 101000933218 Homo sapiens Cathepsin F Proteins 0.000 description 1
• 101000715467 Homo sapiens Caveolin-1 Proteins 0.000 description 1
• 101000740981 Homo sapiens Caveolin-2 Proteins 0.000 description 1
• 101000914537 Homo sapiens Cell death-inducing p53-target protein 1 Proteins 0.000 description 1
• 101000945740 Homo sapiens Cell division cycle 7-related protein kinase Proteins 0.000 description 1
• 101000776447 Homo sapiens Centrosomal protein of 55 kDa Proteins 0.000 description 1
• 101000737602 Homo sapiens Ceramide synthase 1 Proteins 0.000 description 1
• 101000737604 Homo sapiens Ceramide synthase 2 Proteins 0.000 description 1
• 101000883325 Homo sapiens Chitinase-3-like protein 2 Proteins 0.000 description 1
• 101000797578 Homo sapiens Chromobox protein homolog 3 Proteins 0.000 description 1
• 101000777071 Homo sapiens Chromodomain-helicase-DNA-binding protein 3 Proteins 0.000 description 1
• 101000710072 Homo sapiens Cilia- and flagella-associated protein 97 Proteins 0.000 description 1
• 101000777372 Homo sapiens Coiled-coil domain-containing protein 3 Proteins 0.000 description 1
• 101000941581 Homo sapiens Collagen alpha-1(VI) chain Proteins 0.000 description 1
• 101000940372 Homo sapiens Collagen alpha-1(XXVII) chain Proteins 0.000 description 1
• 101000677550 Homo sapiens Complex I assembly factor ACAD9, mitochondrial Proteins 0.000 description 1
• 101000855520 Homo sapiens Cyclic AMP-responsive element-binding protein 3 Proteins 0.000 description 1
• 101000895309 Homo sapiens Cyclic AMP-responsive element-binding protein 3-like protein 4 Proteins 0.000 description 1
• 101000921786 Homo sapiens Cystatin-A Proteins 0.000 description 1
• 101000922020 Homo sapiens Cysteine and glycine-rich protein 1 Proteins 0.000 description 1
• 101000919466 Homo sapiens Cytochrome c oxidase subunit 7A-related protein, mitochondrial Proteins 0.000 description 1
• 101001107795 Homo sapiens Cytosolic Fe-S cluster assembly factor NUBP2 Proteins 0.000 description 1
• 101000909249 Homo sapiens DNA (cytosine-5)-methyltransferase 3B Proteins 0.000 description 1
• 101000801505 Homo sapiens DNA topoisomerase 2-alpha Proteins 0.000 description 1
• 101000686009 Homo sapiens DNA-directed RNA polymerases I, II, and III subunit RPABC2 Proteins 0.000 description 1
• 101000929421 Homo sapiens Deformed epidermal autoregulatory factor 1 homolog Proteins 0.000 description 1
• 101000844963 Homo sapiens Deoxyhypusine synthase Proteins 0.000 description 1
• 101000816741 Homo sapiens Dermatan-sulfate epimerase-like protein Proteins 0.000 description 1
• 101000930818 Homo sapiens Dihydropyrimidinase Proteins 0.000 description 1
• 101001053503 Homo sapiens Dihydropyrimidinase-related protein 2 Proteins 0.000 description 1
• 101000915391 Homo sapiens Disabled homolog 2 Proteins 0.000 description 1
• 101000902114 Homo sapiens Disks large homolog 5 Proteins 0.000 description 1
• 101000845887 Homo sapiens DnaJ homolog subfamily C member 2 Proteins 0.000 description 1
• 101000881127 Homo sapiens Dual specificity protein phosphatase 10 Proteins 0.000 description 1
• 101001057612 Homo sapiens Dual specificity protein phosphatase 5 Proteins 0.000 description 1
• 101001057587 Homo sapiens Dual specificity protein phosphatase 6 Proteins 0.000 description 1
• 101000817629 Homo sapiens Dymeclin Proteins 0.000 description 1
• 101000837994 Homo sapiens Dynactin-associated protein Proteins 0.000 description 1
• 101000871249 Homo sapiens Dysbindin domain-containing protein 2 Proteins 0.000 description 1
• 101001016186 Homo sapiens Dystonin Proteins 0.000 description 1
• 101001049692 Homo sapiens E3 SUMO-protein ligase EGR2 Proteins 0.000 description 1
• 101000994468 Homo sapiens E3 ubiquitin-protein ligase Jade-2 Proteins 0.000 description 1
• 101000670535 Homo sapiens E3 ubiquitin-protein ligase RNF167 Proteins 0.000 description 1
• 101000707245 Homo sapiens E3 ubiquitin-protein ligase SIAH2 Proteins 0.000 description 1
• 101000866909 Homo sapiens EF-hand domain-containing protein D1 Proteins 0.000 description 1
• 101000898776 Homo sapiens ER lumen protein-retaining receptor 3 Proteins 0.000 description 1
• 101000938692 Homo sapiens ESF1 homolog Proteins 0.000 description 1
• 101000813747 Homo sapiens ETS translocation variant 4 Proteins 0.000 description 1
• 101100012018 Homo sapiens ETV4 gene Proteins 0.000 description 1
• 101000896450 Homo sapiens Early growth response protein 3 Proteins 0.000 description 1
• 101001057122 Homo sapiens Electron transfer flavoprotein subunit beta Proteins 0.000 description 1
• 101000841231 Homo sapiens Elongation factor 1-alpha 2 Proteins 0.000 description 1
• 101001050451 Homo sapiens Elongation factor 1-gamma Proteins 0.000 description 1
• 101000921361 Homo sapiens Elongation of very long chain fatty acids protein 5 Proteins 0.000 description 1
• 101000897352 Homo sapiens Endonuclease domain-containing 1 protein Proteins 0.000 description 1
• 101000841213 Homo sapiens Endothelin-3 Proteins 0.000 description 1
• 101000851002 Homo sapiens Epithelial membrane protein 2 Proteins 0.000 description 1
• 101000907855 Homo sapiens Estradiol 17-beta-dehydrogenase 11 Proteins 0.000 description 1
• 101000851788 Homo sapiens Eukaryotic peptide chain release factor GTP-binding subunit ERF3A Proteins 0.000 description 1
• 101000896557 Homo sapiens Eukaryotic translation initiation factor 3 subunit B Proteins 0.000 description 1
• 101000810389 Homo sapiens Eukaryotic translation initiation factor 3 subunit L Proteins 0.000 description 1
• 101001034811 Homo sapiens Eukaryotic translation initiation factor 4 gamma 2 Proteins 0.000 description 1
• 101000866286 Homo sapiens Excitatory amino acid transporter 1 Proteins 0.000 description 1
• 101000866302 Homo sapiens Excitatory amino acid transporter 3 Proteins 0.000 description 1
• 101000911699 Homo sapiens Exocyst complex component 4 Proteins 0.000 description 1
• 101000911670 Homo sapiens Exocyst complex component 6 Proteins 0.000 description 1
• 101000820630 Homo sapiens Extracellular sulfatase Sulf-1 Proteins 0.000 description 1
• 101000938438 Homo sapiens Eyes absent homolog 2 Proteins 0.000 description 1
• 101001026867 Homo sapiens F-box/LRR-repeat protein 4 Proteins 0.000 description 1
• 101000893722 Homo sapiens FXYD domain-containing ion transport regulator 6 Proteins 0.000 description 1
• 101000846893 Homo sapiens Fibrillin-1 Proteins 0.000 description 1
• 101000827688 Homo sapiens Fibroblast growth factor receptor 2 Proteins 0.000 description 1
• 101001059893 Homo sapiens Forkhead box protein P1 Proteins 0.000 description 1
• 101000932133 Homo sapiens Four-jointed box protein 1 Proteins 0.000 description 1
• 101000836545 Homo sapiens Fructose-bisphosphate aldolase C Proteins 0.000 description 1
• 101000980756 Homo sapiens G1/S-specific cyclin-D1 Proteins 0.000 description 1
• 101000980741 Homo sapiens G1/S-specific cyclin-D2 Proteins 0.000 description 1
• 101000997961 Homo sapiens GDNF family receptor alpha-1 Proteins 0.000 description 1
• 101000833389 Homo sapiens GTPase IMAP family member 6 Proteins 0.000 description 1
• 101000894966 Homo sapiens Gap junction alpha-1 protein Proteins 0.000 description 1
• 101001058426 Homo sapiens Glucocorticoid-induced transcript 1 protein Proteins 0.000 description 1
• 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 description 1
• 101000997929 Homo sapiens Glutamine-fructose-6-phosphate aminotransferase [isomerizing] 1 Proteins 0.000 description 1
• 101000748183 Homo sapiens Glycogen phosphorylase, brain form Proteins 0.000 description 1
• 101000805056 Homo sapiens Glycosaminoglycan xylosylkinase Proteins 0.000 description 1
• 101000922994 Homo sapiens Golgi-associated plant pathogenesis-related protein 1 Proteins 0.000 description 1
• 101000893549 Homo sapiens Growth/differentiation factor 15 Proteins 0.000 description 1
• 101000926798 Homo sapiens Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 Proteins 0.000 description 1
• 101001024316 Homo sapiens Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Proteins 0.000 description 1
• 101001038755 Homo sapiens Guanylate cyclase soluble subunit alpha-1 Proteins 0.000 description 1
• 101000986080 Homo sapiens HLA class I histocompatibility antigen, alpha chain F Proteins 0.000 description 1
• 101000903732 Homo sapiens HMG box transcription factor BBX Proteins 0.000 description 1
• 101000985806 Homo sapiens Heat shock-related 70 kDa protein 2 Proteins 0.000 description 1
• 101001081412 Homo sapiens Heme transporter HRG1 Proteins 0.000 description 1
• 101000839078 Homo sapiens Heterogeneous nuclear ribonucleoprotein L Proteins 0.000 description 1
• 101000843187 Homo sapiens Histidine-tRNA ligase, cytoplasmic Proteins 0.000 description 1
• 101001035375 Homo sapiens Histone H1.2 Proteins 0.000 description 1
• 101000944170 Homo sapiens Histone acetyltransferase KAT8 Proteins 0.000 description 1
• 101001028782 Homo sapiens Histone-lysine N-methyltransferase EZH1 Proteins 0.000 description 1
• 101000882127 Homo sapiens Histone-lysine N-methyltransferase EZH2 Proteins 0.000 description 1
• 101000634048 Homo sapiens Histone-lysine N-methyltransferase NSD2 Proteins 0.000 description 1
• 101000962573 Homo sapiens Homeobox protein Hox-D10 Proteins 0.000 description 1
• 101001019057 Homo sapiens Homeobox protein Meis2 Proteins 0.000 description 1
• 101000913079 Homo sapiens IgG receptor FcRn large subunit p51 Proteins 0.000 description 1
• 101000913082 Homo sapiens IgGFc-binding protein Proteins 0.000 description 1
• 101001003310 Homo sapiens Immediate early response gene 5 protein Proteins 0.000 description 1
• 101000977638 Homo sapiens Immunoglobulin superfamily containing leucine-rich repeat protein Proteins 0.000 description 1
• 101001054793 Homo sapiens Importin subunit alpha-7 Proteins 0.000 description 1
• 101001054725 Homo sapiens Inhibin beta B chain Proteins 0.000 description 1
• 101000998969 Homo sapiens Inositol-3-phosphate synthase 1 Proteins 0.000 description 1
• 101001077600 Homo sapiens Insulin receptor substrate 2 Proteins 0.000 description 1
• 101001044927 Homo sapiens Insulin-like growth factor-binding protein 3 Proteins 0.000 description 1
• 101000840572 Homo sapiens Insulin-like growth factor-binding protein 4 Proteins 0.000 description 1
• 101001056814 Homo sapiens Integral membrane protein 2C Proteins 0.000 description 1
• 101000994369 Homo sapiens Integrin alpha-5 Proteins 0.000 description 1
• 101000994365 Homo sapiens Integrin alpha-6 Proteins 0.000 description 1
• 101001015006 Homo sapiens Integrin beta-4 Proteins 0.000 description 1
• 101000840275 Homo sapiens Interferon alpha-inducible protein 27, mitochondrial Proteins 0.000 description 1
• 101001032345 Homo sapiens Interferon regulatory factor 8 Proteins 0.000 description 1
• 101000599056 Homo sapiens Interleukin-6 receptor subunit beta Proteins 0.000 description 1
• 101001044336 Homo sapiens Intraflagellar transport protein 122 homolog Proteins 0.000 description 1
• 101001053444 Homo sapiens Iroquois-class homeodomain protein IRX-1 Proteins 0.000 description 1
• 101000599886 Homo sapiens Isocitrate dehydrogenase [NADP], mitochondrial Proteins 0.000 description 1
• 101001050321 Homo sapiens Junctional adhesion molecule C Proteins 0.000 description 1
• 101000971351 Homo sapiens KRR1 small subunit processome component homolog Proteins 0.000 description 1
• 101001091379 Homo sapiens Kallikrein-5 Proteins 0.000 description 1
• 101000614439 Homo sapiens Keratin, type I cytoskeletal 15 Proteins 0.000 description 1
• 101001049181 Homo sapiens Killer cell lectin-like receptor subfamily B member 1 Proteins 0.000 description 1
• 101001050567 Homo sapiens Kinesin-like protein KIF2C Proteins 0.000 description 1
• 101000590482 Homo sapiens Kinetochore protein Nuf2 Proteins 0.000 description 1
• 101001004313 Homo sapiens LHFPL tetraspan subfamily member 2 protein Proteins 0.000 description 1
• 101100182729 Homo sapiens LY6K gene Proteins 0.000 description 1
• 101001034314 Homo sapiens Lactadherin Proteins 0.000 description 1
• 101001008558 Homo sapiens Laminin subunit beta-2 Proteins 0.000 description 1
• 101000938676 Homo sapiens Liver carboxylesterase 1 Proteins 0.000 description 1
• 101000917839 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-B Proteins 0.000 description 1
• 101001065568 Homo sapiens Lymphocyte antigen 6E Proteins 0.000 description 1
• 101001065550 Homo sapiens Lymphocyte antigen 6K Proteins 0.000 description 1
• 101000972291 Homo sapiens Lymphoid enhancer-binding factor 1 Proteins 0.000 description 1
• 101001115426 Homo sapiens MAGUK p55 subfamily member 3 Proteins 0.000 description 1
• 101100514361 Homo sapiens MRTFB gene Proteins 0.000 description 1
• 101000916644 Homo sapiens Macrophage colony-stimulating factor 1 receptor Proteins 0.000 description 1
• 101001056015 Homo sapiens Mannan-binding lectin serine protease 2 Proteins 0.000 description 1
• 101001000302 Homo sapiens Max-interacting protein 1 Proteins 0.000 description 1
• 101001057154 Homo sapiens Melanoma-associated antigen D2 Proteins 0.000 description 1
• 101000979001 Homo sapiens Methionine aminopeptidase 2 Proteins 0.000 description 1
• 101001003205 Homo sapiens Methylosome subunit pICln Proteins 0.000 description 1
• 101000969087 Homo sapiens Microtubule-associated protein 2 Proteins 0.000 description 1
• 101000957756 Homo sapiens Microtubule-associated protein RP/EB family member 2 Proteins 0.000 description 1
• 101001018298 Homo sapiens Microtubule-associated serine/threonine-protein kinase 4 Proteins 0.000 description 1
• 101000951325 Homo sapiens Mitoferrin-1 Proteins 0.000 description 1
• 101000950669 Homo sapiens Mitogen-activated protein kinase 9 Proteins 0.000 description 1
• 101000896657 Homo sapiens Mitotic checkpoint serine/threonine-protein kinase BUB1 Proteins 0.000 description 1
• 101000957259 Homo sapiens Mitotic spindle assembly checkpoint protein MAD2A Proteins 0.000 description 1
• 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 description 1
• 101001133056 Homo sapiens Mucin-1 Proteins 0.000 description 1
• 101001022780 Homo sapiens Myosin light chain kinase, smooth muscle Proteins 0.000 description 1
• 101000573234 Homo sapiens NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 Proteins 0.000 description 1
• 101001128687 Homo sapiens NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial Proteins 0.000 description 1
• 101000636705 Homo sapiens NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial Proteins 0.000 description 1
• 101000969961 Homo sapiens Neurexin-3 Proteins 0.000 description 1
• 101000969963 Homo sapiens Neurexin-3-beta Proteins 0.000 description 1
• 101000582002 Homo sapiens Neuron navigator 2 Proteins 0.000 description 1
• 101001069237 Homo sapiens Neuronal membrane glycoprotein M6-b Proteins 0.000 description 1
• 101000596404 Homo sapiens Neuronal vesicle trafficking-associated protein 1 Proteins 0.000 description 1
• 101001072765 Homo sapiens Neutral alpha-glucosidase AB Proteins 0.000 description 1
• 101000973211 Homo sapiens Nuclear factor 1 B-type Proteins 0.000 description 1
• 101001103036 Homo sapiens Nuclear receptor ROR-alpha Proteins 0.000 description 1
• 101000974343 Homo sapiens Nuclear receptor coactivator 4 Proteins 0.000 description 1
• 101001121166 Homo sapiens ORM1-like protein 2 Proteins 0.000 description 1
• 101001121539 Homo sapiens P2Y purinoceptor 14 Proteins 0.000 description 1
• 101100297739 Homo sapiens PLEKHO1 gene Proteins 0.000 description 1
• 101001094807 Homo sapiens Paraneoplastic antigen-like protein 8A Proteins 0.000 description 1
• 101001096050 Homo sapiens Perilipin-2 Proteins 0.000 description 1
• 101000741788 Homo sapiens Peroxisome proliferator-activated receptor alpha Proteins 0.000 description 1
• 101001098116 Homo sapiens Phosphatidylinositol 3-kinase regulatory subunit gamma Proteins 0.000 description 1
• 101001093731 Homo sapiens Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q Proteins 0.000 description 1
• 101000929845 Homo sapiens Phospholipase ABHD3 Proteins 0.000 description 1
• 101001094827 Homo sapiens Phosphomannomutase 1 Proteins 0.000 description 1
• 101000611888 Homo sapiens Platelet-derived growth factor C Proteins 0.000 description 1
• 101001126102 Homo sapiens Pleckstrin homology domain-containing family B member 1 Proteins 0.000 description 1
• 101000583225 Homo sapiens Pleckstrin homology domain-containing family H member 2 Proteins 0.000 description 1
• 101000583692 Homo sapiens Pleckstrin homology-like domain family A member 1 Proteins 0.000 description 1
• 101000595198 Homo sapiens Podocalyxin Proteins 0.000 description 1
• 101001113483 Homo sapiens Poly [ADP-ribose] polymerase 1 Proteins 0.000 description 1
• 101000735354 Homo sapiens Poly(rC)-binding protein 1 Proteins 0.000 description 1
• 101001117219 Homo sapiens Polymerase delta-interacting protein 3 Proteins 0.000 description 1
• 101001049841 Homo sapiens Potassium channel subfamily K member 1 Proteins 0.000 description 1
• 101000617546 Homo sapiens Presenilin-2 Proteins 0.000 description 1
• 101000741967 Homo sapiens Presequence protease, mitochondrial Proteins 0.000 description 1
• 101000687549 Homo sapiens Prickle-like protein 4 Proteins 0.000 description 1
• 101001133941 Homo sapiens Prolyl 3-hydroxylase 1 Proteins 0.000 description 1
• 101000881650 Homo sapiens Prolyl hydroxylase EGLN2 Proteins 0.000 description 1
• 101000684673 Homo sapiens Protein APCDD1 Proteins 0.000 description 1
• 101000933604 Homo sapiens Protein BTG2 Proteins 0.000 description 1
• 101001062760 Homo sapiens Protein FAM13A Proteins 0.000 description 1
• 101000911483 Homo sapiens Protein FAM210B, mitochondrial Proteins 0.000 description 1
• 101001027850 Homo sapiens Protein FAM53C Proteins 0.000 description 1
• 101000624382 Homo sapiens Protein MON2 homolog Proteins 0.000 description 1
• 101000707247 Homo sapiens Protein Shroom3 Proteins 0.000 description 1
• 101000620365 Homo sapiens Protein TMEPAI Proteins 0.000 description 1
• 101000764357 Homo sapiens Protein Tob1 Proteins 0.000 description 1
• 101000757216 Homo sapiens Protein arginine N-methyltransferase 1 Proteins 0.000 description 1
• 101000757232 Homo sapiens Protein arginine N-methyltransferase 2 Proteins 0.000 description 1
• 101001098802 Homo sapiens Protein disulfide-isomerase A3 Proteins 0.000 description 1
• 101001026852 Homo sapiens Protein kinase C epsilon type Proteins 0.000 description 1
• 101000687060 Homo sapiens Protein phosphatase 1 regulatory subunit 1A Proteins 0.000 description 1
• 101000742071 Homo sapiens Protein phosphatase 1 regulatory subunit 26 Proteins 0.000 description 1
• 101001093143 Homo sapiens Protein transport protein Sec61 subunit gamma Proteins 0.000 description 1
• 101000647945 Homo sapiens RNA polymerase II subunit A C-terminal domain phosphatase SSU72 Proteins 0.000 description 1
• 101001076715 Homo sapiens RNA-binding protein 39 Proteins 0.000 description 1
• 101001109419 Homo sapiens RNA-binding protein NOB1 Proteins 0.000 description 1
• 101001130290 Homo sapiens Rab GTPase-binding effector protein 1 Proteins 0.000 description 1
• 101000665456 Homo sapiens Ral GTPase-activating protein subunit alpha-2 Proteins 0.000 description 1
• 101000744515 Homo sapiens Ras-related protein M-Ras Proteins 0.000 description 1
• 101000584785 Homo sapiens Ras-related protein Rab-7a Proteins 0.000 description 1
• 101000823237 Homo sapiens Reticulon-1 Proteins 0.000 description 1
• 101000823247 Homo sapiens Reticulon-2 Proteins 0.000 description 1
• 101000640876 Homo sapiens Retinoic acid receptor RXR-beta Proteins 0.000 description 1
• 101000667821 Homo sapiens Rho-related GTP-binding protein RhoE Proteins 0.000 description 1
• 101000707599 Homo sapiens Rhophilin-1 Proteins 0.000 description 1
• 101000945096 Homo sapiens Ribosomal protein S6 kinase alpha-5 Proteins 0.000 description 1
• 101001088125 Homo sapiens Ropporin-1A Proteins 0.000 description 1
• 101000822528 Homo sapiens S-adenosylhomocysteine hydrolase-like protein 1 Proteins 0.000 description 1
• 101000693721 Homo sapiens SAM and SH3 domain-containing protein 1 Proteins 0.000 description 1
• 101000632561 Homo sapiens SH3 domain-binding glutamic acid-rich protein Proteins 0.000 description 1
• 101000881168 Homo sapiens SPARC Proteins 0.000 description 1
• 101000687634 Homo sapiens SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 Proteins 0.000 description 1
• 101000632270 Homo sapiens Semaphorin-3B Proteins 0.000 description 1
• 101000684497 Homo sapiens Sentrin-specific protease 2 Proteins 0.000 description 1
• 101000654734 Homo sapiens Septin-4 Proteins 0.000 description 1
• 101000700735 Homo sapiens Serine/arginine-rich splicing factor 7 Proteins 0.000 description 1
• 101001059454 Homo sapiens Serine/threonine-protein kinase MARK2 Proteins 0.000 description 1
• 101000607332 Homo sapiens Serine/threonine-protein kinase ULK2 Proteins 0.000 description 1
• 101000770774 Homo sapiens Serine/threonine-protein kinase WNK2 Proteins 0.000 description 1
• 101000783373 Homo sapiens Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform Proteins 0.000 description 1
• 101000869480 Homo sapiens Serum amyloid A-1 protein Proteins 0.000 description 1
• 101000760716 Homo sapiens Short-chain specific acyl-CoA dehydrogenase, mitochondrial Proteins 0.000 description 1
• 101000929936 Homo sapiens Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial Proteins 0.000 description 1
• 101000701936 Homo sapiens Signal peptidase complex subunit 1 Proteins 0.000 description 1
• 101000648038 Homo sapiens Signal transducing adapter molecule 2 Proteins 0.000 description 1
• 101000713494 Homo sapiens Small nuclear ribonucleoprotein F Proteins 0.000 description 1
• 101000639975 Homo sapiens Sodium-dependent noradrenaline transporter Proteins 0.000 description 1
• 101000701334 Homo sapiens Sodium/potassium-transporting ATPase subunit alpha-1 Proteins 0.000 description 1
• 101000829127 Homo sapiens Somatostatin receptor type 2 Proteins 0.000 description 1
• 101000908580 Homo sapiens Spliceosome RNA helicase DDX39B Proteins 0.000 description 1
• 101000707770 Homo sapiens Splicing factor 3B subunit 2 Proteins 0.000 description 1
• 101000831940 Homo sapiens Stathmin Proteins 0.000 description 1
• 101000697529 Homo sapiens Stathmin-4 Proteins 0.000 description 1
• 101000631826 Homo sapiens Stearoyl-CoA desaturase Proteins 0.000 description 1
• 101000643865 Homo sapiens Sulfite oxidase, mitochondrial Proteins 0.000 description 1
• 101000692109 Homo sapiens Syndecan-2 Proteins 0.000 description 1
• 101000692107 Homo sapiens Syndecan-3 Proteins 0.000 description 1
• 101000934346 Homo sapiens T-cell surface antigen CD2 Proteins 0.000 description 1
• 101000666730 Homo sapiens T-complex protein 1 subunit alpha Proteins 0.000 description 1
• 101000653663 Homo sapiens T-complex protein 1 subunit epsilon Proteins 0.000 description 1
• 101000891620 Homo sapiens TBC1 domain family member 1 Proteins 0.000 description 1
• 101000665415 Homo sapiens TBC1 domain family member 13 Proteins 0.000 description 1
• 101000891625 Homo sapiens TBC1 domain family member 4 Proteins 0.000 description 1
• 101000801058 Homo sapiens TM2 domain-containing protein 2 Proteins 0.000 description 1
• 101000845189 Homo sapiens Testis-specific Y-encoded protein 1 Proteins 0.000 description 1
• 101000612875 Homo sapiens Testis-specific Y-encoded-like protein 1 Proteins 0.000 description 1
• 101000658628 Homo sapiens Testis-specific Y-encoded-like protein 5 Proteins 0.000 description 1
• 101000759892 Homo sapiens Tetraspanin-13 Proteins 0.000 description 1
• 101000759889 Homo sapiens Tetraspanin-14 Proteins 0.000 description 1
• 101000612997 Homo sapiens Tetraspanin-5 Proteins 0.000 description 1
• 101000753769 Homo sapiens Thiamine-triphosphatase Proteins 0.000 description 1
• 101000837639 Homo sapiens Thyroxine-binding globulin Proteins 0.000 description 1
• 101000662690 Homo sapiens Trafficking protein particle complex subunit 10 Proteins 0.000 description 1
• 101000664703 Homo sapiens Transcription factor SOX-10 Proteins 0.000 description 1
• 101000712658 Homo sapiens Transforming growth factor beta-1-induced transcript 1 protein Proteins 0.000 description 1
• 101000894525 Homo sapiens Transforming growth factor-beta-induced protein ig-h3 Proteins 0.000 description 1
• 101000652736 Homo sapiens Transgelin Proteins 0.000 description 1
• 101000840378 Homo sapiens Translation initiation factor IF-2, mitochondrial Proteins 0.000 description 1
• 101000631620 Homo sapiens Translocation protein SEC63 homolog Proteins 0.000 description 1
• 101000831851 Homo sapiens Transmembrane emp24 domain-containing protein 10 Proteins 0.000 description 1
• 101000852842 Homo sapiens Transmembrane protein 107 Proteins 0.000 description 1
• 101000889485 Homo sapiens Trefoil factor 3 Proteins 0.000 description 1
• 101000664599 Homo sapiens Tripartite motif-containing protein 2 Proteins 0.000 description 1
• 101000634975 Homo sapiens Tripartite motif-containing protein 29 Proteins 0.000 description 1
• 101000801433 Homo sapiens Trophoblast glycoprotein Proteins 0.000 description 1
• 101000850794 Homo sapiens Tropomyosin alpha-3 chain Proteins 0.000 description 1
• 101000851892 Homo sapiens Tropomyosin beta chain Proteins 0.000 description 1
• 101000679921 Homo sapiens Tumor necrosis factor receptor superfamily member 21 Proteins 0.000 description 1
• 101000987003 Homo sapiens Tumor protein 63 Proteins 0.000 description 1
• 101000987017 Homo sapiens Tumor protein p53-inducible protein 11 Proteins 0.000 description 1
• 101001087394 Homo sapiens Tyrosine-protein phosphatase non-receptor type 1 Proteins 0.000 description 1
• 101000747564 Homo sapiens UBX domain-containing protein 1 Proteins 0.000 description 1
• 101000939529 Homo sapiens UDP-glucose 6-dehydrogenase Proteins 0.000 description 1
• 101000672024 Homo sapiens UDP-glucose:glycoprotein glucosyltransferase 1 Proteins 0.000 description 1
• 101000840051 Homo sapiens Ubiquitin-60S ribosomal protein L40 Proteins 0.000 description 1
• 101000807354 Homo sapiens Ubiquitin-conjugating enzyme E2 C Proteins 0.000 description 1
• 101000837565 Homo sapiens Ubiquitin-conjugating enzyme E2 S Proteins 0.000 description 1
• 101000837581 Homo sapiens Ubiquitin-conjugating enzyme E2 T Proteins 0.000 description 1
• 101001057508 Homo sapiens Ubiquitin-like protein ISG15 Proteins 0.000 description 1
• 101000714593 Homo sapiens Uncharacterized protein C1orf226 Proteins 0.000 description 1
• 101000709986 Homo sapiens Uncharacterized protein C7orf50 Proteins 0.000 description 1
• 101000972817 Homo sapiens Uncharacterized protein NKAPD1 Proteins 0.000 description 1
• 101000806601 Homo sapiens V-type proton ATPase catalytic subunit A Proteins 0.000 description 1
• 101000775702 Homo sapiens V-type proton ATPase subunit C 2 Proteins 0.000 description 1
• 101000910342 Homo sapiens VWFA and cache domain-containing protein 1 Proteins 0.000 description 1
• 101000860430 Homo sapiens Versican core protein Proteins 0.000 description 1
• 101000852161 Homo sapiens Vesicle-associated membrane protein 8 Proteins 0.000 description 1
• 101000823796 Homo sapiens Y-box-binding protein 1 Proteins 0.000 description 1
• 101000785710 Homo sapiens Zinc finger protein 281 Proteins 0.000 description 1
• 101000964455 Homo sapiens Zinc finger protein 385A Proteins 0.000 description 1
• 101000964713 Homo sapiens Zinc finger protein 395 Proteins 0.000 description 1
• 101000785690 Homo sapiens Zinc finger protein 521 Proteins 0.000 description 1
• 101000964741 Homo sapiens Zinc finger protein 711 Proteins 0.000 description 1
• 101000734339 Homo sapiens [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial Proteins 0.000 description 1
• 101000614791 Homo sapiens cAMP-dependent protein kinase type I-beta regulatory subunit Proteins 0.000 description 1
• 101000802734 Homo sapiens eIF5-mimic protein 2 Proteins 0.000 description 1
• 101000795753 Homo sapiens mRNA decay activator protein ZFP36 Proteins 0.000 description 1
• 101000830183 Homo sapiens tRNA (guanine-N(7)-)-methyltransferase Proteins 0.000 description 1
• 102000030513 Homogentisate 1,2-Dioxygenase Human genes 0.000 description 1
• 108700023439 Homogentisate 1,2-dioxygenases Proteins 0.000 description 1
• 108700020121 Human Immunodeficiency Virus-1 rev Proteins 0.000 description 1
• VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
• HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 1
• 102000028555 IgG binding proteins Human genes 0.000 description 1
• 108091009325 IgG binding proteins Proteins 0.000 description 1
• 102100026120 IgG receptor FcRn large subunit p51 Human genes 0.000 description 1
• 102100026103 IgGFc-binding protein Human genes 0.000 description 1
• 102100020688 Immediate early response gene 5 protein Human genes 0.000 description 1
• 108010067060 Immunoglobulin Variable Region Proteins 0.000 description 1
• 102000017727 Immunoglobulin Variable Region Human genes 0.000 description 1
• 102100027002 Importin subunit alpha-7 Human genes 0.000 description 1
• 102100027003 Inhibin beta B chain Human genes 0.000 description 1
• 108010061971 Inhibin-beta Subunits Proteins 0.000 description 1
• 102000012407 Inhibin-beta Subunits Human genes 0.000 description 1
• 102100036881 Inositol-3-phosphate synthase 1 Human genes 0.000 description 1
• 102000004877 Insulin Human genes 0.000 description 1
• 108090001061 Insulin Proteins 0.000 description 1
• 108010034219 Insulin Receptor Substrate Proteins Proteins 0.000 description 1
• 102100025087 Insulin receptor substrate 1 Human genes 0.000 description 1
• 102100025092 Insulin receptor substrate 2 Human genes 0.000 description 1
• 101710186630 Insulin-1 Proteins 0.000 description 1
• 102100029224 Insulin-like growth factor-binding protein 4 Human genes 0.000 description 1
• 102100025464 Integral membrane protein 2C Human genes 0.000 description 1
• 102000012355 Integrin beta1 Human genes 0.000 description 1
• 108010022222 Integrin beta1 Proteins 0.000 description 1
• 102100029604 Interferon alpha-inducible protein 27, mitochondrial Human genes 0.000 description 1
• 102100038069 Interferon regulatory factor 8 Human genes 0.000 description 1
• 108010002350 Interleukin-2 Proteins 0.000 description 1
• 108090000978 Interleukin-4 Proteins 0.000 description 1
• 101710152369 Interleukin-6 receptor subunit beta Proteins 0.000 description 1
• 102000009195 Intracellular chloride channels Human genes 0.000 description 1
• 108050000080 Intracellular chloride channels Proteins 0.000 description 1
• 102100021502 Intraflagellar transport protein 122 homolog Human genes 0.000 description 1
• 102100024435 Iroquois-class homeodomain protein IRX-1 Human genes 0.000 description 1
• 102000012011 Isocitrate Dehydrogenase Human genes 0.000 description 1
• 108010075869 Isocitrate Dehydrogenase Proteins 0.000 description 1
• 102100037845 Isocitrate dehydrogenase [NADP], mitochondrial Human genes 0.000 description 1
• 206010023126 Jaundice Diseases 0.000 description 1
• 102100023429 Junctional adhesion molecule C Human genes 0.000 description 1
• 102100021559 KRR1 small subunit processome component homolog Human genes 0.000 description 1
• 102100034868 Kallikrein-5 Human genes 0.000 description 1
• 102100040443 Keratin, type I cytoskeletal 15 Human genes 0.000 description 1
• 208000008839 Kidney Neoplasms Diseases 0.000 description 1
• 102100023678 Killer cell lectin-like receptor subfamily B member 1 Human genes 0.000 description 1
• 108010063296 Kinesin Proteins 0.000 description 1
• 102000010638 Kinesin Human genes 0.000 description 1
• 102100023424 Kinesin-like protein KIF2C Human genes 0.000 description 1
• 102100023890 Kinetochore protein NDC80 homolog Human genes 0.000 description 1
• 102100032431 Kinetochore protein Nuf2 Human genes 0.000 description 1
• 102100020679 Krueppel-like factor 6 Human genes 0.000 description 1
• 108010049058 Kruppel-Like Factor 6 Proteins 0.000 description 1
• XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 1
• ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 1
• 125000002059 L-arginyl group Chemical group O=C([*])[C@](N([H])[H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H] 0.000 description 1
• WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
• ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
• 229930182816 L-glutamine Natural products 0.000 description 1
• 102100024580 L-lactate dehydrogenase B chain Human genes 0.000 description 1
• 102100025687 LHFPL tetraspan subfamily member 2 protein Human genes 0.000 description 1
• 102100024116 LHFPL tetraspan subfamily member 6 protein Human genes 0.000 description 1
• 101710201266 LHFPL tetraspan subfamily member 6 protein Proteins 0.000 description 1
• 101150097504 LHX1 gene Proteins 0.000 description 1
• 102100039648 Lactadherin Human genes 0.000 description 1
• 102100032241 Lactotransferrin Human genes 0.000 description 1
• 102100027454 Laminin subunit beta-2 Human genes 0.000 description 1
• 102100024629 Laminin subunit beta-3 Human genes 0.000 description 1
• 108091026898 Leader sequence (mRNA) Proteins 0.000 description 1
• 102100032913 Leukocyte surface antigen CD47 Human genes 0.000 description 1
• 239000012097 Lipofectamine 2000 Substances 0.000 description 1
• 206010073099 Lobular breast carcinoma in situ Diseases 0.000 description 1
• 102100029193 Low affinity immunoglobulin gamma Fc region receptor III-A Human genes 0.000 description 1
• 108060001084 Luciferase Proteins 0.000 description 1
• 239000005089 Luciferase Substances 0.000 description 1
• 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
• 102100032131 Lymphocyte antigen 6E Human genes 0.000 description 1
• 102100032129 Lymphocyte antigen 6K Human genes 0.000 description 1
• 102100022699 Lymphoid enhancer-binding factor 1 Human genes 0.000 description 1
• 102000004083 Lymphotoxin-alpha Human genes 0.000 description 1
• 108090000542 Lymphotoxin-alpha Proteins 0.000 description 1
• 102100023260 MAGUK p55 subfamily member 3 Human genes 0.000 description 1
• 108010068304 MAP Kinase Kinase 4 Proteins 0.000 description 1
• 108091054455 MAP kinase family Proteins 0.000 description 1
• 102000043136 MAP kinase family Human genes 0.000 description 1
• 102000007651 Macrophage Colony-Stimulating Factor Human genes 0.000 description 1
• 108010046938 Macrophage Colony-Stimulating Factor Proteins 0.000 description 1
• 206010064912 Malignant transformation Diseases 0.000 description 1
• 229920000057 Mannan Polymers 0.000 description 1
• 102100026046 Mannan-binding lectin serine protease 2 Human genes 0.000 description 1
• 238000000585 Mann–Whitney U test Methods 0.000 description 1
• 208000025205 Mantle-Cell Lymphoma Diseases 0.000 description 1
• 102100039809 Matrix Gla protein Human genes 0.000 description 1
• 108010076502 Matrix Metalloproteinase 11 Proteins 0.000 description 1
• 108010016165 Matrix Metalloproteinase 2 Proteins 0.000 description 1
• 102000000424 Matrix Metalloproteinase 2 Human genes 0.000 description 1
• 102100035880 Max-interacting protein 1 Human genes 0.000 description 1
• 102100027251 Melanoma-associated antigen D2 Human genes 0.000 description 1
• 235000006679 Mentha X verticillata Nutrition 0.000 description 1
• 235000002899 Mentha suaveolens Nutrition 0.000 description 1
• 235000001636 Mentha x rotundifolia Nutrition 0.000 description 1
• 229940084845 Metalloproteinase-1 inhibitor Drugs 0.000 description 1
• 102100023174 Methionine aminopeptidase 2 Human genes 0.000 description 1
• 102100020846 Methylosome subunit pICln Human genes 0.000 description 1
• 102000016397 Methyltransferase Human genes 0.000 description 1
• 102000029749 Microtubule Human genes 0.000 description 1
• 108091022875 Microtubule Proteins 0.000 description 1
• 102100033252 Microtubule-associated serine/threonine-protein kinase 4 Human genes 0.000 description 1
• 102100037984 Mitoferrin-1 Human genes 0.000 description 1
• 102100037809 Mitogen-activated protein kinase 9 Human genes 0.000 description 1
• 102100021691 Mitotic checkpoint serine/threonine-protein kinase BUB1 Human genes 0.000 description 1
• 102100038792 Mitotic spindle assembly checkpoint protein MAD2A Human genes 0.000 description 1
• 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 description 1
• 102100034256 Mucin-1 Human genes 0.000 description 1
• 108010063954 Mucins Proteins 0.000 description 1
• 102000015728 Mucins Human genes 0.000 description 1
• 241000699660 Mus musculus Species 0.000 description 1
• 101100381978 Mus musculus Braf gene Proteins 0.000 description 1
• 101000713102 Mus musculus C-C motif chemokine 1 Proteins 0.000 description 1
• 101000777470 Mus musculus C-C motif chemokine 4 Proteins 0.000 description 1
• 101000866285 Mus musculus Excitatory amino acid transporter 1 Proteins 0.000 description 1
• 101100092284 Mus musculus Rragd gene Proteins 0.000 description 1
• 101000868474 Mus musculus Sialoadhesin Proteins 0.000 description 1
• 208000033776 Myeloid Acute Leukemia Diseases 0.000 description 1
• 108700041619 Myeloid Ecotropic Viral Integration Site 1 Proteins 0.000 description 1
• 102000047831 Myeloid Ecotropic Viral Integration Site 1 Human genes 0.000 description 1
• 102100031827 Myeloid zinc finger 1 Human genes 0.000 description 1
• 102100034100 Myocardin-related transcription factor B Human genes 0.000 description 1
• 108060008487 Myosin Proteins 0.000 description 1
• 102000003505 Myosin Human genes 0.000 description 1
• 102100035044 Myosin light chain kinase, smooth muscle Human genes 0.000 description 1
• 102100031919 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial Human genes 0.000 description 1
• XJLXINKUBYWONI-NNYOXOHSSA-O NADP(+) Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-NNYOXOHSSA-O 0.000 description 1
• 108010057466 NF-kappa B Proteins 0.000 description 1
• 102000003945 NF-kappa B Human genes 0.000 description 1
• 206010028813 Nausea Diseases 0.000 description 1
• 102000048850 Neoplasm Genes Human genes 0.000 description 1
• 108700019961 Neoplasm Genes Proteins 0.000 description 1
• 208000003788 Neoplasm Micrometastasis Diseases 0.000 description 1
• 102100021310 Neurexin-3 Human genes 0.000 description 1
• 108010085839 Neurofibromin 2 Proteins 0.000 description 1
• 102000007517 Neurofibromin 2 Human genes 0.000 description 1
• 102100030465 Neuron navigator 2 Human genes 0.000 description 1
• 102100035072 Neuronal vesicle trafficking-associated protein 1 Human genes 0.000 description 1
• 101100476756 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) sec-61 gene Proteins 0.000 description 1
• 102100036592 Neutral alpha-glucosidase AB Human genes 0.000 description 1
• 239000000020 Nitrocellulose Substances 0.000 description 1
• 102000007999 Nuclear Proteins Human genes 0.000 description 1
• 108010089610 Nuclear Proteins Proteins 0.000 description 1
• 102100022165 Nuclear factor 1 B-type Human genes 0.000 description 1
• 108020005497 Nuclear hormone receptor Proteins 0.000 description 1
• 102100022927 Nuclear receptor coactivator 4 Human genes 0.000 description 1
• 102100021010 Nucleolin Human genes 0.000 description 1
• 239000004677 Nylon Substances 0.000 description 1
• 102100026498 ORM1-like protein 2 Human genes 0.000 description 1
• 206010061534 Oesophageal squamous cell carcinoma Diseases 0.000 description 1
• 201000010133 Oligodendroglioma Diseases 0.000 description 1
• 108010020361 Oncogene Protein gp140(v-fms) Proteins 0.000 description 1
• 102000016978 Orphan receptors Human genes 0.000 description 1
• 108070000031 Orphan receptors Proteins 0.000 description 1
• 108010077077 Osteonectin Proteins 0.000 description 1
• 102100025808 P2Y purinoceptor 14 Human genes 0.000 description 1
• 102100029879 PCNA-associated factor Human genes 0.000 description 1
• 238000012408 PCR amplification Methods 0.000 description 1
• 238000002944 PCR assay Methods 0.000 description 1
• 241000282579 Pan Species 0.000 description 1
• 108090000526 Papain Proteins 0.000 description 1
• 241000282520 Papio Species 0.000 description 1
• 102100035458 Paraneoplastic antigen-like protein 8A Human genes 0.000 description 1
• 206010034016 Paronychia Diseases 0.000 description 1
• 241001494479 Pecora Species 0.000 description 1
• 101100001029 Pelophylax perezi ADH8 gene Proteins 0.000 description 1
• 108090000284 Pepsin A Proteins 0.000 description 1
• 102000057297 Pepsin A Human genes 0.000 description 1
• 102000035195 Peptidases Human genes 0.000 description 1
• 108091005804 Peptidases Proteins 0.000 description 1
• 101800005149 Peptide B Proteins 0.000 description 1
• 102000010292 Peptide Elongation Factor 1 Human genes 0.000 description 1
• 108010037490 Peptidyl-Prolyl Cis-Trans Isomerase NIMA-Interacting 4 Proteins 0.000 description 1
• 101710111214 Peptidyl-prolyl cis-trans isomerase C Proteins 0.000 description 1
• 102100031653 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 Human genes 0.000 description 1
• 102100037896 Perilipin-2 Human genes 0.000 description 1
• 208000001300 Perinatal Death Diseases 0.000 description 1
• 102100038831 Peroxisome proliferator-activated receptor alpha Human genes 0.000 description 1
• 102100026169 Phosphatidylinositol 3-kinase regulatory subunit alpha Human genes 0.000 description 1
• 102100037553 Phosphatidylinositol 3-kinase regulatory subunit gamma Human genes 0.000 description 1
• 102100036061 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Human genes 0.000 description 1
• 102100035193 Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q Human genes 0.000 description 1
• 102100035907 Phospholipase ABHD3 Human genes 0.000 description 1
• 102100035367 Phosphomannomutase 1 Human genes 0.000 description 1
• 102000007982 Phosphoproteins Human genes 0.000 description 1
• 108010089430 Phosphoproteins Proteins 0.000 description 1
• 108010001014 Plasminogen Activators Proteins 0.000 description 1
• 102000001938 Plasminogen Activators Human genes 0.000 description 1
• 102100040681 Platelet-derived growth factor C Human genes 0.000 description 1
• 102100030462 Pleckstrin homology domain-containing family B member 1 Human genes 0.000 description 1
• 102100030360 Pleckstrin homology domain-containing family H member 2 Human genes 0.000 description 1
• 102100036265 Pleckstrin homology domain-containing family O member 1 Human genes 0.000 description 1
• 102100030887 Pleckstrin homology-like domain family A member 1 Human genes 0.000 description 1
• 102100036031 Podocalyxin Human genes 0.000 description 1
• 102100023712 Poly [ADP-ribose] polymerase 1 Human genes 0.000 description 1
• 102100034960 Poly(rC)-binding protein 1 Human genes 0.000 description 1
• 108010000598 Polycomb Repressive Complex 1 Proteins 0.000 description 1
• 102100024184 Polymerase delta-interacting protein 3 Human genes 0.000 description 1
• 102100035187 Polymeric immunoglobulin receptor Human genes 0.000 description 1
• ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
• 102100023242 Potassium channel subfamily K member 1 Human genes 0.000 description 1
• 101710163354 Potassium voltage-gated channel subfamily H member 2 Proteins 0.000 description 1
• 101000621511 Potato virus M (strain German) RNA silencing suppressor Proteins 0.000 description 1
• 102100038632 Presequence protease, mitochondrial Human genes 0.000 description 1
• 102100024857 Prickle-like protein 4 Human genes 0.000 description 1
• 102100033237 Pro-epidermal growth factor Human genes 0.000 description 1
• HCBIBCJNVBAKAB-UHFFFAOYSA-N Procaine hydrochloride Chemical compound Cl.CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 HCBIBCJNVBAKAB-UHFFFAOYSA-N 0.000 description 1
• 108010049395 Prokaryotic Initiation Factor-2 Proteins 0.000 description 1
• ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
• 102100037248 Prolyl hydroxylase EGLN2 Human genes 0.000 description 1
• 239000004365 Protease Substances 0.000 description 1
• 108090000708 Proteasome Endopeptidase Complex Proteins 0.000 description 1
• 102000004245 Proteasome Endopeptidase Complex Human genes 0.000 description 1
• 102100023735 Protein APCDD1 Human genes 0.000 description 1
• 102100026034 Protein BTG2 Human genes 0.000 description 1
• 102100030557 Protein FAM13A Human genes 0.000 description 1
• 102100026731 Protein FAM210B, mitochondrial Human genes 0.000 description 1
• 102100037526 Protein FAM53C Human genes 0.000 description 1
• 102100023396 Protein MON2 homolog Human genes 0.000 description 1
• 108010059000 Protein Phosphatase 1 Proteins 0.000 description 1
• 102000005569 Protein Phosphatase 1 Human genes 0.000 description 1
• 102100031747 Protein Shroom3 Human genes 0.000 description 1
• 102100022429 Protein TMEPAI Human genes 0.000 description 1
• 102100022985 Protein arginine N-methyltransferase 1 Human genes 0.000 description 1
• 102100037097 Protein disulfide-isomerase A3 Human genes 0.000 description 1
• 102100037339 Protein kinase C epsilon type Human genes 0.000 description 1
• 102100024606 Protein phosphatase 1 regulatory subunit 1A Human genes 0.000 description 1
• 102100033947 Protein regulator of cytokinesis 1 Human genes 0.000 description 1
• 102100036306 Protein transport protein Sec61 subunit gamma Human genes 0.000 description 1
• 108010003894 Protein-Lysine 6-Oxidase Proteins 0.000 description 1
• 102100026858 Protein-lysine 6-oxidase Human genes 0.000 description 1
• 101710097451 Putative G-protein coupled receptor Proteins 0.000 description 1
• 102100039117 Putative vomeronasal receptor-like protein 4 Human genes 0.000 description 1
• 238000002123 RNA extraction Methods 0.000 description 1
• 238000012228 RNA interference-mediated gene silencing Methods 0.000 description 1
• 102100025249 RNA polymerase II subunit A C-terminal domain phosphatase SSU72 Human genes 0.000 description 1
• 102100025858 RNA-binding protein 39 Human genes 0.000 description 1
• 102100022491 RNA-binding protein NOB1 Human genes 0.000 description 1
• 108010092799 RNA-directed DNA polymerase Proteins 0.000 description 1
• 238000011530 RNeasy Mini Kit Methods 0.000 description 1
• 239000012980 RPMI-1640 medium Substances 0.000 description 1
• 238000010240 RT-PCR analysis Methods 0.000 description 1
• 102100031523 Rab GTPase-binding effector protein 1 Human genes 0.000 description 1
• 102100038186 Ral GTPase-activating protein subunit alpha-2 Human genes 0.000 description 1
• 102100039789 Ras-related protein M-Ras Human genes 0.000 description 1
• 102100030019 Ras-related protein Rab-7a Human genes 0.000 description 1
• 101000585094 Rattus norvegicus Syntaxin-1B Proteins 0.000 description 1
• 102000004278 Receptor Protein-Tyrosine Kinases Human genes 0.000 description 1
• 108090000873 Receptor Protein-Tyrosine Kinases Proteins 0.000 description 1
• 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 1
• 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 1
• 102100022647 Reticulon-1 Human genes 0.000 description 1
• 102100022648 Reticulon-2 Human genes 0.000 description 1
• 102100034253 Retinoic acid receptor RXR-beta Human genes 0.000 description 1
• 102100027609 Rho-related GTP-binding protein RhoD Human genes 0.000 description 1
• 102100039640 Rho-related GTP-binding protein RhoE Human genes 0.000 description 1
• 102100031363 Rhophilin-1 Human genes 0.000 description 1
• 102000004389 Ribonucleoproteins Human genes 0.000 description 1
• 108010081734 Ribonucleoproteins Proteins 0.000 description 1
• 102100033645 Ribosomal protein S6 kinase alpha-5 Human genes 0.000 description 1
• 102100032224 Ropporin-1A Human genes 0.000 description 1
• 102100022479 S-adenosylhomocysteine hydrolase-like protein 1 Human genes 0.000 description 1
• 102100025543 SAM and SH3 domain-containing protein 1 Human genes 0.000 description 1
• 102100028400 SH3 domain-binding glutamic acid-rich protein Human genes 0.000 description 1
• 102000012979 SLC1A1 Human genes 0.000 description 1
• 102000012977 SLC1A3 Human genes 0.000 description 1
• 108091006504 SLC26A3 Proteins 0.000 description 1
• 108091006525 SLC27A2 Proteins 0.000 description 1
• 101150016669 SORBS2 gene Proteins 0.000 description 1
• 101150058731 STAT5A gene Proteins 0.000 description 1
• 102100024837 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 Human genes 0.000 description 1
• 101001070647 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 60S ribosomal protein L20-A Proteins 0.000 description 1
• 101001070655 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 60S ribosomal protein L20-B Proteins 0.000 description 1
• 241000607142 Salmonella Species 0.000 description 1
• 206010039491 Sarcoma Diseases 0.000 description 1
• 108091058545 Secretory proteins Proteins 0.000 description 1
• 102000040739 Secretory proteins Human genes 0.000 description 1
• 102100027979 Semaphorin-3B Human genes 0.000 description 1
• 102100023646 Sentrin-specific protease 2 Human genes 0.000 description 1
• 102100032743 Septin-4 Human genes 0.000 description 1
• 101710151381 Serine protease 2 Proteins 0.000 description 1
• 102100028904 Serine/threonine-protein kinase MARK2 Human genes 0.000 description 1
• 102100039987 Serine/threonine-protein kinase ULK2 Human genes 0.000 description 1
• 102100029063 Serine/threonine-protein kinase WNK2 Human genes 0.000 description 1
• 102100036140 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform Human genes 0.000 description 1
• 102100032277 Serum amyloid A-1 protein Human genes 0.000 description 1
• 244000000231 Sesamum indicum Species 0.000 description 1
• 102100024639 Short-chain specific acyl-CoA dehydrogenase, mitochondrial Human genes 0.000 description 1
• 102100035766 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial Human genes 0.000 description 1
• 108010051611 Signal Recognition Particle Proteins 0.000 description 1
• 102100036268 Signal peptidase complex catalytic subunit SEC11A Human genes 0.000 description 1
• 108050001681 Signal peptidase complex catalytic subunit SEC11A Proteins 0.000 description 1
• 102100030313 Signal peptidase complex subunit 1 Human genes 0.000 description 1
• 102000013598 Signal recognition particle Human genes 0.000 description 1
• 102100027315 Signal recognition particle subunit SRP72 Human genes 0.000 description 1
• 101710132545 Signal recognition particle subunit SRP72 Proteins 0.000 description 1
• 102100024481 Signal transducer and activator of transcription 5A Human genes 0.000 description 1
• 102100025265 Signal transducing adapter molecule 2 Human genes 0.000 description 1
• 102000039471 Small Nuclear RNA Human genes 0.000 description 1
• 102100036758 Small nuclear ribonucleoprotein F Human genes 0.000 description 1
• 102100030458 Sodium/potassium-transporting ATPase subunit alpha-1 Human genes 0.000 description 1
• 102100036804 Solute carrier family 13 member 2 Human genes 0.000 description 1
• 102100023802 Somatostatin receptor type 2 Human genes 0.000 description 1
• 102100026901 Sorbin and SH3 domain-containing protein 2 Human genes 0.000 description 1
• 102100024690 Spliceosome RNA helicase DDX39B Human genes 0.000 description 1
• 102100031436 Splicing factor 3B subunit 2 Human genes 0.000 description 1
• 208000036765 Squamous cell carcinoma of the esophagus Diseases 0.000 description 1
• 229920002472 Starch Polymers 0.000 description 1
• 102000005465 Stathmin Human genes 0.000 description 1
• 108050003387 Stathmin Proteins 0.000 description 1
• 102100024237 Stathmin Human genes 0.000 description 1
• 102100028049 Stathmin-4 Human genes 0.000 description 1
• 102100028897 Stearoyl-CoA desaturase Human genes 0.000 description 1
• 206010072148 Stiff-Person syndrome Diseases 0.000 description 1
• 241000258128 Strongylocentrotus purpuratus Species 0.000 description 1
• 238000000692 Student's t-test Methods 0.000 description 1
• 241000282887 Suidae Species 0.000 description 1
• 102100020951 Sulfite oxidase, mitochondrial Human genes 0.000 description 1
• 108090000054 Syndecan-2 Proteins 0.000 description 1
• 102000003711 Syndecan-2 Human genes 0.000 description 1
• 102100026087 Syndecan-2 Human genes 0.000 description 1
• 102100026084 Syndecan-3 Human genes 0.000 description 1
• 230000006044 T cell activation Effects 0.000 description 1
• 230000024932 T cell mediated immunity Effects 0.000 description 1
• 108091008874 T cell receptors Proteins 0.000 description 1
• 102000016266 T-Cell Antigen Receptors Human genes 0.000 description 1
• 102100025237 T-cell surface antigen CD2 Human genes 0.000 description 1
• 102100038410 T-complex protein 1 subunit alpha Human genes 0.000 description 1
• 102100029886 T-complex protein 1 subunit epsilon Human genes 0.000 description 1
• 102100036476 T-complex protein 1 subunit eta Human genes 0.000 description 1
• 102100040238 TBC1 domain family member 1 Human genes 0.000 description 1
• 102100038723 TBC1 domain family member 13 Human genes 0.000 description 1
• 102100040257 TBC1 domain family member 4 Human genes 0.000 description 1
• 102100033691 TM2 domain-containing protein 2 Human genes 0.000 description 1
• 102100031283 Testis-specific Y-encoded protein 1 Human genes 0.000 description 1
• 102100040953 Testis-specific Y-encoded-like protein 1 Human genes 0.000 description 1
• 102100034914 Testis-specific Y-encoded-like protein 5 Human genes 0.000 description 1
• 102100030169 Tetraspanin-1 Human genes 0.000 description 1
• 101710151653 Tetraspanin-1 Proteins 0.000 description 1
• 102100024996 Tetraspanin-13 Human genes 0.000 description 1
• 102100040872 Tetraspanin-5 Human genes 0.000 description 1
• 102100021911 Thiamine-triphosphatase Human genes 0.000 description 1
• 108091036066 Three prime untranslated region Proteins 0.000 description 1
• IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 1
• 102100028709 Thyroxine-binding globulin Human genes 0.000 description 1
• GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 1
• 102000019347 Tob1 Human genes 0.000 description 1
• 102100037456 Trafficking protein particle complex subunit 10 Human genes 0.000 description 1
• 108090000340 Transaminases Proteins 0.000 description 1
• 102100037116 Transcription elongation factor 1 homolog Human genes 0.000 description 1
• 102100038808 Transcription factor SOX-10 Human genes 0.000 description 1
• 102000004338 Transferrin Human genes 0.000 description 1
• 108090000901 Transferrin Proteins 0.000 description 1
• 102000046299 Transforming Growth Factor beta1 Human genes 0.000 description 1
• 108010009583 Transforming Growth Factors Proteins 0.000 description 1
• 102000009618 Transforming Growth Factors Human genes 0.000 description 1
• 101800002279 Transforming growth factor beta-1 Proteins 0.000 description 1
• 102100033459 Transforming growth factor beta-1-induced transcript 1 protein Human genes 0.000 description 1
• 102100021398 Transforming growth factor-beta-induced protein ig-h3 Human genes 0.000 description 1
• 102100031013 Transgelin Human genes 0.000 description 1
• 102100029550 Translation initiation factor IF-2, mitochondrial Human genes 0.000 description 1
• 102100029006 Translocation protein SEC63 homolog Human genes 0.000 description 1
• 102100024180 Transmembrane emp24 domain-containing protein 10 Human genes 0.000 description 1
• 102100036728 Transmembrane protein 107 Human genes 0.000 description 1
• 108010088412 Trefoil Factor-1 Proteins 0.000 description 1
• 102100039175 Trefoil factor 1 Human genes 0.000 description 1
• 102100038799 Tripartite motif-containing protein 2 Human genes 0.000 description 1
• 102100029519 Tripartite motif-containing protein 29 Human genes 0.000 description 1
• 229920004890 Triton X-100 Polymers 0.000 description 1
• 102100033579 Trophoblast glycoprotein Human genes 0.000 description 1
• 102100033080 Tropomyosin alpha-3 chain Human genes 0.000 description 1
• 102100036471 Tropomyosin beta chain Human genes 0.000 description 1
• 102100034392 Trypsin-2 Human genes 0.000 description 1
• 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 description 1
• 102100022205 Tumor necrosis factor receptor superfamily member 21 Human genes 0.000 description 1
• 102100027881 Tumor protein 63 Human genes 0.000 description 1
• 102100027873 Tumor protein p53-inducible protein 11 Human genes 0.000 description 1
• 102000007537 Type II DNA Topoisomerases Human genes 0.000 description 1
• 102100033001 Tyrosine-protein phosphatase non-receptor type 1 Human genes 0.000 description 1
• 102100040201 UBX domain-containing protein 1 Human genes 0.000 description 1
• 102100040363 UDP-glucose:glycoprotein glucosyltransferase 1 Human genes 0.000 description 1
• 102100028462 Ubiquitin-60S ribosomal protein L40 Human genes 0.000 description 1
• 102100037256 Ubiquitin-conjugating enzyme E2 C Human genes 0.000 description 1
• 102100028705 Ubiquitin-conjugating enzyme E2 T Human genes 0.000 description 1
• 102100027266 Ubiquitin-like protein ISG15 Human genes 0.000 description 1
• 102100036363 Uncharacterized protein C1orf226 Human genes 0.000 description 1
• 102100034425 Uncharacterized protein C7orf50 Human genes 0.000 description 1
• 102100022559 Uncharacterized protein NKAPD1 Human genes 0.000 description 1
• 102100032185 V-type proton ATPase subunit C 2 Human genes 0.000 description 1
• 102100024424 VWFA and cache domain-containing protein 1 Human genes 0.000 description 1
• 102100038388 Vasoactive intestinal polypeptide receptor 1 Human genes 0.000 description 1
• 101710137655 Vasoactive intestinal polypeptide receptor 1 Proteins 0.000 description 1
• 102100028437 Versican core protein Human genes 0.000 description 1
• 102100023048 Very long-chain acyl-CoA synthetase Human genes 0.000 description 1
• 108010017749 Vesicle-Associated Membrane Protein 3 Proteins 0.000 description 1
• 102000004604 Vesicle-Associated Membrane Protein 3 Human genes 0.000 description 1
• 101710205049 Vesicle-associated membrane protein 8 Proteins 0.000 description 1
• 241000700605 Viruses Species 0.000 description 1
• 206010047700 Vomiting Diseases 0.000 description 1
• 102000021095 WAP Four-Disulfide Core Domain Protein 2 Human genes 0.000 description 1
• 108091002660 WAP Four-Disulfide Core Domain Protein 2 Proteins 0.000 description 1
• 108010062653 Wiskott-Aldrich Syndrome Protein Family Proteins 0.000 description 1
• 102000011104 Wiskott-Aldrich Syndrome Protein Family Human genes 0.000 description 1
• 208000006254 Wolf-Hirschhorn Syndrome Diseases 0.000 description 1
• 102000002258 X-ray Repair Cross Complementing Protein 1 Human genes 0.000 description 1
• 108010000443 X-ray Repair Cross Complementing Protein 1 Proteins 0.000 description 1
• 241000269368 Xenopus laevis Species 0.000 description 1
• 102100022224 Y-box-binding protein 1 Human genes 0.000 description 1
• 102100023870 YLP motif-containing protein 1 Human genes 0.000 description 1
• 101150018798 Ylpm1 gene Proteins 0.000 description 1
• 101710185494 Zinc finger protein Proteins 0.000 description 1
• 102100026316 Zinc finger protein 281 Human genes 0.000 description 1
• 102100040308 Zinc finger protein 385A Human genes 0.000 description 1
• 102100040733 Zinc finger protein 395 Human genes 0.000 description 1
• 102100026302 Zinc finger protein 521 Human genes 0.000 description 1
• 102100040724 Zinc finger protein 711 Human genes 0.000 description 1
• 102100023597 Zinc finger protein 816 Human genes 0.000 description 1
• HMNZFMSWFCAGGW-XPWSMXQVSA-N [3-[hydroxy(2-hydroxyethoxy)phosphoryl]oxy-2-[(e)-octadec-9-enoyl]oxypropyl] (e)-octadec-9-enoate Chemical compound CCCCCCCC\C=C\CCCCCCCC(=O)OCC(COP(O)(=O)OCCO)OC(=O)CCCCCCC\C=C\CCCCCCCC HMNZFMSWFCAGGW-XPWSMXQVSA-N 0.000 description 1
• 102100034825 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial Human genes 0.000 description 1
• 239000002253 acid Substances 0.000 description 1
• 230000002378 acidificating effect Effects 0.000 description 1
• 239000013543 active substance Substances 0.000 description 1
• 208000009956 adenocarcinoma Diseases 0.000 description 1
• UDMBCSSLTHHNCD-KQYNXXCUSA-N adenosine 5'-monophosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O UDMBCSSLTHHNCD-KQYNXXCUSA-N 0.000 description 1
• 239000000853 adhesive Substances 0.000 description 1
• 230000001070 adhesive effect Effects 0.000 description 1
• 238000011226 adjuvant chemotherapy Methods 0.000 description 1
• 238000011446 adjuvant hormonal therapy Methods 0.000 description 1
• 239000011543 agarose gel Substances 0.000 description 1
• 108010078127 alcohol dehydrogenase 8 Proteins 0.000 description 1
• 235000010443 alginic acid Nutrition 0.000 description 1
• 239000000783 alginic acid Substances 0.000 description 1
• 229920000615 alginic acid Polymers 0.000 description 1
• 229960001126 alginic acid Drugs 0.000 description 1
• 150000004781 alginic acids Chemical class 0.000 description 1
• 229940037003 alum Drugs 0.000 description 1
• 230000000202 analgesic effect Effects 0.000 description 1
• 229940035676 analgesics Drugs 0.000 description 1
• 238000000540 analysis of variance Methods 0.000 description 1
• 238000010171 animal model Methods 0.000 description 1
• 208000022531 anorexia Diseases 0.000 description 1
• 230000003042 antagnostic effect Effects 0.000 description 1
• 239000005557 antagonist Substances 0.000 description 1
• 239000000730 antalgic agent Substances 0.000 description 1
• 230000000843 anti-fungal effect Effects 0.000 description 1
• 230000003110 anti-inflammatory effect Effects 0.000 description 1
• 230000000719 anti-leukaemic effect Effects 0.000 description 1
• 230000000259 anti-tumor effect Effects 0.000 description 1
• 229940121375 antifungal agent Drugs 0.000 description 1
• 230000000890 antigenic effect Effects 0.000 description 1
• 239000004599 antimicrobial Substances 0.000 description 1
• 230000003078 antioxidant effect Effects 0.000 description 1
• 230000005975 antitumor immune response Effects 0.000 description 1
• 238000013459 approach Methods 0.000 description 1
• 239000007900 aqueous suspension Substances 0.000 description 1
• 238000003491 array Methods 0.000 description 1
• 238000003149 assay kit Methods 0.000 description 1
• 108010038664 atrial natriuretic factor receptor B Proteins 0.000 description 1
• 230000037444 atrophy Effects 0.000 description 1
• 208000028176 atypical lobular breast hyperplasia Diseases 0.000 description 1
• 230000000599 auto-anti-genic effect Effects 0.000 description 1
• 239000000022 bacteriostatic agent Substances 0.000 description 1
• 230000003385 bacteriostatic effect Effects 0.000 description 1
• 150000001556 benzimidazoles Chemical class 0.000 description 1
• 229960002903 benzyl benzoate Drugs 0.000 description 1
• 108010064886 beta-D-galactoside alpha 2-6-sialyltransferase Proteins 0.000 description 1
• WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
• 238000004166 bioassay Methods 0.000 description 1
• 230000003115 biocidal effect Effects 0.000 description 1
• 239000013060 biological fluid Substances 0.000 description 1
• 210000004204 blood vessel Anatomy 0.000 description 1
• 210000001185 bone marrow Anatomy 0.000 description 1
• 201000005389 breast carcinoma in situ Diseases 0.000 description 1
• 230000004611 cancer cell death Effects 0.000 description 1
• 150000001720 carbohydrates Chemical class 0.000 description 1
• 235000014633 carbohydrates Nutrition 0.000 description 1
• 239000001569 carbon dioxide Substances 0.000 description 1
• 229960004424 carbon dioxide Drugs 0.000 description 1
• 231100000357 carcinogen Toxicity 0.000 description 1
• 231100000315 carcinogenic Toxicity 0.000 description 1
• 239000003183 carcinogenic agent Substances 0.000 description 1
• 230000003197 catalytic effect Effects 0.000 description 1
• 210000004323 caveolae Anatomy 0.000 description 1
• 230000005779 cell damage Effects 0.000 description 1
• 230000032823 cell division Effects 0.000 description 1
• 208000037887 cell injury Diseases 0.000 description 1
• 230000004709 cell invasion Effects 0.000 description 1
• 230000032341 cell morphogenesis Effects 0.000 description 1
• 230000003833 cell viability Effects 0.000 description 1
• 230000017455 cell-cell adhesion Effects 0.000 description 1
• 230000035289 cell-matrix adhesion Effects 0.000 description 1
• 210000003570 cell-matrix junction Anatomy 0.000 description 1
• 230000005754 cellular signaling Effects 0.000 description 1
• 239000001913 cellulose Substances 0.000 description 1
• 229920002678 cellulose Polymers 0.000 description 1
• 238000007385 chemical modification Methods 0.000 description 1
• 230000002113 chemopreventative effect Effects 0.000 description 1
• 230000035572 chemosensitivity Effects 0.000 description 1
• 238000002512 chemotherapy Methods 0.000 description 1
• 235000019693 cherries Nutrition 0.000 description 1
• 235000012000 cholesterol Nutrition 0.000 description 1
• 210000003483 chromatin Anatomy 0.000 description 1
• 229910052804 chromium Inorganic materials 0.000 description 1
• 238000003759 clinical diagnosis Methods 0.000 description 1
• 238000007621 cluster analysis Methods 0.000 description 1
• 230000003081 coactivator Effects 0.000 description 1
• 229940110456 cocoa butter Drugs 0.000 description 1
• 235000019868 cocoa butter Nutrition 0.000 description 1
• 229960002424 collagenase Drugs 0.000 description 1
• 230000004732 colorectal carcinogenesis Effects 0.000 description 1
• 238000007906 compression Methods 0.000 description 1
• 230000006835 compression Effects 0.000 description 1
• 235000008504 concentrate Nutrition 0.000 description 1
• 239000012141 concentrate Substances 0.000 description 1
• 230000021615 conjugation Effects 0.000 description 1
• 230000006552 constitutive activation Effects 0.000 description 1
• 238000011109 contamination Methods 0.000 description 1
• 239000013068 control sample Substances 0.000 description 1
• 238000013270 controlled release Methods 0.000 description 1
• 230000001276 controlling effect Effects 0.000 description 1
• 238000007796 conventional method Methods 0.000 description 1
• 101150014604 cpg-3 gene Proteins 0.000 description 1
• 101150075908 cpg-4 gene Proteins 0.000 description 1
• 238000012864 cross contamination Methods 0.000 description 1
• 239000013078 crystal Substances 0.000 description 1
• 230000021953 cytokinesis Effects 0.000 description 1
• 210000004292 cytoskeleton Anatomy 0.000 description 1
• 230000001086 cytosolic effect Effects 0.000 description 1
• 239000002254 cytotoxic agent Substances 0.000 description 1
• 231100000599 cytotoxic agent Toxicity 0.000 description 1
• 230000006378 damage Effects 0.000 description 1
• 238000013480 data collection Methods 0.000 description 1
• 206010061428 decreased appetite Diseases 0.000 description 1
• 230000007812 deficiency Effects 0.000 description 1
• 230000003412 degenerative effect Effects 0.000 description 1
• 238000012217 deletion Methods 0.000 description 1
• 230000037430 deletion Effects 0.000 description 1
• 238000013461 design Methods 0.000 description 1
• 230000001627 detrimental effect Effects 0.000 description 1
• PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 description 1
• 235000019404 dichlorodifluoromethane Nutrition 0.000 description 1
• 229940042935 dichlorodifluoromethane Drugs 0.000 description 1
• 229940087091 dichlorotetrafluoroethane Drugs 0.000 description 1
• 235000014113 dietary fatty acids Nutrition 0.000 description 1
• 108091022884 dihydropyrimidinase Proteins 0.000 description 1
• 239000003085 diluting agent Substances 0.000 description 1
• 230000003292 diminished effect Effects 0.000 description 1
• 230000005750 disease progression Effects 0.000 description 1
• 239000012153 distilled water Substances 0.000 description 1
• 238000009826 distribution Methods 0.000 description 1
• 239000002934 diuretic Substances 0.000 description 1
• 102100035859 eIF5-mimic protein 2 Human genes 0.000 description 1
• 239000008157 edible vegetable oil Substances 0.000 description 1
• 230000007613 environmental effect Effects 0.000 description 1
• 210000003979 eosinophil Anatomy 0.000 description 1
• 210000003617 erythrocyte membrane Anatomy 0.000 description 1
• 230000000925 erythroid effect Effects 0.000 description 1
• 208000007276 esophageal squamous cell carcinoma Diseases 0.000 description 1
• 239000003797 essential amino acid Substances 0.000 description 1
• 235000020776 essential amino acid Nutrition 0.000 description 1
• 230000001036 exonucleolytic effect Effects 0.000 description 1
• 210000002744 extracellular matrix Anatomy 0.000 description 1
• 239000004744 fabric Substances 0.000 description 1
• 230000006126 farnesylation Effects 0.000 description 1
• 235000019197 fats Nutrition 0.000 description 1
• 229930195729 fatty acid Natural products 0.000 description 1
• 239000000194 fatty acid Substances 0.000 description 1
• 150000004665 fatty acids Chemical class 0.000 description 1
• 239000012091 fetal bovine serum Substances 0.000 description 1
• 230000001605 fetal effect Effects 0.000 description 1
• 239000000945 filler Substances 0.000 description 1
• 238000009093 first-line therapy Methods 0.000 description 1
• 239000000796 flavoring agent Substances 0.000 description 1
• 238000002073 fluorescence micrograph Methods 0.000 description 1
• 238000002866 fluorescence resonance energy transfer Methods 0.000 description 1
• 235000013355 food flavoring agent Nutrition 0.000 description 1
• 235000003599 food sweetener Nutrition 0.000 description 1
• 239000012520 frozen sample Substances 0.000 description 1
• 238000010230 functional analysis Methods 0.000 description 1
• XGALLCVXEZPNRQ-UHFFFAOYSA-N gefitinib Chemical compound C=12C=C(OCCCN3CCOCC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 XGALLCVXEZPNRQ-UHFFFAOYSA-N 0.000 description 1
• 239000000499 gel Substances 0.000 description 1
• 238000012226 gene silencing method Methods 0.000 description 1
• 238000001415 gene therapy Methods 0.000 description 1
• 102000034356 gene-regulatory proteins Human genes 0.000 description 1
• 108091006104 gene-regulatory proteins Proteins 0.000 description 1
• 238000012252 genetic analysis Methods 0.000 description 1
• 230000035784 germination Effects 0.000 description 1
• 239000011521 glass Substances 0.000 description 1
• 229940080856 gleevec Drugs 0.000 description 1
• 239000008103 glucose Substances 0.000 description 1
• 235000013922 glutamic acid Nutrition 0.000 description 1
• 239000004220 glutamic acid Substances 0.000 description 1
• 235000011187 glycerol Nutrition 0.000 description 1
• 210000002216 heart Anatomy 0.000 description 1
• 108060003552 hemocyanin Proteins 0.000 description 1
• 230000006801 homologous recombination Effects 0.000 description 1
• 238000002744 homologous recombination Methods 0.000 description 1
• 238000001794 hormone therapy Methods 0.000 description 1
• 102000050479 human NDUFS3 Human genes 0.000 description 1
• 210000004293 human mammary gland Anatomy 0.000 description 1
• 239000003906 humectant Substances 0.000 description 1
• 206010020718 hyperplasia Diseases 0.000 description 1
• 238000003384 imaging method Methods 0.000 description 1
• 230000006303 immediate early viral mRNA transcription Effects 0.000 description 1
• 230000002519 immonomodulatory effect Effects 0.000 description 1
• 210000000987 immune system Anatomy 0.000 description 1
• 230000016784 immunoglobulin production Effects 0.000 description 1
• 238000001114 immunoprecipitation Methods 0.000 description 1
• 229960003444 immunosuppressant agent Drugs 0.000 description 1
• 239000003018 immunosuppressive agent Substances 0.000 description 1
• 230000001024 immunotherapeutic effect Effects 0.000 description 1
• 230000001976 improved effect Effects 0.000 description 1
• 238000000099 in vitro assay Methods 0.000 description 1
• 238000011534 incubation Methods 0.000 description 1
• 239000000411 inducer Substances 0.000 description 1
• 239000003701 inert diluent Substances 0.000 description 1
• 238000001802 infusion Methods 0.000 description 1
• 239000004615 ingredient Substances 0.000 description 1
• 238000003780 insertion Methods 0.000 description 1
• 230000037431 insertion Effects 0.000 description 1
• 229940125396 insulin Drugs 0.000 description 1
• 230000010354 integration Effects 0.000 description 1
• 238000001361 intraarterial administration Methods 0.000 description 1
• 230000003834 intracellular effect Effects 0.000 description 1
• 230000037427 ion transport Effects 0.000 description 1
• ODBLHEXUDAPZAU-UHFFFAOYSA-N isocitric acid Chemical compound OC(=O)C(O)C(C(O)=O)CC(O)=O ODBLHEXUDAPZAU-UHFFFAOYSA-N 0.000 description 1
• 235000015110 jellies Nutrition 0.000 description 1
• 239000008274 jelly Substances 0.000 description 1
• 230000002147 killing effect Effects 0.000 description 1
• 210000002415 kinetochore Anatomy 0.000 description 1
• 238000002372 labelling Methods 0.000 description 1
• 210000000265 leukocyte Anatomy 0.000 description 1
• 230000000670 limiting effect Effects 0.000 description 1
• 229940040145 liniment Drugs 0.000 description 1
• 239000000865 liniment Substances 0.000 description 1
• 206010024627 liposarcoma Diseases 0.000 description 1
• 239000007791 liquid phase Substances 0.000 description 1
• 208000014018 liver neoplasm Diseases 0.000 description 1
• 201000011059 lobular neoplasia Diseases 0.000 description 1
• 235000020978 long-chain polyunsaturated fatty acids Nutrition 0.000 description 1
• 239000007937 lozenge Substances 0.000 description 1
• 201000005202 lung cancer Diseases 0.000 description 1
• 230000000527 lymphocytic effect Effects 0.000 description 1
• 239000012139 lysis buffer Substances 0.000 description 1
• 108010089256 lysyl-aspartyl-glutamyl-leucine Proteins 0.000 description 1
• 102100031622 mRNA decay activator protein ZFP36 Human genes 0.000 description 1
• 235000019359 magnesium stearate Nutrition 0.000 description 1
• 206010025482 malaise Diseases 0.000 description 1
• 230000036212 malign transformation Effects 0.000 description 1
• 210000004962 mammalian cell Anatomy 0.000 description 1
• 210000004216 mammary stem cell Anatomy 0.000 description 1
• 235000010355 mannitol Nutrition 0.000 description 1
• 125000000311 mannosyl group Chemical group C1([C@@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
• 238000013507 mapping Methods 0.000 description 1
• 238000000691 measurement method Methods 0.000 description 1
• 230000001404 mediated effect Effects 0.000 description 1
• 210000003716 mesoderm Anatomy 0.000 description 1
• 230000001394 metastastic effect Effects 0.000 description 1
• 238000012775 microarray technology Methods 0.000 description 1
• 238000012737 microarray-based gene expression Methods 0.000 description 1
• 239000003094 microcapsule Substances 0.000 description 1
• 238000000386 microscopy Methods 0.000 description 1
• 210000004688 microtubule Anatomy 0.000 description 1
• 235000021243 milk fat Nutrition 0.000 description 1
• 230000025205 mitochondrial translational initiation Effects 0.000 description 1
• 239000003226 mitogen Substances 0.000 description 1
• 230000000394 mitotic effect Effects 0.000 description 1
• 238000002156 mixing Methods 0.000 description 1
• 238000002715 modification method Methods 0.000 description 1
• 239000007932 molded tablet Substances 0.000 description 1
• 238000010369 molecular cloning Methods 0.000 description 1
• 210000001616 monocyte Anatomy 0.000 description 1
• 108700000318 mouse Zfp385 Proteins 0.000 description 1
• 238000012243 multiplex automated genomic engineering Methods 0.000 description 1
• 210000003205 muscle Anatomy 0.000 description 1
• 230000000869 mutational effect Effects 0.000 description 1
• 208000025113 myeloid leukemia Diseases 0.000 description 1
• 239000007923 nasal drop Substances 0.000 description 1
• 229940100662 nasal drops Drugs 0.000 description 1
• 230000001452 natriuretic effect Effects 0.000 description 1
• 210000000822 natural killer cell Anatomy 0.000 description 1
• 230000008693 nausea Effects 0.000 description 1
• 239000006199 nebulizer Substances 0.000 description 1
• 230000017095 negative regulation of cell growth Effects 0.000 description 1
• 230000001613 neoplastic effect Effects 0.000 description 1
• 208000007538 neurilemmoma Diseases 0.000 description 1
• 210000002569 neuron Anatomy 0.000 description 1
• 239000002547 new drug Substances 0.000 description 1
• 210000002445 nipple Anatomy 0.000 description 1
• 229920001220 nitrocellulos Polymers 0.000 description 1
• 239000012457 nonaqueous media Substances 0.000 description 1
• 239000002687 nonaqueous vehicle Substances 0.000 description 1
• 239000002736 nonionic surfactant Substances 0.000 description 1
• 230000000683 nonmetastatic effect Effects 0.000 description 1
• 210000000633 nuclear envelope Anatomy 0.000 description 1
• 102000006255 nuclear receptors Human genes 0.000 description 1
• 108020004017 nuclear receptors Proteins 0.000 description 1
• 108010044762 nucleolin Proteins 0.000 description 1
• 229920001778 nylon Polymers 0.000 description 1
• 230000002246 oncogenic effect Effects 0.000 description 1
• 150000002894 organic compounds Chemical class 0.000 description 1
• 230000008520 organization Effects 0.000 description 1
• 230000002611 ovarian Effects 0.000 description 1
• 230000037443 ovarian carcinogenesis Effects 0.000 description 1
• 231100001249 ovarian carcinogenesis Toxicity 0.000 description 1
• 235000019834 papain Nutrition 0.000 description 1
• 229940055729 papain Drugs 0.000 description 1
• 239000012188 paraffin wax Substances 0.000 description 1
• 238000007911 parenteral administration Methods 0.000 description 1
• 230000008506 pathogenesis Effects 0.000 description 1
• 230000007170 pathology Effects 0.000 description 1
• 235000020232 peanut Nutrition 0.000 description 1
• 229940111202 pepsin Drugs 0.000 description 1
• 239000000816 peptidomimetic Substances 0.000 description 1
• 230000035699 permeability Effects 0.000 description 1
• 230000000858 peroxisomal effect Effects 0.000 description 1
• 239000000825 pharmaceutical preparation Substances 0.000 description 1
• 239000002935 phosphatidylinositol 3 kinase inhibitor Substances 0.000 description 1
• 229940127126 plasminogen activator Drugs 0.000 description 1
• 108010089520 pol Gene Products Proteins 0.000 description 1
• 229920000729 poly(L-lysine) polymer Polymers 0.000 description 1
• 238000002264 polyacrylamide gel electrophoresis Methods 0.000 description 1
• 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
• 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
• 208000015768 polyposis Diseases 0.000 description 1
• 229940068968 polysorbate 80 Drugs 0.000 description 1
• 229920000053 polysorbate 80 Polymers 0.000 description 1
• 239000011591 potassium Substances 0.000 description 1
• 229910052700 potassium Inorganic materials 0.000 description 1
• 230000001855 preneoplastic effect Effects 0.000 description 1
• 238000004321 preservation Methods 0.000 description 1
• 229960001309 procaine hydrochloride Drugs 0.000 description 1
• 239000003380 propellant Substances 0.000 description 1
• 210000002307 prostate Anatomy 0.000 description 1
• 235000019833 protease Nutrition 0.000 description 1
• 230000004853 protein function Effects 0.000 description 1
• 238000001243 protein synthesis Methods 0.000 description 1
• 238000000746 purification Methods 0.000 description 1
• 229960003581 pyridoxal Drugs 0.000 description 1
• 235000008164 pyridoxal Nutrition 0.000 description 1
• 239000011674 pyridoxal Substances 0.000 description 1
• 235000008160 pyridoxine Nutrition 0.000 description 1
• 239000011677 pyridoxine Substances 0.000 description 1
• 230000003537 radioprotector Effects 0.000 description 1
• 230000007115 recruitment Effects 0.000 description 1
• 230000000306 recurrent effect Effects 0.000 description 1
• 230000025053 regulation of cell proliferation Effects 0.000 description 1
• 230000002787 reinforcement Effects 0.000 description 1
• BOLDJAUMGUJJKM-LSDHHAIUSA-N renifolin D Natural products CC(=C)[C@@H]1Cc2c(O)c(O)ccc2[C@H]1CC(=O)c3ccc(O)cc3O BOLDJAUMGUJJKM-LSDHHAIUSA-N 0.000 description 1
• 230000003252 repetitive effect Effects 0.000 description 1
• 108010033674 rho GTP-Binding Proteins Proteins 0.000 description 1
• 108010026977 rhophilin Proteins 0.000 description 1
• 108020004418 ribosomal RNA Proteins 0.000 description 1
• 108010008790 ribosomal phosphoprotein P1 Proteins 0.000 description 1
• 108010055738 ribosomal phosphoprotein P2 Proteins 0.000 description 1
• 108010025578 ribosomal protein L17 Proteins 0.000 description 1
• 108010092942 ribosomal protein S20 Proteins 0.000 description 1
• CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
• 229940081974 saccharin Drugs 0.000 description 1
• 235000019204 saccharin Nutrition 0.000 description 1
• 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
• 238000003118 sandwich ELISA Methods 0.000 description 1
• 206010039667 schwannoma Diseases 0.000 description 1
• 238000007423 screening assay Methods 0.000 description 1
• 239000006152 selective media Substances 0.000 description 1
• 238000012163 sequencing technique Methods 0.000 description 1
• 210000002966 serum Anatomy 0.000 description 1
• 239000008159 sesame oil Substances 0.000 description 1
• 235000011803 sesame oil Nutrition 0.000 description 1
• 230000011664 signaling Effects 0.000 description 1
• 239000004055 small Interfering RNA Substances 0.000 description 1
• 150000003384 small molecules Chemical class 0.000 description 1
• 108091029842 small nuclear ribonucleic acid Proteins 0.000 description 1
• 239000011734 sodium Substances 0.000 description 1
• 239000007974 sodium acetate buffer Substances 0.000 description 1
• 239000011780 sodium chloride Substances 0.000 description 1
• 229940054269 sodium pyruvate Drugs 0.000 description 1
• 239000007790 solid phase Substances 0.000 description 1
• 229960002920 sorbitol Drugs 0.000 description 1
• 235000012424 soybean oil Nutrition 0.000 description 1
• 239000003549 soybean oil Substances 0.000 description 1
• 230000019130 spindle checkpoint Effects 0.000 description 1
• 230000002269 spontaneous effect Effects 0.000 description 1
• 238000010186 staining Methods 0.000 description 1
• 230000007103 stamina Effects 0.000 description 1
• 235000019698 starch Nutrition 0.000 description 1
• 239000008107 starch Substances 0.000 description 1
• 239000008174 sterile solution Substances 0.000 description 1
• 238000007920 subcutaneous administration Methods 0.000 description 1
• 235000000346 sugar Nutrition 0.000 description 1
• 150000005846 sugar alcohols Polymers 0.000 description 1
• 150000008163 sugars Chemical class 0.000 description 1
• 239000000829 suppository Substances 0.000 description 1
• 239000003765 sweetening agent Substances 0.000 description 1
• 208000011580 syndromic disease Diseases 0.000 description 1
• 206010042863 synovial sarcoma Diseases 0.000 description 1
• 235000020357 syrup Nutrition 0.000 description 1
• 239000006188 syrup Substances 0.000 description 1
• 230000009897 systematic effect Effects 0.000 description 1
• 230000009885 systemic effect Effects 0.000 description 1
• 102100025028 tRNA (guanine-N(7)-)-methyltransferase Human genes 0.000 description 1
• 230000002123 temporal effect Effects 0.000 description 1
• 239000002562 thickening agent Substances 0.000 description 1
• 108010060887 thrombospondin 2 Proteins 0.000 description 1
• 238000011200 topical administration Methods 0.000 description 1
• 230000000699 topical effect Effects 0.000 description 1
• 239000003053 toxin Substances 0.000 description 1
• 231100000765 toxin Toxicity 0.000 description 1
• 235000010487 tragacanth Nutrition 0.000 description 1
• 239000000196 tragacanth Substances 0.000 description 1
• 229940116362 tragacanth Drugs 0.000 description 1
• 102000014898 transaminase activity proteins Human genes 0.000 description 1
• 239000012096 transfection reagent Substances 0.000 description 1
• 239000012581 transferrin Substances 0.000 description 1
• 229940099456 transforming growth factor beta 1 Drugs 0.000 description 1
• 230000014621 translational initiation Effects 0.000 description 1
• 102000035160 transmembrane proteins Human genes 0.000 description 1
• 108091005703 transmembrane proteins Proteins 0.000 description 1
• CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
• 229940029284 trichlorofluoromethane Drugs 0.000 description 1
• 102000003298 tumor necrosis factor receptor Human genes 0.000 description 1
• 108010087967 type I signal peptidase Proteins 0.000 description 1
• 229940121358 tyrosine kinase inhibitor Drugs 0.000 description 1
• 239000005483 tyrosine kinase inhibitor Substances 0.000 description 1
• 150000004917 tyrosine kinase inhibitor derivatives Chemical class 0.000 description 1
• 230000009452 underexpressoin Effects 0.000 description 1
• 241001430294 unidentified retrovirus Species 0.000 description 1
• 230000003827 upregulation Effects 0.000 description 1
• 210000002700 urine Anatomy 0.000 description 1
• 238000010200 validation analysis Methods 0.000 description 1
• 235000015112 vegetable and seed oil Nutrition 0.000 description 1
• 239000008158 vegetable oil Substances 0.000 description 1
• 230000004735 virus-associated carcinogenesis Effects 0.000 description 1
• 235000019158 vitamin B6 Nutrition 0.000 description 1
• 239000011726 vitamin B6 Substances 0.000 description 1
• 230000008673 vomiting Effects 0.000 description 1
• 235000012431 wafers Nutrition 0.000 description 1
• 239000008215 water for injection Substances 0.000 description 1
• 230000004580 weight loss Effects 0.000 description 1
• 208000016261 weight loss Diseases 0.000 description 1
• 238000001262 western blot Methods 0.000 description 1