ES2354221T3 - Método de resolución óptica de amlodipina. - Google Patents

Método de resolución óptica de amlodipina. Download PDF

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Publication number
ES2354221T3
ES2354221T3 ES05821317T ES05821317T ES2354221T3 ES 2354221 T3 ES2354221 T3 ES 2354221T3 ES 05821317 T ES05821317 T ES 05821317T ES 05821317 T ES05821317 T ES 05821317T ES 2354221 T3 ES2354221 T3 ES 2354221T3
Authority
ES
Spain
Prior art keywords
dibenzoyl
amlodipine
tartrate
hemi
solvate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES05821317T
Other languages
English (en)
Spanish (es)
Inventor
Nam Kyu 242-1504 Ggodmoinouel Sinan Apt. LEE
Jae-Sun Kim
Nam Ho 101-1409 Hyundai Apt. Eunhaeng-dong KIM
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SK Chemicals Co Ltd
Original Assignee
SK Chemicals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SK Chemicals Co Ltd filed Critical SK Chemicals Co Ltd
Application granted granted Critical
Publication of ES2354221T3 publication Critical patent/ES2354221T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ES05821317T 2004-12-02 2005-12-02 Método de resolución óptica de amlodipina. Active ES2354221T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR1020040100613A KR101152608B1 (ko) 2004-12-02 2004-12-02 (ｒ,ｓ)-암로디핀으로부터 암로디핀 이성질체의 분리방법
KR20040100613 2004-12-02
KR20040105612 2004-12-14

Publications (1)

Publication Number Publication Date
ES2354221T3 true ES2354221T3 (es) 2011-03-11

Family

ID=37158205

Family Applications (1)

Application Number Title Priority Date Filing Date
ES05821317T Active ES2354221T3 (es) 2004-12-02 2005-12-02 Método de resolución óptica de amlodipina.

Country Status (3)

Country Link
KR (1) KR101152608B1 (ko)
CN (1) CN101111478B (ko)
ES (1) ES2354221T3 (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100989970B1 (ko) * 2008-07-01 2010-10-26 미래파인켐 주식회사 (ｓ)-(-)-암로디핀의 분리방법
CN101798280B (zh) * 2010-03-22 2012-05-02 河北师范大学 一种手性拆分消旋体氨氯地平制备s-(-)-氨氯地平和r-(+)-氨氯地平的方法
CN105439942B (zh) * 2015-12-02 2018-12-18 扬子江药业集团北京海燕药业有限公司 一种(s)-马尼地平的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9405833D0 (en) 1994-03-24 1994-05-11 Pfizer Ltd Separation of the enantiomers of amlodipine
CA2466806A1 (en) 2001-10-24 2003-05-01 Sepracor Inc. Method of resolving amlodipine racemate
KR100476636B1 (ko) 2002-09-11 2005-03-17 한림제약(주) 엘-(+)-타르트레이트를 이용한 에스-(-)-암로디핀의 제조방법

Also Published As

Publication number Publication date
KR20060061976A (ko) 2006-06-09
CN101111478B (zh) 2012-04-04
KR101152608B1 (ko) 2012-06-07
CN101111478A (zh) 2008-01-23

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