ES2336625T3 - Inhibidores de la proteina quinasa c-met para el tratamiento de trastornos proliferativos. - Google Patents

Inhibidores de la proteina quinasa c-met para el tratamiento de trastornos proliferativos. Download PDF

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Publication number
ES2336625T3
ES2336625T3 ES07753626T ES07753626T ES2336625T3 ES 2336625 T3 ES2336625 T3 ES 2336625T3 ES 07753626 T ES07753626 T ES 07753626T ES 07753626 T ES07753626 T ES 07753626T ES 2336625 T3 ES2336625 T3 ES 2336625T3
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Prior art keywords
compound
pyridin
tetrazol
difluorophenyl
amine
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English (en)
Spanish (es)
Inventor
David J. Lauffer
Robert J. Davies
Dean Stamos
Alexander Aronov
David D. Deininger
Ronald Grey, Jr.
Jinwang Xu
Pan Li
Brian Ledford
Luc Farmer
Randy Scott Bethiel
Dylan Jacobs
Kira Mcginty
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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ES07753626T 2006-03-22 2007-03-21 Inhibidores de la proteina quinasa c-met para el tratamiento de trastornos proliferativos. Active ES2336625T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US78493706P 2006-03-22 2006-03-22
US784937P 2006-03-22
US87597306P 2006-12-20 2006-12-20
US875973P 2006-12-20

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ES2336625T3 true ES2336625T3 (es) 2010-04-14

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ES07753626T Active ES2336625T3 (es) 2006-03-22 2007-03-21 Inhibidores de la proteina quinasa c-met para el tratamiento de trastornos proliferativos.

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US (2) US7872031B2 (xx)
EP (1) EP2004625B1 (xx)
JP (2) JP2009533327A (xx)
KR (1) KR20090007347A (xx)
CN (1) CN101479255B (xx)
AR (1) AR060054A1 (xx)
AT (1) ATE453635T1 (xx)
AU (1) AU2007231577B2 (xx)
CA (1) CA2646701A1 (xx)
CL (1) CL2007000752A1 (xx)
DE (1) DE602007004092D1 (xx)
ES (1) ES2336625T3 (xx)
HK (1) HK1129890A1 (xx)
IL (1) IL194242A0 (xx)
MX (1) MX2008012096A (xx)
NO (1) NO20084435L (xx)
NZ (1) NZ571933A (xx)
RU (1) RU2008141761A (xx)
TW (1) TW200806646A (xx)
WO (1) WO2007111904A2 (xx)

Families Citing this family (95)

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Publication number Priority date Publication date Assignee Title
US8034834B2 (en) 2006-05-25 2011-10-11 Synta Pharmaceuticals Corp. Method for treating proliferative disorders with HSP90 inhibitors
KR101177729B1 (ko) 2006-09-08 2012-09-07 에프. 호프만-라 로슈 아게 벤조트리아졸 키나아제 조절제
GB0625659D0 (en) 2006-12-21 2007-01-31 Cancer Rec Tech Ltd Therapeutic compounds and their use
JP2010526823A (ja) * 2007-05-10 2010-08-05 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー Ｐｉ３キナーゼ阻害物質としてのキノキサリン誘導体
CA2694275A1 (en) * 2007-07-26 2009-01-29 Novartis Ag Organic compounds
ATE502935T1 (de) * 2007-10-03 2011-04-15 Vertex Pharma C-met-proteinkinasehemmer
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