ES2323218T3 - Aislamiento y caracterizacion del receptor de la hormona que libera a la hormona del crecimiento. - Google Patents

Aislamiento y caracterizacion del receptor de la hormona que libera a la hormona del crecimiento. Download PDF

Info

Publication number
ES2323218T3
ES2323218T3 ES01105156T ES01105156T ES2323218T3 ES 2323218 T3 ES2323218 T3 ES 2323218T3 ES 01105156 T ES01105156 T ES 01105156T ES 01105156 T ES01105156 T ES 01105156T ES 2323218 T3 ES2323218 T3 ES 2323218T3
Authority
ES
Spain
Prior art keywords
ghrh
receptor
binding
ligand
hormone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES01105156T
Other languages
English (en)
Spanish (es)
Inventor
Michael Oliver Dr. Thorner
Bruce David Gaylinn
John Ronald Zysk
Cecil Mark Eppler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UVA Licensing and Ventures Group
University of Virginia UVA
Original Assignee
University of Virginia UVA
University of Virginia Patent Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25416459&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2323218(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by University of Virginia UVA, University of Virginia Patent Foundation filed Critical University of Virginia UVA
Application granted granted Critical
Publication of ES2323218T3 publication Critical patent/ES2323218T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01LSEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L27/00Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate
    • H01L27/02Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including semiconductor components specially adapted for rectifying, oscillating, amplifying or switching and having potential barriers; including integrated passive circuit elements having potential barriers
    • H01L27/04Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including semiconductor components specially adapted for rectifying, oscillating, amplifying or switching and having potential barriers; including integrated passive circuit elements having potential barriers the substrate being a semiconductor body
    • H01L27/10Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including semiconductor components specially adapted for rectifying, oscillating, amplifying or switching and having potential barriers; including integrated passive circuit elements having potential barriers the substrate being a semiconductor body including a plurality of individual components in a repetitive configuration
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/60Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575Hormones
    • G01N2333/60Growth-hormone releasing factors (GH-RF) (Somatoliberin)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Power Engineering (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Computer Hardware Design (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Dram (AREA)
ES01105156T 1992-06-23 1993-06-23 Aislamiento y caracterizacion del receptor de la hormona que libera a la hormona del crecimiento. Expired - Lifetime ES2323218T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/902,826 US5973114A (en) 1992-06-23 1992-06-23 Isolation and characterization of the growth hormone releasing hormone receptor
US902826 1992-06-23

Publications (1)

Publication Number Publication Date
ES2323218T3 true ES2323218T3 (es) 2009-07-09

Family

ID=25416459

Family Applications (2)

Application Number Title Priority Date Filing Date
ES93110030T Expired - Lifetime ES2164648T3 (es) 1992-06-23 1993-06-23 Aislamiento y caracterizacion del receptor de la hormona que libera la hormona del crecimiento.
ES01105156T Expired - Lifetime ES2323218T3 (es) 1992-06-23 1993-06-23 Aislamiento y caracterizacion del receptor de la hormona que libera a la hormona del crecimiento.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES93110030T Expired - Lifetime ES2164648T3 (es) 1992-06-23 1993-06-23 Aislamiento y caracterizacion del receptor de la hormona que libera la hormona del crecimiento.

Country Status (16)

Country Link
US (1) US5973114A (pt)
EP (2) EP1104888B1 (pt)
JP (2) JP3410094B2 (pt)
KR (2) KR100329729B1 (pt)
AT (2) ATE424563T1 (pt)
AU (1) AU672975B2 (pt)
CA (1) CA2098972C (pt)
DE (2) DE69334264D1 (pt)
DK (2) DK0576988T3 (pt)
ES (2) ES2164648T3 (pt)
GR (1) GR3036766T3 (pt)
IL (1) IL106112A (pt)
NZ (2) NZ247941A (pt)
PT (2) PT576988E (pt)
WO (1) WO1994000482A1 (pt)
ZA (1) ZA934483B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5852187A (en) * 1992-06-23 1998-12-22 The University Of Virginia Patent Foundation Molecular cloning of the ovine pituitary growth hormone releasing hormone receptor
IL106860A (en) * 1992-09-15 1999-08-17 Thorner Michael O Entertainment, characterization and protein sequencing of a hormone receptor that releases growth hormone and replication of the encoded gene for a hormone that releases growth hormone
US5967795A (en) * 1995-08-30 1999-10-19 Asea Brown Boveri Ab SiC semiconductor device comprising a pn junction with a voltage absorbing edge
US6221617B1 (en) 1996-12-06 2001-04-24 Julie Heinrich Bioassay for growth hormone releasing hormone
US7078514B1 (en) * 1999-06-12 2006-07-18 Michael O. Thorner Chicken growth hormone releasing hormone receptor
WO2000076455A2 (en) * 1999-06-12 2000-12-21 University Of Virginia Patent Foundation Chicken growth hormone releasing hormone receptor

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4833166A (en) * 1987-05-01 1989-05-23 Grosvenor Clark E Growth hormone releasing hormone complementary peptides
NZ237857A (en) * 1990-04-24 1992-05-26 Lilly Co Eli Polypeptide compounds with growth hormone releasing factor activity
NZ238748A (en) * 1990-06-29 1993-09-27 Hoffmann La Roche Growth hormone releasing factor (grf) analogues
US5225543A (en) * 1991-03-28 1993-07-06 American Cyanamid Company Receptors method for purification of g protein-linked
IL106860A (en) * 1992-09-15 1999-08-17 Thorner Michael O Entertainment, characterization and protein sequencing of a hormone receptor that releases growth hormone and replication of the encoded gene for a hormone that releases growth hormone

Also Published As

Publication number Publication date
US5973114A (en) 1999-10-26
JP3456989B2 (ja) 2003-10-14
DE69330695T2 (de) 2002-07-04
PT576988E (pt) 2002-01-30
DE69334264D1 (de) 2009-04-16
EP1104888B1 (en) 2009-03-04
DK0576988T3 (da) 2001-11-12
EP1104888A2 (en) 2001-06-06
WO1994000482A1 (en) 1994-01-06
EP0576988A1 (en) 1994-01-05
ZA934483B (en) 1994-04-18
ES2164648T3 (es) 2002-03-01
DK1104888T3 (da) 2009-05-25
DE69330695D1 (de) 2001-10-11
KR940001411A (ko) 1994-01-11
NZ272761A (en) 1997-04-24
CA2098972A1 (en) 1993-12-24
KR100329729B1 (ko) 2002-07-27
NZ247941A (en) 1997-04-24
JPH07500614A (ja) 1995-01-19
AU4146793A (en) 1994-01-06
KR940005668A (ko) 1994-03-22
PT1104888E (pt) 2009-05-14
AU672975B2 (en) 1996-10-24
IL106112A0 (en) 1993-10-20
EP0576988B1 (en) 2001-09-05
JP3410094B2 (ja) 2003-05-26
ATE424563T1 (de) 2009-03-15
JP2003048898A (ja) 2003-02-21
CA2098972C (en) 2003-08-19
ATE205222T1 (de) 2001-09-15
GR3036766T3 (en) 2002-01-31
EP1104888A3 (en) 2004-03-03
IL106112A (en) 1998-12-06

Similar Documents

Publication Publication Date Title
Robberecht et al. Demonstration of biological activity of brain gastrin-like peptidic material in the human: its relationship with the COOH-terminal octapeptide of cholecystokinin.
Vertongen et al. Autoradiographic visualization of the receptor subclasses for vasoactive intestinal polypeptide (VIP) in rat brain
Gourlet et al. Interaction of lipophilic VIP derivatives with recombinant VIP1/PACAP and VIP2/PACAP receptors
US5583010A (en) Nucleic acid molecule encoding the porcine growth hormone receptor
CN101848926B (zh) 能够结合免疫球蛋白的肽
ES2323218T3 (es) Aislamiento y caracterizacion del receptor de la hormona que libera a la hormona del crecimiento.
US5591641A (en) Nucleic acid encoding the growth hormone releasing hormone receptor
Gaylinn et al. Photoaffinity cross-linking to the pituitary receptor for growth hormone-releasing factor
LEWIS et al. Structural characterization of the somatostatin receptor in rat anterior pituitary membranes
US5852187A (en) Molecular cloning of the ovine pituitary growth hormone releasing hormone receptor
Ji et al. Differential interactions of human choriogonadotropin and its antagonistic aglycosylated analog with their receptor.
JP3393159B2 (ja) 成長ホルモン放出ホルモン
Lorinet et al. Galanin receptors in human hypothalamus: biochemical and structural analysis
Weiner et al. Biochemical analyses of proteolytic nicking of the human glycoprotein hormone alpha-subunit and its effect on conformational epitopes
US5612470A (en) Nucleic acid encoding the growth hormone releasing hormone receptor
US5644046A (en) Cloning of a gene encoding for the growth hormone releasing hormone receptor
FOTI et al. The biological activity of bovine and human thyrotropin is differently affected by trypsin treatment of human thyroid cells: thyroid-stimulating antibody is related to human thyrotropin
JP2835781B2 (ja) Tshトレーサーの製造方法
Sinha et al. Detection of multiple PRL-and GH-like proteins in human pituitary by Western blot analysis
Holst Radioreceptorassays for glucagon
Sohn Identification and Characterization of Contact Sites Between Human Follicle Stimulating Hormone and the Follicle Stimulating Hormone Receptor
Flanagan Gonadotropin releasing hormone receptor ligand interactions