ES2164648T3 - Aislamiento y caracterizacion del receptor de la hormona que libera la hormona del crecimiento. - Google Patents

Aislamiento y caracterizacion del receptor de la hormona que libera la hormona del crecimiento.

Info

Publication number
ES2164648T3
ES2164648T3 ES93110030T ES93110030T ES2164648T3 ES 2164648 T3 ES2164648 T3 ES 2164648T3 ES 93110030 T ES93110030 T ES 93110030T ES 93110030 T ES93110030 T ES 93110030T ES 2164648 T3 ES2164648 T3 ES 2164648T3
Authority
ES
Spain
Prior art keywords
hormone
ligand
growth hormone
characterization
releases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93110030T
Other languages
English (en)
Inventor
Michael Oliver Thorner
Bruce David Gaylinn
John Ronald Zysk
Cecil Mark Eppler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Virginia UVA
University of Virginia Patent Foundation
Original Assignee
University of Virginia UVA
University of Virginia Patent Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25416459&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2164648(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by University of Virginia UVA, University of Virginia Patent Foundation filed Critical University of Virginia UVA
Application granted granted Critical
Publication of ES2164648T3 publication Critical patent/ES2164648T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L27/00—Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate
    • H01L27/02—Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including semiconductor components specially adapted for rectifying, oscillating, amplifying or switching and having at least one potential-jump barrier or surface barrier; including integrated passive circuit elements with at least one potential-jump barrier or surface barrier
    • H01L27/04—Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including semiconductor components specially adapted for rectifying, oscillating, amplifying or switching and having at least one potential-jump barrier or surface barrier; including integrated passive circuit elements with at least one potential-jump barrier or surface barrier the substrate being a semiconductor body
    • H01L27/10—Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including semiconductor components specially adapted for rectifying, oscillating, amplifying or switching and having at least one potential-jump barrier or surface barrier; including integrated passive circuit elements with at least one potential-jump barrier or surface barrier the substrate being a semiconductor body including a plurality of individual components in a repetitive configuration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/60—Growth-hormone releasing factors (GH-RF) (Somatoliberin)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575—Hormones
    • G01N2333/60—Growth-hormone releasing factors (GH-RF) (Somatoliberin)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH

Abstract

SE HA CARACTERIZADO EL ENLACE DEL RECEPTOR DE HORMONAS LIBERADOR DE HORMONAS DE CRECIMIENTO (GHRH) MEDIANTE UN UNICO ENSAYO DE ENLACE UTILIZANDO SONDAS DE GHRH YODADAS. SE HAN CREADO SONDAS DE GHRH DE FOTOAFINIDAD QUE PERMITEN EL FOTOETIQUETADO Y LA CARACTERIZACION DEL RECEPTOR. ADEMAS, SE HAN CREADO ANALOGOS DE GHRH BIOESTAÑADOS DE GRAN AFINIDAD. LA SOLUBILIZACION DE LOS COMPLEJOS DE GHRH-R/GHRH Y LA EXTRACCION DEL GHRH ESPECIFICAMENTE ENLAZADO UTILIZANDO UNA SOLUCION DETERGENTE SUAVE, SEGUIDO DE UNA CROMATOGRAFIA DE AFINIDAD, LLEVA A UN RECEPTOR AISLADO DE GHRH SUSTANCIALMENTE PURIFICADO. EL TRATAMIENTO ELECTROFORETICO DEL RECEPTOR AISLADO DE GHRH PRODUCE UN RECEPTOR DE GHRH LO SUFICIENTEMENTE PURO COMO PARA QUE SE LLEVE A CABO LA SECUENCIACION DEL RECEPTOR.
ES93110030T 1992-06-23 1993-06-23 Aislamiento y caracterizacion del receptor de la hormona que libera la hormona del crecimiento. Expired - Lifetime ES2164648T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/902,826 US5973114A (en) 1992-06-23 1992-06-23 Isolation and characterization of the growth hormone releasing hormone receptor

Publications (1)

Publication Number Publication Date
ES2164648T3 true ES2164648T3 (es) 2002-03-01

Family

ID=25416459

Family Applications (2)

Application Number Title Priority Date Filing Date
ES01105156T Expired - Lifetime ES2323218T3 (es) 1992-06-23 1993-06-23 Aislamiento y caracterizacion del receptor de la hormona que libera a la hormona del crecimiento.
ES93110030T Expired - Lifetime ES2164648T3 (es) 1992-06-23 1993-06-23 Aislamiento y caracterizacion del receptor de la hormona que libera la hormona del crecimiento.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES01105156T Expired - Lifetime ES2323218T3 (es) 1992-06-23 1993-06-23 Aislamiento y caracterizacion del receptor de la hormona que libera a la hormona del crecimiento.

Country Status (16)

Country Link
US (1) US5973114A (es)
EP (2) EP0576988B1 (es)
JP (2) JP3410094B2 (es)
KR (2) KR100329729B1 (es)
AT (2) ATE205222T1 (es)
AU (1) AU672975B2 (es)
CA (1) CA2098972C (es)
DE (2) DE69334264D1 (es)
DK (2) DK1104888T3 (es)
ES (2) ES2323218T3 (es)
GR (1) GR3036766T3 (es)
IL (1) IL106112A (es)
NZ (2) NZ247941A (es)
PT (2) PT1104888E (es)
WO (1) WO1994000482A1 (es)
ZA (1) ZA934483B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5852187A (en) * 1992-06-23 1998-12-22 The University Of Virginia Patent Foundation Molecular cloning of the ovine pituitary growth hormone releasing hormone receptor
IL106860A (en) * 1992-09-15 1999-08-17 Thorner Michael O Entertainment, characterization and protein sequencing of a hormone receptor that releases growth hormone and replication of the encoded gene for a hormone that releases growth hormone
US5967795A (en) * 1995-08-30 1999-10-19 Asea Brown Boveri Ab SiC semiconductor device comprising a pn junction with a voltage absorbing edge
US6221617B1 (en) 1996-12-06 2001-04-24 Julie Heinrich Bioassay for growth hormone releasing hormone
AU5483400A (en) * 1999-06-12 2001-01-02 University Of Virginia Patent Foundation Chicken growth hormone releasing hormone receptor
US7078514B1 (en) * 1999-06-12 2006-07-18 Michael O. Thorner Chicken growth hormone releasing hormone receptor

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4833166A (en) * 1987-05-01 1989-05-23 Grosvenor Clark E Growth hormone releasing hormone complementary peptides
CA2040649A1 (en) * 1990-04-24 1991-10-25 Gerald S. Brooke Growth hormone releasing factor analogs
ZA914983B (en) * 1990-06-29 1992-03-25 Hoffmann La Roche His-grf-analogs
US5225543A (en) * 1991-03-28 1993-07-06 American Cyanamid Company Receptors method for purification of g protein-linked
IL106860A (en) * 1992-09-15 1999-08-17 Thorner Michael O Entertainment, characterization and protein sequencing of a hormone receptor that releases growth hormone and replication of the encoded gene for a hormone that releases growth hormone

Also Published As

Publication number Publication date
EP1104888A2 (en) 2001-06-06
NZ247941A (en) 1997-04-24
PT576988E (pt) 2002-01-30
EP1104888B1 (en) 2009-03-04
DK1104888T3 (da) 2009-05-25
AU4146793A (en) 1994-01-06
EP0576988A1 (en) 1994-01-05
KR940001411A (ko) 1994-01-11
GR3036766T3 (en) 2002-01-31
JP3456989B2 (ja) 2003-10-14
DK0576988T3 (da) 2001-11-12
WO1994000482A1 (en) 1994-01-06
JP3410094B2 (ja) 2003-05-26
IL106112A0 (en) 1993-10-20
EP0576988B1 (en) 2001-09-05
ES2323218T3 (es) 2009-07-09
ZA934483B (en) 1994-04-18
IL106112A (en) 1998-12-06
NZ272761A (en) 1997-04-24
PT1104888E (pt) 2009-05-14
ATE205222T1 (de) 2001-09-15
CA2098972C (en) 2003-08-19
CA2098972A1 (en) 1993-12-24
KR100329729B1 (ko) 2002-07-27
JPH07500614A (ja) 1995-01-19
DE69334264D1 (de) 2009-04-16
US5973114A (en) 1999-10-26
KR940005668A (ko) 1994-03-22
AU672975B2 (en) 1996-10-24
DE69330695D1 (de) 2001-10-11
ATE424563T1 (de) 2009-03-15
DE69330695T2 (de) 2002-07-04
JP2003048898A (ja) 2003-02-21
EP1104888A3 (en) 2004-03-03

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