ES2320239T3 - Virus oncolitico. - Google Patents
Virus oncolitico. Download PDFInfo
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- ES2320239T3 ES2320239T3 ES05025974T ES05025974T ES2320239T3 ES 2320239 T3 ES2320239 T3 ES 2320239T3 ES 05025974 T ES05025974 T ES 05025974T ES 05025974 T ES05025974 T ES 05025974T ES 2320239 T3 ES2320239 T3 ES 2320239T3
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| US8491884B2 (en) | 2000-05-03 | 2013-07-23 | Oncolytics Biotech Inc. | Virus clearance of neoplastic cells from mixed cellular compositions |
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| AU2008201293B2 (en) * | 2001-07-11 | 2011-08-18 | University Of Miami | Recombinant VSV for the treatment of tumor cells |
| JP2004537305A (ja) * | 2001-07-11 | 2004-12-16 | ユニバーシティー オブ マイアミ | 腫瘍細胞の処置のための組換えｖｓｖ |
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| US7731974B2 (en) | 2003-03-27 | 2010-06-08 | Ottawa Hospital Research Institute | Mutant vesicular stomatitis viruses and uses thereof |
| DK1606411T3 (da) * | 2003-03-27 | 2009-03-30 | Ottawa Health Research Inst | Mutant vesikulær stomatitis-vira og anvendelse deraf |
| CA2568772A1 (en) | 2004-06-01 | 2005-12-15 | San Diego State University Foundation | Expression system based on recombinant vesicular stomatitis virus synthesizing t7 rna polymerase |
| ZA200702269B (en) * | 2004-08-20 | 2008-09-25 | Viralytics Ltd | Methods and compositions for treatment of hematologic cancers |
| WO2006017914A1 (en) | 2004-08-20 | 2006-02-23 | Viralytics Limited | Methods and compositions for treatment of hematologic cancers |
| US10668119B2 (en) | 2005-08-01 | 2020-06-02 | Virocure, Inc. | Attenuated reovirus |
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| ES2741138T3 (es) | 2006-09-15 | 2020-02-10 | Childrens Hospital Of Eastern Ontario Res Institute Inc | Rhabdovirus oncolítico de Farmington |
| US10369171B2 (en) | 2007-03-13 | 2019-08-06 | Virocure, Inc. | Attenuated reoviruses for selection of cell populations |
| PE20091104A1 (es) * | 2007-12-21 | 2009-07-18 | Wyeth Corp | Virus de la estomatitis vesicular atenuado modificado geneticamente, composiciones y metodos de uso del mismo |
| US10603351B2 (en) | 2008-08-21 | 2020-03-31 | Turnstone Limited Partnership | Engineered synergistic oncolytic viral symbiosis |
| DE102008050860A1 (de) * | 2008-10-08 | 2010-04-15 | Dorothee Von Laer | LCMV-GP-VSV-Pseudotypvektoren und tumorinfiltrierende Virenproduzentenzellen zur Therapie von Tumoren |
| US9707285B2 (en) | 2009-03-16 | 2017-07-18 | Turnstone Limited Partnership | Vaccination methods |
| EP2510088B1 (en) * | 2009-12-10 | 2016-10-05 | Ottawa Hospital Research Institute | Oncolytic rhabdovirus |
| US9951117B2 (en) | 2010-09-02 | 2018-04-24 | Mayo Foundation For Medical Education And Research | Vesicular stomatitis viruses |
| WO2012031137A2 (en) * | 2010-09-02 | 2012-03-08 | Mayo Foundation For Medical Education And Research | Vesicular stomatitis viruses |
| ES2627529T3 (es) | 2011-06-08 | 2017-07-28 | Children's Hospital Of Eastern Ontario Research Institute Inc. | Composiciones para tratamiento de glioblastoma |
| WO2013050048A2 (en) | 2011-10-07 | 2013-04-11 | Skau Aps | Identification and attenuation of the immunosuppressive domains in fusion proteins of enveloped rna viruses |
| CA2901501C (en) | 2013-02-21 | 2023-03-07 | Children's Hospital Of Eastern Ontario Research Institute Inc. | Vaccine composition |
| EP3906931A3 (en) | 2013-04-10 | 2022-02-23 | iSD Immunotech ApS | Use of immune suppressive domains as medicaments |
| EP3008176B1 (en) | 2013-06-14 | 2019-08-07 | Turnstone Limited Partnership | Compositions and methods for enhancing virus replication |
| EP2826856B9 (en) * | 2013-07-16 | 2016-05-04 | Sia Latima | Genetically stable oncolytic RNA virus, method of manufacturing and use thereof |
| CN107076727B (zh) * | 2014-07-21 | 2019-11-01 | 诺威尔卢斯德克有限公司 | 用于确定患者特定突变的致癌指数的方法和系统 |
| CN105233285B (zh) * | 2015-09-06 | 2018-10-12 | 广州威溶特医药科技有限公司 | Epac直接或间接激动剂与溶瘤病毒的联合应用 |
| CN110636853B (zh) | 2017-05-19 | 2024-10-18 | 佐治亚州立大学研究基金会公司 | 重组溶瘤病毒 |
| US10610583B2 (en) | 2017-08-31 | 2020-04-07 | Regents Of The University Of Minnesota | Methods and compositions for treating glioma and medulloblastoma brain tumors using the zika virus |
| EP4446337A3 (en) | 2017-09-22 | 2025-01-08 | Centre National de la Recherche Scientifique | Mutated glycoprotein of vesicular stomatitis virus |
| CN110499297B (zh) * | 2019-08-29 | 2021-07-09 | 上海市公共卫生临床中心 | 一种新型溶瘤病毒及其制备方法和应用 |
| WO2022033469A1 (zh) * | 2020-08-14 | 2022-02-17 | 上海行深生物科技有限公司 | 重组溶瘤病毒及其构建方法和用途 |
| US20240299540A1 (en) | 2021-02-05 | 2024-09-12 | Iovance Biotherapeutics, Inc. | Adjuvant therapy for cancer |
| US20240218390A1 (en) | 2021-02-26 | 2024-07-04 | Kelonia Therapeutics, Inc. | Lymphocyte targeted lentiviral vectors |
| US20250101122A1 (en) | 2023-09-25 | 2025-03-27 | Kelonia Therapeutics, Inc. | Antigen binding polypeptides |
| US12403194B2 (en) | 2023-09-25 | 2025-09-02 | Kelonia Therapeutics, Inc. | Compositions for treating cancer |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1118403B (de) | 1960-01-27 | 1961-11-30 | Hoechst Ag | Verfahren zur Gewinnung von antitumorwirksamen Sporen |
| GB1069144A (en) | 1963-07-10 | 1967-05-17 | Merck & Co Inc | Method for the treatment of malignant tumors |
| US4806347A (en) | 1985-12-11 | 1989-02-21 | Schering Corporation | Interferon combinations |
| ES2188593T3 (es) * | 1992-03-24 | 2003-07-01 | United Cancer Res Inst | Vacuna que contiene un virus vivo. |
| GB9415320D0 (en) | 1994-07-29 | 1994-09-21 | Medical Res Council | Cancer treatment |
| US7153510B1 (en) * | 1995-05-04 | 2006-12-26 | Yale University | Recombinant vesiculoviruses and their uses |
| ATE241994T1 (de) | 1996-01-25 | 2003-06-15 | Univ Glasgow | Hsv-mutant-1716 zur behandlung von mesotheliomen |
| DE69837764T2 (de) * | 1997-07-11 | 2008-01-31 | Yale University, New Haven | Rhabdovirus mit gentechnisch veränderter hülle |
| CA2305269C (en) * | 1997-10-09 | 2012-07-03 | Pro-Virus, Inc. | Treatment of neoplasms with viruses |
| WO1999032648A1 (en) * | 1997-12-22 | 1999-07-01 | The University Of Tennessee Research Corporation | Recombinant rhabdovirus containing a heterologous fusion protein |
| AU3001799A (en) * | 1998-03-12 | 1999-09-27 | Trustees Of The University Of Pennsylvania, The | Producer cells for replication selective viruses in the treatment of malignancy |
| WO1999064570A1 (en) * | 1998-06-12 | 1999-12-16 | Mount Sinai School Of Medicine Of The City University Of New York | Novel methods and interferon deficient substrates for the propagation of viruses |
| CN1477964A (zh) * | 1999-04-15 | 2004-02-25 | 应用病毒治疗肿瘤 |
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- 2000-09-18 DE DE60041210T patent/DE60041210D1/de not_active Expired - Lifetime
- 2000-09-18 NZ NZ523805A patent/NZ523805A/en not_active IP Right Cessation
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| EP1218019A2 (en) | 2002-07-03 |
| AU7588200A (en) | 2001-04-17 |
| IL148621A (en) | 2010-02-17 |
| MXPA02002772A (es) | 2004-04-02 |
| JP5060694B2 (ja) | 2012-10-31 |
| DE60041210D1 (de) | 2009-02-05 |
| WO2001019380A3 (en) | 2001-11-22 |
| HK1044708B (en) | 2006-10-27 |
| DE60026554T2 (de) | 2006-09-28 |
| WO2001019380A2 (en) | 2001-03-22 |
| CA2386920A1 (en) | 2001-03-22 |
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| EP1716858A2 (en) | 2006-11-02 |
| JP2004525855A (ja) | 2004-08-26 |
| EP1716858B9 (en) | 2009-08-12 |
| CA2386920C (en) | 2012-01-24 |
| EP1218019B1 (en) | 2006-03-08 |
| NZ523805A (en) | 2004-09-24 |
| NZ534307A (en) | 2005-07-29 |
| CN1496268A (zh) | 2004-05-12 |
| HK1044708A1 (en) | 2002-11-01 |
| DE60026554D1 (de) | 2006-05-04 |
| AU782402B2 (en) | 2005-07-28 |
| ATE319460T1 (de) | 2006-03-15 |
| EP1716858B1 (en) | 2008-12-24 |
| CN1289098C (zh) | 2006-12-13 |
| ES2260057T3 (es) | 2006-11-01 |
| NZ517573A (en) | 2004-02-27 |
| EP1716858A3 (en) | 2007-08-15 |
| IL148621A0 (en) | 2002-09-12 |
| ATE418341T1 (de) | 2009-01-15 |
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