ES2314446T3 - Derivados de tetrahidrocarbazol y su uso farmaceutico. - Google Patents

Derivados de tetrahidrocarbazol y su uso farmaceutico. Download PDF

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Publication number
ES2314446T3
ES2314446T3 ES04776279T ES04776279T ES2314446T3 ES 2314446 T3 ES2314446 T3 ES 2314446T3 ES 04776279 T ES04776279 T ES 04776279T ES 04776279 T ES04776279 T ES 04776279T ES 2314446 T3 ES2314446 T3 ES 2314446T3
Authority
ES
Spain
Prior art keywords
tetrahydro
carbazol
amine
bromo
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES04776279T
Other languages
English (en)
Spanish (es)
Inventor
Sharon Davis Boggs
Kristjan S. Gudmundsson
Leah D'aurora Richardson
Paul Richard Sebahar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Application granted granted Critical
Publication of ES2314446T3 publication Critical patent/ES2314446T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
ES04776279T 2003-06-10 2004-06-07 Derivados de tetrahidrocarbazol y su uso farmaceutico. Expired - Lifetime ES2314446T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US47725103P 2003-06-10 2003-06-10
US477251P 2003-06-10
US49782303P 2003-08-26 2003-08-26
US497823P 2003-08-26

Publications (1)

Publication Number Publication Date
ES2314446T3 true ES2314446T3 (es) 2009-03-16

Family

ID=33555453

Family Applications (1)

Application Number Title Priority Date Filing Date
ES04776279T Expired - Lifetime ES2314446T3 (es) 2003-06-10 2004-06-07 Derivados de tetrahidrocarbazol y su uso farmaceutico.

Country Status (16)

Country Link
US (1) US7351733B2 (enExample)
EP (1) EP1654228B1 (enExample)
JP (1) JP2007501284A (enExample)
KR (1) KR20060017545A (enExample)
AT (1) ATE411981T1 (enExample)
AU (1) AU2004247676A1 (enExample)
BR (1) BRPI0411085A (enExample)
CA (1) CA2528321A1 (enExample)
CO (1) CO5660287A2 (enExample)
DE (1) DE602004017326D1 (enExample)
ES (1) ES2314446T3 (enExample)
IL (1) IL171974A0 (enExample)
MA (1) MA27880A1 (enExample)
NO (1) NO20055741L (enExample)
RU (1) RU2318810C2 (enExample)
WO (1) WO2004110999A1 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602004019541D1 (de) 2003-08-26 2009-04-02 Smithkline Beecham Corp Cycloalkyläbü kondensierte indole
US8076352B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Administration of carboline derivatives useful in the treatment of cancer and other diseases
US7767689B2 (en) 2004-03-15 2010-08-03 Ptc Therapeutics, Inc. Carboline derivatives useful in the treatment of cancer
SG184755A1 (en) 2004-03-15 2012-10-30 Ptc Therapeutics Inc Carboline derivatives useful in the inhibition of angiogenesis
US8076353B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Inhibition of VEGF translation
WO2006012310A2 (en) * 2004-06-25 2006-02-02 Genzyme Corporation Carbazole derivatives for treating polycystic kidney disease
EP1824476A2 (en) * 2004-11-22 2007-08-29 SmithKline Beecham Corporation Tetrahydrocarbazole derivatives for treating flaviridae viruses
JP2008520742A (ja) * 2004-11-23 2008-06-19 ピーティーシー セラピューティクス， インコーポレイテッド Ｖｅｇｆ産生の阻害に有用なカルバゾール誘導体、カルボリン誘導体およびインドール誘導体
WO2007002051A1 (en) * 2005-06-22 2007-01-04 Smithkline Beecham Corporation Carboline derivatives and their use as inhibitors of flaviviridae infections
WO2013139929A1 (en) * 2012-03-22 2013-09-26 Ludwig-Maximilians-Universität München Novel means and methods for treating diseases of the central nervous system, metabolic and cardiac diseases and aging
JP6653573B2 (ja) 2012-05-22 2020-02-26 トラスティーズ・オブ・ダートマウス・カレッジ シクロアルカニル［ｂ］インドール、シクロアルカニル［ｂ］ベンゾフラン、シクロアルカニル［ｂ］ベンゾチオフェンを合成するための方法、化合物および使用の方法
EP2690091A1 (en) 2012-07-25 2014-01-29 Studiengesellschaft Kohle mbH Process for preparing substituted indole derivatives
KR101671484B1 (ko) 2016-07-21 2016-11-01 김정환 오셀타미비르(Oseltamivir)를 포함하는 인유두종 바이러스 치료용 약학적 조성물
US10882821B1 (en) 2017-09-26 2021-01-05 The Board Of Trustees Of The Leland Stanford Junior University Enantiomeric compound for the reduction of the deleterious activity of extended nucleotide repeat containing genes
WO2021183980A1 (en) * 2020-03-13 2021-09-16 Fmc Corporation Substituted pyrimidines and triazines as herbicides
CN113995758B (zh) * 2021-11-04 2023-06-02 中山大学 咔唑-嘧啶衍生物在制备治疗抗肿瘤药物中的应用
KR20240075403A (ko) 2022-11-22 2024-05-29 이경엽 알칼로이드 함유 인유두종 바이러스 감염의 예방 또는 치료용 조성물
KR20240075422A (ko) 2022-11-22 2024-05-29 이경엽 인유두종 바이러스 감염에 의한 후두유두종의 예방 또는 치료용 조성물

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE507797C (de) * 1927-05-14 1930-09-20 I G Farbenindustrie Akt Ges Verfahren zur Herstellung von 1-Aminocarbazol und seinen Derivaten
GB8924392D0 (en) * 1989-10-30 1989-12-20 Bayer Ag Substituted cycloalkano/b/dihydroindole-and-indolesulphonamides
GB9008108D0 (en) * 1990-04-10 1990-06-06 Bayer Ag Cycloalkano(b)dihydroindoles and-indolesulphonamides substituted by heterocycles
US5100891A (en) 1991-01-18 1992-03-31 Hoechst-Roussel Pharmaceuticals Inc. Substituted 1,2,3,4-tetrahydrocyclopent[b]indoles, 1,2,3,3a,4,8a-hexahydrocyclopent[B]indoles and related compounds
CA2106642C (en) * 1992-10-14 2005-08-16 Peter Bod Carbazolone derivatives and process for preparing the same
JP2950433B2 (ja) * 1995-07-10 1999-09-20 インターナシヨナル・ビジネス・マシーンズ・コーポレーシヨン バッテリ収納装置
GB0015904D0 (en) * 2000-06-28 2000-08-23 Hoffmann La Roche Inhibitors of HPV E1 helicase enzyme
DE10164564B4 (de) * 2001-12-14 2007-05-16 Zentaris Gmbh Tetrahydrocarbazolderivate als Liganden für G-Protein gekoppelte Rezeptoren (GPCR)
CA2468880A1 (en) * 2001-12-14 2003-06-26 Zentaris Gmbh Tetrahydrocarbazole derivatives as ligands for g-protein coupled receptors (gpcr)

Also Published As

Publication number Publication date
US7351733B2 (en) 2008-04-01
ATE411981T1 (de) 2008-11-15
AU2004247676A1 (en) 2004-12-23
RU2005138124A (ru) 2006-07-10
NO20055741D0 (no) 2005-12-05
WO2004110999A1 (en) 2004-12-23
EP1654228B1 (en) 2008-10-22
KR20060017545A (ko) 2006-02-23
US20060161002A1 (en) 2006-07-20
DE602004017326D1 (de) 2008-12-04
BRPI0411085A (pt) 2006-07-25
RU2318810C2 (ru) 2008-03-10
IL171974A0 (en) 2006-04-10
JP2007501284A (ja) 2007-01-25
MA27880A1 (fr) 2006-05-02
EP1654228A1 (en) 2006-05-10
NO20055741L (no) 2006-01-06
CO5660287A2 (es) 2006-07-31
CA2528321A1 (en) 2004-12-23

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