ES2290337T3 - Metodos para aumentar los niveles de expresion del receptor tnf humano. - Google Patents

Metodos para aumentar los niveles de expresion del receptor tnf humano. Download PDF

Info

Publication number
ES2290337T3
ES2290337T3 ES02777356T ES02777356T ES2290337T3 ES 2290337 T3 ES2290337 T3 ES 2290337T3 ES 02777356 T ES02777356 T ES 02777356T ES 02777356 T ES02777356 T ES 02777356T ES 2290337 T3 ES2290337 T3 ES 2290337T3
Authority
ES
Spain
Prior art keywords
tnfred
proline
mutant
cells
expression
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES02777356T
Other languages
English (en)
Spanish (es)
Inventor
William Brondyk
Xuliang Jiang
Rene Lynn Schweickhardt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Serono SA
Serono Laboratories UK Ltd
Original Assignee
Laboratoires Serono SA
Serono Laboratories UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Serono SA, Serono Laboratories UK Ltd filed Critical Laboratoires Serono SA
Application granted granted Critical
Publication of ES2290337T3 publication Critical patent/ES2290337T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/02Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7151Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00Peptide or protein sequence
    • Y10S930/01Peptide or protein sequence
    • Y10S930/14Lymphokine; related peptides
    • Y10S930/144Tumor necrosis factor

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Saccharide Compounds (AREA)
ES02777356T 2001-11-30 2002-11-21 Metodos para aumentar los niveles de expresion del receptor tnf humano. Expired - Lifetime ES2290337T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34064801P 2001-11-30 2001-11-30
US340648P 2001-11-30

Publications (1)

Publication Number Publication Date
ES2290337T3 true ES2290337T3 (es) 2008-02-16

Family

ID=23334343

Family Applications (1)

Application Number Title Priority Date Filing Date
ES02777356T Expired - Lifetime ES2290337T3 (es) 2001-11-30 2002-11-21 Metodos para aumentar los niveles de expresion del receptor tnf humano.

Country Status (12)

Country Link
US (2) US7258997B2 (https=)
EP (1) EP1448772B1 (https=)
JP (1) JP2005535281A (https=)
AT (1) ATE367438T1 (https=)
AU (1) AU2002338947B2 (https=)
CA (1) CA2466298A1 (https=)
DE (1) DE60221273D1 (https=)
DK (1) DK1448772T3 (https=)
ES (1) ES2290337T3 (https=)
IL (1) IL162133A0 (https=)
PT (1) PT1448772E (https=)
WO (1) WO2003046160A2 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002338947B2 (en) * 2001-11-30 2007-09-13 Laboratoires Serono Sa Methods of increasing protein expression levels
US20070099266A1 (en) * 2003-12-23 2007-05-03 Applied Research Systems Ars Holding N.V. Process for the production of tumor necrosis factor-binding proteins
US8722348B2 (en) 2008-05-28 2014-05-13 Wayne State University Method and composition for a protein transduction technology and its applications
PL2705143T3 (pl) 2011-05-02 2021-07-19 Wayne State University Technologia indukowanych białkiem komórek pluripotencjalnych, jej zastosowania
CA2934065C (en) 2013-10-25 2023-05-09 Qurgen, Inc. Methods, systems and compositions relating to cell conversion via protein-induced in-vivo cell reprogramming
KR20220056847A (ko) * 2019-06-21 2022-05-06 커날 바이오로직스, 인크. 조작된 종양선택적 단백질 발현
EP4100038A4 (en) * 2020-02-03 2024-02-28 Premas Biotech Private Limited RECOMBINANT EXPRESSION PLATFORM, CONSTRUCTS AND METHODS FOR EXPRESSING HARD-TO-EXPRESS PROTEINS (DTE-PS)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0393438T3 (da) * 1989-04-21 2005-05-30 Amgen Inc TNF-receptor, TNF-bindende proteiner og DNAér, der koder herfor
WO1993010755A1 (en) * 1991-11-25 1993-06-10 Richardson-Vicks, Inc. Compositions for regulating skin wrinkles and/or skin atrophy
IL107268A0 (en) * 1993-10-12 1994-01-25 Yeda Res & Dev Molecules influencing the shedding of the tnf receptor, their preparation and their use
EP1390497A2 (en) * 2001-05-25 2004-02-25 Genset Human cdnas and proteins and uses thereof
AU2002338947B2 (en) * 2001-11-30 2007-09-13 Laboratoires Serono Sa Methods of increasing protein expression levels

Also Published As

Publication number Publication date
DE60221273D1 (de) 2007-08-30
US7258997B2 (en) 2007-08-21
WO2003046160A2 (en) 2003-06-05
US20080014635A1 (en) 2008-01-17
AU2002338947A1 (en) 2003-06-10
DK1448772T3 (da) 2007-11-19
EP1448772B1 (en) 2007-07-18
AU2002338947B2 (en) 2007-09-13
EP1448772A2 (en) 2004-08-25
ATE367438T1 (de) 2007-08-15
IL162133A0 (en) 2005-11-20
WO2003046160A3 (en) 2003-07-31
PT1448772E (pt) 2007-10-02
US20050074840A1 (en) 2005-04-07
JP2005535281A (ja) 2005-11-24
CA2466298A1 (en) 2003-06-05

Similar Documents

Publication Publication Date Title
Cornish et al. Site-specific incorporation of biophysical probes into proteins.
US20210284698A1 (en) Stabilized soluble pre-fusion rsv f polypeptides
ES2280857T3 (es) Replegado de polipeptidos.
Hovgaard et al. Pharmaceutical formulation development of peptides and proteins
JP4972191B2 (ja) ペプチド、蛋白質及びペプチドミメティック合成のための方法及び組成物
US20080286834A1 (en) Leader Sequences For Directing Secretion of Polypeptides and Methods For Production Thereof
JP2003501035A (ja) 安定性に関して改変されたサイトカイン
JP2008500816A (ja) 改善された性質を有するbmp−7変異体
CN108884154A (zh) 具有独特剪接活性的断裂内含肽
EP0238101A1 (en) Microbial expression of interleukin II
CN108912221A (zh) 用于生产重组融合蛋白的辅助蛋白、编码基因、重组融合蛋白、重组表达载体及制备方法
EP4071178A1 (en) Method for producing peptide having physiological activity, and peptide comprising short linker
ES2290337T3 (es) Metodos para aumentar los niveles de expresion del receptor tnf humano.
ES2942024T3 (es) Métodos para caracterizar enlaces disulfuro
JP2004531225A5 (https=)
KR20130020206A (ko) 수용성 bmp-2를 생산하는 재조합 대장균 및 이를 이용한 수용성 bmp-2의 제조방법
Tran et al. Evaluation of efficient non-reducing enzymatic and chemical ligation strategies for complex disulfide-rich peptides
ES2620410T3 (es) Selección de células que expresan polipéptidos heterómeros
IL192096A (en) Nucleic acid encoding fsh mutant, its preparation and pharmaceutical compositions containing it
ES2389835T3 (es) Glicoproteínas mutantes
CN103709253A (zh) 一种生物合成制备glp-1及其类似物的方法
CN112375741A (zh) 一种高表达sars-cov2-rbd的细胞株及其方法
RU2858871C1 (ru) Плазмиды для экспрессии рекомбинантного агониста рецептора глюкагоноподобного пептида-1 человека, слитого с кристаллизуемым фрагментом иммуноглобулина человека (дулаглутида), моноклональная линия клеток млекопитающих - продуцент дулаглутида, способ получения дулаглутида
RU2834784C1 (ru) Плазмида для экспрессии рекомбинантного хорионического гонадотропина человека (ХГЧ), плазмида для экспрессии рекомбинантных альфа- и бета-субъединиц ХГЧ, моноклональная линия клеток млекопитающих - продуцент ХГЧ, способ получения рекомбинантного ХГЧ
US9006393B1 (en) Molecular constructs and uses thereof in ribosomal translational events