ES2288946T3 - Aumento y abultamiento de tejido blando y hueso utilizando celulas progenitoras derivadas de musculo, sus composiciones y tratamientos. - Google Patents

Aumento y abultamiento de tejido blando y hueso utilizando celulas progenitoras derivadas de musculo, sus composiciones y tratamientos. Download PDF

Info

Publication number
ES2288946T3
ES2288946T3 ES01924998T ES01924998T ES2288946T3 ES 2288946 T3 ES2288946 T3 ES 2288946T3 ES 01924998 T ES01924998 T ES 01924998T ES 01924998 T ES01924998 T ES 01924998T ES 2288946 T3 ES2288946 T3 ES 2288946T3
Authority
ES
Spain
Prior art keywords
tissue
muscle
cells
mdc
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES01924998T
Other languages
English (en)
Spanish (es)
Inventor
Michael B. Chancellor
Johnny Huard
Christopher C. Capelli
Zhuqing Qu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Pittsburgh
Original Assignee
University of Pittsburgh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24195003&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2288946(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US09/549,937 external-priority patent/US7115417B1/en
Application filed by University of Pittsburgh filed Critical University of Pittsburgh
Application granted granted Critical
Publication of ES2288946T3 publication Critical patent/ES2288946T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/34—Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0658—Skeletal muscle cells, e.g. myocytes, myotubes, myoblasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0658—Skeletal muscle cells, e.g. myocytes, myotubes, myoblasts
    • C12N5/0659—Satellite cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/70—Undefined extracts
    • C12N2500/80—Undefined extracts from animals
    • C12N2500/84—Undefined extracts from animals from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Rheumatology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Neurology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
ES01924998T 2000-04-14 2001-04-12 Aumento y abultamiento de tejido blando y hueso utilizando celulas progenitoras derivadas de musculo, sus composiciones y tratamientos. Expired - Lifetime ES2288946T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US549937 2000-04-14
US09/549,937 US7115417B1 (en) 1998-05-01 2000-04-14 Soft tissue and bone augmentation and bulking utilizing muscle-derived progenito compositions, and treatments thereof

Publications (1)

Publication Number Publication Date
ES2288946T3 true ES2288946T3 (es) 2008-02-01

Family

ID=24195003

Family Applications (1)

Application Number Title Priority Date Filing Date
ES01924998T Expired - Lifetime ES2288946T3 (es) 2000-04-14 2001-04-12 Aumento y abultamiento de tejido blando y hueso utilizando celulas progenitoras derivadas de musculo, sus composiciones y tratamientos.

Country Status (13)

Country Link
US (3) US9499791B2 (OSRAM)
EP (1) EP1272204B1 (OSRAM)
JP (2) JP5684963B2 (OSRAM)
AT (1) ATE365045T1 (OSRAM)
AU (2) AU2001251599B2 (OSRAM)
CA (1) CA2406393C (OSRAM)
CY (1) CY1108090T1 (OSRAM)
DE (1) DE60129007T2 (OSRAM)
DK (1) DK1272204T3 (OSRAM)
ES (1) ES2288946T3 (OSRAM)
HK (1) HK1052645B (OSRAM)
PT (1) PT1272204E (OSRAM)
WO (1) WO2001078754A2 (OSRAM)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6485723B1 (en) 1995-02-10 2002-11-26 Purdue Research Foundation Enhanced submucosal tissue graft constructs
US8211423B2 (en) * 2006-11-28 2012-07-03 University Of Pittsburgh Muscle derived cells for the treatment of cardiac pathologies and methods of making and using the same
US6866842B1 (en) 1998-05-01 2005-03-15 University Of Pittsburgh Muscle-derived cells (MDCs) for treating muscle-or bone-related injury or dysfunction
US7115417B1 (en) 1998-05-01 2006-10-03 Chancellor Michael B Soft tissue and bone augmentation and bulking utilizing muscle-derived progenito compositions, and treatments thereof
DK1272204T3 (da) 2000-04-14 2007-09-10 Univ Pittsburgh Forstærkning og bulking af blödt væv og knoglevæv under anvendelse af muskelafledte progenitorceller, præparater deraf og behandling dermed
EP1372398B1 (en) 2001-02-23 2013-07-10 The University of Pittsburgh Rapid preparation of stem cell matrices for use in tissue and organ treatement and repair
US20030082153A1 (en) * 2001-10-22 2003-05-01 The Government Of The United States Of America Stem cells that transform to beating cardiomyocytes
AU2003234317B2 (en) 2002-05-02 2009-04-09 Purdue Research Foundation Vascularization enhanced graft constructs
WO2003092381A1 (en) 2002-05-02 2003-11-13 Purdue Research Foundation Vascularization enhanced graft constructs
WO2003092471A2 (en) 2002-05-02 2003-11-13 Cook Biotech Incorporated Cell-seeded extracellular matrix grafts
CA2483913C (en) 2002-05-02 2014-07-15 Purdue Research Foundation Vascularization enhanced graft constructs comprising basement membrane
CA2484265C (en) * 2002-05-06 2012-08-07 Becton, Dickinson And Company Method and device for controlling drug pharmacokinetics
WO2004017972A1 (en) * 2002-08-23 2004-03-04 Law Peter K Biologic skin repair and enhancement
CN1812800B (zh) * 2003-04-25 2013-01-16 匹兹堡大学 用于促进和增强神经修复和再生的肌肉来源的细胞(mdc)
EP1691852A2 (en) 2003-11-10 2006-08-23 Angiotech International AG Medical implants and fibrosis-inducing agents
WO2005070328A1 (en) 2004-01-09 2005-08-04 Regeneration Technologies, Inc. Muscle-based grafts/implants
US7001430B2 (en) 2004-01-09 2006-02-21 Regeneration Technologies, Inc. Matrix composition for human grafts/implants
WO2005070439A1 (en) * 2004-01-09 2005-08-04 Regeneration Technologies Inc. Implant comprising a human muscle tissue matrix
DE602006014534D1 (de) * 2005-05-30 2010-07-08 Commw Scient Ind Res Org Herstellung und verwendung von basalmembranpartikeln
US20070065415A1 (en) * 2005-09-16 2007-03-22 Kleinsek Donald A Compositions and methods for the augmentation and repair of defects in tissue
US7815923B2 (en) 2005-12-29 2010-10-19 Cook Biotech Incorporated Implantable graft material
US9121009B2 (en) 2006-12-18 2015-09-01 University of Pittsburgh—Of the Commonweath System of Higher Education Muscle derived cells for the treatment of gastro-esophageal pathologies and methods of making and using the same
US20100158875A1 (en) 2006-12-18 2010-06-24 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Muscle derived cells for the treatment of gastro-esophageal pathologies and methods of making and using the same
WO2008086040A1 (en) 2007-01-11 2008-07-17 University Of Pittsburgh Muscle derived cells for the treatment of urinary tract pathologies and methods of making and using the same
ATE554160T1 (de) * 2007-05-29 2012-05-15 Univ Pittsburgh Knochenaufbau anhand von vorläuferzusammensetzungen aus muskeln und behandlungen damit
EP2209482A4 (en) * 2007-10-04 2016-06-01 Univ Pittsburgh SKELETAL MUSCLE REINFORCEMENT WITH MUSCLE PRESERVATORY COMPOSITIONS AND TREATMENTS THEREOF
CA2734858C (en) 2008-08-18 2019-01-15 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Bone augmentation utilizing muscle-derived progenitor compositions in biocompatible matrix, and treatments thereof
US20130123647A1 (en) 2011-05-03 2013-05-16 The Research Foundation Of State University Of New York Methods Useful in Optimizing the Treatment of Neuropathies and Targeting Tissues with Cosmetic Botulinum Injections
US9878071B2 (en) 2013-10-16 2018-01-30 Purdue Research Foundation Collagen compositions and methods of use
EP3185922B1 (en) 2014-08-27 2025-04-02 Purdue Research Foundation Collagen-based therapeutic delivery systems
WO2016172365A1 (en) 2015-04-21 2016-10-27 Purdue Research Foundation Office Of Technology Commercialization Cell-collagen-silica composites and methods of making and using the same
CN110446500B (zh) 2017-01-31 2024-11-26 格尼菲斯公司 用于基质制备的方法和组合物
US11739291B2 (en) 2017-04-25 2023-08-29 Purdue Research Foundation 3-dimensional (3D) tissue-engineered muscle for tissue restoration
CA3085483A1 (en) 2017-12-14 2019-06-20 Innovacell Biotechnologie Ag Methods for obtaining muscle derived cells
DK3942020T3 (da) 2019-03-22 2024-07-15 Innovacell Gmbh Metoder til opnåelse af inducerede gladte muskelceller
EP3778875A1 (en) * 2019-08-14 2021-02-17 MaxiVax SA Immortalized myoblast cell lines and uses thereof
EP4096635A4 (en) 2020-01-27 2024-02-21 GeniPhys, Inc. BIOLOGICAL FILLER FOR TISSUE RESTORATION AND REGENERATION
CN119894553A (zh) 2022-09-02 2025-04-25 苏黎世大学 注射装置
EP4622706A1 (en) 2022-11-21 2025-10-01 Ecole Polytechnique Fédérale de Lausanne (EPFL) System for control of spasticity
EP4627056A1 (en) 2022-12-01 2025-10-08 Universität Zürich Method of preparing a mass culture of muscle precursor cells (mpcs) and uses thereof
JP2025041170A (ja) * 2023-09-13 2025-03-26 昌毅 本田 肛門狭窄化治療法

Family Cites Families (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4424208A (en) 1982-01-11 1984-01-03 Collagen Corporation Collagen implant material and method for augmenting soft tissue
US4851521A (en) 1985-07-08 1989-07-25 Fidia, S.P.A. Esters of hyaluronic acid
US5902741A (en) * 1986-04-18 1999-05-11 Advanced Tissue Sciences, Inc. Three-dimensional cartilage cultures
US5863531A (en) * 1986-04-18 1999-01-26 Advanced Tissue Sciences, Inc. In vitro preparation of tubular tissue structures by stromal cell culture on a three-dimensional framework
US5266480A (en) * 1986-04-18 1993-11-30 Advanced Tissue Sciences, Inc. Three-dimensional skin culture system
US5510254A (en) * 1986-04-18 1996-04-23 Advanced Tissue Sciences, Inc. Three dimensional cell and tissue culture system
US5053050A (en) * 1988-04-29 1991-10-01 Samuel Itay Compositions for repair of cartilage and bone
US5130141A (en) * 1988-05-24 1992-07-14 Law Peter K Compositions for and methods of treating muscle degeneration and weakness
US5082670A (en) * 1988-12-15 1992-01-21 The Regents Of The University Of California Method of grafting genetically modified cells to treat defects, disease or damage or the central nervous system
US5045601A (en) * 1989-06-13 1991-09-03 Biointerface Technologies, Inc. Pressure-sensitive adhesive compositions suitable for medical uses
US5538722A (en) 1989-06-13 1996-07-23 Stanford University Isolation, growth, differentiation and genetic engineering of human muscle cells
EP0502081B1 (en) 1989-11-24 1996-05-22 Monash University Proliferative action of leukaemia inhibitory factor on satellite cells
US5206028A (en) * 1991-02-11 1993-04-27 Li Shu Tung Dense collagen membrane matrices for medical uses
US6497872B1 (en) * 1991-07-08 2002-12-24 Neurospheres Holdings Ltd. Neural transplantation using proliferated multipotent neural stem cells and their progeny
JP3004724B2 (ja) * 1992-04-06 2000-01-31 ユーロプラスティ インコーポレイテッド ミクロ粒子注入による逆流障害の処置
FI951239A7 (fi) 1992-09-28 1995-03-16 Brown Univ Research Foundation Kitosaanimatriisit kapseloituja soluja varten
EP0784487A1 (en) 1993-03-19 1997-07-23 Medinvent A composition and a method for tissue augmentation
US5709854A (en) * 1993-04-30 1998-01-20 Massachusetts Institute Of Technology Tissue formation by injecting a cell-polymeric solution that gels in vivo
US6001654A (en) * 1994-01-28 1999-12-14 California Institute Of Technology Methods for differentiating neural stem cells to neurons or smooth muscle cells using TGT-β super family growth factors
US5656478A (en) * 1994-02-25 1997-08-12 The Regents Of The University Of California Smooth muscle tissue formation in vivo using cultured smooth muscle cells combined with an extracellular matrix
US6174333B1 (en) * 1994-06-06 2001-01-16 Osiris Therapeutics, Inc. Biomatrix for soft tissue regeneration using mesenchymal stem cells
US5516532A (en) * 1994-08-05 1996-05-14 Children's Medical Center Corporation Injectable non-immunogenic cartilage and bone preparation
US5594032A (en) * 1994-11-10 1997-01-14 Gonzalez-Cadavid; Nestor F. Amelioration of human erectile dysfunction by treatment with iNOS, inducers of iNOS or iNOS cDNA
CA2183167A1 (en) 1994-12-13 1996-06-20 Peter K. Law Myoblast therapy for mammalian diseases
US7141072B2 (en) * 1998-10-05 2006-11-28 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Method for promoting regeneration of surface cartilage in a damaged joint using multi-layer covering
US5833978A (en) * 1995-03-16 1998-11-10 Universite Laval Method of in vitro preconditioning healthy donor's myoblasts before transplantation thereof in compatible patients suffering of recessive myopathies like muscular dystrophy, for improving transplantation success
US5733337A (en) * 1995-04-07 1998-03-31 Organogenesis, Inc. Tissue repair fabric
US6121042A (en) * 1995-04-27 2000-09-19 Advanced Tissue Sciences, Inc. Apparatus and method for simulating in vivo conditions while seeding and culturing three-dimensional tissue constructs
US5855610A (en) * 1995-05-19 1999-01-05 Children's Medical Center Corporation Engineering of strong, pliable tissues
WO1996039035A1 (en) * 1995-06-06 1996-12-12 Case Western Reserve University Myogenic differentiation of human mesenchymal stem cells
US5591444A (en) 1995-07-28 1997-01-07 Isolagen Technologies, Inc. Use of autologous dermal fibroblasts for the repair of skin and soft tissue defects
US5869041A (en) * 1996-01-12 1999-02-09 The Miriam Hospital Delivery of bioactive compounds to an organism
US6200606B1 (en) * 1996-01-16 2001-03-13 Depuy Orthopaedics, Inc. Isolation of precursor cells from hematopoietic and nonhematopoietic tissues and their use in vivo bone and cartilage regeneration
US5858351A (en) * 1996-01-18 1999-01-12 Avigen, Inc. Methods for delivering DNA to muscle cells using recombinant adeno-associated virus vectors
US5876447A (en) 1996-02-14 1999-03-02 Implantech Associates Silicone implant for facial plastic surgery
US5842477A (en) * 1996-02-21 1998-12-01 Advanced Tissue Sciences, Inc. Method for repairing cartilage
US6299905B1 (en) * 1996-04-16 2001-10-09 Depuy Orthopaedics, Inc. Bioerodable polymeric adhesives for tissue repair
US5895745A (en) * 1996-09-25 1999-04-20 W.R. Grace & Co.-Conn. Method of thawing cryopreserved cells
US6150338A (en) 1997-02-13 2000-11-21 Albert Einstein College Of Medicine Of Yeshiva University Gene therapy for alleviating erectile dysfunction
US6337184B1 (en) * 1997-04-01 2002-01-08 Jeffrey B. Miller Molecular marker for muscle stem cells
US6110459A (en) 1997-05-28 2000-08-29 Mickle; Donald A. G. Transplants for myocardial scars and methods and cellular preparations
US6099832A (en) * 1997-05-28 2000-08-08 Genzyme Corporation Transplants for myocardial scars
US20020068048A1 (en) * 1997-09-05 2002-06-06 Patrick A. Dreyfus Method for the treatment or diagnosis of human pathologies with disseminated or difficult to access cells or tissues
US6171340B1 (en) * 1998-02-27 2001-01-09 Mcdowell Charles L. Method and device for regenerating cartilage in articulating joints
CA2322954C (en) * 1998-03-06 2011-06-07 Biosepra Inc. Implantable particles for tissue bulking and the treatment of gastroesophageal reflux disease, urinary incontinence, and skin wrinkles
US6355239B1 (en) * 1998-03-13 2002-03-12 Osiris Therapeutics, Inc. Uses for non-autologous mesenchymal stem cells
DE69929681T2 (de) 1998-03-18 2006-10-26 Osiris Therapeutics, Inc. Mesenchymale stammzellen für die prävention und behandlung von immunantworten bei transplantationen
US7115417B1 (en) * 1998-05-01 2006-10-03 Chancellor Michael B Soft tissue and bone augmentation and bulking utilizing muscle-derived progenito compositions, and treatments thereof
US8211423B2 (en) * 2006-11-28 2012-07-03 University Of Pittsburgh Muscle derived cells for the treatment of cardiac pathologies and methods of making and using the same
ES2319660T3 (es) 1998-05-01 2009-05-11 University Of Pittsburgh Uso de mioblastos en la fabricacion de un medicamento para tratar la incontinencia urinaria de esfuerzo.
US6866842B1 (en) * 1998-05-01 2005-03-15 University Of Pittsburgh Muscle-derived cells (MDCs) for treating muscle-or bone-related injury or dysfunction
AU3697899A (en) 1998-05-05 1999-11-23 Institut Fur Diagnostikforschung Gmbh An Der Freien Universitat Berlin Diagnostic agent for mr diagnosis
MXPA00012061A (es) * 1998-06-05 2003-04-22 Organogenesis Inc Protesis de injerto vascular biodisenadas.
US6190893B1 (en) 1998-09-18 2001-02-20 Massachusetts Institute Of Technology Electroactive materials for stimulation of biological activity of bone marrow stromal cells
AU1626500A (en) 1998-11-16 2000-06-05 Osiris Therapeutics, Inc. Alginate layer system for chondrogenic differentiation of human mesenchymal stemcells
JP2000287683A (ja) 1999-04-08 2000-10-17 Frontier:Kk ニューロン生存活性を有する筋由来成分およびｒｎａ
US6328762B1 (en) * 1999-04-27 2001-12-11 Sulzer Biologics, Inc. Prosthetic grafts
US6306424B1 (en) * 1999-06-30 2001-10-23 Ethicon, Inc. Foam composite for the repair or regeneration of tissue
WO2001019966A2 (en) 1999-09-14 2001-03-22 Children's Medical Center Corporation, The Isolation of muscle-derived stem cells and uses therefor
DE60035894T2 (de) * 1999-12-03 2008-04-17 The University Of Leeds Wiederherstellung von beschädigtem gewebe
US6368859B1 (en) * 1999-12-29 2002-04-09 Children's Medical Center Corporation Methods and compositions for producing a fascial sling
AU2006202380B2 (en) 2000-04-14 2007-06-21 University Of Pittsburgh Soft tissue and bone augmentation and bulking utilizing muscle-derived progenitor cells, compositions and treatments thereof
DK1272204T3 (da) 2000-04-14 2007-09-10 Univ Pittsburgh Forstærkning og bulking af blödt væv og knoglevæv under anvendelse af muskelafledte progenitorceller, præparater deraf og behandling dermed
CN1313080C (zh) * 2000-04-20 2007-05-02 斯凯伊药品加拿大公司 改进的水不溶性药物粒子的制备方法
FR2810045B1 (fr) * 2000-06-07 2004-09-03 Assist Publ Hopitaux De Paris Procede d'obtention de population cellulaires caracterisees d'origine musculaire et utilisations
WO2002056796A1 (en) * 2000-12-01 2002-07-25 Nephros Therapeutics, Inc. Intravascular blood conditioning device and use thereof
EP1372398B1 (en) * 2001-02-23 2013-07-10 The University of Pittsburgh Rapid preparation of stem cell matrices for use in tissue and organ treatement and repair
CA2338124C (en) 2001-02-26 2010-08-03 Valerie Dumont Dicianna Self-tanning composition in sheeted substrate
CA2443993A1 (en) 2001-04-13 2002-10-24 Anterogen Co., Ltd. Methods and reagents for cell transplantation
US20050281788A1 (en) 2002-07-30 2005-12-22 Cosimo De Bari Compositions comprising muscle progenitor cells and uses thereof
CN1812800B (zh) 2003-04-25 2013-01-16 匹兹堡大学 用于促进和增强神经修复和再生的肌肉来源的细胞(mdc)
CA2577447C (en) * 2004-08-16 2017-08-01 Cellresearch Corporation Pte Ltd Isolation of stem/progenitor cells from amniotic membrane of umbilical cord
JP2008545008A (ja) * 2005-06-30 2008-12-11 プロシディオン・リミテッド Ｇｐｃｒアゴニスト
US9121009B2 (en) * 2006-12-18 2015-09-01 University of Pittsburgh—Of the Commonweath System of Higher Education Muscle derived cells for the treatment of gastro-esophageal pathologies and methods of making and using the same
WO2008086040A1 (en) 2007-01-11 2008-07-17 University Of Pittsburgh Muscle derived cells for the treatment of urinary tract pathologies and methods of making and using the same
TW200902007A (en) 2007-05-25 2009-01-16 Astrazeneca Ab Spirocyclopropyl piperidine derivatives
ATE554160T1 (de) 2007-05-29 2012-05-15 Univ Pittsburgh Knochenaufbau anhand von vorläuferzusammensetzungen aus muskeln und behandlungen damit
CA2734858C (en) 2008-08-18 2019-01-15 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Bone augmentation utilizing muscle-derived progenitor compositions in biocompatible matrix, and treatments thereof

Also Published As

Publication number Publication date
AU5159901A (en) 2001-10-30
US20160303169A9 (en) 2016-10-20
DE60129007T2 (de) 2008-02-28
ATE365045T1 (de) 2007-07-15
US9499791B2 (en) 2016-11-22
HK1052645B (en) 2008-03-20
JP2012180355A (ja) 2012-09-20
DE60129007D1 (de) 2007-08-02
EP1272204A2 (en) 2003-01-08
WO2001078754A2 (en) 2001-10-25
CA2406393A1 (en) 2001-10-25
JP5684963B2 (ja) 2015-03-18
JP2003531125A (ja) 2003-10-21
DK1272204T3 (da) 2007-09-10
US20090098094A1 (en) 2009-04-16
EP1272204B1 (en) 2007-06-20
CY1108090T1 (el) 2014-02-12
PT1272204E (pt) 2007-10-02
US20210145892A1 (en) 2021-05-20
WO2001078754A3 (en) 2002-04-25
AU2001251599B2 (en) 2006-03-02
US20170209495A1 (en) 2017-07-27
HK1052645A1 (en) 2003-09-26
CA2406393C (en) 2012-10-02

Similar Documents

Publication Publication Date Title
ES2288946T3 (es) Aumento y abultamiento de tejido blando y hueso utilizando celulas progenitoras derivadas de musculo, sus composiciones y tratamientos.
US8685385B2 (en) Soft tissue and bone augmentation and bulking utilizing muscle-derived progenitor cells, compositions and treatments thereof
AU2001251599A1 (en) Soft tissue and bone augmentation and bulking utilizing muscle-derived progenitor cells, compositions and treatments thereof
JP5425641B2 (ja) 尿路病状の処置のための筋由来細胞ならびにその作製および使用の方法
US8211423B2 (en) Muscle derived cells for the treatment of cardiac pathologies and methods of making and using the same
US20250152635A1 (en) Bone augmentation utilizing muscle-derived progenitor compositions, and treatments thereof
AU2006202380B2 (en) Soft tissue and bone augmentation and bulking utilizing muscle-derived progenitor cells, compositions and treatments thereof