ATE554160T1 - Knochenaufbau anhand von vorläuferzusammensetzungen aus muskeln und behandlungen damit - Google Patents
Knochenaufbau anhand von vorläuferzusammensetzungen aus muskeln und behandlungen damitInfo
- Publication number
- ATE554160T1 ATE554160T1 AT08767926T AT08767926T ATE554160T1 AT E554160 T1 ATE554160 T1 AT E554160T1 AT 08767926 T AT08767926 T AT 08767926T AT 08767926 T AT08767926 T AT 08767926T AT E554160 T1 ATE554160 T1 AT E554160T1
- Authority
- AT
- Austria
- Prior art keywords
- bone
- decrease
- muscle
- progenitor cells
- methods
- Prior art date
Links
- 210000003205 muscle Anatomy 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 2
- 238000011282 treatment Methods 0.000 title abstract 2
- 230000037176 bone building Effects 0.000 title 1
- 239000002243 precursor Substances 0.000 title 1
- 210000000988 bone and bone Anatomy 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 3
- 210000000130 stem cell Anatomy 0.000 abstract 3
- 210000004872 soft tissue Anatomy 0.000 abstract 2
- 238000002054 transplantation Methods 0.000 abstract 2
- 208000010392 Bone Fractures Diseases 0.000 abstract 1
- 208000010191 Osteitis Deformans Diseases 0.000 abstract 1
- 206010031243 Osteogenesis imperfecta Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 208000027868 Paget disease Diseases 0.000 abstract 1
- 230000003416 augmentation Effects 0.000 abstract 1
- 230000037182 bone density Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000001054 cortical effect Effects 0.000 abstract 1
- 238000002513 implantation Methods 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 230000007774 longterm Effects 0.000 abstract 1
- 208000027202 mammary Paget disease Diseases 0.000 abstract 1
- 208000005368 osteomalacia Diseases 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000004083 survival effect Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0658—Skeletal muscle cells, e.g. myocytes, myotubes, myoblasts
- C12N5/0659—Satellite cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/34—Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0654—Osteocytes, Osteoblasts, Odontocytes; Bones, Teeth
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0658—Skeletal muscle cells, e.g. myocytes, myotubes, myoblasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/105—Insulin-like growth factors [IGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/11—Epidermal growth factor [EGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/165—Vascular endothelial growth factor [VEGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/39—Steroid hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/90—Polysaccharides
- C12N2501/91—Heparin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Rheumatology (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Developmental Biology & Embryology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Vascular Medicine (AREA)
- Virology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94057607P | 2007-05-29 | 2007-05-29 | |
| US97247607P | 2007-09-14 | 2007-09-14 | |
| PCT/US2008/006781 WO2008153813A2 (en) | 2007-05-29 | 2008-05-29 | Bone augmentation utilizing muscle-derived progenitor compositions, and treatments thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE554160T1 true ATE554160T1 (de) | 2012-05-15 |
Family
ID=40130390
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08767926T ATE554160T1 (de) | 2007-05-29 | 2008-05-29 | Knochenaufbau anhand von vorläuferzusammensetzungen aus muskeln und behandlungen damit |
Country Status (7)
| Country | Link |
|---|---|
| US (7) | US20090155221A1 (de) |
| EP (1) | EP2164503B1 (de) |
| JP (1) | JP5624461B2 (de) |
| AT (1) | ATE554160T1 (de) |
| AU (1) | AU2008263134B2 (de) |
| CA (1) | CA2722758C (de) |
| WO (1) | WO2008153813A2 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU5159901A (en) | 2000-04-14 | 2001-10-30 | Univ Pittsburgh | Soft tissue and bone augmentation and bulking utilizing muscle-derived progenitor cells, compositions and treatments thereof |
| ATE482713T1 (de) | 2003-04-25 | 2010-10-15 | Univ Pittsburgh | Von muskeln stammende zellen (mdcs) zur förderung und verbesserung der nervenreparatur und - regeneration |
| WO2016172004A1 (en) * | 2015-04-18 | 2016-10-27 | The Johns Hopkins University | Bone healing, angiogenesis-promoting and vasculogenesis-producing system |
| KR102780297B1 (ko) * | 2017-12-14 | 2025-03-12 | 이노바셀 바이오테크놀로지 아게 | 근육 유래 세포를 수득하는 방법 |
| KR20220002315A (ko) | 2019-03-22 | 2022-01-06 | 이노바셀 아게 | 유도된 평활근 세포를 수득하는 방법 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4424208A (en) * | 1982-01-11 | 1984-01-03 | Collagen Corporation | Collagen implant material and method for augmenting soft tissue |
| US4851521A (en) * | 1985-07-08 | 1989-07-25 | Fidia, S.P.A. | Esters of hyaluronic acid |
| US5053050A (en) * | 1988-04-29 | 1991-10-01 | Samuel Itay | Compositions for repair of cartilage and bone |
| US5130141A (en) * | 1988-05-24 | 1992-07-14 | Law Peter K | Compositions for and methods of treating muscle degeneration and weakness |
| US5538722A (en) * | 1989-06-13 | 1996-07-23 | Stanford University | Isolation, growth, differentiation and genetic engineering of human muscle cells |
| US5206028A (en) * | 1991-02-11 | 1993-04-27 | Li Shu Tung | Dense collagen membrane matrices for medical uses |
| JP3004724B2 (ja) * | 1992-04-06 | 2000-01-31 | ユーロプラスティ インコーポレイテッド | ミクロ粒子注入による逆流障害の処置 |
| US5516532A (en) * | 1994-08-05 | 1996-05-14 | Children's Medical Center Corporation | Injectable non-immunogenic cartilage and bone preparation |
| US6099832A (en) * | 1997-05-28 | 2000-08-08 | Genzyme Corporation | Transplants for myocardial scars |
| US7115417B1 (en) * | 1998-05-01 | 2006-10-03 | Chancellor Michael B | Soft tissue and bone augmentation and bulking utilizing muscle-derived progenito compositions, and treatments thereof |
| US8211423B2 (en) * | 2006-11-28 | 2012-07-03 | University Of Pittsburgh | Muscle derived cells for the treatment of cardiac pathologies and methods of making and using the same |
| US6866842B1 (en) * | 1998-05-01 | 2005-03-15 | University Of Pittsburgh | Muscle-derived cells (MDCs) for treating muscle-or bone-related injury or dysfunction |
| AU763021B2 (en) * | 1999-09-14 | 2003-07-10 | Children's Medical Center Corporation | Isolation of muscle-derived stem cells and uses therefor |
| AU5159901A (en) * | 2000-04-14 | 2001-10-30 | Univ Pittsburgh | Soft tissue and bone augmentation and bulking utilizing muscle-derived progenitor cells, compositions and treatments thereof |
| FR2810045B1 (fr) * | 2000-06-07 | 2004-09-03 | Assist Publ Hopitaux De Paris | Procede d'obtention de population cellulaires caracterisees d'origine musculaire et utilisations |
| WO2008076435A1 (en) * | 2006-12-18 | 2008-06-26 | University Of Pittsburgh | Muscle derived cells for the treatment of gastro-esophageal pathologies and methods of making and using the same |
-
2008
- 2008-05-29 US US12/129,272 patent/US20090155221A1/en not_active Abandoned
- 2008-05-29 CA CA2722758A patent/CA2722758C/en active Active
- 2008-05-29 AT AT08767926T patent/ATE554160T1/de active
- 2008-05-29 EP EP08767926A patent/EP2164503B1/de active Active
- 2008-05-29 WO PCT/US2008/006781 patent/WO2008153813A2/en not_active Ceased
- 2008-05-29 JP JP2010510329A patent/JP5624461B2/ja active Active
- 2008-05-29 AU AU2008263134A patent/AU2008263134B2/en active Active
-
2013
- 2013-02-14 US US13/766,901 patent/US20130156741A1/en not_active Abandoned
-
2015
- 2015-12-22 US US14/978,894 patent/US20160213716A1/en not_active Abandoned
-
2017
- 2017-07-19 US US15/654,046 patent/US20180071341A1/en not_active Abandoned
-
2019
- 2019-06-24 US US16/449,867 patent/US20200101115A1/en not_active Abandoned
-
2021
- 2021-05-18 US US17/323,114 patent/US20220105137A1/en not_active Abandoned
-
2024
- 2024-06-25 US US18/753,253 patent/US20250152635A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP5624461B2 (ja) | 2014-11-12 |
| EP2164503A4 (de) | 2010-06-16 |
| EP2164503B1 (de) | 2012-04-18 |
| US20130156741A1 (en) | 2013-06-20 |
| EP2164503A2 (de) | 2010-03-24 |
| JP2010529017A (ja) | 2010-08-26 |
| US20250152635A1 (en) | 2025-05-15 |
| WO2008153813A2 (en) | 2008-12-18 |
| AU2008263134A1 (en) | 2008-12-18 |
| US20220105137A1 (en) | 2022-04-07 |
| WO2008153813A3 (en) | 2009-02-12 |
| CA2722758A1 (en) | 2008-12-18 |
| WO2008153813A8 (en) | 2011-09-01 |
| US20090155221A1 (en) | 2009-06-18 |
| US20200101115A1 (en) | 2020-04-02 |
| US20180071341A1 (en) | 2018-03-15 |
| US20160213716A1 (en) | 2016-07-28 |
| CA2722758C (en) | 2017-04-25 |
| AU2008263134B2 (en) | 2014-06-19 |
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