ES2288757T3 - Derivados sinteticos de bacterioclorofila sustituidos con metales y uso de los mismos. - Google Patents

Derivados sinteticos de bacterioclorofila sustituidos con metales y uso de los mismos. Download PDF

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Publication number
ES2288757T3
ES2288757T3 ES96938445T ES96938445T ES2288757T3 ES 2288757 T3 ES2288757 T3 ES 2288757T3 ES 96938445 T ES96938445 T ES 96938445T ES 96938445 T ES96938445 T ES 96938445T ES 2288757 T3 ES2288757 T3 ES 2288757T3
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ES
Spain
Prior art keywords
bchl
metal
formula
group
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96938445T
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English (en)
Spanish (es)
Inventor
Avigdor Scherz
Yoram Salomon
Hugo Scheer
Gerhard Hartwich
Alexander Brandis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yeda Research and Development Co Ltd
Original Assignee
Yeda Research and Development Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Research and Development Co Ltd filed Critical Yeda Research and Development Co Ltd
Application granted granted Critical
Publication of ES2288757T3 publication Critical patent/ES2288757T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/10Anti-acne agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/12Keratolytics, e.g. wart or anti-corn preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Virology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ES96938445T 1995-11-24 1996-11-24 Derivados sinteticos de bacterioclorofila sustituidos con metales y uso de los mismos. Expired - Lifetime ES2288757T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL11612695A IL116126A0 (en) 1995-11-24 1995-11-24 Process for the preparation of bacteriochlorophyllis some novel compounds of this type and pharmaceutical compositions comprising them
IL116126 1995-11-24

Publications (1)

Publication Number Publication Date
ES2288757T3 true ES2288757T3 (es) 2008-01-16

Family

ID=11068225

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96938445T Expired - Lifetime ES2288757T3 (es) 1995-11-24 1996-11-24 Derivados sinteticos de bacterioclorofila sustituidos con metales y uso de los mismos.

Country Status (18)

Country Link
US (1) US6333319B1 (OSRAM)
EP (1) EP0863903B1 (OSRAM)
JP (1) JP2000500763A (OSRAM)
CN (1) CN1085211C (OSRAM)
AT (1) ATE365741T1 (OSRAM)
AU (1) AU718961B2 (OSRAM)
BR (1) BR9611452A (OSRAM)
DE (1) DE69637149T2 (OSRAM)
DK (1) DK0863903T3 (OSRAM)
ES (1) ES2288757T3 (OSRAM)
HU (1) HU223379B1 (OSRAM)
IL (1) IL116126A0 (OSRAM)
MX (1) MX9804143A (OSRAM)
NO (1) NO323478B1 (OSRAM)
PL (1) PL188811B1 (OSRAM)
PT (1) PT863903E (OSRAM)
RU (1) RU2193038C2 (OSRAM)
WO (1) WO1997019081A1 (OSRAM)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6413436B1 (en) * 1999-01-27 2002-07-02 Semitool, Inc. Selective treatment of the surface of a microelectronic workpiece
CA2353554C (en) * 1998-12-09 2011-04-26 Yeda Research And Development Co. Ltd. Palladium-substituted bacteriochlorophyll derivatives and use thereof
IL133253A0 (en) * 1999-12-01 2001-04-30 Yeda Res & Dev Chlorophyll and bacteriochlorophyll esters, their preparation and pharmaceutical compositions comprising them
US7045117B2 (en) * 1999-12-01 2006-05-16 Yeda Research And Development Co. Ltd. Method for tumor diagnosis comprising administering of palladium-substituted bacteriochlorophyll derivatives
WO2002013820A1 (en) * 2000-08-11 2002-02-21 Ceramoptec Industries, Inc. Photosensitizing ointment
RU2183956C1 (ru) * 2001-03-30 2002-06-27 Общество с ограниченной ответственностью "РАДА-ФАРМА" Фотосенсибилизатор и способ его получения
EP1277470A1 (fr) * 2001-07-17 2003-01-22 Steba Biotech N.V. Formulation galénique injectable pour utilisation dans un diagnostic ou une thérapie photodynamique et son procédé de préparation
IL148921A0 (en) * 2002-03-26 2002-09-12 Peptor Ltd Photo active backbone cyclized somatostatin analogs for optical imaging and photodynamic therapy
AU2003230164B2 (en) 2002-05-08 2008-05-01 Yeda Research And Development Co. Ltd. Sensitized online BOLD-MRI imaging method
CN2595398Y (zh) 2002-09-25 2003-12-31 王健 动态加静态磁脉冲理疗仪
IL152900A0 (en) * 2002-11-17 2003-06-24 Yeda Res & Dev Water-soluble bacteriochlorophyll derivatives and their pharmaceutical uses
CA2437638A1 (en) 2003-08-20 2005-02-20 John Robert North Photodynamic therapy
CA2457214A1 (en) 2004-02-06 2005-08-06 Qlt Inc. Photodynamic therapy for the treatment of acne
EP2322173B1 (en) * 2004-06-07 2016-08-10 Yeda Research And Development Co., Ltd. Cationic bacteriochlorophyll derivatives and uses thereof
MX2007000338A (es) 2004-06-09 2007-03-28 Quadra Logic Tech Inc Terapia fotodinamica para el tratamiento de trastornos hiperactivos de glandulas sebaceas.
AU2007282846A1 (en) * 2006-08-07 2008-02-14 Kodesh S.A Tetraarylporphine derivatives and uses thereof
JP2010502574A (ja) * 2006-08-23 2010-01-28 イエダ リサーチ アンド デベロップメント カンパニー リミテッド Rgdペプチドとポルフィリン又は(バクテリオ)クロロフィル光合成剤とのコンジュゲート及びその使用
EP2155691B1 (en) * 2007-02-23 2016-01-13 Yeda Research and Development Co. Ltd. Antibodies and pharmaceutical compositions containing same useful for inhibiting activity of metalloproteins
US20090036952A1 (en) 2007-07-30 2009-02-05 National Yang-Ming University Induction driven light module and use thereof
EP2244787A1 (en) * 2008-01-28 2010-11-03 Yeda Research And Development Company Ltd. Endoscopic imaging photodynamic therapy system and methods of use
KR101595138B1 (ko) 2008-02-27 2016-02-18 예다 리서치 앤드 디벨럽먼트 캄파니 리미티드 괴사종양의 광역학요법 및 영상용 알지디(박테리오)클로로필 컨쥬게이트
RU2415868C1 (ru) 2009-09-10 2011-04-10 Общество С Ограниченной Ответственностью "Фарминтерпрайсез" Производные гемина, обладающие антимикробной активностью, или их фармацевтически приемлемые соли, способ получения, фармкомпозиция и применение
CN102584837A (zh) * 2012-01-18 2012-07-18 河北联合大学 天然叶绿素铁铬盐及制备方法
CN103405769A (zh) * 2013-03-07 2013-11-27 北京亿仁赛博医疗科技研发中心有限公司 光敏剂在制备治疗疾病的病毒灭活药物中的应用
AU2014229637B2 (en) 2013-03-11 2017-05-04 Tookad Ip Sarl Method for producing bacteriochlorophyll a
CN109679110B (zh) * 2018-12-25 2020-10-09 北京科技大学 一种基于菌绿素的纳米金属-有机框架光敏剂及制备方法
CN114005684B (zh) * 2021-11-05 2023-05-05 吉林大学 不饱和叶绿素的电化学聚合薄膜及其在超级电容器上的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5171741A (en) * 1989-04-21 1992-12-15 Health Research, Inc. Bacteriochlorophyll-a derivatives useful in photodynamic therapy
DE4121876A1 (de) 1991-07-02 1993-01-14 Scheer Hugo Modifizierte bakteriochlorophylle, verfahren zu ihrer herstellung und ihre verwendung
IL102645A (en) 1992-07-26 1998-02-22 Yeda Res & Dev Chlorophyll and bacteriochlorophyll derivatives, their preparation and pharmaceutical compositions comprising them
US5591847A (en) * 1994-05-23 1997-01-07 Health Research, Inc. Long wavelength absorbing photosensitizers related to purpurin-18, bacteriopurpurin-18 and related compounds with imide linkages

Also Published As

Publication number Publication date
MX9804143A (es) 1998-09-30
NO982348L (no) 1998-07-23
ATE365741T1 (de) 2007-07-15
EP0863903A1 (en) 1998-09-16
PL188811B1 (pl) 2005-04-29
NO982348D0 (no) 1998-05-22
WO1997019081A1 (en) 1997-05-29
CN1085211C (zh) 2002-05-22
JP2000500763A (ja) 2000-01-25
DE69637149T2 (de) 2008-02-28
AU718961B2 (en) 2000-05-04
DK0863903T3 (da) 2007-09-24
NO323478B1 (no) 2007-05-21
HUP9903582A3 (en) 2002-02-28
US6333319B1 (en) 2001-12-25
HUP9903582A2 (hu) 2000-02-28
EP0863903B1 (en) 2007-06-27
DE69637149D1 (de) 2007-08-09
RU2193038C2 (ru) 2002-11-20
PT863903E (pt) 2007-09-07
BR9611452A (pt) 1999-02-17
CN1207741A (zh) 1999-02-10
IL116126A0 (en) 1996-01-31
PL326745A1 (en) 1998-10-26
AU7585796A (en) 1997-06-11
HU223379B1 (hu) 2004-06-28

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