ES2281851T3 - Forma de dosis co-extruida resistente a la manipulacion conteniendo un agente activo y un agente adverso y proceso para preparar el mismo. - Google Patents
Forma de dosis co-extruida resistente a la manipulacion conteniendo un agente activo y un agente adverso y proceso para preparar el mismo. Download PDFInfo
- Publication number
- ES2281851T3 ES2281851T3 ES04813471T ES04813471T ES2281851T3 ES 2281851 T3 ES2281851 T3 ES 2281851T3 ES 04813471 T ES04813471 T ES 04813471T ES 04813471 T ES04813471 T ES 04813471T ES 2281851 T3 ES2281851 T3 ES 2281851T3
- Authority
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- Spain
- Prior art keywords
- center
- dose form
- opioid
- agent
- active agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- ALFGKMXHOUSVAD-UHFFFAOYSA-N Ketobemidone Chemical compound C=1C=CC(O)=CC=1C1(C(=O)CC)CCN(C)CC1 ALFGKMXHOUSVAD-UHFFFAOYSA-N 0.000 claims description 3
- IDBPHNDTYPBSNI-UHFFFAOYSA-N N-(1-(2-(4-Ethyl-5-oxo-2-tetrazolin-1-yl)ethyl)-4-(methoxymethyl)-4-piperidyl)propionanilide Chemical compound C1CN(CCN2C(N(CC)N=N2)=O)CCC1(COC)N(C(=O)CC)C1=CC=CC=C1 IDBPHNDTYPBSNI-UHFFFAOYSA-N 0.000 claims description 3
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Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Emergency Medicine (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52855003P | 2003-12-09 | 2003-12-09 | |
| US528550P | 2003-12-09 |
Publications (1)
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| ES2281851T3 true ES2281851T3 (es) | 2007-10-01 |
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| Application Number | Title | Priority Date | Filing Date |
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| ES04813471T Expired - Lifetime ES2281851T3 (es) | 2003-12-09 | 2004-12-08 | Forma de dosis co-extruida resistente a la manipulacion conteniendo un agente activo y un agente adverso y proceso para preparar el mismo. |
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|---|---|
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| EP (1) | EP1691892B1 (enExample) |
| JP (3) | JP4917893B2 (enExample) |
| AT (1) | ATE355103T1 (enExample) |
| CA (1) | CA2548834C (enExample) |
| CY (1) | CY1106600T1 (enExample) |
| DE (1) | DE602004005076T2 (enExample) |
| DK (1) | DK1691892T3 (enExample) |
| ES (1) | ES2281851T3 (enExample) |
| PL (1) | PL1691892T3 (enExample) |
| PT (1) | PT1691892E (enExample) |
| SI (1) | SI1691892T1 (enExample) |
| WO (1) | WO2005055981A2 (enExample) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1592609A (zh) * | 2001-05-11 | 2005-03-09 | 恩德制药公司 | 抗滥用阿片样物质剂型 |
| US20030157168A1 (en) | 2001-08-06 | 2003-08-21 | Christopher Breder | Sequestered antagonist formulations |
| US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
| EP1615625A4 (en) | 2003-04-21 | 2010-12-15 | Euro Celtique Sa | SAFETY DOSING FORM WITH COEXTRUDED PARTICLES OF AN UNWANTED MEDIUM AND METHOD OF MANUFACTURING THEREOF |
| DE10361596A1 (de) | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
| DE10336400A1 (de) | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
| DE102005005446A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
| US8075872B2 (en) | 2003-08-06 | 2011-12-13 | Gruenenthal Gmbh | Abuse-proofed dosage form |
| DE102004032051A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform |
| US20070048228A1 (en) | 2003-08-06 | 2007-03-01 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
| US20070269505A1 (en) * | 2003-12-09 | 2007-11-22 | Flath Robert P | Tamper Resistant Co-Extruded Dosage Form Containing An Active Agent And An Adverse Agent And Process Of Making Same |
| PL1729730T3 (pl) | 2004-03-30 | 2009-06-30 | Euro Celtique Sa | Odporna na zniszczenie postać dawkowania zawierająca adsorbent i środek przeciwdziałający |
| DE102004032049A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
| DE102005005449A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
| WO2007070632A2 (en) * | 2005-12-13 | 2007-06-21 | Biodelivery Sciences International, Inc. | Abuse resistant transmucosal drug delivery device |
| KR101486228B1 (ko) | 2006-06-19 | 2015-01-26 | 알파마 파머슈티컬스 엘엘씨 | 약제학적 조성물 |
| AU2007275581B2 (en) | 2006-07-21 | 2011-09-08 | Biodelivery Sciences International, Inc. | Transmucosal delivery devices with enhanced uptake |
| CA2665726C (en) * | 2006-10-11 | 2016-04-19 | Alpharma, Inc. | Pharmaceutical compositions |
| DE102007011485A1 (de) | 2007-03-07 | 2008-09-11 | Grünenthal GmbH | Darreichungsform mit erschwertem Missbrauch |
| CA2923102C (en) * | 2007-08-13 | 2019-10-15 | Omeho Life Sciences Inc. | Abuse resistant drugs, method of use and method of making |
| AU2015200313B2 (en) * | 2007-12-17 | 2016-12-01 | Alpharma Pharmaceuticals, Llc | Pharmaceutical composition |
| WO2009079518A1 (en) * | 2007-12-17 | 2009-06-25 | Alpharma Pharmaceuticals. Llc | Pharmaceutical composition |
| WO2009076764A1 (en) | 2007-12-17 | 2009-06-25 | Labopharm Inc. | Misuse preventative, controlled release formulation |
| AU2008343267A1 (en) * | 2007-12-17 | 2009-07-09 | Alpharma Pharmaceuticals, Llc | Pharmaceutical composition |
| AU2008346870A1 (en) * | 2007-12-17 | 2009-07-16 | Alpharma Pharmaceuticals, Llc | Pharmaceutical composition |
| US20090196890A1 (en) * | 2007-12-17 | 2009-08-06 | Alpharma Pharmaceuticals, Llc | Pharmaceutical compositions |
| CA2713128C (en) | 2008-01-25 | 2016-04-05 | Gruenenthal Gmbh | Pharmaceutical dosage form |
| JP2011511782A (ja) | 2008-02-12 | 2011-04-14 | アボット・ラボラトリーズ | 長期放出性ヒドロコドンアセトアミノフェンならびにその関連方法および用途 |
| BRPI0912014A2 (pt) | 2008-05-09 | 2019-03-06 | Grünenthal GmbH | processo para a preparação de uma formulação em pó intermediária e uma forma de dosagem sólida final sob uso de uma etapa de congelamento por atomização |
| CN102209540A (zh) * | 2008-11-11 | 2011-10-05 | 塔加西普特公司 | 使用α7-选择性配体的治疗方法 |
| WO2010066034A1 (en) | 2008-12-12 | 2010-06-17 | Paladin Labs Inc. | Methadone formulation |
| CN102316857A (zh) | 2008-12-16 | 2012-01-11 | 莱博法姆公司 | 防止误用的控释配方 |
| BRPI1001091A2 (pt) * | 2009-04-22 | 2011-03-22 | Dr Suwelack Skin & Health Care Ag | artigo moldado revestido secado por congelamento |
| RU2015138422A (ru) | 2009-07-22 | 2018-12-25 | Грюненталь Гмбх | Стабильная при окислении, прочная на излом лекарственная форма |
| CN102573805A (zh) | 2009-07-22 | 2012-07-11 | 格吕伦塔尔有限公司 | 热熔挤出的控制释放剂型 |
| BR112013005234A2 (pt) | 2010-09-02 | 2016-05-03 | Gruenenthal Gmbh | forma de dosagem resistente à violação compreendendo um polímero aniônico. |
| NZ607392A (en) | 2010-09-02 | 2015-03-27 | Gruenenthal Chemie | Tamper resistant dosage form comprising inorganic salt |
| ITVR20110069A1 (it) * | 2011-04-06 | 2012-10-07 | Eurocoating S P A | Metodo per la realizzazione di un biomateriale a base di calcio fosfato sotto forma di granuli e/o loro aggregati e biomateriale ottenuto con lo stesso |
| RS56527B1 (sr) | 2011-07-29 | 2018-02-28 | Gruenenthal Gmbh | Tableta za trenutno oslobađanje leka rezistentna na zloupotrebu |
| PE20141638A1 (es) | 2011-07-29 | 2014-11-22 | Gruenenthal Chemie | Tableta a prueba de manipulacion que proporciona liberacion de farmaco inmediato |
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-
2004
- 2004-12-08 US US10/582,256 patent/US20070269505A1/en not_active Abandoned
- 2004-12-08 ES ES04813471T patent/ES2281851T3/es not_active Expired - Lifetime
- 2004-12-08 JP JP2006543959A patent/JP4917893B2/ja not_active Expired - Lifetime
- 2004-12-08 SI SI200430281T patent/SI1691892T1/sl unknown
- 2004-12-08 AT AT04813471T patent/ATE355103T1/de active
- 2004-12-08 EP EP04813471A patent/EP1691892B1/en not_active Expired - Lifetime
- 2004-12-08 DK DK04813471T patent/DK1691892T3/da active
- 2004-12-08 PL PL04813471T patent/PL1691892T3/pl unknown
- 2004-12-08 DE DE602004005076T patent/DE602004005076T2/de not_active Expired - Lifetime
- 2004-12-08 PT PT04813471T patent/PT1691892E/pt unknown
- 2004-12-08 CA CA002548834A patent/CA2548834C/en not_active Expired - Lifetime
- 2004-12-08 WO PCT/US2004/041154 patent/WO2005055981A2/en not_active Ceased
-
2007
- 2007-05-17 CY CY20071100667T patent/CY1106600T1/el unknown
-
2011
- 2011-02-02 JP JP2011020960A patent/JP5473958B2/ja not_active Expired - Lifetime
- 2011-12-13 JP JP2011272389A patent/JP2012082214A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP4917893B2 (ja) | 2012-04-18 |
| WO2005055981A3 (en) | 2005-08-11 |
| WO2005055981A2 (en) | 2005-06-23 |
| CA2548834C (en) | 2009-08-11 |
| US20070269505A1 (en) | 2007-11-22 |
| CY1106600T1 (el) | 2012-01-25 |
| JP2012082214A (ja) | 2012-04-26 |
| JP2007513960A (ja) | 2007-05-31 |
| CA2548834A1 (en) | 2005-06-23 |
| JP5473958B2 (ja) | 2014-04-16 |
| DE602004005076D1 (de) | 2007-04-12 |
| DE602004005076T2 (de) | 2007-11-15 |
| JP2011126895A (ja) | 2011-06-30 |
| EP1691892A2 (en) | 2006-08-23 |
| PL1691892T3 (pl) | 2007-07-31 |
| DK1691892T3 (da) | 2007-06-25 |
| ATE355103T1 (de) | 2006-03-15 |
| EP1691892B1 (en) | 2007-02-28 |
| SI1691892T1 (sl) | 2007-08-31 |
| PT1691892E (pt) | 2007-05-31 |
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