ES2243801T3 - Equivalente de piel/cabello con papilas reconstruidas. - Google Patents
Equivalente de piel/cabello con papilas reconstruidas.Info
- Publication number
- ES2243801T3 ES2243801T3 ES02804895T ES02804895T ES2243801T3 ES 2243801 T3 ES2243801 T3 ES 2243801T3 ES 02804895 T ES02804895 T ES 02804895T ES 02804895 T ES02804895 T ES 02804895T ES 2243801 T3 ES2243801 T3 ES 2243801T3
- Authority
- ES
- Spain
- Prior art keywords
- reconstructed
- hair
- papils
- skin
- equivalent skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002537 cosmetic Substances 0.000 abstract 1
- 210000004207 dermis Anatomy 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
- C12N5/0627—Hair cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/10—Hair or skin implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/24—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/60—Materials for use in artificial skin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
- C12N5/0698—Skin equivalents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/18—Materials or treatment for tissue regeneration for hair reconstruction
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/09—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells
- C12N2502/094—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells keratinocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
- C12N2502/1323—Adult fibroblasts
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Animal Behavior & Ethology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Public Health (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Botany (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Biophysics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Materials For Medical Uses (AREA)
- Cosmetics (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Un proceso para la producción de un equivalente piel/pelo, más particularmente un modelo piel/pelo con papilas reconstruidas (pseudopapilas; PP) en una dermis reconstruida (pseudodermis; PD), comprendiendo el proceso las siguientes etapas: (a) proveer una dermis reconstruida (pseudodermis; PD) o una preparación de pseudodermis; (b) proveer papilas reconstruidas (pseudopapilas; PP) comprendiendo células papilares dérmicas (células papilares de pelo), sobre un portador apropiado y/o una matriz apropiada, más particularmente matriz de gel, po proveer los precursores correspondientes de tales papilas reconstruidas (pseudopapilas; PP) que comprenden células papilares dérmicas cultivadas, en un medio MFMPP apropiado formador de matriz, más particularmente una matriz de gel, in situ, más particularmente en la dermis reconstruida (pseudodermis; PD (c) introducir o insertar las papilas reconstruidas (PP) o sus precursores provistos en la etapa (b) en la pseudodermis (PD) o en la preparación de pseudodermis provista en la etapa (a); (d) aplicar opcionalmente una epidermis reconstruida (psesudoepidermis; PE) o una peridermis reconstruida (pseudoperidermis; PI) a la pseudodermis (PD).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10162814A DE10162814B4 (de) | 2001-12-19 | 2001-12-19 | Rekonstruiertes Haarfollikelmodell |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2243801T3 true ES2243801T3 (es) | 2005-12-01 |
Family
ID=7710083
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES02804895T Expired - Lifetime ES2243801T3 (es) | 2001-12-19 | 2002-12-13 | Equivalente de piel/cabello con papilas reconstruidas. |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1455854B1 (es) |
JP (1) | JP2005525088A (es) |
AT (1) | ATE296124T1 (es) |
AU (1) | AU2002366280A1 (es) |
DE (2) | DE10162814B4 (es) |
ES (1) | ES2243801T3 (es) |
WO (1) | WO2003051419A1 (es) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101082621B1 (ko) * | 2003-10-06 | 2011-11-10 | 가부시키가이샤 시세이도 | 모유두 세포 조제품의 조제 방법 |
CN1968713B (zh) * | 2004-06-14 | 2012-02-29 | 株式会社资生堂 | 通过抑制具有毛囊形成抑制能力的基因或通过活化具有毛囊形成诱导能力的基因而再生毛囊的方法 |
KR100616752B1 (ko) | 2004-11-29 | 2006-08-31 | 박정극 | 모낭 유도 능력이 있는 모유두 조직의 제조방법 |
US8846393B2 (en) | 2005-11-29 | 2014-09-30 | Gamida-Cell Ltd. | Methods of improving stem cell homing and engraftment |
GB0605450D0 (en) * | 2006-03-17 | 2006-04-26 | Intercytex Ltd | Cell co-culture |
FR2903702B1 (fr) | 2006-07-13 | 2012-10-19 | Oreal | Equivalent d'epiderme capable de se pigmenter obtenu a partir de cellules de la matrice, procede de preparation et utilisation |
DE102006043767A1 (de) | 2006-09-13 | 2008-03-27 | Henkel Kgaa | Extrakt aus Apium graveleons zur Stimulierung des Haarwuchses |
GB2442271B (en) * | 2006-09-27 | 2011-06-15 | Denis Eon Solomon | An in vitro human skin assay protocol which directly uses the natural cellular interactions between un-manipulated autologous human epidermal and dermal cells |
JP5097387B2 (ja) * | 2006-11-16 | 2012-12-12 | ライオン株式会社 | 人工皮膚 |
DE102007032393A1 (de) | 2007-07-10 | 2009-01-29 | Henkel Ag & Co. Kgaa | Advanced Glycation Endproducts als Wirkstoffe |
DE102007048409A1 (de) * | 2007-10-09 | 2009-04-16 | Carl Zeiss Microimaging Gmbh | Verfahren zum Positionieren von biologischen Proben in einer mikroskopischen Anordnung |
EP2105499A1 (en) | 2008-03-28 | 2009-09-30 | Technische Universität Berlin | Methods for producing de novo papillae and hair microfollicles and their use for in vitro tests and in vivo implantations |
DE102009043486A1 (de) | 2009-09-30 | 2010-07-01 | Henkel Ag & Co. Kgaa | Verwendung von Wirkstoffen, erhältlich aus Pflanzen, zur Verhinderung und/oder Verminderung der Auswirkungen von psychoemotionalem Stress auf das Haar |
KR101859500B1 (ko) | 2010-12-01 | 2018-05-21 | (주)아모레퍼시픽 | 3차원 매트릭스 |
FR2976001B1 (fr) * | 2011-05-30 | 2014-10-31 | Oreal | Modele de cuir chevelu reconstruit et procede de screening de molecules actives |
EP2814951B1 (en) | 2012-02-13 | 2019-04-03 | Gamida-Cell Ltd. | Culturing of mesenchymal stem cells |
US9567569B2 (en) | 2012-07-23 | 2017-02-14 | Gamida Cell Ltd. | Methods of culturing and expanding mesenchymal stem cells |
US9175266B2 (en) | 2012-07-23 | 2015-11-03 | Gamida Cell Ltd. | Enhancement of natural killer (NK) cell proliferation and activity |
DE102012220154A1 (de) | 2012-11-06 | 2014-05-08 | Henkel Ag & Co. Kgaa | Mund- und Zahnpflege- und -reinigungsmittel mit Vitamin E |
JP2014204711A (ja) * | 2013-03-19 | 2014-10-30 | 国立大学法人 千葉大学 | 三次元培養皮膚モデルの製造方法およびその利用 |
JP6469655B2 (ja) * | 2013-05-03 | 2019-02-13 | ザ ヘンリー エム. ジャクソン ファウンデーション フォー ザ アドヴァンスメント オブ ミリタリー メディシン インコーポレイテッド | 代用皮膚および毛包新生の方法 |
CN103721294B (zh) * | 2013-12-27 | 2015-05-13 | 太原理工大学 | 一种人体表皮组织的快速构建制备方法 |
DE102014212921A1 (de) | 2014-07-03 | 2016-01-07 | Henkel Ag & Co. Kgaa | Verwendung von speziellen Oligopeptiden zur Stimulierung des natürlichen Pigmentierungsprozesses in Hautanhangsgebilden |
CN104195101B (zh) * | 2014-09-09 | 2016-04-13 | 武斌 | 一种毛囊单位保存培养液 |
CN104491931B (zh) * | 2014-12-02 | 2017-04-12 | 清华大学深圳研究生院 | 含有皮脂腺的皮肤组织及其形成方法和用途 |
CN108367099B (zh) * | 2015-10-21 | 2021-11-23 | 印第安纳大学研究与技术公司 | 来自多能干细胞的人皮肤类器官的衍生 |
DE102015119877B4 (de) | 2015-11-17 | 2017-09-21 | Technische Universität Berlin | Verfahren zur Herstellung eines Hautäquivalents sowie dessen Verwendung für in vitro Tests und in vivo Transplantate |
AU2017282306A1 (en) * | 2016-06-21 | 2019-10-17 | Organ Technologies, Inc. | Method for producing artificial skin having hair follicles, sebaceous glands, and pores |
CN109735486B (zh) * | 2019-01-31 | 2022-02-22 | 中国疾病预防控制中心辐射防护与核安全医学所 | 一种用于研究uvb照射致早衰的原代黑素细胞培养方法 |
CN112300981A (zh) * | 2020-11-14 | 2021-02-02 | 厦门思明银河整形外科门诊部有限公司 | 一种体外培养毛囊的方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8604360D0 (en) * | 1986-02-21 | 1986-03-26 | Univ Dundee | Stimulation of hair growth |
FR2612938B1 (fr) * | 1987-03-26 | 1989-06-23 | Cird | Procede d'obtention d'un equivalent de peau et equivalent de peau correspondant |
AU1829097A (en) * | 1996-01-18 | 1997-08-11 | Johnson & Johnson Consumer Products, Inc. | Methods for regenerating scarless skin and compositions used therein |
CA2253724A1 (en) * | 1996-04-26 | 1997-11-06 | Case Western Reserve University | Skin regeneration using mesenchymal stem cells |
WO1999001034A1 (en) * | 1997-07-01 | 1999-01-14 | Cooley Jerry E | Method for producing new hair growth |
ES2402739T3 (es) * | 1998-11-19 | 2013-05-08 | Organogenesis Inc. | Constructos tisulares modificados por bioingeniería y métodos para producirlos y utilizarlos |
EP1005873B1 (en) * | 1998-11-30 | 2003-04-09 | IsoTis N.V. | Artificial skin |
-
2001
- 2001-12-19 DE DE10162814A patent/DE10162814B4/de not_active Expired - Fee Related
-
2002
- 2002-12-13 WO PCT/EP2002/014212 patent/WO2003051419A1/en active IP Right Grant
- 2002-12-13 ES ES02804895T patent/ES2243801T3/es not_active Expired - Lifetime
- 2002-12-13 EP EP02804895A patent/EP1455854B1/en not_active Revoked
- 2002-12-13 AT AT02804895T patent/ATE296124T1/de not_active IP Right Cessation
- 2002-12-13 AU AU2002366280A patent/AU2002366280A1/en not_active Abandoned
- 2002-12-13 JP JP2003552350A patent/JP2005525088A/ja active Pending
- 2002-12-13 DE DE60204352T patent/DE60204352T2/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP1455854A1 (en) | 2004-09-15 |
WO2003051419A1 (en) | 2003-06-26 |
DE10162814B4 (de) | 2005-06-23 |
DE10162814A1 (de) | 2003-07-10 |
ATE296124T1 (de) | 2005-06-15 |
DE60204352D1 (de) | 2005-06-30 |
AU2002366280A1 (en) | 2003-06-30 |
JP2005525088A (ja) | 2005-08-25 |
DE60204352T2 (de) | 2006-01-26 |
EP1455854B1 (en) | 2005-05-25 |
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