ES2231684T3 - Procedimiento para la produccion continua de sustancias medicamentosas inhalables. - Google Patents
Procedimiento para la produccion continua de sustancias medicamentosas inhalables.Info
- Publication number
- ES2231684T3 ES2231684T3 ES02722039T ES02722039T ES2231684T3 ES 2231684 T3 ES2231684 T3 ES 2231684T3 ES 02722039 T ES02722039 T ES 02722039T ES 02722039 T ES02722039 T ES 02722039T ES 2231684 T3 ES2231684 T3 ES 2231684T3
- Authority
- ES
- Spain
- Prior art keywords
- solution
- temperature
- drug substance
- segmenter
- particles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- 239000000150 Sympathomimetic Substances 0.000 description 2
- UYVYDRXVNVNQEA-BJTOFBPUSA-N [2-[(8s,9r,10s,11s,13s,14s,16s,17r)-9-chloro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] 4-(acetamidomethyl)cyclohexane-1-carboxylate Chemical compound O=C([C@]1(O)[C@@]2(C)C[C@H](O)[C@]3(Cl)[C@@]4(C)C=CC(=O)C=C4CC[C@H]3[C@@H]2C[C@@H]1C)COC(=O)C1CCC(CNC(C)=O)CC1 UYVYDRXVNVNQEA-BJTOFBPUSA-N 0.000 description 2
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- 230000003266 anti-allergic effect Effects 0.000 description 2
- 229940092705 beclomethasone Drugs 0.000 description 2
- NBMKJKDGKREAPL-DVTGEIKXSA-N beclomethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O NBMKJKDGKREAPL-DVTGEIKXSA-N 0.000 description 2
- 229960002537 betamethasone Drugs 0.000 description 2
- UREBDLICKHMUKA-DVTGEIKXSA-N betamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-DVTGEIKXSA-N 0.000 description 2
- 229960004436 budesonide Drugs 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 229960001146 clobetasone Drugs 0.000 description 2
- XXIFVOHLGBURIG-OZCCCYNHSA-N clobetasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CCl)(O)[C@@]1(C)CC2=O XXIFVOHLGBURIG-OZCCCYNHSA-N 0.000 description 2
- 229960002219 cloprednol Drugs 0.000 description 2
- YTJIBEDMAQUYSZ-FDNPDPBUSA-N cloprednol Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3C=C(Cl)C2=C1 YTJIBEDMAQUYSZ-FDNPDPBUSA-N 0.000 description 2
- 229960001145 deflazacort Drugs 0.000 description 2
- FBHSPRKOSMHSIF-GRMWVWQJSA-N deflazacort Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(C)=N[C@@]3(C(=O)COC(=O)C)[C@@]1(C)C[C@@H]2O FBHSPRKOSMHSIF-GRMWVWQJSA-N 0.000 description 2
- 238000013461 design Methods 0.000 description 2
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- XWTIDFOGTCVGQB-FHIVUSPVSA-N fluocortin butyl Chemical group C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@@H](C)[C@H](C(=O)C(=O)OCCCC)[C@@]2(C)C[C@@H]1O XWTIDFOGTCVGQB-FHIVUSPVSA-N 0.000 description 2
- 229960001664 mometasone Drugs 0.000 description 2
- QLIIKPVHVRXHRI-CXSFZGCWSA-N mometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CCl)(O)[C@@]1(C)C[C@@H]2O QLIIKPVHVRXHRI-CXSFZGCWSA-N 0.000 description 2
- 229960002744 mometasone furoate Drugs 0.000 description 2
- WOFMFGQZHJDGCX-ZULDAHANSA-N mometasone furoate Chemical compound O([C@]1([C@@]2(C)C[C@H](O)[C@]3(Cl)[C@@]4(C)C=CC(=O)C=C4CC[C@H]3[C@@H]2C[C@H]1C)C(=O)CCl)C(=O)C1=CC=CO1 WOFMFGQZHJDGCX-ZULDAHANSA-N 0.000 description 2
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- MIXMJCQRHVAJIO-TZHJZOAOSA-N qk4dys664x Chemical compound O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O MIXMJCQRHVAJIO-TZHJZOAOSA-N 0.000 description 2
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- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
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- A61K9/1682—Processes
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- B01F25/31—Injector mixers in conduits or tubes through which the main component flows
- B01F25/313—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced in the centre of the conduit
- B01F25/3132—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced in the centre of the conduit by using two or more injector devices
- B01F25/31324—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced in the centre of the conduit by using two or more injector devices arranged concentrically
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
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- B01F33/3012—Interdigital streams, e.g. lamellae
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
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- B01J2219/00984—Residence time
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/02—Apparatus characterised by their chemically-resistant properties
- B01J2219/0204—Apparatus characterised by their chemically-resistant properties comprising coatings on the surfaces in direct contact with the reactive components
- B01J2219/0245—Apparatus characterised by their chemically-resistant properties comprising coatings on the surfaces in direct contact with the reactive components of synthetic organic material
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
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- Otolaryngology (AREA)
- Physics & Mathematics (AREA)
- Thermal Sciences (AREA)
- Pulmonology (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10119718A DE10119718A1 (de) | 2001-04-21 | 2001-04-21 | Verfahren zur kontinuierlichen Herstellung inhalierfähiger Arzneistoffe, Vorrichtung zur Durchführung des Verfahrens und nach diesem Verfahren hergestellter Arzneistoff |
| DE10119718 | 2001-04-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2231684T3 true ES2231684T3 (es) | 2005-05-16 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES02722039T Expired - Lifetime ES2231684T3 (es) | 2001-04-21 | 2002-01-29 | Procedimiento para la produccion continua de sustancias medicamentosas inhalables. |
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|---|---|
| US (3) | US6663848B2 (enExample) |
| EP (2) | EP1470814A1 (enExample) |
| JP (1) | JP2004528899A (enExample) |
| AR (1) | AR033240A1 (enExample) |
| AT (1) | ATE279178T1 (enExample) |
| DE (2) | DE10119718A1 (enExample) |
| DK (1) | DK1381351T3 (enExample) |
| ES (1) | ES2231684T3 (enExample) |
| PT (1) | PT1381351E (enExample) |
| TR (1) | TR200402820T4 (enExample) |
| TW (1) | TW559562B (enExample) |
| WO (1) | WO2002085329A1 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19954516A1 (de) * | 1999-11-12 | 2001-05-17 | Boehringer Ingelheim Int | Epinastin-haltige Lösungen |
| US7718099B2 (en) | 2002-04-25 | 2010-05-18 | Tosoh Corporation | Fine channel device, fine particle producing method and solvent extraction method |
| DE10244795A1 (de) * | 2002-09-26 | 2004-04-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pulverinhalator |
| US7208485B2 (en) * | 2003-01-13 | 2007-04-24 | Chemagis Ltd. | Crystalline forms of halobetasol propionate |
| US20040138192A1 (en) * | 2003-01-13 | 2004-07-15 | Chemagis Ltd. | Crystalline forms of halobetasol propionate |
| JP2007520546A (ja) * | 2004-02-03 | 2007-07-26 | ケマジス リミティド | モンテルカストナトリウムの安定な非晶質性形態 |
| DE102005003965A1 (de) * | 2005-01-27 | 2006-08-10 | Ehrfeld Mikrotechnik Gmbh | Mikromischer |
| EP1718402B1 (de) | 2004-02-17 | 2008-08-13 | Ehrfeld Mikrotechnik BTS GmbH | Mikromischer |
| DE102004012093A1 (de) * | 2004-03-05 | 2005-09-22 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pulverinhalator mit Merkanaldüse |
| GB0502398D0 (en) * | 2005-02-04 | 2005-03-16 | Q Chip Ltd | Device and method for producing spherical segmented flow |
| DE102004049730B4 (de) * | 2004-10-11 | 2007-05-03 | Technische Universität Darmstadt | Mikrokapillarreaktor und Verfahren zum kontrollierten Vermengen von nicht homogen mischbaren Fluiden unter Verwendung dieses Mikrokapillarreaktors |
| US20070249572A1 (en) * | 2005-12-20 | 2007-10-25 | Verus Pharmaceuticals, Inc. | Systems and methods for the delivery of corticosteroids |
| US20070160542A1 (en) * | 2005-12-20 | 2007-07-12 | Verus Pharmaceuticals, Inc. | Methods and systems for the delivery of corticosteroids having an enhanced pharmacokinetic profile |
| US20070197486A1 (en) * | 2005-12-20 | 2007-08-23 | Verus Pharmaceuticals, Inc. | Methods and systems for the delivery of corticosteroids |
| US20070178049A1 (en) * | 2005-12-20 | 2007-08-02 | Verus Pharmaceuticals, Inc. | Systems and methods for the delivery of corticosteroids having an enhanced pharmacokinetic profile |
| US20070185066A1 (en) * | 2005-12-20 | 2007-08-09 | Verus Pharmaceuticals, Inc. | Systems and methods for the delivery of corticosteroids |
| WO2007095342A2 (en) * | 2006-02-15 | 2007-08-23 | Tika Läkemedel Ab | Stable corticosteroid mixtures |
| US20060223999A1 (en) * | 2006-05-10 | 2006-10-05 | Chemagis Ltd. | Process for preparing montelukast and precursors thereof |
| EP2275198A1 (en) | 2006-05-11 | 2011-01-19 | Corning Incorporated | Microfluidic manifold devices |
| GB0619442D0 (en) * | 2006-10-02 | 2006-11-08 | Q Chip Ltd | Beads for use in reactions for the amplification and/or synthesis of a polynucleotide |
| DE102008037025C5 (de) * | 2008-08-08 | 2016-07-07 | Jesalis Pharma Gmbh | Verfahren zur Herstellung kristalliner Wirkstoff-Mikropartikel bzw. einer Wirkstoffpartikel-Festkörperform |
| US20100294986A1 (en) * | 2009-05-19 | 2010-11-25 | Massachusetts Institute Of Technology | Supercritical fluid facilitated particle formation in microfluidic systems |
| US20100298602A1 (en) * | 2009-05-19 | 2010-11-25 | Massachusetts Institute Of Technology | Systems and methods for microfluidic crystallization |
| US8589344B2 (en) * | 2009-11-30 | 2013-11-19 | Red Hat, Inc. | Systems and methods for generating iterated distributions of data in a hierarchical database |
| JP5749987B2 (ja) * | 2011-06-22 | 2015-07-15 | 株式会社神戸製鋼所 | 液体混合方法及び装置 |
| DE102011078979A1 (de) * | 2011-07-11 | 2013-01-17 | Böwe Systec Gmbh | Vorrichtung und Verfahren zum Transport einer Hülle |
| JP5864236B2 (ja) * | 2011-12-07 | 2016-02-17 | 東芝機械株式会社 | マイクロミキサー、マイクロミキサーエレメントおよびその製造方法 |
| JP6006969B2 (ja) * | 2012-04-24 | 2016-10-12 | 東芝機械株式会社 | マイクロミキサー、マイクロミキサーエレメントおよびその製造方法 |
| DE102012221219B4 (de) * | 2012-11-20 | 2014-05-28 | Jesalis Pharma Gmbh | Verfahren zur Vergrößerung der Partikelgröße kristalliner Wirkstoff-Mikropartikel |
| WO2016194802A1 (ja) * | 2015-05-29 | 2016-12-08 | 昭栄化学工業株式会社 | 流体分割装置、流体混合分割装置、連続流反応システムおよびナノ粒子の製造方法 |
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|---|---|---|---|---|
| DE1794084C3 (de) * | 1968-09-04 | 1973-10-25 | Union Rheinische Braunkohlen Kraftstoff Ag, 5047 Wesseling | Vorrichtung zum kontinuierlichen Gewinnen von Kristallen aus einer Schmelze oder Losung |
| US5394706A (en) * | 1993-05-20 | 1995-03-07 | Waterworks International, Inc. | Freeze crystallization for the removal of water from a solution of dissolved solids |
| WO1998033585A1 (en) * | 1997-02-05 | 1998-08-06 | California Institute Of Technology | Microfluidic sub-millisecond mixers |
| US6045703A (en) * | 1998-06-15 | 2000-04-04 | Union Carbide Chemicals & Plastics Technology Corporation | Separation processes |
| DE19917156B4 (de) * | 1999-04-16 | 2006-01-19 | INSTITUT FüR MIKROTECHNIK MAINZ GMBH | Verfahren zur Herstellung einer Wasser-in-Dieselöl-Emulsion als Kraftstoff sowie dessen Verwendungen |
| GB9919693D0 (en) * | 1999-08-19 | 1999-10-20 | Rhone Poulenc Rorer Ltd | Process |
| DE60037687D1 (de) * | 1999-11-30 | 2008-02-14 | Biogal Gyogyszergyar | Verfahren zur Rückgewinnung von Statinverbindungen aus einer Fermentationsbrühe |
| DE10005549A1 (de) * | 2000-02-09 | 2001-09-06 | Cpc Cellular Process Chemistry | Mikroreaktor für Reaktionsmedien in Form einer Suspension |
| JP4182273B2 (ja) * | 2000-06-27 | 2008-11-19 | 住友化学株式会社 | ε−カプロラクタムの製造方法 |
| US6858596B2 (en) * | 2000-08-05 | 2005-02-22 | Smithkline Beecham Corporation | Formulation containing anti-inflammatory androstane derivative |
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2001
- 2001-04-21 DE DE10119718A patent/DE10119718A1/de not_active Ceased
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- 2002-01-29 DE DE2002501306 patent/DE50201306D1/de not_active Expired - Lifetime
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- 2002-01-29 EP EP04017279A patent/EP1470814A1/de not_active Ceased
- 2002-01-29 ES ES02722039T patent/ES2231684T3/es not_active Expired - Lifetime
- 2002-01-29 WO PCT/EP2002/000885 patent/WO2002085329A1/de not_active Ceased
- 2002-01-29 DK DK02722039T patent/DK1381351T3/da active
- 2002-01-29 TR TR2004/02820T patent/TR200402820T4/xx unknown
- 2002-01-29 PT PT02722039T patent/PT1381351E/pt unknown
- 2002-01-29 EP EP02722039A patent/EP1381351B1/de not_active Expired - Lifetime
- 2002-01-29 JP JP2002582903A patent/JP2004528899A/ja active Pending
- 2002-04-04 TW TW091106833A patent/TW559562B/zh active
- 2002-04-18 US US10/125,044 patent/US6663848B2/en not_active Expired - Lifetime
- 2002-04-19 AR ARP020101437A patent/AR033240A1/es not_active Application Discontinuation
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Also Published As
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| DK1381351T3 (da) | 2004-11-29 |
| WO2002085329A1 (de) | 2002-10-31 |
| US7066171B2 (en) | 2006-06-27 |
| JP2004528899A (ja) | 2004-09-24 |
| TR200402820T4 (tr) | 2004-11-22 |
| EP1381351B1 (de) | 2004-10-13 |
| US6663848B2 (en) | 2003-12-16 |
| US20050244314A1 (en) | 2005-11-03 |
| DE10119718A1 (de) | 2002-10-31 |
| US20030175187A1 (en) | 2003-09-18 |
| US20030015194A1 (en) | 2003-01-23 |
| EP1381351A1 (de) | 2004-01-21 |
| PT1381351E (pt) | 2005-02-28 |
| TW559562B (en) | 2003-11-01 |
| EP1470814A1 (de) | 2004-10-27 |
| AR033240A1 (es) | 2003-12-10 |
| DE50201306D1 (de) | 2004-11-18 |
| ATE279178T1 (de) | 2004-10-15 |
| US7249599B2 (en) | 2007-07-31 |
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