ES2217406T3 - 2,3-benzodiazepin-4-onas sustituidas y su uso. - Google Patents
2,3-benzodiazepin-4-onas sustituidas y su uso.Info
- Publication number
- ES2217406T3 ES2217406T3 ES97916722T ES97916722T ES2217406T3 ES 2217406 T3 ES2217406 T3 ES 2217406T3 ES 97916722 T ES97916722 T ES 97916722T ES 97916722 T ES97916722 T ES 97916722T ES 2217406 T3 ES2217406 T3 ES 2217406T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- benzodiazepin
- dihydro
- methylenedioxy
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- ZREPCAXZLIBMDG-UHFFFAOYSA-N methyl 2-[6-(2-chloro-4-nitrobenzoyl)-1,3-benzodioxol-5-yl]acetate Chemical compound COC(=O)CC1=CC=2OCOC=2C=C1C(=O)C1=CC=C([N+]([O-])=O)C=C1Cl ZREPCAXZLIBMDG-UHFFFAOYSA-N 0.000 description 1
- CHWTWRBHKJJMHW-UHFFFAOYSA-N methyl 2-[6-(3-methoxy-4-nitrobenzoyl)-1,3-benzodioxol-5-yl]acetate Chemical compound COC(=O)CC1=CC=2OCOC=2C=C1C(=O)C1=CC=C([N+]([O-])=O)C(OC)=C1 CHWTWRBHKJJMHW-UHFFFAOYSA-N 0.000 description 1
- IEMQDQVIQIMCLA-UHFFFAOYSA-N methyl 2-[6-(3-methyl-4-nitrobenzoyl)-1,3-benzodioxol-5-yl]acetate Chemical compound COC(=O)CC1=CC=2OCOC=2C=C1C(=O)C1=CC=C([N+]([O-])=O)C(C)=C1 IEMQDQVIQIMCLA-UHFFFAOYSA-N 0.000 description 1
- VPJNVZORYJEMOC-UHFFFAOYSA-N methyl 2-[6-(3-nitrobenzoyl)-1,3-benzodioxol-5-yl]acetate Chemical compound COC(=O)CC1=CC=2OCOC=2C=C1C(=O)C1=CC=CC([N+]([O-])=O)=C1 VPJNVZORYJEMOC-UHFFFAOYSA-N 0.000 description 1
- JSCZANNMYBUKJA-UHFFFAOYSA-N methyl 2-[6-(4-fluorobenzoyl)-1,3-benzodioxol-5-yl]acetate Chemical compound COC(=O)CC1=CC=2OCOC=2C=C1C(=O)C1=CC=C(F)C=C1 JSCZANNMYBUKJA-UHFFFAOYSA-N 0.000 description 1
- NGXNADOTFBPSML-UHFFFAOYSA-N methyl 2-[6-(4-methoxybenzoyl)-1,3-benzodioxol-5-yl]acetate Chemical compound COC(=O)CC1=CC=2OCOC=2C=C1C(=O)C1=CC=C(OC)C=C1 NGXNADOTFBPSML-UHFFFAOYSA-N 0.000 description 1
- XTWPYPVQQFQLDB-UHFFFAOYSA-N methyl 2-[6-(4-methylbenzoyl)-1,3-benzodioxol-5-yl]acetate Chemical compound COC(=O)CC1=CC=2OCOC=2C=C1C(=O)C1=CC=C(C)C=C1 XTWPYPVQQFQLDB-UHFFFAOYSA-N 0.000 description 1
- XAIMYQGVNXSMPS-UHFFFAOYSA-N methyl 2-[6-(4-nitrobenzoyl)-1,3-benzodioxol-5-yl]acetate Chemical compound COC(=O)CC1=CC=2OCOC=2C=C1C(=O)C1=CC=C([N+]([O-])=O)C=C1 XAIMYQGVNXSMPS-UHFFFAOYSA-N 0.000 description 1
- HYDHNYHBKZFKBA-UHFFFAOYSA-N methyl 2-[6-(4-nitrobenzoyl)-1,3-benzodioxol-5-yl]propanoate Chemical compound COC(=O)C(C)C1=CC=2OCOC=2C=C1C(=O)C1=CC=C([N+]([O-])=O)C=C1 HYDHNYHBKZFKBA-UHFFFAOYSA-N 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
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- XAWRFNNHUHTBGT-UHFFFAOYSA-N n-[4-(8-oxo-7,9-dihydro-[1,3]dioxolo[4,5-h][2,3]benzodiazepin-5-yl)phenyl]acetamide Chemical compound C1=CC(NC(=O)C)=CC=C1C(C1=C2)=NNC(=O)CC1=CC1=C2OCO1 XAWRFNNHUHTBGT-UHFFFAOYSA-N 0.000 description 1
- KGVROGWGQGUTCZ-UHFFFAOYSA-N n-methyl-8-oxo-5-phenyl-9h-[1,3]dioxolo[4,5-h][2,3]benzodiazepine-7-carboxamide Chemical compound C12=CC=3OCOC=3C=C2CC(=O)N(C(=O)NC)N=C1C1=CC=CC=C1 KGVROGWGQGUTCZ-UHFFFAOYSA-N 0.000 description 1
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
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- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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- 235000006408 oxalic acid Nutrition 0.000 description 1
- 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 description 1
- 125000001312 palmitoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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- 238000000746 purification Methods 0.000 description 1
- NYJWYCAHJRGKMI-UHFFFAOYSA-N pyrido[1,2-a]pyrimidin-4-one Chemical compound C1=CC=CN2C(=O)C=CN=C21 NYJWYCAHJRGKMI-UHFFFAOYSA-N 0.000 description 1
- 229940044551 receptor antagonist Drugs 0.000 description 1
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- 239000011780 sodium chloride Substances 0.000 description 1
- ZVCDLGYNFYZZOK-UHFFFAOYSA-M sodium cyanate Chemical compound [Na]OC#N ZVCDLGYNFYZZOK-UHFFFAOYSA-M 0.000 description 1
- 235000010288 sodium nitrite Nutrition 0.000 description 1
- VGTPCRGMBIAPIM-UHFFFAOYSA-M sodium thiocyanate Chemical compound [Na+].[S-]C#N VGTPCRGMBIAPIM-UHFFFAOYSA-M 0.000 description 1
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- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 230000000946 synaptic effect Effects 0.000 description 1
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- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
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- HPGGPRDJHPYFRM-UHFFFAOYSA-J tin(iv) chloride Chemical compound Cl[Sn](Cl)(Cl)Cl HPGGPRDJHPYFRM-UHFFFAOYSA-J 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/02—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1381396P | 1996-03-21 | 1996-03-21 | |
| US13813P | 1996-03-21 |
Publications (1)
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|---|---|
| ES2217406T3 true ES2217406T3 (es) | 2004-11-01 |
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|---|---|---|---|
| ES97916722T Expired - Lifetime ES2217406T3 (es) | 1996-03-21 | 1997-03-21 | 2,3-benzodiazepin-4-onas sustituidas y su uso. |
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|---|---|
| US (1) | US5891871A (2) |
| EP (1) | EP1021418B1 (2) |
| JP (1) | JP2000506890A (2) |
| AT (1) | ATE267177T1 (2) |
| AU (1) | AU2527097A (2) |
| DE (1) | DE69729227T2 (2) |
| DK (1) | DK1021418T3 (2) |
| ES (1) | ES2217406T3 (2) |
| PT (1) | PT1021418E (2) |
| WO (1) | WO1997034878A1 (2) |
| ZA (1) | ZA972496B (2) |
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| DE19604919A1 (de) | 1996-02-01 | 1997-08-07 | Schering Ag | Neue 2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel |
| DE19604920A1 (de) * | 1996-02-01 | 1997-08-07 | Schering Ag | Neue 2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel |
| US6635632B1 (en) * | 1996-12-23 | 2003-10-21 | Athena Neurosciences, Inc. | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
| HU227128B1 (en) * | 1999-07-07 | 2010-07-28 | Egyt Gyogyszervegyeszeti Gyar | New 2,3-benzodiazepine derivatives |
| DE10004572A1 (de) * | 2000-02-02 | 2001-08-09 | Boehringer Ingelheim Pharma | Neue positive allosterische AMPA-Rezeptor Modulatoren (PAARM), Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
| IL152848A0 (en) | 2000-06-12 | 2003-06-24 | Eisai Co Ltd | 1,2-dihydropyridine derivatives, pharmaceutical compositions containing the same and methods for the production thereof |
| US6432944B1 (en) | 2000-07-06 | 2002-08-13 | Bristol-Myers Squibb Company | Benzodiazepinone β-amyloid inhibitors: arylacetamidoalanyl derivatives |
| HU225100B1 (hu) * | 2000-12-21 | 2006-06-28 | Egyt Gyogyszervegyeszeti Gyar | 2,3-Benzodiazepinszármazékok, ilyen hatóanyagot tartalmazó gyógyászati készítmények és alkalmazásuk |
| US6649607B2 (en) * | 2001-05-18 | 2003-11-18 | Vela Pharmaceuticals, Inc. | Compositions and methods for treating or preventing convulsions or seizures |
| IL159105A0 (en) * | 2001-06-07 | 2004-05-12 | Neuro3D | Cyclic nucleotide phosphodiesterase inhibitors, preparation and uses thereof |
| GB0129260D0 (en) | 2001-12-06 | 2002-01-23 | Eisai London Res Lab Ltd | Pharmaceutical compositions and their uses |
| US7022700B2 (en) * | 2002-12-03 | 2006-04-04 | Vela Pharmaceuticals, Inc. | Method of increasing neutrophil production using optically-pure (R)-2,3-benzodiazepines |
| CA2510275A1 (en) * | 2002-12-03 | 2004-08-19 | Vela Pharmaceuticals, Inc. | Pharmaceutical composition of 1-(3-hydroxy-4-methoxyphenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5h-2,3-benzodiazepine and uses therof |
| US6638928B1 (en) | 2002-12-03 | 2003-10-28 | Vela Pharmaceuticals, Inc. | Treatment of irritable bowel syndrome and nonulcer dyspepsia with substituted 2,3-benzodiazepines |
| AU2003293405A1 (en) * | 2002-12-03 | 2004-06-23 | Vela Pharmaceuticals, Inc. | Pharmaceutical composition of 1-(3,4-dimethoxyphenyl)-4-methyl-5-ethyl-7-methoxy-8-hydroxy-5h-2,3-benzodiazepine and uses thereof |
| US6864251B2 (en) * | 2002-12-03 | 2005-03-08 | Vela Pharmaceuticals, Inc. | Treatment of LTB4-mediated inflammatory disorders with optically-pure (R)-2,3-benzodiazepines |
| KR20050094840A (ko) | 2003-01-13 | 2005-09-28 | 코텍스 파마슈티칼스, 인크. | 수면 부족 및 스트레스로 인한 인식 저하의 치료방법 |
| US20040152694A1 (en) * | 2003-02-04 | 2004-08-05 | Istvan Kurucz | Methods and compositions for treating inflammatory disorders of the airways |
| US20040162284A1 (en) * | 2003-02-19 | 2004-08-19 | Harris Herbert W. | Method of lowering body temperature with (S) tofisopam |
| US20040224943A1 (en) * | 2003-02-19 | 2004-11-11 | Leventer Steven M. | Method of lowering body temperature with (R) - 2,3-benzodiazepines |
| GB0325175D0 (en) * | 2003-10-28 | 2003-12-03 | Novartis Ag | Organic compounds |
| MY148809A (en) | 2004-07-06 | 2013-05-31 | Eisai R&D Man Co Ltd | Crystals of 1,2-dihydropyridine compound and their production process |
| JP2007153755A (ja) * | 2005-12-01 | 2007-06-21 | Gifu Univ | プロリン類縁体 |
| EP2338492A1 (en) | 2009-12-24 | 2011-06-29 | Universidad del Pais Vasco | Methods and compositions for the treatment of alzheimer |
| FR2972454B1 (fr) * | 2011-03-08 | 2013-03-01 | Servier Lab | Nouveaux derives dihydro-oxazolobenzodiazepinones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| WO2014026997A1 (de) | 2012-08-16 | 2014-02-20 | Bayer Pharma Aktiengesellschaft | 2,3-benzodiazepine |
| CA2901352A1 (en) | 2013-02-19 | 2014-08-28 | Bayer Pharma Aktiengesellschaft | Bicyclo 2,3-benzodiazepines and spirocyclically substituted 2,3-benzodiazepines |
| US20160009725A1 (en) | 2013-02-22 | 2016-01-14 | Bayer Pharma Aktiengesellschaft | Pyrrolo- and pyrazolo-triazolodiazepines as bet-protein inhibitors for treating hyperproliferative diseases |
| EP2958923A1 (de) | 2013-02-22 | 2015-12-30 | Bayer Pharma Aktiengesellschaft | 4-substituierte pyrrolo- und pyrazolo-diazepine |
| EP3008167A4 (en) | 2013-06-13 | 2017-06-07 | VeroScience LLC | Compositions and methods for treating metabolic disorders |
| EP3436021A4 (en) | 2016-03-29 | 2019-11-06 | RespireRx Pharmaceuticals Inc. | COMPOSITIONS AND METHODS FOR TREATING ATTENTION DEFICIT DISORDER |
| WO2020124090A1 (en) | 2018-12-14 | 2020-06-18 | Eisai R&D Management Co., Ltd. | Aqueous based pharmaceutical formulations of 1,2-dihydropyridine compounds |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| FR2085645A1 (en) * | 1970-04-22 | 1971-12-31 | Chimidrog | 1-phenyl-2,3-benzodiazepin-4-ones - as tranquillizers |
| HU191698B (en) * | 1984-07-27 | 1987-03-30 | Gyogyszerkutato Intezet | Process for producing new 1-aryl-5h-2beta-benzodiazepines |
| HU198494B (en) * | 1986-08-15 | 1989-10-30 | Gyogyszerkutato Intezet | Process for producing new 3,4-dihydro-5h-2,3-benzodiazepine derivative and acid addition salts thereof, as well as pharmaceutical compositions comprising same |
| HU219778B (hu) * | 1990-12-21 | 2001-07-30 | Gyógyszerkutató Intézet Közös Vállalat | Eljárás N-acil-2,3-benzodiazepin-származékok, savaddíciós sóik és az ezeket tartalmazó gyógyászati készítmények előállítására, valamint a vegyületek egy csoportja, és az ezeket tartalmazó gyógyászati készítmények |
| US5550124A (en) * | 1991-12-10 | 1996-08-27 | University Of Southern California | Use of peripheral-type benzodiazpine sites for treatment of CNS trauma or disease |
| US5922773A (en) * | 1992-12-04 | 1999-07-13 | The Children's Medical Center Corp. | Glaucoma treatment |
| DE19604920A1 (de) * | 1996-02-01 | 1997-08-07 | Schering Ag | Neue 2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel |
-
1997
- 1997-03-20 US US08/821,638 patent/US5891871A/en not_active Expired - Fee Related
- 1997-03-21 DE DE69729227T patent/DE69729227T2/de not_active Expired - Fee Related
- 1997-03-21 ES ES97916722T patent/ES2217406T3/es not_active Expired - Lifetime
- 1997-03-21 WO PCT/US1997/003462 patent/WO1997034878A1/en not_active Ceased
- 1997-03-21 JP JP9533496A patent/JP2000506890A/ja not_active Ceased
- 1997-03-21 DK DK97916722T patent/DK1021418T3/da active
- 1997-03-21 PT PT97916722T patent/PT1021418E/pt unknown
- 1997-03-21 AT AT97916722T patent/ATE267177T1/de not_active IP Right Cessation
- 1997-03-21 EP EP97916722A patent/EP1021418B1/en not_active Expired - Lifetime
- 1997-03-21 AU AU25270/97A patent/AU2527097A/en not_active Abandoned
- 1997-03-24 ZA ZA9702496A patent/ZA972496B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2527097A (en) | 1997-10-10 |
| PT1021418E (pt) | 2004-10-29 |
| DK1021418T3 (da) | 2004-09-20 |
| EP1021418A4 (en) | 2001-06-13 |
| DE69729227D1 (de) | 2004-06-24 |
| DE69729227T2 (de) | 2005-05-04 |
| ATE267177T1 (de) | 2004-06-15 |
| JP2000506890A (ja) | 2000-06-06 |
| ZA972496B (en) | 1997-10-02 |
| US5891871A (en) | 1999-04-06 |
| EP1021418B1 (en) | 2004-05-19 |
| WO1997034878A1 (en) | 1997-09-25 |
| EP1021418A1 (en) | 2000-07-26 |
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