ES2213593T3 - Esteres aromaticos de camptotecinas y metodos para el tratamiento del cancer. - Google Patents

Esteres aromaticos de camptotecinas y metodos para el tratamiento del cancer.

Info

Publication number
ES2213593T3
ES2213593T3 ES00950619T ES00950619T ES2213593T3 ES 2213593 T3 ES2213593 T3 ES 2213593T3 ES 00950619 T ES00950619 T ES 00950619T ES 00950619 T ES00950619 T ES 00950619T ES 2213593 T3 ES2213593 T3 ES 2213593T3
Authority
ES
Spain
Prior art keywords
camptothecin
group
carbon atoms
aromatic ester
moles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES00950619T
Other languages
English (en)
Spanish (es)
Inventor
Zhisong Cao
Beppino C. Giovanella
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Stehlin Foundation for Cancer Research
Original Assignee
Stehlin Foundation for Cancer Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stehlin Foundation for Cancer Research filed Critical Stehlin Foundation for Cancer Research
Application granted granted Critical
Publication of ES2213593T3 publication Critical patent/ES2213593T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ES00950619T 1999-08-03 2000-07-25 Esteres aromaticos de camptotecinas y metodos para el tratamiento del cancer. Expired - Lifetime ES2213593T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US365633 1999-08-03
US09/365,633 US6228855B1 (en) 1999-08-03 1999-08-03 Aromatic esters of camptothecins and methods to treat cancers

Publications (1)

Publication Number Publication Date
ES2213593T3 true ES2213593T3 (es) 2004-09-01

Family

ID=23439682

Family Applications (1)

Application Number Title Priority Date Filing Date
ES00950619T Expired - Lifetime ES2213593T3 (es) 1999-08-03 2000-07-25 Esteres aromaticos de camptotecinas y metodos para el tratamiento del cancer.

Country Status (9)

Country Link
US (2) US6228855B1 (enExample)
EP (1) EP1200443B1 (enExample)
JP (1) JP5301066B2 (enExample)
AT (1) ATE260282T1 (enExample)
AU (1) AU6369900A (enExample)
CA (1) CA2380022C (enExample)
DE (1) DE60008540T2 (enExample)
ES (1) ES2213593T3 (enExample)
WO (1) WO2001009139A1 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4465109B2 (ja) 1997-12-17 2010-05-19 エンゾン ファーマシューティカルズ，インコーポレーテッド アミノ及びヒドロキシル含有生物活性剤のポリマープロドラッグ
US6534080B2 (en) 2001-02-12 2003-03-18 Super Gen, Inc. Method for administering camptothecins via injection of pharmaceutical composition comprising coated particles of a camptothecin
US20020150615A1 (en) * 2001-02-12 2002-10-17 Howard Sands Injectable pharmaceutical composition comprising microdroplets of a camptothecin
US6509027B2 (en) 2001-02-12 2003-01-21 Supergen, Inc. Injectable pharmaceutical composition comprising coated particles of camptothecin
US6497896B2 (en) 2001-02-12 2002-12-24 Supergen, Inc. Method for administering camptothecins via injection of a pharmaceutical composition comprising microdroplets containing a camptothecin
US6699875B2 (en) 2002-05-06 2004-03-02 The Stehlin Foundation For Cancer Research Cascade esters of camptothecins and methods of treating cancer using these compounds
US6703399B2 (en) 2002-05-06 2004-03-09 The Stehlin Foundation For Cancer Research Halo-alkyl esters of camptothecins and methods of treating cancer using these compounds
ITRM20020306A1 (it) 2002-05-31 2003-12-01 Sigma Tau Ind Farmaceuti Esteri in posizione 20 di camptotecine.
CN100443486C (zh) * 2002-09-11 2008-12-17 中国医学科学院药物研究所 7-酯化和7,20-双酯化的喜树碱衍生物及其制法和其药物组合物与用途
US20040204435A1 (en) * 2003-04-09 2004-10-14 Joachim Liehr Alternating treatment with topoisomerase I and topoisomerase II inhibitors
WO2005062991A2 (en) * 2003-12-23 2005-07-14 American Bioscience, Inc. Ten and 20-di-esterification derivatives of camptothecins and methods to treat cancers
WO2005062985A2 (en) * 2003-12-23 2005-07-14 American Bioscience, Inc. Di-ester prodrugs of camptothecin, process for their preparation and their therapeutical applications
WO2005070936A1 (en) * 2004-01-09 2005-08-04 Institute Of Mataria Medica, Chinese Academy Of Medical Sciences 20-esterized camptothecin derivatives, their preparation and the pharmaceutical compositions and the use
US20060135546A1 (en) * 2004-12-16 2006-06-22 Jagadevappa Basavaraja Methods for the purification of 20(S)- camptothecin
US7875602B2 (en) * 2005-10-21 2011-01-25 Sutter West Bay Hospitals Camptothecin derivatives as chemoradiosensitizing agents
JP2010500350A (ja) * 2006-08-11 2010-01-07 ザ クリストゥス ステーリン ファウンデーション フォー キャンサー リサーチ カンプトテシンのエステルの製造法
US7572803B2 (en) * 2007-10-25 2009-08-11 The Christus Stehlin Foundation For Cancer Research Hydrated crystalline esters of camptothecin
US20130121921A1 (en) 2011-11-11 2013-05-16 The Christus Stehlin Foundation For Cancer Research Rodent Therapeutic Model And Methods
CN115073483B (zh) * 2022-07-27 2022-10-25 泽升科技(广州)有限公司 一种伊立替康的对映体的制备方法

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3894029A (en) 1971-08-26 1975-07-08 Basf Ag Production of camptothecin and camptothecin-like compounds
US4399282A (en) 1979-07-10 1983-08-16 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives
JPS56108787A (en) 1980-01-31 1981-08-28 Sato Yakugaku Kenkyusho:Kk Camptothecin coline salt and its preparation
US4473692A (en) * 1981-09-04 1984-09-25 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives and process for preparing same
JPS6019790A (ja) * 1983-07-14 1985-01-31 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体
US4894456A (en) 1987-03-31 1990-01-16 Research Triangle Institute Synthesis of camptothecin and analogs thereof
US5227380A (en) * 1987-03-31 1993-07-13 Research Triangle Institute Pharmaceutical compositions and methods employing camptothecins
US5106742A (en) 1987-03-31 1992-04-21 Wall Monroe E Camptothecin analogs as potent inhibitors of topoisomerase I
US5053512A (en) 1987-04-14 1991-10-01 Research Triangle Institute Total synthesis of 20(S) and 20(R)-camptothecin and compthothecin derivatives
US5180722A (en) 1987-04-14 1993-01-19 Research Triangle Institute 10,11-methylenedioxy-20(RS)-camptothecin and 10,11-methylenedioxy-20(S)-camptothecin analogs
CA1332413C (en) 1987-06-25 1994-10-11 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives and process for preparing same
JPS6461482A (en) 1987-08-31 1989-03-08 Yakult Honsha Kk Dehydrocamptothecin and production thereof
US4943579A (en) 1987-10-06 1990-07-24 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Water soluble prodrugs of camptothecin
US5552154A (en) 1989-11-06 1996-09-03 The Stehlin Foundation For Cancer Research Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
US5225404A (en) 1989-11-06 1993-07-06 New York University Methods of treating colon tumors with tumor-inhibiting camptothecin compounds
DK0547165T3 (da) 1990-09-28 2000-03-27 Smithkline Beecham Corp Fremgangsmåde til fremstilling af vandopløselige camptothecinanaloger såvel som forbindelserne 10-hydroxy-11-C(1-6)-alkoxyc
US5126351A (en) 1991-01-24 1992-06-30 Glaxo Inc. Antitumor compounds
JP2738979B2 (ja) 1991-02-21 1998-04-08 スミスクライン・ビーチャム・コーポレイション 非小細胞肺癌の治療
US5391745A (en) 1992-07-23 1995-02-21 Sloan-Kettering Institute For Cancer Research Methods of preparation of camptothecin analogs
US5646154A (en) 1992-10-07 1997-07-08 Sumitomo Pharmaceuticals Co., Ltd. Pharmaceutical compositions for inhibiting the formation of tumor necrosis factor
US5552156A (en) 1992-10-23 1996-09-03 Ohio State University Liposomal and micellular stabilization of camptothecin drugs
FR2697752B1 (fr) 1992-11-10 1995-04-14 Rhone Poulenc Rorer Sa Compositions antitumorales contenant des dérivés du taxane.
EP0602361B1 (de) 1992-11-17 1997-01-22 C. Rob. Hammerstein GmbH Rückenlehnengelenk für einen Fahrzeugsitz
US5352789A (en) 1993-02-25 1994-10-04 The Stehlin Foundation For Cancer Research Methods for purifying camptothecin compounds
US5527913A (en) 1993-02-25 1996-06-18 The Stehlin Foundation For Cancer Research Methods for purifying camptothecin compounds
US5880131A (en) 1993-10-20 1999-03-09 Enzon, Inc. High molecular weight polymer-based prodrugs
US5840900A (en) 1993-10-20 1998-11-24 Enzon, Inc. High molecular weight polymer-based prodrugs
GB9402934D0 (en) 1994-02-16 1994-04-06 Erba Carlo Spa Camptothecin derivatives and process for their preparation
GB9410388D0 (en) 1994-05-24 1994-07-13 Erba Carlo Spa Method for the preparation of 9-amino camptothecin
US5786344A (en) 1994-07-05 1998-07-28 Arch Development Corporation Camptothecin drug combinations and methods with reduced side effects
US5646159A (en) 1994-07-20 1997-07-08 Research Triangle Institute Water-soluble esters of camptothecin compounds
US5736156A (en) 1995-03-22 1998-04-07 The Ohio State University Liposomal anf micellular stabilization of camptothecin drugs
US5834012A (en) 1995-05-03 1998-11-10 Roman Perez-Soler Lipid complexed topoisomerase I inhibitors
GB9510716D0 (en) 1995-05-26 1995-07-19 Pharmacia Spa Substituted camptothecin derivatives and process for their preparation
US5726181A (en) 1995-06-05 1998-03-10 Bionumerik Pharmaceuticals, Inc. Formulations and compositions of poorly water soluble camptothecin derivatives
SG50747A1 (en) 1995-08-02 1998-07-20 Tanabe Seiyaku Co Comptothecin derivatives
CA2192725C (en) 1995-12-28 2004-04-20 Kenji Tsujihara Camptothecin derivatives
US5731316A (en) 1996-01-30 1998-03-24 The Stehlin Foundation For Cancer Research Derivatives of camptothecin and methods of treating cancer using these derivatives
CA2262745C (en) 1996-08-19 2006-04-04 Bionumerik Pharmaceuticals, Inc. Highly lipophilic camptothecin derivatives
US5827533A (en) 1997-02-06 1998-10-27 Duke University Liposomes containing active agents aggregated with lipid surfactants
US6111107A (en) 1997-11-20 2000-08-29 Enzon, Inc. High yield method for stereoselective acylation of tertiary alcohols

Also Published As

Publication number Publication date
AU6369900A (en) 2001-02-19
CA2380022C (en) 2010-10-19
US20020049324A1 (en) 2002-04-25
EP1200443A1 (en) 2002-05-02
US6228855B1 (en) 2001-05-08
DE60008540D1 (de) 2004-04-01
CA2380022A1 (en) 2001-02-08
WO2001009139A1 (en) 2001-02-08
JP2003506378A (ja) 2003-02-18
DE60008540T2 (de) 2004-07-29
ATE260282T1 (de) 2004-03-15
JP5301066B2 (ja) 2013-09-25
EP1200443B1 (en) 2004-02-25
US6407239B1 (en) 2002-06-18

Similar Documents

Publication Publication Date Title
ES2213593T3 (es) Esteres aromaticos de camptotecinas y metodos para el tratamiento del cancer.
US6218399B1 (en) Derivatives of camptothecin and methods of treating cancer using these derivatives
JP4584538B2 (ja) 窒素を基礎とするカンプトテシン誘導体
KR100794417B1 (ko) 토포이소머라제 ⅰ 억제작용이 있는10,11-디플루오로메틸렌디옥시캄프토테신 화합물
ES2246864T3 (es) Esteres de camptotecin-beta-alanina con inhibicion de la topoisemorasa i.
US6699875B2 (en) Cascade esters of camptothecins and methods of treating cancer using these compounds
EP1638978B1 (en) 7-substituted camptothecin and camptothecin analogs and methods for preparing same
CA2484816C (en) Halo-alkyl esters of camptothecins and methods of treating cancer using these compounds
US6407118B1 (en) Derivatives of camptothecin and methods of treating cancer using these derivatives
Cao et al. Synthesis and antitumor activity of aromatic camptothecin esters
US20050096338A1 (en) Camptothecin analogs having an E-ring ketone
CN119176815A (zh) 一类喜树碱-20-位酯衍生物及其制法和其药物组合物与用途