JP5301066B2 - カンプトセシン芳香族エステルおよび癌治療方法 - Google Patents
カンプトセシン芳香族エステルおよび癌治療方法 Download PDFInfo
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- JP5301066B2 JP5301066B2 JP2001514342A JP2001514342A JP5301066B2 JP 5301066 B2 JP5301066 B2 JP 5301066B2 JP 2001514342 A JP2001514342 A JP 2001514342A JP 2001514342 A JP2001514342 A JP 2001514342A JP 5301066 B2 JP5301066 B2 JP 5301066B2
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- camptothecin
- nitrocamptothecin
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/365,633 | 1999-08-03 | ||
| US09/365,633 US6228855B1 (en) | 1999-08-03 | 1999-08-03 | Aromatic esters of camptothecins and methods to treat cancers |
| PCT/US2000/020133 WO2001009139A1 (en) | 1999-08-03 | 2000-07-25 | Aromatic esters of camptothecins and methods to treat cancers |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003506378A JP2003506378A (ja) | 2003-02-18 |
| JP2003506378A5 JP2003506378A5 (enExample) | 2011-03-31 |
| JP5301066B2 true JP5301066B2 (ja) | 2013-09-25 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001514342A Expired - Fee Related JP5301066B2 (ja) | 1999-08-03 | 2000-07-25 | カンプトセシン芳香族エステルおよび癌治療方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US6228855B1 (enExample) |
| EP (1) | EP1200443B1 (enExample) |
| JP (1) | JP5301066B2 (enExample) |
| AT (1) | ATE260282T1 (enExample) |
| AU (1) | AU6369900A (enExample) |
| CA (1) | CA2380022C (enExample) |
| DE (1) | DE60008540T2 (enExample) |
| ES (1) | ES2213593T3 (enExample) |
| WO (1) | WO2001009139A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4465109B2 (ja) | 1997-12-17 | 2010-05-19 | エンゾン ファーマシューティカルズ，インコーポレーテッド | アミノ及びヒドロキシル含有生物活性剤のポリマープロドラッグ |
| US6534080B2 (en) | 2001-02-12 | 2003-03-18 | Super Gen, Inc. | Method for administering camptothecins via injection of pharmaceutical composition comprising coated particles of a camptothecin |
| US20020150615A1 (en) * | 2001-02-12 | 2002-10-17 | Howard Sands | Injectable pharmaceutical composition comprising microdroplets of a camptothecin |
| US6509027B2 (en) | 2001-02-12 | 2003-01-21 | Supergen, Inc. | Injectable pharmaceutical composition comprising coated particles of camptothecin |
| US6497896B2 (en) | 2001-02-12 | 2002-12-24 | Supergen, Inc. | Method for administering camptothecins via injection of a pharmaceutical composition comprising microdroplets containing a camptothecin |
| US6699875B2 (en) | 2002-05-06 | 2004-03-02 | The Stehlin Foundation For Cancer Research | Cascade esters of camptothecins and methods of treating cancer using these compounds |
| US6703399B2 (en) | 2002-05-06 | 2004-03-09 | The Stehlin Foundation For Cancer Research | Halo-alkyl esters of camptothecins and methods of treating cancer using these compounds |
| ITRM20020306A1 (it) | 2002-05-31 | 2003-12-01 | Sigma Tau Ind Farmaceuti | Esteri in posizione 20 di camptotecine. |
| CN100443486C (zh) * | 2002-09-11 | 2008-12-17 | 中国医学科学院药物研究所 | 7-酯化和7,20-双酯化的喜树碱衍生物及其制法和其药物组合物与用途 |
| US20040204435A1 (en) * | 2003-04-09 | 2004-10-14 | Joachim Liehr | Alternating treatment with topoisomerase I and topoisomerase II inhibitors |
| WO2005062991A2 (en) * | 2003-12-23 | 2005-07-14 | American Bioscience, Inc. | Ten and 20-di-esterification derivatives of camptothecins and methods to treat cancers |
| WO2005062985A2 (en) * | 2003-12-23 | 2005-07-14 | American Bioscience, Inc. | Di-ester prodrugs of camptothecin, process for their preparation and their therapeutical applications |
| WO2005070936A1 (en) * | 2004-01-09 | 2005-08-04 | Institute Of Mataria Medica, Chinese Academy Of Medical Sciences | 20-esterized camptothecin derivatives, their preparation and the pharmaceutical compositions and the use |
| US20060135546A1 (en) * | 2004-12-16 | 2006-06-22 | Jagadevappa Basavaraja | Methods for the purification of 20(S)- camptothecin |
| US7875602B2 (en) * | 2005-10-21 | 2011-01-25 | Sutter West Bay Hospitals | Camptothecin derivatives as chemoradiosensitizing agents |
| JP2010500350A (ja) * | 2006-08-11 | 2010-01-07 | ザ クリストゥス ステーリン ファウンデーション フォー キャンサー リサーチ | カンプトテシンのエステルの製造法 |
| US7572803B2 (en) * | 2007-10-25 | 2009-08-11 | The Christus Stehlin Foundation For Cancer Research | Hydrated crystalline esters of camptothecin |
| US20130121921A1 (en) | 2011-11-11 | 2013-05-16 | The Christus Stehlin Foundation For Cancer Research | Rodent Therapeutic Model And Methods |
| CN115073483B (zh) * | 2022-07-27 | 2022-10-25 | 泽升科技(广州)有限公司 | 一种伊立替康的对映体的制备方法 |
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| US3894029A (en) | 1971-08-26 | 1975-07-08 | Basf Ag | Production of camptothecin and camptothecin-like compounds |
| US4399282A (en) | 1979-07-10 | 1983-08-16 | Kabushiki Kaisha Yakult Honsha | Camptothecin derivatives |
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| JPS6019790A (ja) * | 1983-07-14 | 1985-01-31 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体 |
| US4894456A (en) | 1987-03-31 | 1990-01-16 | Research Triangle Institute | Synthesis of camptothecin and analogs thereof |
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| DK0547165T3 (da) | 1990-09-28 | 2000-03-27 | Smithkline Beecham Corp | Fremgangsmåde til fremstilling af vandopløselige camptothecinanaloger såvel som forbindelserne 10-hydroxy-11-C(1-6)-alkoxyc |
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| US5552156A (en) | 1992-10-23 | 1996-09-03 | Ohio State University | Liposomal and micellular stabilization of camptothecin drugs |
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| US5352789A (en) | 1993-02-25 | 1994-10-04 | The Stehlin Foundation For Cancer Research | Methods for purifying camptothecin compounds |
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-
1999
- 1999-08-03 US US09/365,633 patent/US6228855B1/en not_active Expired - Lifetime
-
2000
- 2000-07-25 CA CA2380022A patent/CA2380022C/en not_active Expired - Fee Related
- 2000-07-25 AT AT00950619T patent/ATE260282T1/de not_active IP Right Cessation
- 2000-07-25 AU AU63699/00A patent/AU6369900A/en not_active Abandoned
- 2000-07-25 EP EP00950619A patent/EP1200443B1/en not_active Expired - Lifetime
- 2000-07-25 DE DE60008540T patent/DE60008540T2/de not_active Expired - Lifetime
- 2000-07-25 JP JP2001514342A patent/JP5301066B2/ja not_active Expired - Fee Related
- 2000-07-25 ES ES00950619T patent/ES2213593T3/es not_active Expired - Lifetime
- 2000-07-25 WO PCT/US2000/020133 patent/WO2001009139A1/en not_active Ceased
- 2000-12-22 US US09/747,450 patent/US6407239B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU6369900A (en) | 2001-02-19 |
| CA2380022C (en) | 2010-10-19 |
| US20020049324A1 (en) | 2002-04-25 |
| EP1200443A1 (en) | 2002-05-02 |
| US6228855B1 (en) | 2001-05-08 |
| DE60008540D1 (de) | 2004-04-01 |
| CA2380022A1 (en) | 2001-02-08 |
| WO2001009139A1 (en) | 2001-02-08 |
| JP2003506378A (ja) | 2003-02-18 |
| DE60008540T2 (de) | 2004-07-29 |
| ATE260282T1 (de) | 2004-03-15 |
| EP1200443B1 (en) | 2004-02-25 |
| ES2213593T3 (es) | 2004-09-01 |
| US6407239B1 (en) | 2002-06-18 |
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