ES2212849T3 - Sintesis y purificacion mejoradas de hidrocloruro de (r*,r*)-2-((dimetilamino)metil)-1-(3-metoxifenil)ciclohexanol. - Google Patents
Sintesis y purificacion mejoradas de hidrocloruro de (r*,r*)-2-((dimetilamino)metil)-1-(3-metoxifenil)ciclohexanol.Info
- Publication number
- ES2212849T3 ES2212849T3 ES99930115T ES99930115T ES2212849T3 ES 2212849 T3 ES2212849 T3 ES 2212849T3 ES 99930115 T ES99930115 T ES 99930115T ES 99930115 T ES99930115 T ES 99930115T ES 2212849 T3 ES2212849 T3 ES 2212849T3
- Authority
- ES
- Spain
- Prior art keywords
- tramadol
- trans
- hydrochloride
- amine
- cis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/10—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B49/00—Grignard reactions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8649898P | 1998-05-22 | 1998-05-22 | |
| US86498P | 1998-05-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2212849T3 true ES2212849T3 (es) | 2004-08-01 |
Family
ID=22198976
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES99930115T Expired - Lifetime ES2212849T3 (es) | 1998-05-22 | 1999-05-20 | Sintesis y purificacion mejoradas de hidrocloruro de (r*,r*)-2-((dimetilamino)metil)-1-(3-metoxifenil)ciclohexanol. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6399829B1 (https=) |
| EP (1) | EP1077923B1 (https=) |
| JP (1) | JP2002516302A (https=) |
| AT (1) | ATE257147T1 (https=) |
| CA (1) | CA2330142A1 (https=) |
| DE (1) | DE69913955T2 (https=) |
| DK (1) | DK1077923T3 (https=) |
| ES (1) | ES2212849T3 (https=) |
| WO (1) | WO1999061405A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001510180A (ja) * | 1997-07-15 | 2001-07-31 | ラシンスキィ・リミテッド | トラマドール、その塩酸塩、及びそれらの製造方法 |
| KR100342919B1 (ko) * | 1999-10-21 | 2002-07-04 | 박노중 | 트랜스체 염산 트라마돌의 분리 제조방법 |
| RU2165922C1 (ru) * | 2000-07-19 | 2001-04-27 | Государственный научно-исследовательский институт органической химии и технологии | Способ получения трамадола |
| DE10049483A1 (de) * | 2000-09-29 | 2002-05-02 | Gruenenthal Gmbh | Substituierte 1-Aminobutan-3-ol-Derivate |
| DE10049481A1 (de) | 2000-09-29 | 2002-05-02 | Gruenenthal Gmbh | Substituierte C-Cyclohexylmethylamin-Derivate |
| DE10108308A1 (de) | 2001-02-21 | 2002-08-29 | Gruenenthal Gmbh | Verfahren zur Isolierung und Reinigung von (1RS,2RS)-2[(Dimethylamino)methyl]-1-(3-methoxyphenyl)-cyclohexanol |
| US6649783B2 (en) | 2001-10-03 | 2003-11-18 | Euro-Celtique, S.A. | Synthesis of (+/-)-2-((dimethylamino)methyl)-1-(aryl)cyclohexanols |
| DE10236510A1 (de) * | 2002-08-09 | 2004-02-19 | Grünenthal GmbH | Verfahren zur Herstellung von 2-[(Dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol |
| JP2004115510A (ja) * | 2002-09-05 | 2004-04-15 | Toray Fine Chemicals Co Ltd | ピペラジン誘導体の製造方法 |
| EP1785412A1 (en) * | 2005-11-14 | 2007-05-16 | IPCA Laboratories Limited | Tramadol recovery process |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3652589A (en) * | 1967-07-27 | 1972-03-28 | Gruenenthal Chemie | 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols |
| IL103096A (en) * | 1992-09-08 | 1996-12-05 | Chemagis Ltd | Process for purification 2 -]) Dimethylamino (methyl-1-) 3-methoxycinyl (cyclohexanol and its salts. |
| IL116281A (en) * | 1995-12-07 | 1999-06-20 | Chemagis Ltd | Process for the purification of (rr,ss)-2-dimethylaminomethyl-1-(3-methoxyphenyl) cyclohexanol and its salts |
-
1999
- 1999-05-20 EP EP99930115A patent/EP1077923B1/en not_active Expired - Lifetime
- 1999-05-20 WO PCT/US1999/011336 patent/WO1999061405A1/en not_active Ceased
- 1999-05-20 US US09/700,889 patent/US6399829B1/en not_active Expired - Fee Related
- 1999-05-20 DK DK99930115T patent/DK1077923T3/da active
- 1999-05-20 CA CA002330142A patent/CA2330142A1/en not_active Abandoned
- 1999-05-20 ES ES99930115T patent/ES2212849T3/es not_active Expired - Lifetime
- 1999-05-20 DE DE69913955T patent/DE69913955T2/de not_active Expired - Fee Related
- 1999-05-20 AT AT99930115T patent/ATE257147T1/de not_active IP Right Cessation
- 1999-05-20 JP JP2000550815A patent/JP2002516302A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP1077923A1 (en) | 2001-02-28 |
| WO1999061405A1 (en) | 1999-12-02 |
| JP2002516302A (ja) | 2002-06-04 |
| EP1077923B1 (en) | 2004-01-02 |
| US6399829B1 (en) | 2002-06-04 |
| DE69913955D1 (de) | 2004-02-05 |
| CA2330142A1 (en) | 1999-12-02 |
| DE69913955T2 (de) | 2004-12-16 |
| ATE257147T1 (de) | 2004-01-15 |
| DK1077923T3 (da) | 2004-04-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TW555752B (en) | Secondary alcohol useful in producing oxazolidinones and its preparation | |
| ES2628755T3 (es) | Procesos para fabricar catalizadores de Ru (II) | |
| ES2212849T3 (es) | Sintesis y purificacion mejoradas de hidrocloruro de (r*,r*)-2-((dimetilamino)metil)-1-(3-metoxifenil)ciclohexanol. | |
| ES2209158T3 (es) | Resolucion de aminas. | |
| TW200815358A (en) | Organic compounds | |
| BRPI0001486B1 (pt) | processos e intermediários para preparar compostos anticancerígenos | |
| JP6290186B2 (ja) | 光学的に純粋で置換基を有していてもよい２−（１−ヒドロキシ−アルキル）クロメン−４−オン誘導体の調製方法および医薬品調製におけるそれらの使用 | |
| JP5735659B2 (ja) | シタグリプチンの中間体の製造方法 | |
| ES2583262T3 (es) | Procedimiento para la purificación de pirazoles | |
| JP2005507900A (ja) | シタロプラムの製造方法 | |
| JP3119872B2 (ja) | 前もって固定された対称性をもつキレート化剤のための中間体およびそれらの製造方法 | |
| ES2741505T3 (es) | Procedimiento para la preparación de acetato de abiraterona y sus productos intermedios | |
| EP3081554B1 (en) | Method for preparing silodosin and intermediate thereof | |
| KR20050044381A (ko) | 중수소화된 피라졸로피리미디논류 및 이를 함유한 약물 | |
| ES2362913B1 (es) | Nuevo método para la preparación de (s)-pregabalina. | |
| ES2290317T3 (es) | Procedimiento de produccion de biperideno. | |
| JP2002510699A (ja) | ホスフィンリガンドの調製 | |
| ES2267399B1 (es) | Procedimiento para la obtencion de carbamatos de fenilo. | |
| CN111808040A (zh) | 多构型2-氧代噁唑烷-4-羧酸类化合物的合成方法 | |
| TWI309639B (https=) | ||
| JPH0446175A (ja) | ５―ヒドロキシ―３，４―メチレンジオキシ安息香酸誘導体の製造法 | |
| TW200918534A (en) | Racemization process of R-zopiclone | |
| KR100958678B1 (ko) | 시스-디메크로틴산 및 이의 염의 제조방법 | |
| JP2008531487A5 (https=) | ||
| JP2008531487A (ja) | カンプトセシンサブユニットの新規の合成法 |