ES2201899B1 - Derivados de la azaindolilpiperidina como agentes antihistaminicos y antialergicos. - Google Patents

Derivados de la azaindolilpiperidina como agentes antihistaminicos y antialergicos.

Info

Publication number
ES2201899B1
ES2201899B1 ES200200753A ES200200753A ES2201899B1 ES 2201899 B1 ES2201899 B1 ES 2201899B1 ES 200200753 A ES200200753 A ES 200200753A ES 200200753 A ES200200753 A ES 200200753A ES 2201899 B1 ES2201899 B1 ES 2201899B1
Authority
ES
Spain
Prior art keywords
pyrrolo
pyridin
piperidin
ylmethyl
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES200200753A
Other languages
English (en)
Spanish (es)
Other versions
ES2201899A1 (es
Inventor
Silvia Fonquerna Pou
Luis Miguel Pages Santacana
Carlos Puig Duran
Jose Manuel Prieto Soto
Aranzazu Cardus Figueras
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Almirall SA
Original Assignee
Almirall Prodesfarma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES200200753A priority Critical patent/ES2201899B1/es
Application filed by Almirall Prodesfarma SA filed Critical Almirall Prodesfarma SA
Priority to PCT/EP2003/003377 priority patent/WO2003082867A1/en
Priority to SI200330318T priority patent/SI1497292T1/sl
Priority to PT03745302T priority patent/PT1497292E/pt
Priority to JP2003580332A priority patent/JP2005526816A/ja
Priority to US10/509,279 priority patent/US7622480B2/en
Priority to DK03745302T priority patent/DK1497292T3/da
Priority to EP03745302A priority patent/EP1497292B1/en
Priority to DE60306138T priority patent/DE60306138T2/de
Priority to ES03745302T priority patent/ES2265577T3/es
Priority to AT03745302T priority patent/ATE329916T1/de
Priority to AU2003226765A priority patent/AU2003226765A1/en
Publication of ES2201899A1 publication Critical patent/ES2201899A1/es
Application granted granted Critical
Publication of ES2201899B1 publication Critical patent/ES2201899B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ES200200753A 2002-04-01 2002-04-01 Derivados de la azaindolilpiperidina como agentes antihistaminicos y antialergicos. Expired - Fee Related ES2201899B1 (es)

Priority Applications (12)

Application Number Priority Date Filing Date Title
ES200200753A ES2201899B1 (es) 2002-04-01 2002-04-01 Derivados de la azaindolilpiperidina como agentes antihistaminicos y antialergicos.
DE60306138T DE60306138T2 (de) 2002-04-01 2003-04-01 Azaindolylpiperidinderivate als antihistaminika und antiallergika
PT03745302T PT1497292E (pt) 2002-04-01 2003-04-01 Derivados de azaindolilpiperidina como agentes anti-histaminicos e antialergicos
JP2003580332A JP2005526816A (ja) 2002-04-01 2003-04-01 抗ヒスタミン薬および抗アレルギー薬としてのアザインドリルピペリジン誘導体
US10/509,279 US7622480B2 (en) 2002-04-01 2003-04-01 Azaindolylpiperidine derivatives as antihistaminic and antiallergic agents
DK03745302T DK1497292T3 (da) 2002-04-01 2003-04-01 Azaindolylpiperidinderivater som antihistamin- og antiallergimidler
PCT/EP2003/003377 WO2003082867A1 (en) 2002-04-01 2003-04-01 Azaindolylpiperidine derivatives as antihistaminic and antiallergic agents
SI200330318T SI1497292T1 (sl) 2002-04-01 2003-04-01 Derivati azaindolilpiperidina kot antihistaminicna in antialergijska sredstva
ES03745302T ES2265577T3 (es) 2002-04-01 2003-04-01 Derivados de azaindolilpiperidina como agentes antihistaminicos y antialergicos.
AT03745302T ATE329916T1 (de) 2002-04-01 2003-04-01 Azaindolylpiperidinderivate als antihistaminika und antiallergika
AU2003226765A AU2003226765A1 (en) 2002-04-01 2003-04-01 Azaindolylpiperidine derivatives as antihistaminic and antiallergic agents
EP03745302A EP1497292B1 (en) 2002-04-01 2003-04-01 Azaindolylpiperidine derivatives as antihistaminic and antiallergic agents

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200200753A ES2201899B1 (es) 2002-04-01 2002-04-01 Derivados de la azaindolilpiperidina como agentes antihistaminicos y antialergicos.

Publications (2)

Publication Number Publication Date
ES2201899A1 ES2201899A1 (es) 2004-03-16
ES2201899B1 true ES2201899B1 (es) 2005-06-01

Family

ID=28459671

Family Applications (2)

Application Number Title Priority Date Filing Date
ES200200753A Expired - Fee Related ES2201899B1 (es) 2002-04-01 2002-04-01 Derivados de la azaindolilpiperidina como agentes antihistaminicos y antialergicos.
ES03745302T Expired - Lifetime ES2265577T3 (es) 2002-04-01 2003-04-01 Derivados de azaindolilpiperidina como agentes antihistaminicos y antialergicos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES03745302T Expired - Lifetime ES2265577T3 (es) 2002-04-01 2003-04-01 Derivados de azaindolilpiperidina como agentes antihistaminicos y antialergicos.

Country Status (10)

Country Link
US (1) US7622480B2 (enExample)
EP (1) EP1497292B1 (enExample)
JP (1) JP2005526816A (enExample)
AT (1) ATE329916T1 (enExample)
AU (1) AU2003226765A1 (enExample)
DE (1) DE60306138T2 (enExample)
DK (1) DK1497292T3 (enExample)
ES (2) ES2201899B1 (enExample)
PT (1) PT1497292E (enExample)
WO (1) WO2003082867A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA06004626A (es) * 2003-11-17 2006-06-27 Boehringer Ingelheim Int Indoles sustituidos con piperidina o sus heteroderivados y su uso como moduladores del receptor de quemocina (ccr3).
ATE461925T1 (de) * 2005-04-26 2010-04-15 Hypnion Inc Benzisoxazolpiperidinverbindungen und verfahren zu deren anwendung
WO2006117314A2 (en) * 2005-04-30 2006-11-09 Boehringer Ingelheim International Gmbh Novel piperidin- substituted indoles and their use as ccr-3 modulators
WO2007050381A2 (en) * 2005-10-24 2007-05-03 Janssen Pharmaceutica, N.V. 3-piperidin-4-yl-indole orl-1 receptor modulators
ATE537166T1 (de) * 2006-10-27 2011-12-15 Boehringer Ingelheim Int Piperidylpropanthiole als ccr3-modulatoren
WO2008049875A1 (en) * 2006-10-27 2008-05-02 Boehringer Ingelheim International Gmbh Novel substituted piperidyl-propane-thiols
JP2014515368A (ja) 2011-05-26 2014-06-30 第一三共株式会社 プロテインキナーゼ阻害剤としての複素環化合物
MA40759A (fr) 2014-09-26 2017-08-01 Pfizer Modulateurs de rorc2 de type pyrrolopyridine substitué par un méthyle et trifluorométhyle et leurs procédés d'utilisation
CA3081443A1 (en) 2014-12-15 2016-06-23 The Regents Of The University Of Michigan Small molecule inhibitors of egfr and pi3k
KR101660863B1 (ko) * 2015-04-03 2016-09-28 주식회사 녹십자 IKKε 및 TBK1 억제제로서의 7-아자인돌 또는 4,7-다이아자인돌 유도체 및 이를 포함하는 약학적 조성물
US11673876B2 (en) 2020-12-22 2023-06-13 Mekanistic Therapeutics Llc Substituted aminobenzyl heteroaryl compounds as EGFR and/or PI3K inhibitors

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2086112A1 (en) * 1991-04-23 1992-10-24 Katsuhiro Shibayama Tricyclic triazolo derivatives, processes for producing the same and uses of the same
AU3176297A (en) * 1996-06-25 1998-01-14 Novartis Ag Substituted 7-amino-pyrrolo{3,2-d}pyrimidines and the use thereof
ZA979961B (en) * 1996-11-15 1999-05-05 Lilly Co Eli 5-HT1F agonists
ES2165274B1 (es) * 1999-06-04 2003-04-01 Almirall Prodesfarma Sa Nuevos derivados de indolilpiperidina como agentes antihistaminicos y antialergicos.
HK1052705B (en) * 2000-08-14 2006-09-29 Ortho-Mcneil Pharmaceutical, Inc. Substituted pyrazole
ATE402699T1 (de) 2000-09-06 2008-08-15 Ortho Mcneil Pharm Inc Verwendung von substituierten pyrazolen zur behandlung von allergien
ES2172436B1 (es) * 2000-10-31 2004-01-16 Almirall Prodesfarma Sa Derivados de indolilpiperidina como agentes antihistaminicos y antialergicos.
EA200300717A1 (ru) 2000-12-22 2003-12-25 Уайт Гетероциклилиндазольные и -азаиндазольные соединения в качестве 5-гидрокситриптамин-6-лигандов
WO2002079151A1 (en) 2001-03-29 2002-10-10 Smithkline Beecham P.L.C. 3-substituted indoels or fused pyrroles as antagonists of the chemokine mcp-1 (ccr2b) receptor

Also Published As

Publication number Publication date
WO2003082867A1 (en) 2003-10-09
DE60306138D1 (de) 2006-07-27
US20050176751A1 (en) 2005-08-11
PT1497292E (pt) 2006-10-31
WO2003082867A8 (en) 2004-11-04
US7622480B2 (en) 2009-11-24
ATE329916T1 (de) 2006-07-15
JP2005526816A (ja) 2005-09-08
AU2003226765A8 (en) 2003-10-13
AU2003226765A1 (en) 2003-10-13
EP1497292B1 (en) 2006-06-14
ES2265577T3 (es) 2007-02-16
ES2201899A1 (es) 2004-03-16
DK1497292T3 (da) 2006-10-16
EP1497292A1 (en) 2005-01-19
DE60306138T2 (de) 2007-05-03

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