ES2196250T3 - Procedimiento para la obtencion de (r o s)-1- (4 metoxibencil) 1,2,3,4,5,6,7,8-octahidro-isoquinolina opticamente activa. - Google Patents

Procedimiento para la obtencion de (r o s)-1- (4 metoxibencil) 1,2,3,4,5,6,7,8-octahidro-isoquinolina opticamente activa.

Info

Publication number
ES2196250T3
ES2196250T3 ES97122627T ES97122627T ES2196250T3 ES 2196250 T3 ES2196250 T3 ES 2196250T3 ES 97122627 T ES97122627 T ES 97122627T ES 97122627 T ES97122627 T ES 97122627T ES 2196250 T3 ES2196250 T3 ES 2196250T3
Authority
ES
Spain
Prior art keywords
acid
optically active
octahidro
procedure
metoxibential
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97122627T
Other languages
English (en)
Inventor
Emil Albin Broger
Michelangelo Scalone
Christof Wehrli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2196250T3 publication Critical patent/ES2196250T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA FABRICAR ADUCTOS DE R O S 1- (4 METOXI BENZIL) 1,2,3,4,5,6,7,8 OCTAHIDRO ISOQUIOLINAS OPTICAMENTE ACTIVAS DE FORMULA GENERAL, EN LA CUAL HX SIGNIFICA UN ACIDO MINERAL DEL GRUPO DE HBF 4 , H 2 SO 4 , HPF 6 , HB R, HI, HCI, HSBF 6 , HCIO 4 , ACIDOS ORGANICOS DEL GRUPO DE C 1-8 ALQUILSO 3 H, ACIDO PICRICO, ACIDO FORMIC O, UN ACIDO CARBOXILICO DE ALQUILO INFERIOR O ARILO O UN ACIDO DICARBOXILICO, A PARTIR DE UNA COMPOSICION DE FORMULA GENERAL, EN LA CUAL HX TIENE LA SIGNIFICACION ARRIBA DADA, HIDROGENANDOSE ASIMETRICAMENTE EN PRESENCIA DE UN COMPLEJO FORMADO POR LIGANDOS DE DIFOSFINA OPICAMENTE ACTIVOS CON IRIDIO, OPCIONALMENTE EN PRESENCIA DE UN ADITIVO.
ES97122627T 1996-12-23 1997-12-22 Procedimiento para la obtencion de (r o s)-1- (4 metoxibencil) 1,2,3,4,5,6,7,8-octahidro-isoquinolina opticamente activa. Expired - Lifetime ES2196250T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP96120844 1996-12-23

Publications (1)

Publication Number Publication Date
ES2196250T3 true ES2196250T3 (es) 2003-12-16

Family

ID=8223556

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97122627T Expired - Lifetime ES2196250T3 (es) 1996-12-23 1997-12-22 Procedimiento para la obtencion de (r o s)-1- (4 metoxibencil) 1,2,3,4,5,6,7,8-octahidro-isoquinolina opticamente activa.

Country Status (9)

Country Link
US (1) US5880285A (es)
EP (1) EP0850931B1 (es)
JP (1) JP3040366B2 (es)
KR (2) KR19980064495A (es)
CN (1) CN1139576C (es)
AT (1) ATE238992T1 (es)
DE (1) DE59709968D1 (es)
DK (1) DK0850931T3 (es)
ES (1) ES2196250T3 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999016752A1 (en) * 1997-09-30 1999-04-08 Molecular Designs International, Inc. β3-ADRENORECEPTOR AGONISTS, AGONIST COMPOSITIONS AND METHODS OF USING
KR100382364B1 (ko) * 2000-04-20 2003-05-01 학교법인 포항공과대학교 호모키랄 다공성 결정 물질
US6593341B2 (en) 2001-03-29 2003-07-15 Molecular Design International, Inc. β3-adrenoreceptor agonists, agonist compositions and methods of making and using the same
WO2003078399A1 (en) * 2002-03-19 2003-09-25 Dsm Ip Assets B.V. Process for asymmetric hydrogenation of hexahydroquinoline salts
US6596734B1 (en) 2002-10-11 2003-07-22 Molecular Design International, Inc. Tetrahydroisoquinoline compounds for use as β3-adrenoreceptor agonists
CN102241630A (zh) * 2011-05-20 2011-11-16 杭州保灵集团有限公司 一种镇咳嗽药磷酸二甲啡烷的制备方法
CN111333573B (zh) * 2020-04-10 2021-09-28 浙江工业大学 一种右美沙芬中间体的制备工艺

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4115389A (en) * 1977-05-02 1978-09-19 Bristol-Myers Company Process of N-demethylating (-)-1-(p-methoxybenzyl)-2-methyl-1,2,3,4,5,6,7,8-octahydroisoquinoline
DE3436179A1 (de) * 1984-10-03 1986-04-10 Merck Patent Gmbh, 6100 Darmstadt Verfahren zur herstellung optisch aktiver amine
JPH0667947B2 (ja) * 1987-09-08 1994-08-31 高砂香料工業株式会社 ルテニウム−ホスフイン錯体
DK168069B1 (da) * 1987-11-11 1994-01-31 Hoffmann La Roche Isoquinolinderivater og en fremgangsmaade til fremstilling af octahydroisoquinoliner ud fra derivaterne
SG42938A1 (en) * 1993-02-26 1997-10-17 Ciba Geigy Ag Ferrocenc diphosphines as ligands for homogeneous catalysts

Also Published As

Publication number Publication date
US5880285A (en) 1999-03-09
DK0850931T3 (da) 2003-08-18
EP0850931A2 (de) 1998-07-01
ATE238992T1 (de) 2003-05-15
CN1139576C (zh) 2004-02-25
EP0850931B1 (de) 2003-05-02
KR19980064495A (ko) 1998-10-07
CN1186073A (zh) 1998-07-01
JPH10182612A (ja) 1998-07-07
JP3040366B2 (ja) 2000-05-15
DE59709968D1 (de) 2003-06-05
EP0850931A3 (de) 2000-04-26
KR100248685B1 (ko) 2000-04-01

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