ES2196145T3 - Capa de soporte mejorada para mebranas laminadas de electrodo enzimatico. - Google Patents
Capa de soporte mejorada para mebranas laminadas de electrodo enzimatico.Info
- Publication number
- ES2196145T3 ES2196145T3 ES96907178T ES96907178T ES2196145T3 ES 2196145 T3 ES2196145 T3 ES 2196145T3 ES 96907178 T ES96907178 T ES 96907178T ES 96907178 T ES96907178 T ES 96907178T ES 2196145 T3 ES2196145 T3 ES 2196145T3
- Authority
- ES
- Spain
- Prior art keywords
- layer
- lips
- improved support
- electrode laminated
- enzymatic electrode
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
- C12Q1/002—Electrode membranes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/817—Enzyme or microbe electrode
Abstract
Una membrana laminada que contiene una enzima se prepara para su utilización con un electrodo de una célula polarográfica para ensayar un analito como glucosa o lactato. La membrana (28) y tiene una capa externa o de soporte (30) una capa interna o barrera (32) y una capa enzimática (34) entre las capas externa e interna. La capa externa puede estar hecha de policarbonato, celulosa regenerada o polímero de poliuretano, y tiene una dimensiones de poros mayores que aproximadamente 200 Angstrom y preferentemente entre 380 y 750 Angstrom, una porosidad de entre 0,005 y 0,2% y un espesor de aproximadamente entre 5 y 7 micras. La capa interna puede estar hecha de un polímero de butirato de acetato de celulosa/acetato de celulosa y tiene un espesor de menos de 2 micras. La capa enzimática está normalmente reticulada in situ entre la capa externa y la capa interna utilizando glutaraldehído. La capa externa puede tener una estructura multicapa.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/373,596 US5520788A (en) | 1995-01-17 | 1995-01-17 | Support layer for enzyme electrode laminated membranes |
PCT/US1996/002915 WO1997032976A1 (en) | 1995-01-17 | 1996-03-04 | Improved support layer for enzyme electrode laminated membranes |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2196145T3 true ES2196145T3 (es) | 2003-12-16 |
Family
ID=26790904
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES96907178T Expired - Lifetime ES2196145T3 (es) | 1995-01-17 | 1996-03-04 | Capa de soporte mejorada para mebranas laminadas de electrodo enzimatico. |
Country Status (7)
Country | Link |
---|---|
US (1) | US5520788A (es) |
EP (1) | EP0973877B1 (es) |
JP (1) | JP2000506972A (es) |
DE (1) | DE69628468T2 (es) |
ES (1) | ES2196145T3 (es) |
HK (1) | HK1025359A1 (es) |
WO (1) | WO1997032976A1 (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5766839A (en) * | 1994-06-17 | 1998-06-16 | Ysi Incorporated | Processes for preparing barrier layer films for use in enzyme electrodes and films made thereby |
US5696314A (en) * | 1996-07-12 | 1997-12-09 | Chiron Diagnostics Corporation | Multilayer enzyme electrode membranes and methods of making same |
US6020052A (en) * | 1996-07-30 | 2000-02-01 | Ysi Incorporated | Laminated membrane structure for polarographic measurement and methods of making said structures |
US5804048A (en) * | 1996-08-15 | 1998-09-08 | Via Medical Corporation | Electrode assembly for assaying glucose |
US5932799A (en) * | 1997-07-21 | 1999-08-03 | Ysi Incorporated | Microfluidic analyzer module |
US6073482A (en) * | 1997-07-21 | 2000-06-13 | Ysi Incorporated | Fluid flow module |
US6293012B1 (en) | 1997-07-21 | 2001-09-25 | Ysi Incorporated | Method of making a fluid flow module |
US8364229B2 (en) | 2003-07-25 | 2013-01-29 | Dexcom, Inc. | Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise |
US7613491B2 (en) | 2002-05-22 | 2009-11-03 | Dexcom, Inc. | Silicone based membranes for use in implantable glucose sensors |
US20070173709A1 (en) * | 2005-04-08 | 2007-07-26 | Petisce James R | Membranes for an analyte sensor |
US9763609B2 (en) | 2003-07-25 | 2017-09-19 | Dexcom, Inc. | Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise |
WO2006110193A2 (en) * | 2005-04-08 | 2006-10-19 | Dexcom, Inc. | Cellulosic-based interference domain for an analyte sensor |
US20090143658A1 (en) * | 2006-02-27 | 2009-06-04 | Edwards Lifesciences Corporation | Analyte sensor |
US20200037875A1 (en) | 2007-05-18 | 2020-02-06 | Dexcom, Inc. | Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise |
WO2010027771A1 (en) | 2008-08-27 | 2010-03-11 | Edwards Lifesciences Corporation | Analyte sensor |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1442303A (en) * | 1972-09-08 | 1976-07-14 | Radiometer As | Cell for electro-chemical analysis |
US3979274A (en) * | 1975-09-24 | 1976-09-07 | The Yellow Springs Instrument Company, Inc. | Membrane for enzyme electrodes |
US4415666A (en) * | 1981-11-05 | 1983-11-15 | Miles Laboratories, Inc. | Enzyme electrode membrane |
US4418148A (en) * | 1981-11-05 | 1983-11-29 | Miles Laboratories, Inc. | Multilayer enzyme electrode membrane |
JPS59164953A (ja) * | 1983-03-10 | 1984-09-18 | Fuji Electric Corp Res & Dev Ltd | 固定化酵素膜およびその製造方法 |
US4484987A (en) * | 1983-05-19 | 1984-11-27 | The Regents Of The University Of California | Method and membrane applicable to implantable sensor |
JPS60185153A (ja) * | 1984-03-02 | 1985-09-20 | Fuji Electric Corp Res & Dev Ltd | 固定化酵素膜 |
US5030333A (en) * | 1984-09-13 | 1991-07-09 | Children's Hospital Medical Center | Polarographic method for measuring both analyte and oxygen with the same detecting electrode of an electroenzymatic sensor |
JPS61145447A (ja) * | 1984-12-19 | 1986-07-03 | Fuji Electric Co Ltd | 固定化酵素膜 |
GB8514176D0 (en) * | 1985-06-05 | 1985-07-10 | Ici Plc | Membrane |
GB8522834D0 (en) * | 1985-09-16 | 1985-10-23 | Ici Plc | Sensor |
GB8529300D0 (en) * | 1985-11-28 | 1986-01-02 | Ici Plc | Membrane |
US4759828A (en) * | 1987-04-09 | 1988-07-26 | Nova Biomedical Corporation | Glucose electrode and method of determining glucose |
US5352348A (en) * | 1987-04-09 | 1994-10-04 | Nova Biomedical Corporation | Method of using enzyme electrode |
GB2209836A (en) * | 1987-09-16 | 1989-05-24 | Cambridge Life Sciences | Multilayer enzyme electrode membrane and method of making same |
EP0327018B1 (en) * | 1988-02-05 | 1995-05-03 | Nova Biomedical Corporation | Enzyme Electrode |
US5196340A (en) * | 1989-08-04 | 1993-03-23 | Nec Corporation | Enzyme electrode containing an enzyme and a coenzyme immobilized in separate layers of a membrane |
US5429726A (en) * | 1993-04-30 | 1995-07-04 | The Yellow Springs Instrument Company, Inc. | Methods for reducing level of interferants in biosensor systems and solutions used in these methods |
-
1995
- 1995-01-17 US US08/373,596 patent/US5520788A/en not_active Expired - Lifetime
-
1996
- 1996-03-04 JP JP09531724A patent/JP2000506972A/ja active Pending
- 1996-03-04 WO PCT/US1996/002915 patent/WO1997032976A1/en not_active Application Discontinuation
- 1996-03-04 DE DE69628468T patent/DE69628468T2/de not_active Revoked
- 1996-03-04 EP EP96907178A patent/EP0973877B1/en not_active Revoked
- 1996-03-04 ES ES96907178T patent/ES2196145T3/es not_active Expired - Lifetime
-
2000
- 2000-07-25 HK HK00104612A patent/HK1025359A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE69628468T2 (de) | 2004-04-01 |
EP0973877B1 (en) | 2003-05-28 |
HK1025359A1 (en) | 2000-11-10 |
JP2000506972A (ja) | 2000-06-06 |
WO1997032976A1 (en) | 1997-09-12 |
DE69628468D1 (de) | 2003-07-03 |
EP0973877A4 (en) | 2000-01-26 |
US5520788A (en) | 1996-05-28 |
EP0973877A1 (en) | 2000-01-26 |
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