ES2195040T3 - Conjugado que incluye un principio activo, un polipeptido y varios polieteres y su uso como medicamento. - Google Patents

Conjugado que incluye un principio activo, un polipeptido y varios polieteres y su uso como medicamento.

Info

Publication number
ES2195040T3
ES2195040T3 ES96946222T ES96946222T ES2195040T3 ES 2195040 T3 ES2195040 T3 ES 2195040T3 ES 96946222 T ES96946222 T ES 96946222T ES 96946222 T ES96946222 T ES 96946222T ES 2195040 T3 ES2195040 T3 ES 2195040T3
Authority
ES
Spain
Prior art keywords
polypeptide
polieteres
conjugado
various
active principle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96946222T
Other languages
English (en)
Inventor
Hannsjorg Sinn
Wolfgang Maier-Borst
Hans-Hermann Schrenk
Gerd Stehle
Heinz-H Fiebig
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Deutsches Krebsforschungszentrum DKFZ
Original Assignee
Deutsches Krebsforschungszentrum DKFZ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deutsches Krebsforschungszentrum DKFZ filed Critical Deutsches Krebsforschungszentrum DKFZ
Application granted granted Critical
Publication of ES2195040T3 publication Critical patent/ES2195040T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/06—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules
    • A61K51/065—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules conjugates with carriers being macromolecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Abstract

LA PRESENTE INVENCION TRATA DE CONJUGADOS, QUE COMPRENDEN UN PRINCIPIO ACTIVO, UN POLIPEPTIDO Y UN POLIETER, PROCEDIMIENTO PARA LA PREPARACION DE TALES CONJUGADOS ASI COMO SU UTILIZACION.
ES96946222T 1995-12-21 1996-12-20 Conjugado que incluye un principio activo, un polipeptido y varios polieteres y su uso como medicamento. Expired - Lifetime ES2195040T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19548114A DE19548114C2 (de) 1995-12-21 1995-12-21 Konjugat, umfassend einen Wirkstoff, ein Polypeptid und einen Polyether

Publications (1)

Publication Number Publication Date
ES2195040T3 true ES2195040T3 (es) 2003-12-01

Family

ID=7780997

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96946222T Expired - Lifetime ES2195040T3 (es) 1995-12-21 1996-12-20 Conjugado que incluye un principio activo, un polipeptido y varios polieteres y su uso como medicamento.

Country Status (8)

Country Link
US (1) US6395254B1 (es)
EP (1) EP0952853B1 (es)
JP (1) JP2000502109A (es)
AT (1) ATE234636T1 (es)
DE (2) DE19548114C2 (es)
DK (1) DK0952853T3 (es)
ES (1) ES2195040T3 (es)
WO (1) WO1997023240A2 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6818626B1 (en) * 1998-07-17 2004-11-16 Mirus Corporation Chelating systems for use in the delivery of compounds to cells
US6852334B1 (en) * 1999-04-20 2005-02-08 The University Of British Columbia Cationic peg-lipids and methods of use
US7189705B2 (en) * 2000-04-20 2007-03-13 The University Of British Columbia Methods of enhancing SPLP-mediated transfection using endosomal membrane destabilizers
CN1969190A (zh) * 2004-04-20 2007-05-23 爱默蕾大学 多峰性纳米结构，其制造方法以及其使用方法
JP5237821B2 (ja) 2005-12-05 2013-07-17 日東電工株式会社 ポリグルタミン酸−アミノ酸結合体および方法
US20080181852A1 (en) * 2007-01-29 2008-07-31 Nitto Denko Corporation Multi-functional Drug Carriers
CN101674852A (zh) * 2007-04-10 2010-03-17 日东电工株式会社 多功能聚谷氨酸盐药物载体
US20080279782A1 (en) * 2007-05-09 2008-11-13 Nitto Denko Corporation Polymers conjugated with platinum drugs
KR20100017540A (ko) * 2007-05-09 2010-02-16 닛토덴코 가부시키가이샤 소수성 화합물 및 폴리아미노산 콘쥬게이트를 포함하는 조성물
EP2155253A2 (en) * 2007-05-09 2010-02-24 Nitto Denko Corporation Polyglutamate conjugates and polyglutamate-amino acid conjugates having a plurality of drugs
MX2010009670A (es) * 2008-03-06 2010-09-22 Nitto Denko Corp Conjugados de paclitaxel polimericos y metodos para tratamiento de cancer.
GB201401453D0 (en) * 2014-01-28 2014-03-12 Univ Birmingham Transmucosal and transepithelial drug delivery system
JP6830907B2 (ja) * 2016-01-08 2021-02-17 日本化薬株式会社 マクロライド系免疫抑制剤の高分子誘導体
WO2019018350A1 (en) 2017-07-17 2019-01-24 Keith Roizman TOPICAL ADMINISTRATION OF THERAPEUTIC AGENTS COMPRISING CELL PENETRATION PEPTIDES, FOR USE IN THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION AND OTHER OCULAR DISEASES

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4318846A (en) * 1979-09-07 1982-03-09 Syva Company Novel ether substituted fluorescein polyamino acid compounds as fluorescers and quenchers
US5308604A (en) * 1989-04-19 1994-05-03 Deutsches Krebsforschungsinstitut Conjugates for tumor localization and/or tumor therapy
JP2517760B2 (ja) 1989-05-11 1996-07-24 新技術事業団 水溶性高分子化医薬製剤
DE4017439C2 (de) 1990-05-30 1994-06-23 Deutsches Krebsforsch Polyethersubstituierte Tumormittel
WO1994005203A1 (en) 1992-09-04 1994-03-17 The General Hospital Corporation Biocompatible polymers containing diagnostic or therapeutic moieties
US5605672A (en) 1993-06-09 1997-02-25 The General Hospital Corporation Blood pool imaging composition and method of its use
US5567410A (en) 1994-06-24 1996-10-22 The General Hospital Corporation Composotions and methods for radiographic imaging
AU2701395A (en) 1994-06-27 1996-01-19 General Hospital Corporation, The Graft co-polymer adducts of platinum (ii) compounds
US5958372A (en) * 1994-06-28 1999-09-28 Nycomed Imaging As Low viscosity chelating polymers for diagnostic imaging

Also Published As

Publication number Publication date
EP0952853A2 (de) 1999-11-03
DE59610251D1 (de) 2003-04-24
WO1997023240A3 (de) 1997-10-09
JP2000502109A (ja) 2000-02-22
DK0952853T3 (da) 2003-07-14
DE19548114A1 (de) 1997-06-26
DE19548114C2 (de) 2000-04-27
WO1997023240A2 (de) 1997-07-03
US6395254B1 (en) 2002-05-28
ATE234636T1 (de) 2003-04-15
EP0952853B1 (de) 2003-03-19

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