ES2191044T3 - Procedimiento para preparar poliazamacrociclos. - Google Patents

Procedimiento para preparar poliazamacrociclos.

Info

Publication number
ES2191044T3
ES2191044T3 ES95903571T ES95903571T ES2191044T3 ES 2191044 T3 ES2191044 T3 ES 2191044T3 ES 95903571 T ES95903571 T ES 95903571T ES 95903571 T ES95903571 T ES 95903571T ES 2191044 T3 ES2191044 T3 ES 2191044T3
Authority
ES
Spain
Prior art keywords
followed
polar solvent
basic
optionally
basic hydrolysis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95903571T
Other languages
English (en)
Inventor
Phillip S Athey
Garry E Kiefer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dow Global Technologies LLC
Original Assignee
Dow Global Technologies LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/320,620 external-priority patent/US5587451A/en
Application filed by Dow Global Technologies LLC filed Critical Dow Global Technologies LLC
Application granted granted Critical
Publication of ES2191044T3 publication Critical patent/ES2191044T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/06—Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromolecule

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

PROCESO PARA PREPARAR COMPUESTOS POLIAZAMACROCICLICOS UTILIZANDO UNA IMIDAZOLINA NUCLEOFILICA CON (A) UN OXIDO DE ETILENO O CARBONATO DE ETILENO, EN UN DISOLVENTE APROTICO, SEGUIDO DE AMINACION INTRAMOLECULAR Y, DESPUES, HIDROLISIS BASICA O ACIDA; O (B) UN SUSTRATO ELECTROFILICO, EN UN DISOLVENTE POLAR, OPCIONALMENTE EN PRESENCIA DE UNA BASE NO NUCLEOFILICA, PARA FORMAR UN INTERMEDIO, SEGUIDA DE UNA HIDROLISIS BASICA; O (C) UN SUSTRATO ELECTROFILICO, EN UN DISOLVENTE POLAR, OPCIONALMENTE EN PRESENCIA DE UNA BASE NO NUCLEOFILICA, SEGUIDO DE UN CALENTAMIENTO PROLONGADO EN UN DISOLVENTE POLAR O POR TRATAMIENTO CON UNA SOLUCION DE PEROXIDO, SEGUIDO DE HIDROLISIS BASICA PARA FORMAR UNA UREA, DESPUES UNA HIDROLISIS BASICA BAJO PRESION; Y SEPARANDO EL POLIAZAMACROCICLO DESEADO. LOS COMPUESTOS ASI PREPARADOS SON UTILES EN APLICACIONES FARMACEUTICAS.
ES95903571T 1993-11-26 1994-11-18 Procedimiento para preparar poliazamacrociclos. Expired - Lifetime ES2191044T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15865493A 1993-11-26 1993-11-26
US08/320,620 US5587451A (en) 1993-11-26 1994-10-07 Process for preparing polyazamacrocycles

Publications (1)

Publication Number Publication Date
ES2191044T3 true ES2191044T3 (es) 2003-09-01

Family

ID=26855246

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95903571T Expired - Lifetime ES2191044T3 (es) 1993-11-26 1994-11-18 Procedimiento para preparar poliazamacrociclos.

Country Status (10)

Country Link
EP (1) EP0730616B1 (es)
JP (1) JPH09507837A (es)
AT (1) ATE232220T1 (es)
AU (1) AU679140B2 (es)
CA (1) CA2176595A1 (es)
DE (1) DE69432105T2 (es)
ES (1) ES2191044T3 (es)
HU (1) HUT72671A (es)
IL (1) IL111754A0 (es)
WO (1) WO1995014726A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5834456A (en) * 1996-02-23 1998-11-10 The Dow Chemical Company Polyazamacrocyclofluoromonoalkylphosphonic acids, and their complexes, for use as contrast agents
IT1293777B1 (it) * 1997-07-25 1999-03-10 Bracco Spa Processo per la preparazione di tetraazamacrocicli
IT1297034B1 (it) 1997-12-30 1999-08-03 Bracco Spa Acido 1,4,7,10-tetraazaciclododecan-1,4-diacetico
US6685914B1 (en) 1999-09-13 2004-02-03 Bristol-Myers Squibb Pharma Company Macrocyclic chelants for metallopharmaceuticals
FR2830253B1 (fr) * 2001-09-28 2005-02-04 Air Liquide Nouveau procede de preparation de macrocycles azotes c-fonctionnalises et nouveaux intermediaires obtenus
CN104387336B (zh) * 2014-10-24 2016-04-27 上海应用技术学院 1,4,7,10-四氮杂环十二烷及其纳滤膜的制备方法
CN108794416B (zh) * 2018-07-02 2021-09-28 成都药云科技有限公司 一种轮环藤宁生产纯化方法
CN110669020A (zh) * 2019-10-28 2020-01-10 西南化工研究设计院有限公司 一种轮环藤宁的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2614020B1 (fr) * 1987-04-14 1989-07-28 Guerbet Sa Nouveaux ligands cycliques azotes, complexes metalliques formes par ces ligands, compositions de diagnostic contenant ces complexes et procede de preparation des ligands.
DE3713842A1 (de) * 1987-04-22 1988-11-17 Schering Ag Substituierte cyclische komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel

Also Published As

Publication number Publication date
EP0730616B1 (en) 2003-02-05
WO1995014726A1 (en) 1995-06-01
CA2176595A1 (en) 1995-06-01
EP0730616A1 (en) 1996-09-11
IL111754A0 (en) 1995-01-24
DE69432105D1 (de) 2003-03-13
HU9502025D0 (en) 1995-09-28
JPH09507837A (ja) 1997-08-12
AU679140B2 (en) 1997-06-19
HUT72671A (en) 1996-05-28
EP0730616A4 (en) 1997-02-26
DE69432105T2 (de) 2003-10-09
AU1258095A (en) 1995-06-13
ATE232220T1 (de) 2003-02-15

Similar Documents

Publication Publication Date Title
MXPA94009157A (es) Proceso para la preparacion de poliazamacrociclos.
ES2085297T3 (es) Procedimiento para preparar derivados de poli(etilenglicol) y proteina modificada.
NO20042816L (no) Fremgangsmater for maling av kraften av glatirameracetat
UY27381A1 (es) 2-tio-3,5-diciano-4-fenil-6-aminopiridinas sustituidas y su uso
DE3374407D1 (en) Dihydropyrimidines, process for their preparation and their use in medicaments
PT93959A (pt) Processo para a preparacao de derivados de sacarina uteis como inibidores proteoliticos de enzima
ES2191044T3 (es) Procedimiento para preparar poliazamacrociclos.
MX9803672A (es) Nuevos derivados de fenilamidina, procedimiento para su preparacion y su utilizacion como medicamentos.
ES8800161A1 (es) Procedimiento para la fabricacion de derivados quinolilglicinamidas
ES2185196T3 (es) Un procedimiento para la preparacion de tetraazamacrociclos.
GR1001018B (el) Μεθοδος παρασκευης προδρομικων πεπτικων παραγωγων.
YU6087A (en) Process for obtaining 2-benzimidazole-ilalkylthiosulphinyl or sulphonyl derivatives
DK0720617T3 (da) Hidtil ukendte urethanholdige aminosteroidforbindelser
DK313587D0 (da) Tetrahydrobenzothiazolforbindelser, deres fremstilling og anvendelse
AU4034095A (en) Cyclohexapeptides and their mixtures, a process for preparing them, and their use
ES2058542T3 (es) Imidas biciclicas puenteadas de 4-(4-(3-benzoisotiazolil)-1-piperazinil)butilo antipsicoticas.
ES2136856T3 (es) Procedimiento para la obtencion de aminoacidos n-z-protegidos n-alquilados.
DK199801009A (da) Fremgangsmåde til fremstilling af et naphthalenderivat og naphthalenderivat anvendeligt som mellemprodukt i denne fremgangs
EP1247880A3 (de) Verfahren zur Herstellung von Glycinderivaten und deren Verwendung
ES2105772T3 (es) Procedimiento para la obtencion de aminoacidos n-protegidos n-alquilados.
DK222886D0 (da) Propionylanilider, fremgangsmaade til fremstilling heraf og farmaceutiske praeparater indeholdende disse forbindelser
ZA881322B (en) Benzylaminoaryl-dihydropyridinelactones,process for their preparation,and their use in medicaments