MXPA94009157A - Proceso para la preparacion de poliazamacrociclos. - Google Patents

Proceso para la preparacion de poliazamacrociclos.

Info

Publication number
MXPA94009157A
MXPA94009157A MXPA94009157A MX9409157A MXPA94009157A MX PA94009157 A MXPA94009157 A MX PA94009157A MX PA94009157 A MXPA94009157 A MX PA94009157A MX 9409157 A MX9409157 A MX 9409157A MX PA94009157 A MXPA94009157 A MX PA94009157A
Authority
MX
Mexico
Prior art keywords
followed
polar solvent
basic
preparing
optionally
Prior art date
Application number
MXPA94009157A
Other languages
English (en)
Inventor
Garry E Kiefer
Phillip S Athey
Original Assignee
Dow Global Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Global Technologies Inc filed Critical Dow Global Technologies Inc
Publication of MXPA94009157A publication Critical patent/MXPA94009157A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/06—Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromolecule

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Un proceso para la preparación de compuestos poliazamacrociclos, utilizando una imidazolina nucleofílica, con: (A) un óxido de etileno o un carbonato de etileno, en un solvente aprótico, seguido por aminación intramolecular, y luego hidrólisis básica o ácida; o (B) un sustrato electrofílico, en un solvente polar, opcionalmente en la presencia de una base no nucleofílica, para formar un intermediario, seguido por hidrólisis básicas; o (C) un sustrato electrofílico, en un solvente polar, opcionalmente en lar presencia de una base no nucleofílica, seguido por calentamiento prolongado en un solvente polar, o por tratamiento con una solución de peróxido, seguido por hidrólisis básica para formar una urea, y luego hidrólisis básica bajo presión; y separar el poliazamacrociclo deseado. Los compuestos así preparados son útiles en aplicaciones farmacéuticas.
MXPA94009157A 1993-11-26 1994-11-25 Proceso para la preparacion de poliazamacrociclos. MXPA94009157A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15865493A 1993-11-26 1993-11-26
US08/320,620 US5587451A (en) 1993-11-26 1994-10-07 Process for preparing polyazamacrocycles

Publications (1)

Publication Number Publication Date
MXPA94009157A true MXPA94009157A (es) 2010-11-12

Family

ID=22569098

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA94009157A MXPA94009157A (es) 1993-11-26 1994-11-25 Proceso para la preparacion de poliazamacrociclos.

Country Status (2)

Country Link
US (1) US5587451A (es)
MX (1) MXPA94009157A (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1284046B1 (it) * 1996-06-21 1998-05-08 Bracco Spa Processo per la preparazione di tetraazamacrocicli
IT1291673B1 (it) * 1997-04-28 1999-01-19 Bracco Spa Processo per la preparazione di 1,4,7,10 - tetraazaciclododecano
IT1293778B1 (it) * 1997-07-25 1999-03-10 Bracco Spa 1,4,7,10-tetraazabiciclo(8.2.2.)tetradecan-2 one, sua preparazione e suo uso per la preparazione di tetraazamacrocicli
EP1191948A2 (en) 1999-06-11 2002-04-03 Neorx Corporation High dose radionuclide complexes for bone marrow suppression
US7094885B2 (en) 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies
WO2002062398A2 (en) 2001-01-08 2002-08-15 Neorx Corporation Radioactively labelled conjugates of phosphonates
EP1458416A1 (en) 2001-12-13 2004-09-22 Dow Global Technologies Inc. Treatment of osteomyelitis with radiopharmaceuticals
WO2003095398A2 (en) * 2002-05-07 2003-11-20 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Polydiazeniumdiolated cyclic polyamines with polyphasic nitric oxide release and related compounds, compositions comprising same and methods of using same
CA2557582A1 (en) * 2004-02-17 2006-03-09 Thomas E. Johnson Methods, compositions, and apparatuses for forming macrocyclic compounds
EP2682451B1 (en) * 2012-07-06 2015-11-18 Infineum International Limited Detergent modification
CN102942532A (zh) * 2012-11-29 2013-02-27 太仓市茜泾化工有限公司 一种1,4,7,10-四氮杂十二烷的制备方法
WO2016005892A1 (en) 2014-07-08 2016-01-14 Eni S.P.A. Process for the preparation of substituted polyazamacrocycles
WO2016046779A1 (en) 2014-09-25 2016-03-31 Eni S.P.A. Zinc polyazamacrocyclic complexes
EP4067348A1 (en) 2021-03-30 2022-10-05 Bracco Imaging SPA Process for the preparation of cyclen
CN113321624A (zh) * 2021-06-15 2021-08-31 仪征市海帆化工有限公司 一种1,4,7-三氮环壬烷的合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4639365A (en) * 1984-10-18 1987-01-27 The Board Of Regents, The University Of Texas System Gadolinium chelates as NMR contrast agents
US4976950A (en) * 1988-12-19 1990-12-11 The Dow Chemical Company Bone marrow suppressing agents

Also Published As

Publication number Publication date
US5587451A (en) 1996-12-24

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Legal Events

Date Code Title Description
GB Transfer or rights

Owner name: DOW GLOBAL TECHNOLOGIES INC.

FA Abandonment or withdrawal