ES2190503T3 - Heterociclos de 5 anillos en calidad de inhibidores de la adhesion de leucocitos y antagonistas de vla-4. - Google Patents

Heterociclos de 5 anillos en calidad de inhibidores de la adhesion de leucocitos y antagonistas de vla-4.

Info

Publication number
ES2190503T3
ES2190503T3 ES97119638T ES97119638T ES2190503T3 ES 2190503 T3 ES2190503 T3 ES 2190503T3 ES 97119638 T ES97119638 T ES 97119638T ES 97119638 T ES97119638 T ES 97119638T ES 2190503 T3 ES2190503 T3 ES 2190503T3
Authority
ES
Spain
Prior art keywords
adhesion
compositions
vla
formula
diseases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97119638T
Other languages
English (en)
Inventor
Hans Ulrich Dr Stilz
Volkmar Dr Wehner
Jochen Dr Knolle
Eckart Dr Bartnik
Christoph Dr Huls
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of ES2190503T3 publication Critical patent/ES2190503T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

LAS COMPOSICIONES DE FORMULA I, EN LA CUAL B, D, E, R, W, Y, Z, B, C, D, E, F, G Y H TIENEN LAS SIGNIFICACIONES DADAS EN LAS REIVINDICACIONES, SON INHIBIDORES DE LA ADHESION Y MIGRACION DE LEUCOCITOS Y/O ANTAGONISTAS DE LOS RECEPTORES DE ADHESION VLA 4 QUE PERTENECEN AL GRUPO DE LAS INTEGRINAS. LA INVENCION TRATA DEL USO DE COMPOSICIONES DE FORMULA I Y DE PREPARACIONES FARMACEUTICAS QUE CONTIENEN DICHAS COMPOSICIONES, INDICADAS PARA EL TRATAMIENTO Y LA PROFILAXIS DE ENFERMEDADES OCASIONADAS POR EXTENDERSE DE FORMA NO DESEADA LA ADHESION DE LEUCOCITOS Y/O LA MIGRACION DE LEUCOCITOS, ENFERMEDADES RELACIONADAS CON ELLO O ENFERMEDADES EN LAS QUE ENTRAN EN JUEGO INTERACCIONES DE CELULA CELULA O MATRIZ CELULA QUE SE BASAN EN INTERACCIONES DE LOS RECEPTORES DE VLA 4 CON SUS LIGANDOS, POR EJEMPLO EN PROCESOS INFLAMATORIOS, ARTRITIS REUMATOIDE O ENFERMEDADES ALERGICAS. LA INVENCION TRATA ASIMISMO DEL USO DE COMPOSICIONES DE FORMULA I PARA LA FABRICACION DE MEDICAMENTOS DESTINADOS A EMPLEARSE EN TALES ENFERMEDADES. TAMBIEN TRATA DE NUEVAS COMPOSICIONES DE FORMULA I.
ES97119638T 1996-11-15 1997-11-10 Heterociclos de 5 anillos en calidad de inhibidores de la adhesion de leucocitos y antagonistas de vla-4. Expired - Lifetime ES2190503T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19647380A DE19647380A1 (de) 1996-11-15 1996-11-15 5-Ring-Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten

Publications (1)

Publication Number Publication Date
ES2190503T3 true ES2190503T3 (es) 2003-08-01

Family

ID=7811830

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97119638T Expired - Lifetime ES2190503T3 (es) 1996-11-15 1997-11-10 Heterociclos de 5 anillos en calidad de inhibidores de la adhesion de leucocitos y antagonistas de vla-4.

Country Status (30)

Country Link
US (1) US20040220148A1 (es)
EP (1) EP0842943B1 (es)
JP (1) JPH10147573A (es)
KR (1) KR19980042457A (es)
CN (1) CN1135236C (es)
AR (1) AR010067A1 (es)
AT (1) ATE233276T1 (es)
AU (1) AU747789B2 (es)
BR (1) BR9705727A (es)
CA (1) CA2220784A1 (es)
CZ (1) CZ293351B6 (es)
DE (2) DE19647380A1 (es)
DK (1) DK0842943T3 (es)
ES (1) ES2190503T3 (es)
HR (1) HRP970605B1 (es)
HU (1) HUP9702035A3 (es)
ID (1) ID19010A (es)
IL (1) IL122188A0 (es)
MX (1) MX9708782A (es)
MY (1) MY119617A (es)
NO (1) NO317241B1 (es)
NZ (1) NZ329178A (es)
PL (1) PL323128A1 (es)
PT (1) PT842943E (es)
RU (1) RU2229296C2 (es)
SI (1) SI0842943T1 (es)
SK (1) SK284377B6 (es)
TR (1) TR199701354A3 (es)
TW (1) TW496874B (es)
ZA (1) ZA9710244B (es)

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ZA9710244B (en) 1998-05-15
PL323128A1 (en) 1998-05-25
CN1135236C (zh) 2004-01-21
CZ293351B6 (cs) 2004-04-14
SK284377B6 (sk) 2005-02-04
NO975244D0 (no) 1997-11-14
TR199701354A2 (xx) 1998-06-22
IL122188A0 (en) 1998-04-05
HRP970605B1 (en) 2003-08-31
AR010067A1 (es) 2000-05-17
ID19010A (id) 1998-06-04
MX9708782A (es) 1998-05-31
HU9702035D0 (en) 1998-01-28
NO975244L (no) 1998-05-18
NZ329178A (en) 2001-01-26
JPH10147573A (ja) 1998-06-02
ATE233276T1 (de) 2003-03-15
US20040220148A1 (en) 2004-11-04
CZ359997A3 (cs) 1998-06-17
AU747789B2 (en) 2002-05-23
PT842943E (pt) 2003-07-31
SI0842943T1 (en) 2003-08-31
TW496874B (en) 2002-08-01
NO317241B1 (no) 2004-09-27
MY119617A (en) 2005-06-30
DK0842943T3 (da) 2003-06-02
HRP970605A2 (en) 1998-08-31
SK152697A3 (en) 1998-06-03
DE19647380A1 (de) 1998-05-20
CN1187490A (zh) 1998-07-15
DE59709383D1 (de) 2003-04-03
AU4515997A (en) 1998-05-21
HUP9702035A3 (en) 1998-12-28
KR19980042457A (ko) 1998-08-17
HUP9702035A2 (hu) 1998-07-28
EP0842943B1 (de) 2003-02-26
BR9705727A (pt) 2000-03-21
EP0842943A3 (de) 1999-02-24
CA2220784A1 (en) 1998-05-15
RU2229296C2 (ru) 2004-05-27
EP0842943A2 (de) 1998-05-20
TR199701354A3 (tr) 1998-06-22

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