ES2190426T3 - Derivados de acidos arilo o heteroarilo quinolinil-fosfonicos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. - Google Patents
Derivados de acidos arilo o heteroarilo quinolinil-fosfonicos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.Info
- Publication number
- ES2190426T3 ES2190426T3 ES01400407T ES01400407T ES2190426T3 ES 2190426 T3 ES2190426 T3 ES 2190426T3 ES 01400407 T ES01400407 T ES 01400407T ES 01400407 T ES01400407 T ES 01400407T ES 2190426 T3 ES2190426 T3 ES 2190426T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- aryl
- cycloalkyl
- amino
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 8
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 6
- 125000003118 aryl group Chemical group 0.000 abstract 5
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- -1 cyano, nitro, amino Chemical group 0.000 abstract 2
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000006684 polyhaloalkyl group Polymers 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000006267 biphenyl group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000006165 cyclic alkyl group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Chemical group 0.000 abstract 1
- 239000011593 sulfur Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/60—Quinoline or hydrogenated quinoline ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0002013A FR2805262A1 (fr) | 2000-02-18 | 2000-02-18 | Nouveaux derives d'acides aryle ou heteroaryle quinolinyl phosphoniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2190426T3 true ES2190426T3 (es) | 2003-08-01 |
Family
ID=8847124
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES01400407T Expired - Lifetime ES2190426T3 (es) | 2000-02-18 | 2001-02-16 | Derivados de acidos arilo o heteroarilo quinolinil-fosfonicos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6420386B1 (fr) |
| EP (1) | EP1125940B1 (fr) |
| JP (1) | JP2001278890A (fr) |
| KR (1) | KR20010082704A (fr) |
| CN (1) | CN1317489A (fr) |
| AR (1) | AR027431A1 (fr) |
| AT (1) | ATE231154T1 (fr) |
| AU (1) | AU2303901A (fr) |
| BR (1) | BR0100600A (fr) |
| CA (1) | CA2337301A1 (fr) |
| DE (1) | DE60100080T2 (fr) |
| DK (1) | DK1125940T3 (fr) |
| EA (1) | EA200100157A3 (fr) |
| ES (1) | ES2190426T3 (fr) |
| FR (1) | FR2805262A1 (fr) |
| HK (1) | HK1039943A1 (fr) |
| HU (1) | HUP0100751A3 (fr) |
| MX (1) | MXPA01001559A (fr) |
| NO (1) | NO20010802L (fr) |
| NZ (1) | NZ510003A (fr) |
| PL (1) | PL345917A1 (fr) |
| SI (1) | SI1125940T1 (fr) |
| ZA (1) | ZA200101337B (fr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2805260A1 (fr) * | 2000-02-18 | 2001-08-24 | Adir | Nouveaux derives d'acides 6-sulfamoyl-3-quinolinyl phosphoniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| EP2348018A4 (fr) | 2008-09-25 | 2012-04-25 | Kyorin Seiyaku Kk | Dérivé biarylique hétérocyclique et inhibiteur de pde le renfermant en tant qu'ingrédient actif |
| US20110224250A1 (en) * | 2008-10-09 | 2011-09-15 | Yasushi Kohno | Isoquinoline derivative, and pde inhibitor comprising same as active ingredient |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2683818B1 (fr) * | 1991-11-14 | 1993-12-31 | Adir Cie | Nouveaux derives de 3-sulfonylamino-2-(1h)-quinoleinone, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| US5342946A (en) * | 1992-12-02 | 1994-08-30 | Guilford Pharmaceuticals Inc. | Phosphonoalkylquinolin-2-ones as novel antagonists of non-NMDA ionotropic excitatory amino acid receptors |
| FR2709489B1 (fr) * | 1993-08-31 | 1995-10-20 | Adir | Nouveaux dérivés de 2-(1H)-quinoléinone, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
| FR2750988B1 (fr) * | 1996-07-11 | 1998-09-18 | Adir | Nouveaux derives de 2-(1h)-quinoleinone, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
-
2000
- 2000-02-18 FR FR0002013A patent/FR2805262A1/fr active Pending
-
2001
- 2001-02-07 JP JP2001030600A patent/JP2001278890A/ja not_active Ceased
- 2001-02-12 MX MXPA01001559A patent/MXPA01001559A/es not_active Application Discontinuation
- 2001-02-14 US US09/783,192 patent/US6420386B1/en not_active Expired - Fee Related
- 2001-02-15 AR ARP010100678A patent/AR027431A1/es unknown
- 2001-02-16 NZ NZ510003A patent/NZ510003A/en unknown
- 2001-02-16 CA CA002337301A patent/CA2337301A1/fr not_active Abandoned
- 2001-02-16 ZA ZA200101337A patent/ZA200101337B/xx unknown
- 2001-02-16 DK DK01400407T patent/DK1125940T3/da active
- 2001-02-16 BR BR0100600-2A patent/BR0100600A/pt not_active IP Right Cessation
- 2001-02-16 KR KR1020010007745A patent/KR20010082704A/ko active IP Right Grant
- 2001-02-16 AT AT01400407T patent/ATE231154T1/de not_active IP Right Cessation
- 2001-02-16 ES ES01400407T patent/ES2190426T3/es not_active Expired - Lifetime
- 2001-02-16 NO NO20010802A patent/NO20010802L/no not_active Application Discontinuation
- 2001-02-16 DE DE60100080T patent/DE60100080T2/de not_active Expired - Fee Related
- 2001-02-16 AU AU23039/01A patent/AU2303901A/en not_active Abandoned
- 2001-02-16 EP EP01400407A patent/EP1125940B1/fr not_active Expired - Lifetime
- 2001-02-16 HU HU0100751A patent/HUP0100751A3/hu unknown
- 2001-02-16 SI SI200130007T patent/SI1125940T1/xx unknown
- 2001-02-16 PL PL01345917A patent/PL345917A1/xx not_active IP Right Cessation
- 2001-02-16 CN CN01112383A patent/CN1317489A/zh active Pending
- 2001-02-19 EA EA200100157A patent/EA200100157A3/ru unknown
-
2002
- 2002-02-18 HK HK02101181.5A patent/HK1039943A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0100751A3 (en) | 2002-09-30 |
| HUP0100751A2 (hu) | 2002-01-28 |
| FR2805262A1 (fr) | 2001-08-24 |
| CA2337301A1 (fr) | 2001-08-18 |
| ZA200101337B (en) | 2001-08-21 |
| EA200100157A3 (ru) | 2001-10-22 |
| DE60100080T2 (de) | 2003-11-20 |
| EP1125940B1 (fr) | 2003-01-15 |
| HU0100751D0 (en) | 2001-04-28 |
| CN1317489A (zh) | 2001-10-17 |
| NZ510003A (en) | 2001-09-28 |
| AR027431A1 (es) | 2003-03-26 |
| PL345917A1 (en) | 2001-08-27 |
| ATE231154T1 (de) | 2003-02-15 |
| EA200100157A2 (ru) | 2001-08-27 |
| MXPA01001559A (es) | 2002-08-06 |
| SI1125940T1 (en) | 2003-04-30 |
| NO20010802L (no) | 2001-08-20 |
| DE60100080D1 (de) | 2003-02-20 |
| KR20010082704A (ko) | 2001-08-30 |
| HK1039943A1 (zh) | 2002-05-17 |
| US6420386B1 (en) | 2002-07-16 |
| JP2001278890A (ja) | 2001-10-10 |
| NO20010802D0 (no) | 2001-02-16 |
| AU2303901A (en) | 2001-08-23 |
| EP1125940A1 (fr) | 2001-08-22 |
| DK1125940T3 (da) | 2003-05-05 |
| BR0100600A (pt) | 2001-09-18 |
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