ES2189003T3 - Enantiomeros 3-piridilo y su utilizacion como analgesicos. - Google Patents

Enantiomeros 3-piridilo y su utilizacion como analgesicos.

Info

Publication number
ES2189003T3
ES2189003T3 ES97952392T ES97952392T ES2189003T3 ES 2189003 T3 ES2189003 T3 ES 2189003T3 ES 97952392 T ES97952392 T ES 97952392T ES 97952392 T ES97952392 T ES 97952392T ES 2189003 T3 ES2189003 T3 ES 2189003T3
Authority
ES
Spain
Prior art keywords
analgesic
piridile
enantiomers
formula
invention refers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97952392T
Other languages
English (en)
Inventor
Mark W Holladay
Stephen P Arneric
Hao Bai
Michael J Dart
Nan-Horng Lin
John K Lynch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Application granted granted Critical
Publication of ES2189003T3 publication Critical patent/ES2189003T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UN PROCEDIMIENTO DE CONTROL DEL DOLOR EN LOS MAMIFEROS, INCLUYENDO LOS SERES HUMANOS, QUE COMPRENDE LA ADMINISTRACION A UN MAMIFERO O A UN PACIENTE QUE NECESITA ESTE TRATAMIENTO, DE COMPUESTOS SELECCIONADOS DE LA FORMULA (I) O UNA SAL FARMACEUTICAMENTE ACEPTABLE DE LOS MISMOS. ESTA INVENCION SE REFIERE TAMBIEN A UNOS COMPUESTOS (R) Y (S) SELECCIONADOS DE LA FORMULA (I) QUE SON UTILES COMO ANALGESICOS Y COMO AGENTES DE PREVENCION DE LA DESTRUCCION CELULAR Y NEURONAL O COMO ANTIINFLAMATORIOS.
ES97952392T 1996-12-10 1997-12-10 Enantiomeros 3-piridilo y su utilizacion como analgesicos. Expired - Lifetime ES2189003T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3232196P 1996-12-10 1996-12-10
US76327896A 1996-12-10 1996-12-10

Publications (1)

Publication Number Publication Date
ES2189003T3 true ES2189003T3 (es) 2003-07-01

Family

ID=26708255

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97952392T Expired - Lifetime ES2189003T3 (es) 1996-12-10 1997-12-10 Enantiomeros 3-piridilo y su utilizacion como analgesicos.

Country Status (21)

Country Link
EP (1) EP0950057B1 (es)
JP (2) JP4272261B2 (es)
KR (2) KR100472154B1 (es)
CN (1) CN1125064C (es)
AT (1) ATE227717T1 (es)
AU (1) AU733881B2 (es)
BG (1) BG64196B1 (es)
BR (1) BR9714677A (es)
CA (2) CA2273917C (es)
DE (1) DE69717148T2 (es)
DK (1) DK0950057T3 (es)
ES (1) ES2189003T3 (es)
HU (1) HUP0001110A3 (es)
IL (1) IL130083A0 (es)
NO (1) NO992705L (es)
NZ (1) NZ335810A (es)
PL (1) PL333920A1 (es)
PT (1) PT950057E (es)
SK (1) SK75999A3 (es)
TR (1) TR199901904T2 (es)
WO (1) WO1998025920A1 (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2317572A1 (en) 1998-04-02 1999-10-14 Jared Miller Wagner Pharmaceutical compositions and methods for use
US6054451A (en) * 1998-04-21 2000-04-25 Algos Pharmaceutical Corporation Analgesic composition and method for alleviating pain
US6362371B1 (en) 1998-06-08 2002-03-26 Advanced Medicine, Inc. β2- adrenergic receptor agonists
US20010031771A1 (en) 1999-05-24 2001-10-18 Gary Maurice Dull Pharmaceutical compositions and methods for use
US6103911A (en) * 1999-06-15 2000-08-15 Abbott Laboratories Process for reduction of (2R)-4-oxoazetidinone-2-carboxylic acid
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US6818787B2 (en) 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
CA2485466A1 (en) * 2002-05-15 2003-11-27 Abbott Laboratories Treatment of neuropathic pain
EP1741709A1 (en) 2005-06-28 2007-01-10 Sanofi-Aventis Deutschland GmbH Heteroaryl-substituted amides comprising a saturated linker group, and their use as pharmaceuticals
DE602006010433D1 (de) 2005-12-09 2009-12-24 Hoffmann La Roche Für die behandlung von obesitas geeignete tricyclische amidderivate
TW200800020A (en) * 2006-01-26 2008-01-01 Basf Ag Methods to use 3-pyridyl derivatives as pesticides
EP2255848A3 (en) 2006-09-04 2011-04-06 NeuroSearch AS Pharmaceutical combinations of a nicotine receptor modulator and a cognitive enhancer
JP4939192B2 (ja) * 2006-12-05 2012-05-23 ユニ・チャーム株式会社 不織布、不織布の製造方法及び吸収性物品
DE102007058504A1 (de) 2007-12-05 2009-07-09 Acino Ag Transdermales therapeutisches System mit einem Gehalt an einem Modulator für nikotinische Acetylcholinrezeptoren (nAChR)
CN102216289A (zh) 2008-10-14 2011-10-12 塞扣吉尼克斯公司 烟碱乙酰胆碱受体配体及其用途
AR075988A1 (es) * 2009-04-09 2011-05-11 Lilly Co Eli Compuesto de piridiloxi - pirrolidina inhibidor de recaptacion de serotonina y norepinefrina, composicion farmaceutica que lo comprende y su uso para la manufactura de un medicamento util para el tratamiento de dolor cronico
US8474529B2 (en) * 2009-04-09 2013-07-02 Regency Technologies Llc Control of concentric tubing direction
RU2014103098A (ru) 2011-06-30 2015-08-10 Торэй Индастриз, Инк. Противозудный агент
US9890137B2 (en) 2013-03-27 2018-02-13 Georgetown University 2-halo-5-alkynyl-pyridyl nicotinic ligands
EP4233989A3 (en) 2017-06-07 2023-10-11 Shifamed Holdings, LLC Intravascular fluid movement devices, systems, and methods of use
US11511103B2 (en) 2017-11-13 2022-11-29 Shifamed Holdings, Llc Intravascular fluid movement devices, systems, and methods of use
JP7410034B2 (ja) 2018-02-01 2024-01-09 シファメド・ホールディングス・エルエルシー 血管内血液ポンプならびに使用および製造の方法
JP2022540616A (ja) 2019-07-12 2022-09-16 シファメド・ホールディングス・エルエルシー 血管内血液ポンプならびに製造および使用の方法
WO2021016372A1 (en) 2019-07-22 2021-01-28 Shifamed Holdings, Llc Intravascular blood pumps with struts and methods of use and manufacture
EP4034184A4 (en) 2019-09-25 2023-10-18 Shifamed Holdings, LLC CATHETER BLOOD PUMP AND COLLAPSIBLE BLOOD LINES
EP4034221A4 (en) 2019-09-25 2023-10-11 Shifamed Holdings, LLC CATHETER BLOOD PUMPS AND FOLDABLE PUMP HOUSINGS
EP4034192A4 (en) 2019-09-25 2023-11-29 Shifamed Holdings, LLC INTRAVASCULAR BLOOD PUMP SYSTEMS AND METHODS OF USE AND CONTROL THEREOF

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8301702D0 (en) * 1983-01-21 1983-02-23 Shell Int Research Azetidine compounds
US4902684A (en) * 1988-06-20 1990-02-20 E. R. Squibb & Sons, Inc. Benzazepine and benzothiazepine derivatives
US5068234A (en) * 1990-02-26 1991-11-26 Sterling Drug Inc. 3-arylcarbonyl-1-(c-attached-n-heteryl)-1h-indoles
IL107184A (en) * 1992-10-09 1997-08-14 Abbott Lab Heterocyclic ether compounds that enhance cognitive function
US5585388A (en) * 1995-04-07 1996-12-17 Sibia Neurosciences, Inc. Substituted pyridines useful as modulators of acetylcholine receptors
IL118279A (en) * 1995-06-07 2006-10-05 Abbott Lab Compounds 3 - Pyridyloxy (or Thio) Alkyl Heterocyclic Pharmaceutical Compositions Containing Them and Their Uses for Preparing Drugs to Control Synaptic Chemical Transmission
US5629325A (en) * 1996-06-06 1997-05-13 Abbott Laboratories 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission

Also Published As

Publication number Publication date
JP5364872B2 (ja) 2013-12-11
AU5601098A (en) 1998-07-03
CA2273917C (en) 2010-05-25
BG103556A (en) 2000-06-30
KR20040004476A (ko) 2004-01-13
SK75999A3 (en) 2000-05-16
EP0950057B1 (en) 2002-11-13
CA2698384A1 (en) 1998-06-18
ATE227717T1 (de) 2002-11-15
DE69717148T2 (de) 2003-10-02
CA2273917A1 (en) 1998-06-18
TR199901904T2 (xx) 1999-10-21
AU733881B2 (en) 2001-05-31
HUP0001110A3 (en) 2002-04-29
JP2001504857A (ja) 2001-04-10
NO992705L (no) 1999-08-03
JP2009143924A (ja) 2009-07-02
WO1998025920A1 (en) 1998-06-18
IL130083A0 (en) 2000-02-29
EP0950057A1 (en) 1999-10-20
JP4272261B2 (ja) 2009-06-03
DK0950057T3 (da) 2003-03-10
HUP0001110A2 (hu) 2001-04-28
PT950057E (pt) 2003-04-30
KR100472154B1 (ko) 2005-02-21
CA2698384C (en) 2012-05-01
PL333920A1 (en) 2000-01-31
NO992705D0 (no) 1999-06-03
DE69717148D1 (de) 2002-12-19
BG64196B1 (bg) 2004-04-30
KR100422995B1 (ko) 2004-03-12
KR20000069399A (ko) 2000-11-25
CN1245496A (zh) 2000-02-23
NZ335810A (en) 2001-03-30
CN1125064C (zh) 2003-10-22
BR9714677A (pt) 2000-10-03

Similar Documents

Publication Publication Date Title
ES2189003T3 (es) Enantiomeros 3-piridilo y su utilizacion como analgesicos.
PA8513101A1 (es) Derivados de eteres de pirazol como agentes anti- inflamatorios/analgesicos
ES2171933T3 (es) Derivados de androsteno.
CY1108070T1 (el) Παραγωγα κινολινονης, ως αναστολεις κινασης τυροσινης
ES2187575T3 (es) Hexapeptidos ciclicos dotados de actividad antibiotica.
DK0933995T3 (da) Fremgangsmåde til behandling af endotelskader
ES2080042T3 (es) Composiciones para modular el efecto de tnf e il-1.
ES2169147T3 (es) Derivados de beta-carbolina agonistas de la melatonina, sus procedimientos de preparacion y su utilizacion a titulo de medicamento.
ES2096168T3 (es) Nuevos usos terapeuticos de derivados de ftalazinona.
HN2000000050A (es) Sal mutua de amlodipino y atorvastatina
PA8457001A1 (es) Derivados del 2-(4-aril o heteroaril-piperazin-i-ilmetil)-1h-indol
DE3875866D1 (de) Sulfonamidolphenyl-derivate und diese enthaltende therapeutische und vorbeugend wirkende mittel gegen arrhythmie.
DE60031016D1 (de) Verwendung von Antiseptika zur Herstellung von Arzneimitteln zur Prophylaxe und Behandlung von Entzündungen im Korperinneren des Menschen
DE3579224D1 (de) Hygienische zusatzkappen fuer therapeutische lasergeraete.
ES2159357T3 (es) Derivados terpenoides (sarcodictinas) utiles como agentes antitumorales.
CA2203463A1 (fr) Nouveaux acides et esters de la diosmetine, et les compositions pharmaceutiques les contenant
DK1294732T3 (da) Ruthenium (II)-forbindelser til anvendelse i cancerterapi
ATE428438T1 (de) Tcf-ii enthaltende medizinische zusammensetzung
DK0617959T3 (da) Lægemiddel til behandling af hudsygdomme
DK0559145T3 (da) Lægemiddel til truende abort
DE69739482D1 (de) Therapeutische formulierungen, die schlangen- und/oder insektengift enthalten, zur prophylaxe und therapie von neoplasmen
DK532087D0 (da) Farmaceutiske praeparater til behandling af hjernelidelser paa funktional og organisk basis
ES2171838T3 (es) Uso de 3-(4-hexiloxi-1,2,5-tiadiazol-3-il)-1,2,5,6-tetrahidro-1-metilpiridina (xanomelina) para el tratamiento del trastorno bipolar.
DE59101818D1 (de) Arzneimittelzubereitung, enthaltend Stigmasta-4-en-3-on sowie deren Verwendung.
ES2078319T3 (es) Composiciones que contienen inhibidores de aldosa reductasa para el tratamiento de ulceras.