ES2187483T3 - Procedimiento para la preparacion de acido a-lipoico esento de disolvente. - Google Patents
Procedimiento para la preparacion de acido a-lipoico esento de disolvente.Info
- Publication number
- ES2187483T3 ES2187483T3 ES00954620T ES00954620T ES2187483T3 ES 2187483 T3 ES2187483 T3 ES 2187483T3 ES 00954620 T ES00954620 T ES 00954620T ES 00954620 T ES00954620 T ES 00954620T ES 2187483 T3 ES2187483 T3 ES 2187483T3
- Authority
- ES
- Spain
- Prior art keywords
- lipoic acid
- solvent
- alpha
- procedure
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/02—Five-membered rings
- C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Abstract
Procedimiento para la preparación de ácido -lipoico exento de disolvente, caracterizado porque a) Se disuelve el ácido -lipoico a purificar en solución acuosa alcalina, o se disuelven sus sales en agua y se ajusta un valor pH alcalino, b) Se separan de la solución acuosa de la etapa a) las impurificaciones sólidas eventualmente presentes, c) Se ajusta la solución acuosa de la etapa a) o b) a un valor pH de -1,0 a 5,0 con ayuda de un ácido, y d) Se separa el ácido -lipoico precipitado.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19938621A DE19938621A1 (de) | 1999-08-14 | 1999-08-14 | Verfahren zur Herstellung von lösemittelfreier alpha-Liponsäure |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2187483T3 true ES2187483T3 (es) | 2003-06-16 |
Family
ID=7918432
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES00954620T Expired - Lifetime ES2187483T3 (es) | 1999-08-14 | 2000-08-10 | Procedimiento para la preparacion de acido a-lipoico esento de disolvente. |
Country Status (11)
Country | Link |
---|---|
US (1) | US6462202B1 (es) |
EP (1) | EP1202983B1 (es) |
CN (1) | CN1131227C (es) |
AT (1) | ATE231854T1 (es) |
AU (1) | AU6701300A (es) |
CA (1) | CA2380495C (es) |
DE (2) | DE19938621A1 (es) |
DK (1) | DK1202983T3 (es) |
ES (1) | ES2187483T3 (es) |
PT (1) | PT1202983E (es) |
WO (1) | WO2001012620A1 (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1319196B1 (it) * | 2000-10-10 | 2003-09-26 | Laboratorio Chimico Int Spa | Sintesi dell'acido r(+)alfa-lipoico. |
IT1319195B1 (it) * | 2000-10-10 | 2003-09-26 | Laboratorio Chimico Int Spa | Processo per la produzione dell'acido r(+)alfa-lipoico. |
DE10159245A1 (de) * | 2001-12-03 | 2003-06-18 | Degussa | Stabile, saure, wässrige Lösung enthaltend alpha-Liponsäure(-Derivate), Verfahren zu deren Herstellung sowie ihre Verwendung |
DE10201464B4 (de) * | 2002-01-16 | 2005-06-16 | Viatris Gmbh & Co. Kg | Verfahren zur Herstellung reiner Thioctsäure |
ITMI20050466A1 (it) * | 2005-03-22 | 2006-09-23 | Laboratorio Chimico Int Spa | Processo di purificazione in acqua di acido tiottico |
CN100375745C (zh) * | 2005-12-21 | 2008-03-19 | 重庆药友制药有限责任公司 | 硫辛酸的精制方法 |
CN100387593C (zh) * | 2006-01-26 | 2008-05-14 | 南京师范大学 | 连续逆流液液萃取分离二硫辛酸与乙醇及碱水溶液的方法 |
DE102007038849A1 (de) * | 2007-08-16 | 2009-02-19 | Adscil Gmbh | Verwendung von R(+)-alpha-Liponsäure zur Behandlung der kryptogenen Neuropathie |
JP2012510511A (ja) * | 2008-12-01 | 2012-05-10 | インヴアスク セラピューテイックス インコーポレイテッド | レニン−アンジオテンシン−アルドステロン系阻害剤及びリポ酸化合物を含有する組成物、並びに、レニン−アンジオテンシン−アルドステロン系に関連した疾患の治療のためのそれらの使用 |
CN102603709B (zh) * | 2012-03-02 | 2013-09-25 | 海南灵康制药有限公司 | 一种硫辛酸化合物及其制法 |
CN105798322B (zh) * | 2016-03-17 | 2018-04-24 | 湖北大学 | 银纳米簇的制备方法及其应用 |
CN114163418A (zh) * | 2021-12-24 | 2022-03-11 | 山东龙辰药业有限公司 | 一种右旋硫辛酸的合成方法 |
CN115490861B (zh) * | 2022-08-22 | 2023-11-17 | 北京化工大学 | 一种聚硫辛酸可再生高分子材料制备方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19726519A1 (de) | 1997-06-23 | 1998-12-24 | Asta Medica Ag | Verfahren zur Herstellung trockener Thioctsäure |
-
1999
- 1999-08-14 DE DE19938621A patent/DE19938621A1/de not_active Withdrawn
-
2000
- 2000-08-10 CA CA002380495A patent/CA2380495C/en not_active Expired - Fee Related
- 2000-08-10 US US10/030,491 patent/US6462202B1/en not_active Expired - Lifetime
- 2000-08-10 AT AT00954620T patent/ATE231854T1/de active
- 2000-08-10 PT PT00954620T patent/PT1202983E/pt unknown
- 2000-08-10 AU AU67013/00A patent/AU6701300A/en not_active Abandoned
- 2000-08-10 EP EP00954620A patent/EP1202983B1/de not_active Expired - Lifetime
- 2000-08-10 CN CN00808557A patent/CN1131227C/zh not_active Expired - Fee Related
- 2000-08-10 DE DE50001184T patent/DE50001184D1/de not_active Expired - Lifetime
- 2000-08-10 WO PCT/EP2000/007802 patent/WO2001012620A1/de active IP Right Grant
- 2000-08-10 ES ES00954620T patent/ES2187483T3/es not_active Expired - Lifetime
- 2000-08-10 DK DK00954620T patent/DK1202983T3/da active
Also Published As
Publication number | Publication date |
---|---|
US6462202B1 (en) | 2002-10-08 |
CA2380495C (en) | 2006-10-17 |
CA2380495A1 (en) | 2001-02-22 |
EP1202983A1 (de) | 2002-05-08 |
DE19938621A1 (de) | 2001-02-22 |
DK1202983T3 (da) | 2003-05-26 |
AU6701300A (en) | 2001-03-13 |
EP1202983B1 (de) | 2003-01-29 |
DE50001184D1 (de) | 2003-03-06 |
CN1131227C (zh) | 2003-12-17 |
WO2001012620A1 (de) | 2001-02-22 |
PT1202983E (pt) | 2003-06-30 |
CN1354748A (zh) | 2002-06-19 |
ATE231854T1 (de) | 2003-02-15 |
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